Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1)

Identity

Alias_nameshomocysteine-inducible
Alias_symbol (synonym)KIAA0025
Mif1
HERP
SUP
Other alias
HGNC (Hugo) HERPUD1
LocusID (NCBI) 9709
Atlas_Id 53491
Location 16q13  [Link to chromosome band 16q13]
Location_base_pair Starts at 56932090 and ends at 56943881 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERG (21q22.2) / HERPUD1 (16q13)FUBP3 (9q34.11) / HERPUD1 (16q13)HERPUD1 (16q13) / BRAF (7q34)
HERPUD1 (16q13) / ERG (21q22.2)USP34 (2p15) / HERPUD1 (16q13)WDR77 (1p13.2) / HERPUD1 (16q13)
HERPUD1 16q13 / BRAF 7q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Prostate tumors: an overview
Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)HERPUD1   13744
Cards
Entrez_Gene (NCBI)HERPUD1  9709  homocysteine inducible ER protein with ubiquitin like domain 1
AliasesHERP; Mif1; SUP
GeneCards (Weizmann)HERPUD1
Ensembl hg19 (Hinxton)ENSG00000051108 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000051108 [Gene_View]  chr16:56932090-56943881 [Contig_View]  HERPUD1 [Vega]
ICGC DataPortalENSG00000051108
TCGA cBioPortalHERPUD1
AceView (NCBI)HERPUD1
Genatlas (Paris)HERPUD1
WikiGenes9709
SOURCE (Princeton)HERPUD1
Genetics Home Reference (NIH)HERPUD1
Genomic and cartography
GoldenPath hg38 (UCSC)HERPUD1  -     chr16:56932090-56943881 +  16q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HERPUD1  -     16q13   [Description]    (hg19-Feb_2009)
EnsemblHERPUD1 - 16q13 [CytoView hg19]  HERPUD1 - 16q13 [CytoView hg38]
Mapping of homologs : NCBIHERPUD1 [Mapview hg19]  HERPUD1 [Mapview hg38]
OMIM608070   
Gene and transcription
Genbank (Entrez)AB034989 AF055001 AF055003 AF217990 AK223233
RefSeq transcript (Entrez)NM_001010989 NM_001010990 NM_001272103 NM_014685
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HERPUD1
Cluster EST : UnigeneHs.146393 [ NCBI ]
CGAP (NCI)Hs.146393
Alternative Splicing GalleryENSG00000051108
Gene ExpressionHERPUD1 [ NCBI-GEO ]   HERPUD1 [ EBI - ARRAY_EXPRESS ]   HERPUD1 [ SEEK ]   HERPUD1 [ MEM ]
Gene Expression Viewer (FireBrowse)HERPUD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9709
GTEX Portal (Tissue expression)HERPUD1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15011   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15011  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15011
Splice isoforms : SwissVarQ15011
PhosPhoSitePlusQ15011
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Ubiquitin-rel_dom    Ubiquitin_dom   
Domain families : Pfam (Sanger)ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)HERPUD1
DMDM Disease mutations9709
Blocks (Seattle)HERPUD1
PDB (SRS)1WGD   
PDB (PDBSum)1WGD   
PDB (IMB)1WGD   
PDB (RSDB)1WGD   
Structural Biology KnowledgeBase1WGD   
SCOP (Structural Classification of Proteins)1WGD   
CATH (Classification of proteins structures)1WGD   
SuperfamilyQ15011
Human Protein AtlasENSG00000051108
Peptide AtlasQ15011
HPRD07456
IPIIPI00014171   IPI00219266   IPI00179347   IPI00845462   IPI00910970   IPI00553182   
Protein Interaction databases
DIP (DOE-UCLA)Q15011
IntAct (EBI)Q15011
FunCoupENSG00000051108
BioGRIDHERPUD1
STRING (EMBL)HERPUD1
ZODIACHERPUD1
Ontologies - Pathways
QuickGOQ15011
Ontology : AmiGOmolecular_function  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  ubiquitin-dependent protein catabolic process  response to unfolded protein  membrane  retrograde protein transport, ER to cytosol  regulation of protein ubiquitination  positive regulation of protein binding  endoplasmic reticulum calcium ion homeostasis  calcium channel complex  response to endoplasmic reticulum stress  PERK-mediated unfolded protein response  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  ion channel binding  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  Lewy body core  negative regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBImolecular_function  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  ubiquitin-dependent protein catabolic process  response to unfolded protein  membrane  retrograde protein transport, ER to cytosol  regulation of protein ubiquitination  positive regulation of protein binding  endoplasmic reticulum calcium ion homeostasis  calcium channel complex  response to endoplasmic reticulum stress  PERK-mediated unfolded protein response  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  ion channel binding  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  Lewy body core  negative regulation of intrinsic apoptotic signaling pathway  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkHERPUD1
Atlas of Cancer Signalling NetworkHERPUD1
Wikipedia pathwaysHERPUD1
Orthology - Evolution
OrthoDB9709
GeneTree (enSembl)ENSG00000051108
Phylogenetic Trees/Animal Genes : TreeFamHERPUD1
HOVERGENQ15011
HOGENOMQ15011
Homologs : HomoloGeneHERPUD1
Homology/Alignments : Family Browser (UCSC)HERPUD1
Gene fusions - Rearrangements
Fusion : MitelmanHERPUD1/ERG [16q13/21q22.2]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHERPUD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HERPUD1
dbVarHERPUD1
ClinVarHERPUD1
1000_GenomesHERPUD1 
Exome Variant ServerHERPUD1
ExAC (Exome Aggregation Consortium)HERPUD1 (select the gene name)
Genetic variants : HAPMAP9709
Genomic Variants (DGV)HERPUD1 [DGVbeta]
DECIPHERHERPUD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHERPUD1 
Mutations
ICGC Data PortalHERPUD1 
TCGA Data PortalHERPUD1 
Broad Tumor PortalHERPUD1
OASIS PortalHERPUD1 [ Somatic mutations - Copy number]
Cancer Gene: CensusHERPUD1 
Somatic Mutations in Cancer : COSMICHERPUD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHERPUD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HERPUD1
DgiDB (Drug Gene Interaction Database)HERPUD1
DoCM (Curated mutations)HERPUD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HERPUD1 (select a term)
intoGenHERPUD1
Cancer3DHERPUD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608070   
Orphanet
MedgenHERPUD1
Genetic Testing Registry HERPUD1
NextProtQ15011 [Medical]
TSGene9709
GENETestsHERPUD1
Target ValidationHERPUD1
Huge Navigator HERPUD1 [HugePedia]
snp3D : Map Gene to Disease9709
BioCentury BCIQHERPUD1
ClinGenHERPUD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9709
Chemical/Pharm GKB GenePA29252
Clinical trialHERPUD1
Miscellaneous
canSAR (ICR)HERPUD1 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHERPUD1
EVEXHERPUD1
GoPubMedHERPUD1
iHOPHERPUD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:02:53 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.