HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4)

2007-04-01  

Identity

HGNC
LOCATION
10q21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 26091
MIM: 609248
HGNC: 24521
Ensembl: ENSG00000148634

Variants:

dbSNP: 26091
ClinVar: 26091
TCGA: ENSG00000148634
COSMIC: HERC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148634ENST00000277817Q5GLZ8
ENSG00000148634ENST00000373700Q5GLZ8
ENSG00000148634ENST00000373700A0A024QZN8
ENSG00000148634ENST00000395198Q5GLZ8
ENSG00000148634ENST00000412272Q5GLZ8
ENSG00000148634ENST00000427635H0Y6K7
ENSG00000148634ENST00000473533Q5GLZ8
ENSG00000148634ENST00000492996Q5GLZ8
ENSG00000148634ENST00000506515D6RFK9
ENSG00000148634ENST00000513996D6RCL5

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
156762742005The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.27
256844802015Expression of HERC4 in lung cancer and its correlation with clinicopathological parameters.5
284305272017HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells.3
288567242018SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis.3
307103192019A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.2

Citation

Dessen P

HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46857/herc4