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HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6)

Identity

Alias_nameshect domain and RLD 6
Alias_symbol (synonym)FLJ20637
Other alias-
HGNC (Hugo) HERC6
LocusID (NCBI) 55008
Atlas_Id 47372
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 88378739 and ends at 88443097 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HERC6 (4q22.1) / LRBA (4q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HERC6   26072
Cards
Entrez_Gene (NCBI)HERC6  55008  HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
Aliases
GeneCards (Weizmann)HERC6
Ensembl hg19 (Hinxton)ENSG00000138642 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138642 [Gene_View]  chr4:88378739-88443097 [Contig_View]  HERC6 [Vega]
ICGC DataPortalENSG00000138642
TCGA cBioPortalHERC6
AceView (NCBI)HERC6
Genatlas (Paris)HERC6
WikiGenes55008
SOURCE (Princeton)HERC6
Genetics Home Reference (NIH)HERC6
Genomic and cartography
GoldenPath hg38 (UCSC)HERC6  -     chr4:88378739-88443097 +  4q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HERC6  -     4q22.1   [Description]    (hg19-Feb_2009)
EnsemblHERC6 - 4q22.1 [CytoView hg19]  HERC6 - 4q22.1 [CytoView hg38]
Mapping of homologs : NCBIHERC6 [Mapview hg19]  HERC6 [Mapview hg38]
OMIM609249   
Gene and transcription
Genbank (Entrez)AF336798 AK000644 AK092403 AK097168 AK225506
RefSeq transcript (Entrez)NM_001013000 NM_001013002 NM_001013005 NM_001165136 NM_017912
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HERC6
Cluster EST : UnigeneHs.529317 [ NCBI ]
CGAP (NCI)Hs.529317
Alternative Splicing GalleryENSG00000138642
Gene ExpressionHERC6 [ NCBI-GEO ]   HERC6 [ EBI - ARRAY_EXPRESS ]   HERC6 [ SEEK ]   HERC6 [ MEM ]
Gene Expression Viewer (FireBrowse)HERC6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55008
GTEX Portal (Tissue expression)HERC6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVU3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVU3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVU3
Splice isoforms : SwissVarQ8IVU3
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   
PhosPhoSitePlusQ8IVU3
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    RCC1_2 (PS00626)    RCC1_3 (PS50012)   
Domains : Interpro (EBI)HECT_dom    RCC1/BLIP-II    Reg_chr_condens   
Domain families : Pfam (Sanger)HECT (PF00632)    RCC1 (PF00415)   
Domain families : Pfam (NCBI)pfam00632    pfam00415   
Domain families : Smart (EMBL)HECTc (SM00119)  
Conserved Domain (NCBI)HERC6
DMDM Disease mutations55008
Blocks (Seattle)HERC6
SuperfamilyQ8IVU3
Human Protein AtlasENSG00000138642
Peptide AtlasQ8IVU3
HPRD13647
IPIIPI00455627   IPI00554785   IPI00168048   IPI00942513   IPI01010470   IPI00964636   IPI00964262   
Protein Interaction databases
DIP (DOE-UCLA)Q8IVU3
IntAct (EBI)Q8IVU3
FunCoupENSG00000138642
BioGRIDHERC6
STRING (EMBL)HERC6
ZODIACHERC6
Ontologies - Pathways
QuickGOQ8IVU3
Ontology : AmiGOprotein polyubiquitination  hematopoietic progenitor cell differentiation  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  nucleus  cytosol  cytosol  
Ontology : EGO-EBIprotein polyubiquitination  hematopoietic progenitor cell differentiation  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  nucleus  cytosol  cytosol  
NDEx NetworkHERC6
Atlas of Cancer Signalling NetworkHERC6
Wikipedia pathwaysHERC6
Orthology - Evolution
OrthoDB55008
GeneTree (enSembl)ENSG00000138642
Phylogenetic Trees/Animal Genes : TreeFamHERC6
HOVERGENQ8IVU3
HOGENOMQ8IVU3
Homologs : HomoloGeneHERC6
Homology/Alignments : Family Browser (UCSC)HERC6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHERC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HERC6
dbVarHERC6
ClinVarHERC6
1000_GenomesHERC6 
Exome Variant ServerHERC6
ExAC (Exome Aggregation Consortium)HERC6 (select the gene name)
Genetic variants : HAPMAP55008
Genomic Variants (DGV)HERC6 [DGVbeta]
DECIPHERHERC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHERC6 
Mutations
ICGC Data PortalHERC6 
TCGA Data PortalHERC6 
Broad Tumor PortalHERC6
OASIS PortalHERC6 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHERC6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HERC6
DgiDB (Drug Gene Interaction Database)HERC6
DoCM (Curated mutations)HERC6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HERC6 (select a term)
intoGenHERC6
Cancer3DHERC6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609249   
Orphanet
MedgenHERC6
Genetic Testing Registry HERC6
NextProtQ8IVU3 [Medical]
TSGene55008
GENETestsHERC6
Target ValidationHERC6
Huge Navigator HERC6 [HugePedia]
snp3D : Map Gene to Disease55008
BioCentury BCIQHERC6
ClinGenHERC6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55008
Chemical/Pharm GKB GenePA134894313
Clinical trialHERC6
Miscellaneous
canSAR (ICR)HERC6 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHERC6
EVEXHERC6
GoPubMedHERC6
iHOPHERC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:02:53 CEST 2017

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