HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3)

2007-04-01  

Identity

HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 8916
MIM: 605200
HGNC: 4876
Ensembl: ENSG00000287542

Variants:

dbSNP: 8916
ClinVar: 8916
TCGA: ENSG00000287542
COSMIC: HERC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000287542ENST00000512194H0Y8G9

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
264764522015The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation.11
221242662011Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.8
298808572018ΔNp63α down-regulates c-Myc modulator MM1 via E3 ligase HERC3 in the regulation of cell senescence.4

Citation

Dessen P

HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47468/herc3