Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8916
MIM: 605200
HGNC: 4876
Ensembl: ENSG00000287542
Variants:
dbSNP: 8916
ClinVar: 8916
TCGA: ENSG00000287542
COSMIC: HERC3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000287542 | ENST00000512194 | H0Y8G9 |
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38722278 | 2024 | HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains. | 0 |
| 38722278 | 2024 | HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains. | 0 |
| 36598329 | 2023 | HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity. | 7 |
| 36598329 | 2023 | HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity. | 7 |
| 35064108 | 2022 | HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer. | 13 |
| 35637966 | 2022 | HERC3 directly targets RPL23A for ubiquitination degradation and further regulates Colorectal Cancer proliferation and the cell cycle. | 11 |
| 35064108 | 2022 | HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer. | 13 |
| 35637966 | 2022 | HERC3 directly targets RPL23A for ubiquitination degradation and further regulates Colorectal Cancer proliferation and the cell cycle. | 11 |
| 30862693 | 2019 | HERC3-Mediated SMAD7 Ubiquitination Degradation Promotes Autophagy-Induced EMT and Chemoresistance in Glioblastoma. | 57 |
| 30862693 | 2019 | HERC3-Mediated SMAD7 Ubiquitination Degradation Promotes Autophagy-Induced EMT and Chemoresistance in Glioblastoma. | 57 |
| 29880857 | 2018 | ΔNp63α down-regulates c-Myc modulator MM1 via E3 ligase HERC3 in the regulation of cell senescence. | 20 |
| 29880857 | 2018 | ΔNp63α down-regulates c-Myc modulator MM1 via E3 ligase HERC3 in the regulation of cell senescence. | 20 |
| 26476452 | 2015 | The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. | 20 |
| 26476452 | 2015 | The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. | 20 |
| 22124266 | 2011 | Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability. | 16 |
Citation
Dessen P
HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47468/herc3
