Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4)

Identity

Alias_nameshect domain and RLD 4
Alias_symbol (synonym)DKFZP564G092
KIAA1593
Other alias-
HGNC (Hugo) HERC4
LocusID (NCBI) 26091
Atlas_Id 46857
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 67921899 and ends at 68075346 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTNNA3 (10q21.3) / HERC4 (10q21.3)HERC4 (10q21.3) / CDKAL1 (6p22.3)HERC4 (10q21.3) / CTNNA3 (10q21.3)
HERC4 (10q21.3) / RACK1 (5q35.3)HERC4 (10q21.3) / RUFY2 (10q21.3)THUMPD1 (16p12.3) / HERC4 (10q21.3)
HERC4 10q21.3 / CDKAL1 6p22.3HERC4 10q21.3 / CTNNA3 10q21.3HERC4 10q21.3 / RUFY2 10q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HERC4   24521
Cards
Entrez_Gene (NCBI)HERC4  26091  HECT and RLD domain containing E3 ubiquitin protein ligase 4
Aliases
GeneCards (Weizmann)HERC4
Ensembl hg19 (Hinxton)ENSG00000148634 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148634 [Gene_View]  chr10:67921899-68075346 [Contig_View]  HERC4 [Vega]
ICGC DataPortalENSG00000148634
TCGA cBioPortalHERC4
AceView (NCBI)HERC4
Genatlas (Paris)HERC4
WikiGenes26091
SOURCE (Princeton)HERC4
Genetics Home Reference (NIH)HERC4
Genomic and cartography
GoldenPath hg38 (UCSC)HERC4  -     chr10:67921899-68075346 -  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HERC4  -     10q21.3   [Description]    (hg19-Feb_2009)
EnsemblHERC4 - 10q21.3 [CytoView hg19]  HERC4 - 10q21.3 [CytoView hg38]
Mapping of homologs : NCBIHERC4 [Mapview hg19]  HERC4 [Mapview hg38]
OMIM609248   
Gene and transcription
Genbank (Entrez)AB046813 AK021844 AK026808 AK027835 AK292809
RefSeq transcript (Entrez)NM_001017972 NM_001278185 NM_001278186 NM_001278187 NM_015601 NM_022079
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HERC4
Cluster EST : UnigeneHs.51891 [ NCBI ]
CGAP (NCI)Hs.51891
Alternative Splicing GalleryENSG00000148634
Gene ExpressionHERC4 [ NCBI-GEO ]   HERC4 [ EBI - ARRAY_EXPRESS ]   HERC4 [ SEEK ]   HERC4 [ MEM ]
Gene Expression Viewer (FireBrowse)HERC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26091
GTEX Portal (Tissue expression)HERC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5GLZ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5GLZ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5GLZ8
Splice isoforms : SwissVarQ5GLZ8
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   
PhosPhoSitePlusQ5GLZ8
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    RCC1_2 (PS00626)    RCC1_3 (PS50012)   
Domains : Interpro (EBI)HECT_dom    RCC1/BLIP-II    Reg_chr_condens   
Domain families : Pfam (Sanger)HECT (PF00632)    RCC1 (PF00415)   
Domain families : Pfam (NCBI)pfam00632    pfam00415   
Domain families : Smart (EMBL)HECTc (SM00119)  
Conserved Domain (NCBI)HERC4
DMDM Disease mutations26091
Blocks (Seattle)HERC4
SuperfamilyQ5GLZ8
Human Protein AtlasENSG00000148634
Peptide AtlasQ5GLZ8
HPRD13646
IPIIPI00333067   IPI00604497   IPI00827948   IPI00827992   IPI00552050   IPI00827523   IPI00963823   IPI00965869   IPI00965070   
Protein Interaction databases
DIP (DOE-UCLA)Q5GLZ8
IntAct (EBI)Q5GLZ8
FunCoupENSG00000148634
BioGRIDHERC4
STRING (EMBL)HERC4
ZODIACHERC4
Ontologies - Pathways
QuickGOQ5GLZ8
Ontology : AmiGOfibrillar center  ubiquitin-protein transferase activity  cytosol  spermatogenesis  protein ubiquitination  cell differentiation  
Ontology : EGO-EBIfibrillar center  ubiquitin-protein transferase activity  cytosol  spermatogenesis  protein ubiquitination  cell differentiation  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkHERC4
Atlas of Cancer Signalling NetworkHERC4
Wikipedia pathwaysHERC4
Orthology - Evolution
OrthoDB26091
GeneTree (enSembl)ENSG00000148634
Phylogenetic Trees/Animal Genes : TreeFamHERC4
HOVERGENQ5GLZ8
HOGENOMQ5GLZ8
Homologs : HomoloGeneHERC4
Homology/Alignments : Family Browser (UCSC)HERC4
Gene fusions - Rearrangements
Fusion : MitelmanHERC4/CDKAL1 [10q21.3/6p22.3]  
Fusion : MitelmanHERC4/CTNNA3 [10q21.3/10q21.3]  [t(10;10)(q21;q21)]  
Fusion : MitelmanHERC4/RUFY2 [10q21.3/10q21.3]  [t(10;10)(q21;q21)]  
Fusion: TCGAHERC4 10q21.3 CDKAL1 6p22.3 BLCA
Fusion: TCGAHERC4 10q21.3 CTNNA3 10q21.3 HNSC
Fusion: TCGAHERC4 10q21.3 RUFY2 10q21.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHERC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HERC4
dbVarHERC4
ClinVarHERC4
1000_GenomesHERC4 
Exome Variant ServerHERC4
ExAC (Exome Aggregation Consortium)HERC4 (select the gene name)
Genetic variants : HAPMAP26091
Genomic Variants (DGV)HERC4 [DGVbeta]
DECIPHERHERC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHERC4 
Mutations
ICGC Data PortalHERC4 
TCGA Data PortalHERC4 
Broad Tumor PortalHERC4
OASIS PortalHERC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHERC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHERC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HERC4
DgiDB (Drug Gene Interaction Database)HERC4
DoCM (Curated mutations)HERC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HERC4 (select a term)
intoGenHERC4
Cancer3DHERC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609248   
Orphanet
MedgenHERC4
Genetic Testing Registry HERC4
NextProtQ5GLZ8 [Medical]
TSGene26091
GENETestsHERC4
Target ValidationHERC4
Huge Navigator HERC4 [HugePedia]
snp3D : Map Gene to Disease26091
BioCentury BCIQHERC4
ClinGenHERC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26091
Chemical/Pharm GKB GenePA134949021
Clinical trialHERC4
Miscellaneous
canSAR (ICR)HERC4 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHERC4
EVEXHERC4
GoPubMedHERC4
iHOPHERC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:36:39 CEST 2017

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