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HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3)

Identity

Alias_nameshect domain and RLD 3
Alias_symbol (synonym)KIAA0032
Other alias-
HGNC (Hugo) HERC3
LocusID (NCBI) 8916
Atlas_Id 47468
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 89513574 and ends at 89629693 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAPN14 (2p23.1) / HERC3 (4q22.1)EPCAM (2p21) / HERC3 (4q22.1)HERC3 (4q22.1) / FAM13A-AS1 (4q22.1)
HERC3 (4q22.1) / FAM13AOS ()HERC3 (4q22.1) / NGLY1 (3p24.2)HERC3 (4q22.1) / PSPH (7p11.2)
HERC3 (4q22.1) / STRAP (12p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HERC3   4876
Cards
Entrez_Gene (NCBI)HERC3  8916  HECT and RLD domain containing E3 ubiquitin protein ligase 3
Aliases
GeneCards (Weizmann)HERC3
Ensembl hg19 (Hinxton)ENSG00000138641 [Gene_View]  chr4:89513574-89629693 [Contig_View]  HERC3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000138641 [Gene_View]  chr4:89513574-89629693 [Contig_View]  HERC3 [Vega]
ICGC DataPortalENSG00000138641
TCGA cBioPortalHERC3
AceView (NCBI)HERC3
Genatlas (Paris)HERC3
WikiGenes8916
SOURCE (Princeton)HERC3
Genetics Home Reference (NIH)HERC3
Genomic and cartography
GoldenPath hg19 (UCSC)HERC3  -     chr4:89513574-89629693 +  4q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HERC3  -     4q22.1   [Description]    (hg38-Dec_2013)
EnsemblHERC3 - 4q22.1 [CytoView hg19]  HERC3 - 4q22.1 [CytoView hg38]
Mapping of homologs : NCBIHERC3 [Mapview hg19]  HERC3 [Mapview hg38]
OMIM605200   
Gene and transcription
Genbank (Entrez)AK289990 AK296379 AK296397 BC038960 BC166672
RefSeq transcript (Entrez)NM_001271602 NM_001318505 NM_014606
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)HERC3
Cluster EST : UnigeneHs.35804 [ NCBI ]
CGAP (NCI)Hs.35804
Alternative Splicing GalleryENSG00000138641
Gene ExpressionHERC3 [ NCBI-GEO ]   HERC3 [ EBI - ARRAY_EXPRESS ]   HERC3 [ SEEK ]   HERC3 [ MEM ]
Gene Expression Viewer (FireBrowse)HERC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8916
GTEX Portal (Tissue expression)HERC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15034   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15034  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15034
Splice isoforms : SwissVarQ15034
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ15034
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    RCC1_2 (PS00626)    RCC1_3 (PS50012)   
Domains : Interpro (EBI)HECT_dom    RCC1/BLIP-II    Reg_chr_condens   
Domain families : Pfam (Sanger)HECT (PF00632)    RCC1 (PF00415)   
Domain families : Pfam (NCBI)pfam00632    pfam00415   
Domain families : Smart (EMBL)HECTc (SM00119)  
Conserved Domain (NCBI)HERC3
DMDM Disease mutations8916
Blocks (Seattle)HERC3
SuperfamilyQ15034
Human Protein AtlasENSG00000138641
Peptide AtlasQ15034
HPRD16093
IPIIPI00014216   IPI00966754   IPI00879301   IPI00879769   IPI00879618   IPI00880066   IPI00879907   IPI01011616   
Protein Interaction databases
DIP (DOE-UCLA)Q15034
IntAct (EBI)Q15034
FunCoupENSG00000138641
BioGRIDHERC3
STRING (EMBL)HERC3
ZODIACHERC3
Ontologies - Pathways
QuickGOQ15034
Ontology : AmiGOubiquitin-protein transferase activity  nucleus  cytoplasm  cytoplasmic, membrane-bounded vesicle  ligase activity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIubiquitin-protein transferase activity  nucleus  cytoplasm  cytoplasmic, membrane-bounded vesicle  ligase activity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkHERC3
Atlas of Cancer Signalling NetworkHERC3
Wikipedia pathwaysHERC3
Orthology - Evolution
OrthoDB8916
GeneTree (enSembl)ENSG00000138641
Phylogenetic Trees/Animal Genes : TreeFamHERC3
HOVERGENQ15034
HOGENOMQ15034
Homologs : HomoloGeneHERC3
Homology/Alignments : Family Browser (UCSC)HERC3
Gene fusions - Rearrangements
Fusion : MitelmanHERC3/FAM13A-AS1 [4q22.1/4q22.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHERC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HERC3
dbVarHERC3
ClinVarHERC3
1000_GenomesHERC3 
Exome Variant ServerHERC3
ExAC (Exome Aggregation Consortium)HERC3 (select the gene name)
Genetic variants : HAPMAP8916
Genomic Variants (DGV)HERC3 [DGVbeta]
DECIPHER (Syndromes)4:89513574-89629693  ENSG00000138641
CONAN: Copy Number AnalysisHERC3 
Mutations
ICGC Data PortalHERC3 
TCGA Data PortalHERC3 
Broad Tumor PortalHERC3
OASIS PortalHERC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHERC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHERC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HERC3
DgiDB (Drug Gene Interaction Database)HERC3
DoCM (Curated mutations)HERC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HERC3 (select a term)
intoGenHERC3
Cancer3DHERC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605200   
Orphanet
MedgenHERC3
Genetic Testing Registry HERC3
NextProtQ15034 [Medical]
TSGene8916
GENETestsHERC3
Huge Navigator HERC3 [HugePedia]
snp3D : Map Gene to Disease8916
BioCentury BCIQHERC3
ClinGenHERC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8916
Chemical/Pharm GKB GenePA29251
Clinical trialHERC3
Miscellaneous
canSAR (ICR)HERC3 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHERC3
EVEXHERC3
GoPubMedHERC3
iHOPHERC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:03:36 CEST 2017

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