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HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4)

Identity

Alias (NCBI)-
HGNC (Hugo) HERC4
HGNC Alias symbDKFZP564G092
KIAA1593
HGNC Previous namehect domain and RLD 4
LocusID (NCBI) 26091
Atlas_Id 46857
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 67921906 and ends at 68075283 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTNNA3 (10q21.3) / HERC4 (10q21.3)HERC4 (10q21.3) / CDKAL1 (6p22.3)HERC4 (10q21.3) / CTNNA3 (10q21.3)
HERC4 (10q21.3) / RACK1 (5q35.3)HERC4 (10q21.3) / RUFY2 (10q21.3)THUMPD1 (16p12.3) / HERC4 (10q21.3)
HERC4 10q21.3 / CDKAL1 6p22.3HERC4 10q21.3 / CTNNA3 10q21.3HERC4 10q21.3 / RUFY2 10q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HERC4   24521
Cards
Entrez_Gene (NCBI)HERC4    HECT and RLD domain containing E3 ubiquitin protein ligase 4
Aliases
GeneCards (Weizmann)HERC4
Ensembl hg19 (Hinxton)ENSG00000148634 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148634 [Gene_View]  ENSG00000148634 [Sequence]  chr10:67921906-68075283 [Contig_View]  HERC4 [Vega]
ICGC DataPortalENSG00000148634
TCGA cBioPortalHERC4
AceView (NCBI)HERC4
Genatlas (Paris)HERC4
SOURCE (Princeton)HERC4
Genetics Home Reference (NIH)HERC4
Genomic and cartography
GoldenPath hg38 (UCSC)HERC4  -     chr10:67921906-68075283 -  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HERC4  -     10q21.3   [Description]    (hg19-Feb_2009)
GoldenPathHERC4 - 10q21.3 [CytoView hg19]  HERC4 - 10q21.3 [CytoView hg38]
ImmunoBaseENSG00000148634
Genome Data Viewer NCBIHERC4 [Mapview hg19]  
OMIM609248   
Gene and transcription
Genbank (Entrez)AB046813 AK021844 AK026808 AK027835 AK292809
RefSeq transcript (Entrez)NM_001017972 NM_001278185 NM_001278186 NM_001278187 NM_015601 NM_022079
Consensus coding sequences : CCDS (NCBI)HERC4
Gene ExpressionHERC4 [ NCBI-GEO ]   HERC4 [ EBI - ARRAY_EXPRESS ]   HERC4 [ SEEK ]   HERC4 [ MEM ]
Gene Expression Viewer (FireBrowse)HERC4 [ Firebrowse - Broad ]
GenevisibleExpression of HERC4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26091
GTEX Portal (Tissue expression)HERC4
Human Protein AtlasENSG00000148634-HERC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5GLZ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5GLZ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5GLZ8
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ5GLZ8
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    RCC1_2 (PS00626)    RCC1_3 (PS50012)   
Domains : Interpro (EBI)HECT_dom    Hect_E3_ubiquitin_ligase    RCC1/BLIP-II    Reg_chr_condens   
Domain families : Pfam (Sanger)HECT (PF00632)    RCC1 (PF00415)   
Domain families : Pfam (NCBI)pfam00632    pfam00415   
Domain families : Smart (EMBL)HECTc (SM00119)  
Conserved Domain (NCBI)HERC4
SuperfamilyQ5GLZ8
AlphaFold pdb e-kbQ5GLZ8   
Human Protein Atlas [tissue]ENSG00000148634-HERC4 [tissue]
HPRD13646
Protein Interaction databases
DIP (DOE-UCLA)Q5GLZ8
IntAct (EBI)Q5GLZ8
BioGRIDHERC4
STRING (EMBL)HERC4
ZODIACHERC4
Ontologies - Pathways
QuickGOQ5GLZ8
Ontology : AmiGOfibrillar center  ubiquitin-protein transferase activity  cytosol  spermatogenesis  protein ubiquitination  cell differentiation  negative regulation of smoothened signaling pathway  
Ontology : EGO-EBIfibrillar center  ubiquitin-protein transferase activity  cytosol  spermatogenesis  protein ubiquitination  cell differentiation  negative regulation of smoothened signaling pathway  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkHERC4
Atlas of Cancer Signalling NetworkHERC4
Wikipedia pathwaysHERC4
Orthology - Evolution
OrthoDB26091
GeneTree (enSembl)ENSG00000148634
Phylogenetic Trees/Animal Genes : TreeFamHERC4
Homologs : HomoloGeneHERC4
Homology/Alignments : Family Browser (UCSC)HERC4
Gene fusions - Rearrangements
Fusion : MitelmanHERC4/CDKAL1 [10q21.3/6p22.3]  
Fusion : MitelmanHERC4/CTNNA3 [10q21.3/10q21.3]  
Fusion : MitelmanHERC4/RUFY2 [10q21.3/10q21.3]  
Fusion : QuiverHERC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHERC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HERC4
dbVarHERC4
ClinVarHERC4
MonarchHERC4
1000_GenomesHERC4 
Exome Variant ServerHERC4
GNOMAD BrowserENSG00000148634
Varsome BrowserHERC4
ACMGHERC4 variants
VarityQ5GLZ8
Genomic Variants (DGV)HERC4 [DGVbeta]
DECIPHERHERC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHERC4 
Mutations
ICGC Data PortalHERC4 
TCGA Data PortalHERC4 
Broad Tumor PortalHERC4
OASIS PortalHERC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHERC4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHERC4
Mutations and Diseases : HGMDHERC4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHERC4
DgiDB (Drug Gene Interaction Database)HERC4
DoCM (Curated mutations)HERC4
CIViC (Clinical Interpretations of Variants in Cancer)HERC4
Cancer3DHERC4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609248   
Orphanet
DisGeNETHERC4
MedgenHERC4
Genetic Testing Registry HERC4
NextProtQ5GLZ8 [Medical]
GENETestsHERC4
Target ValidationHERC4
Huge Navigator HERC4 [HugePedia]
ClinGenHERC4
Clinical trials, drugs, therapy
MyCancerGenomeHERC4
Protein Interactions : CTDHERC4
Pharm GKB GenePA134949021
PharosQ5GLZ8
Clinical trialHERC4
Miscellaneous
canSAR (ICR)HERC4
HarmonizomeHERC4
DataMed IndexHERC4
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHERC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:17 CEST 2021

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