Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HEMK1 (HemK methyltransferase family member 1)

Identity

Alias_symbol (synonym)MTQ1
Other aliasHEMK
HGNC (Hugo) HEMK1
LocusID (NCBI) 51409
Atlas_Id 64235
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 50606909 and ends at 50622421 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MAPKAPK3 (3p21.2) / HEMK1 (3p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HEMK1   24923
Cards
Entrez_Gene (NCBI)HEMK1  51409  HemK methyltransferase family member 1
AliasesHEMK; MTQ1
GeneCards (Weizmann)HEMK1
Ensembl hg19 (Hinxton)ENSG00000114735 [Gene_View]  chr3:50606909-50622421 [Contig_View]  HEMK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114735 [Gene_View]  chr3:50606909-50622421 [Contig_View]  HEMK1 [Vega]
ICGC DataPortalENSG00000114735
TCGA cBioPortalHEMK1
AceView (NCBI)HEMK1
Genatlas (Paris)HEMK1
WikiGenes51409
SOURCE (Princeton)HEMK1
Genetics Home Reference (NIH)HEMK1
Genomic and cartography
GoldenPath hg19 (UCSC)HEMK1  -     chr3:50606909-50622421 +  3p21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HEMK1  -     3p21.2   [Description]    (hg38-Dec_2013)
EnsemblHEMK1 - 3p21.2 [CytoView hg19]  HEMK1 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIHEMK1 [Mapview hg19]  HEMK1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF074992 AF131220 AF172244 AK025973 AK124369
RefSeq transcript (Entrez)NM_016173
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)HEMK1
Cluster EST : UnigeneHs.599362 [ NCBI ]
CGAP (NCI)Hs.599362
Alternative Splicing GalleryENSG00000114735
Gene ExpressionHEMK1 [ NCBI-GEO ]   HEMK1 [ EBI - ARRAY_EXPRESS ]   HEMK1 [ SEEK ]   HEMK1 [ MEM ]
Gene Expression Viewer (FireBrowse)HEMK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51409
GTEX Portal (Tissue expression)HEMK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5R4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5R4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5R4
Splice isoforms : SwissVarQ9Y5R4
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ9Y5R4
Domaine pattern : Prosite (Expaxy)N6_MTASE (PS00092)   
Domains : Interpro (EBI)D21N6_MeTrfase    DNA_methylase_N6_adenine_CS    Modification_methylase_HemK    Release_fac_Glu-N5_MeTfrase    SAM-dependent_MTases   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)HEMK1
DMDM Disease mutations51409
Blocks (Seattle)HEMK1
SuperfamilyQ9Y5R4
Human Protein AtlasENSG00000114735
Peptide AtlasQ9Y5R4
HPRD13645
IPIIPI00007739   IPI00926968   IPI00926456   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5R4
IntAct (EBI)Q9Y5R4
FunCoupENSG00000114735
BioGRIDHEMK1
STRING (EMBL)HEMK1
ZODIACHEMK1
Ontologies - Pathways
QuickGOQ9Y5R4
Ontology : AmiGODNA binding  protein binding  mitochondrion  DNA methylation  protein methylation  N-methyltransferase activity  protein methyltransferase activity  
Ontology : EGO-EBIDNA binding  protein binding  mitochondrion  DNA methylation  protein methylation  N-methyltransferase activity  protein methyltransferase activity  
Pathways : KEGGHistidine metabolism    Tyrosine metabolism   
NDEx NetworkHEMK1
Atlas of Cancer Signalling NetworkHEMK1
Wikipedia pathwaysHEMK1
Orthology - Evolution
OrthoDB51409
GeneTree (enSembl)ENSG00000114735
Phylogenetic Trees/Animal Genes : TreeFamHEMK1
HOVERGENQ9Y5R4
HOGENOMQ9Y5R4
Homologs : HomoloGeneHEMK1
Homology/Alignments : Family Browser (UCSC)HEMK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHEMK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HEMK1
dbVarHEMK1
ClinVarHEMK1
1000_GenomesHEMK1 
Exome Variant ServerHEMK1
ExAC (Exome Aggregation Consortium)HEMK1 (select the gene name)
Genetic variants : HAPMAP51409
Genomic Variants (DGV)HEMK1 [DGVbeta]
DECIPHER (Syndromes)3:50606909-50622421  ENSG00000114735
CONAN: Copy Number AnalysisHEMK1 
Mutations
ICGC Data PortalHEMK1 
TCGA Data PortalHEMK1 
Broad Tumor PortalHEMK1
OASIS PortalHEMK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHEMK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHEMK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HEMK1
DgiDB (Drug Gene Interaction Database)HEMK1
DoCM (Curated mutations)HEMK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HEMK1 (select a term)
intoGenHEMK1
Cancer3DHEMK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenHEMK1
Genetic Testing Registry HEMK1
NextProtQ9Y5R4 [Medical]
TSGene51409
GENETestsHEMK1
Huge Navigator HEMK1 [HugePedia]
snp3D : Map Gene to Disease51409
BioCentury BCIQHEMK1
ClinGenHEMK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51409
Chemical/Pharm GKB GenePA134884011
Clinical trialHEMK1
Miscellaneous
canSAR (ICR)HEMK1 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHEMK1
EVEXHEMK1
GoPubMedHEMK1
iHOPHEMK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:07:37 CET 2017

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