HERC2 (hect domain and RLD 2)

Identity

Other names	D15F37S1
	DKFZp547P028
	KIAA0393
	SHEP1
	jdf2
	p528
HGNC	HERC2
Location	15q13
Location_base_pair	Starts at 26029783 and ends at 26240890 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	HERC2   4868
Entrez_Gene	HERC2  8924  hect domain and RLD 2
	Cards
GeneCards	HERC2
Ensembl	HERC2 [Search_View]   ENSG00000128731 [Gene_View]
Genatlas	HERC2
GeneLynx	HERC2
eGenome	HERC2
euGene	8924
	Genomic and cartography
GoldenPath	HERC2  -  15q13   chr15:26029783-26240890 -  15q13.1   [Description]    (hg18-March_2006)
Ensembl	HERC2 - 15q13.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	HERC2
	Gene and transcription
Genbank	AF071172 [ ENTREZ ]
Genbank	AI820017 [ ENTREZ ]
Genbank	AK122977 [ ENTREZ ]
Genbank	AK125229 [ ENTREZ ]
Genbank	AL834183 [ ENTREZ ]
RefSeq	NM_004667 [ SRS ]    NM_004667 [ ENTREZ ]
RefSeq	AC_000058 [ SRS ]    AC_000058 [ ENTREZ ]
RefSeq	AC_000147 [ SRS ]    AC_000147 [ ENTREZ ]
RefSeq	NC_000015 [ SRS ]    NC_000015 [ ENTREZ ]
RefSeq	NT_010280 [ SRS ]    NT_010280 [ ENTREZ ]
RefSeq	NW_001838195 [ SRS ]    NW_001838195 [ ENTREZ ]
RefSeq	NW_925783 [ SRS ]    NW_925783 [ ENTREZ ]
AceView	HERC2 AceView - NCBI
Unigene	Hs.610412 [ SRS ]    Hs.610412 [ NCBI ]     HS610412 [ spliceNest ]
Fast-db	512 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O95714 [ SRS]    O95714 [ EXPASY ]     O95714 [ INTERPRO ]     O95714 [ UNIPROT ]
Prosite	PS00191 CYTOCHROME_B5_1 [ SRS ]    PS00191 CYTOCHROME_B5_1 [ Expasy ]
Prosite	PS50255 CYTOCHROME_B5_2 [ SRS ]    PS50255 CYTOCHROME_B5_2 [ Expasy ]
Prosite	PS51284 DOC [ SRS ]    PS51284 DOC [ Expasy ]
Prosite	PS50237 HECT [ SRS ]    PS50237 HECT [ Expasy ]
Prosite	PS00625 RCC1_1 [ SRS ]    PS00625 RCC1_1 [ Expasy ]
Prosite	PS00626 RCC1_2 [ SRS ]    PS00626 RCC1_2 [ Expasy ]
Prosite	PS50012 RCC1_3 [ SRS ]    PS50012 RCC1_3 [ Expasy ]
Prosite	PS00678 WD_REPEATS_1 [ SRS ]    PS00678 WD_REPEATS_1 [ Expasy ]
Prosite	PS50082 WD_REPEATS_2 [ SRS ]    PS50082 WD_REPEATS_2 [ Expasy ]
Prosite	PS50294 WD_REPEATS_REGION [ SRS ]    PS50294 WD_REPEATS_REGION [ Expasy ]
Prosite	PS01357 ZF_ZZ_1 [ SRS ]    PS01357 ZF_ZZ_1 [ Expasy ]
Prosite	PS50135 ZF_ZZ_2 [ SRS ]    PS50135 ZF_ZZ_2 [ Expasy ]
Interpro	IPR001199 Cyt_B5 [ SRS ]    IPR001199 Cyt_B5 [ EBI ]
Interpro	IPR000569 HECT [ SRS ]    IPR000569 HECT [ EBI ]
Interpro	IPR010606 MIB_HERC2 [ SRS ]    IPR010606 MIB_HERC2 [ EBI ]
Interpro	IPR000408 Reg_chr_condens [ SRS ]    IPR000408 Reg_chr_condens [ EBI ]
Interpro	IPR009091 Reg_csome_cond/b-lactamase_inh [ SRS ]    IPR009091 Reg_csome_cond/b-lactamase_inh [ EBI ]
Interpro	IPR006624 TECPR [ SRS ]    IPR006624 TECPR [ EBI ]
Interpro	IPR001680 WD40_repeat [ SRS ]    IPR001680 WD40_repeat [ EBI ]
Interpro	IPR000433 Znf_ZZ [ SRS ]    IPR000433 Znf_ZZ [ EBI ]
CluSTr	O95714
Pfam	PF00173 Cyt-b5 [ SRS ]    PF00173 Cyt-b5 [ Sanger ]    pfam00173 [ NCBI-CDD ]
Pfam	PF00632 HECT [ SRS ]    PF00632 HECT [ Sanger ]    pfam00632 [ NCBI-CDD ]
Pfam	PF06701 MIB_HERC2 [ SRS ]    PF06701 MIB_HERC2 [ Sanger ]    pfam06701 [ NCBI-CDD ]
Pfam	PF00415 RCC1 [ SRS ]    PF00415 RCC1 [ Sanger ]    pfam00415 [ NCBI-CDD ]
Pfam	PF00569 ZZ [ SRS ]    PF00569 ZZ [ Sanger ]    pfam00569 [ NCBI-CDD ]
Smart	SM00119 HECTc [EMBL]
Smart	SM00706 TECPR [EMBL]
Smart	SM00291 ZnF_ZZ [EMBL]
Prodom	PD000612 Cyt_B5[INRA-Toulouse]
Prodom	O95714 HERC2_HUMAN [ Domain structure ]   O95714 HERC2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O95714
HPRD	06905
	Protein Interaction databases
DIP	O95714
IntAct	O95714
	Polymorphism : SNP, mutations, diseases
OMIM	227220;605837    [ map ]
GENECLINICS	227220;605837
SNP	HERC2 [dbSNP-NCBI]
SNP	NM_004667 [SNP-NCI]
SNP	HERC2 [GeneSNPs - Utah]  HERC2] [HGBASE - SRS]
HAPMAP	HERC2 [HAPMAP]
COSMIC	HERC2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	HERC2
	General knowledge
Family Browser	HERC2 [UCSC Family Browser]
SOURCE	NM_004667
SMD	Hs.610412
SAGE	Hs.610412
Enzyme	6.3.2.- [ Enzyme-Expasy ]   6.3.2.- [ Enzyme-SRS ]   6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   6.3.2.- [ WIT ]
GO	ubiquitin-protein ligase activity [Amigo]  ubiquitin-protein ligase activity
GO	ubiquitin-protein ligase activity [Amigo]  ubiquitin-protein ligase activity
GO	guanyl-nucleotide exchange factor activity [Amigo]  guanyl-nucleotide exchange factor activity
GO	cellular_component [Amigo]  cellular_component
GO	intracellular [Amigo]  intracellular
GO	protein modification process [Amigo]  protein modification process
GO	protein modification process [Amigo]  protein modification process
GO	intracellular protein transport [Amigo]  intracellular protein transport
GO	zinc ion binding [Amigo]  zinc ion binding
GO	ligase activity [Amigo]  ligase activity
GO	heme binding [Amigo]  heme binding
KEGG	Ubiquitin mediated proteolysis
PubGene	HERC2
TreeFam	HERC2
CTD	8924 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	HERC2 Related clones (RZPD - Berlin)
	PubMed
PubMed	19 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:44:33 2008