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HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1)

Identity

Alias (NCBI)HERP
Mif1
SUP
HGNC (Hugo) HERPUD1
HGNC Alias symbKIAA0025
Mif1
HERP
SUP
HGNC Previous namehomocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
LocusID (NCBI) 9709
Atlas_Id 53491
Location 16q13  [Link to chromosome band 16q13]
Location_base_pair Starts at 56932142 and ends at 56944864 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERG (21q22.2) / HERPUD1 (16q13)FUBP3 (9q34.11) / HERPUD1 (16q13)HERPUD1 (16q13) / BRAF (7q34)
HERPUD1 (16q13) / ERG (21q22.2)USP34 (2p15) / HERPUD1 (16q13)WDR77 (1p13.2) / HERPUD1 (16q13)
HERPUD1 16q13 / BRAF 7q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HERPUD1   13744
Cards
Entrez_Gene (NCBI)HERPUD1    homocysteine inducible ER protein with ubiquitin like domain 1
AliasesHERP; Mif1; SUP
GeneCards (Weizmann)HERPUD1
Ensembl hg19 (Hinxton)ENSG00000051108 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000051108 [Gene_View]  ENSG00000051108 [Sequence]  chr16:56932142-56944864 [Contig_View]  HERPUD1 [Vega]
ICGC DataPortalENSG00000051108
TCGA cBioPortalHERPUD1
AceView (NCBI)HERPUD1
Genatlas (Paris)HERPUD1
SOURCE (Princeton)HERPUD1
Genetics Home Reference (NIH)HERPUD1
Genomic and cartography
GoldenPath hg38 (UCSC)HERPUD1  -     chr16:56932142-56944864 +  16q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HERPUD1  -     16q13   [Description]    (hg19-Feb_2009)
GoldenPathHERPUD1 - 16q13 [CytoView hg19]  HERPUD1 - 16q13 [CytoView hg38]
ImmunoBaseENSG00000051108
Genome Data Viewer NCBIHERPUD1 [Mapview hg19]  
OMIM608070   
Gene and transcription
Genbank (Entrez)AB034989 AF055001 AF055003 AF217990 AK223233
RefSeq transcript (Entrez)NM_001010989 NM_001010990 NM_001272103 NM_014685
Consensus coding sequences : CCDS (NCBI)HERPUD1
Gene ExpressionHERPUD1 [ NCBI-GEO ]   HERPUD1 [ EBI - ARRAY_EXPRESS ]   HERPUD1 [ SEEK ]   HERPUD1 [ MEM ]
Gene Expression Viewer (FireBrowse)HERPUD1 [ Firebrowse - Broad ]
GenevisibleExpression of HERPUD1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9709
GTEX Portal (Tissue expression)HERPUD1
Human Protein AtlasENSG00000051108-HERPUD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15011   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15011  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15011
PhosPhoSitePlusQ15011
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)HERPUD1/2    Ubiquitin-like_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)HERPUD1
PDB (RSDB)1WGD   
PDB Europe1WGD   
PDB (PDBSum)1WGD   
PDB (IMB)1WGD   
Structural Biology KnowledgeBase1WGD   
SCOP (Structural Classification of Proteins)1WGD   
CATH (Classification of proteins structures)1WGD   
SuperfamilyQ15011
AlphaFold pdb e-kbQ15011   
Human Protein Atlas [tissue]ENSG00000051108-HERPUD1 [tissue]
HPRD07456
Protein Interaction databases
DIP (DOE-UCLA)Q15011
IntAct (EBI)Q15011
BioGRIDHERPUD1
STRING (EMBL)HERPUD1
ZODIACHERPUD1
Ontologies - Pathways
QuickGOQ15011
Ontology : AmiGOmolecular_function  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  ubiquitin-dependent protein catabolic process  response to unfolded protein  membrane  integral component of membrane  protein ubiquitination  ubiquitin-dependent ERAD pathway  endoplasmic reticulum unfolded protein response  retrograde protein transport, ER to cytosol  regulation of protein ubiquitination  endoplasmic reticulum calcium ion homeostasis  endoplasmic reticulum calcium ion homeostasis  response to endoplasmic reticulum stress  PERK-mediated unfolded protein response  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  endoplasmic reticulum quality control compartment  ion channel binding  ion channel binding  protein targeting to ER  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  regulation of ER-associated ubiquitin-dependent protein catabolic process  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  Lewy body core  ubiquitin ligase-substrate adaptor activity  negative regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBImolecular_function  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  ubiquitin-dependent protein catabolic process  response to unfolded protein  membrane  integral component of membrane  protein ubiquitination  ubiquitin-dependent ERAD pathway  endoplasmic reticulum unfolded protein response  retrograde protein transport, ER to cytosol  regulation of protein ubiquitination  endoplasmic reticulum calcium ion homeostasis  endoplasmic reticulum calcium ion homeostasis  response to endoplasmic reticulum stress  PERK-mediated unfolded protein response  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  endoplasmic reticulum quality control compartment  ion channel binding  ion channel binding  protein targeting to ER  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  regulation of ER-associated ubiquitin-dependent protein catabolic process  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  Lewy body core  ubiquitin ligase-substrate adaptor activity  negative regulation of intrinsic apoptotic signaling pathway  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkHERPUD1
Atlas of Cancer Signalling NetworkHERPUD1
Wikipedia pathwaysHERPUD1
Orthology - Evolution
OrthoDB9709
GeneTree (enSembl)ENSG00000051108
Phylogenetic Trees/Animal Genes : TreeFamHERPUD1
Homologs : HomoloGeneHERPUD1
Homology/Alignments : Family Browser (UCSC)HERPUD1
Gene fusions - Rearrangements
Fusion : MitelmanHERPUD1/ERG [16q13/21q22.2]  
Fusion : QuiverHERPUD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHERPUD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HERPUD1
dbVarHERPUD1
ClinVarHERPUD1
MonarchHERPUD1
1000_GenomesHERPUD1 
Exome Variant ServerHERPUD1
GNOMAD BrowserENSG00000051108
Varsome BrowserHERPUD1
ACMGHERPUD1 variants
VarityQ15011
Genomic Variants (DGV)HERPUD1 [DGVbeta]
DECIPHERHERPUD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHERPUD1 
Mutations
ICGC Data PortalHERPUD1 
TCGA Data PortalHERPUD1 
Broad Tumor PortalHERPUD1
OASIS PortalHERPUD1 [ Somatic mutations - Copy number]
Cancer Gene: CensusHERPUD1 
Somatic Mutations in Cancer : COSMICHERPUD1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHERPUD1
Mutations and Diseases : HGMDHERPUD1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHERPUD1
DgiDB (Drug Gene Interaction Database)HERPUD1
DoCM (Curated mutations)HERPUD1
CIViC (Clinical Interpretations of Variants in Cancer)HERPUD1
Cancer3DHERPUD1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608070   
Orphanet
DisGeNETHERPUD1
MedgenHERPUD1
Genetic Testing Registry HERPUD1
NextProtQ15011 [Medical]
GENETestsHERPUD1
Target ValidationHERPUD1
Huge Navigator HERPUD1 [HugePedia]
ClinGenHERPUD1
Clinical trials, drugs, therapy
MyCancerGenomeHERPUD1
Protein Interactions : CTDHERPUD1
Pharm GKB GenePA29252
PharosQ15011
Clinical trialHERPUD1
Miscellaneous
canSAR (ICR)HERPUD1
HarmonizomeHERPUD1
DataMed IndexHERPUD1
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHERPUD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:17 CEST 2021

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