Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HES2 (hes family bHLH transcription factor 2)

Identity

Alias (NCBI)bHLHb40
HGNC (Hugo) HES2
HGNC Alias symbbHLHb40
HGNC Previous namehairy and enhancer of split 2 (Drosophila)
LocusID (NCBI) 54626
Atlas_Id 40812
Location 1p36.31  [Link to chromosome band 1p36]
Location_base_pair Starts at 6415234 and ends at 6419919 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANP32A (15q23)::HES2 (1p36.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HES2   16005
Cards
Entrez_Gene (NCBI)HES2    hes family bHLH transcription factor 2
AliasesbHLHb40
GeneCards (Weizmann)HES2
Ensembl hg19 (Hinxton)ENSG00000069812 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069812 [Gene_View]  ENSG00000069812 [Sequence]  chr1:6415234-6419919 [Contig_View]  HES2 [Vega]
ICGC DataPortalENSG00000069812
TCGA cBioPortalHES2
AceView (NCBI)HES2
Genatlas (Paris)HES2
SOURCE (Princeton)HES2
Genetics Home Reference (NIH)HES2
Genomic and cartography
GoldenPath hg38 (UCSC)HES2  -     chr1:6415234-6419919 -  1p36.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HES2  -     1p36.31   [Description]    (hg19-Feb_2009)
GoldenPathHES2 - 1p36.31 [CytoView hg19]  HES2 - 1p36.31 [CytoView hg38]
ImmunoBaseENSG00000069812
Genome Data Viewer NCBIHES2 [Mapview hg19]  
OMIM609970   
Gene and transcription
Genbank (Entrez)AK023754 AK091122 BC012091 BC132698 BC136963
RefSeq transcript (Entrez)NM_019089
Consensus coding sequences : CCDS (NCBI)HES2
Gene ExpressionHES2 [ NCBI-GEO ]   HES2 [ EBI - ARRAY_EXPRESS ]   HES2 [ SEEK ]   HES2 [ MEM ]
Gene Expression Viewer (FireBrowse)HES2 [ Firebrowse - Broad ]
GenevisibleExpression of HES2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54626
GTEX Portal (Tissue expression)HES2
Human Protein AtlasENSG00000069812-HES2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y543   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y543  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y543
PhosPhoSitePlusQ9Y543
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    ORANGE (PS51054)   
Domains : Interpro (EBI)bHLH_dom    HLH_DNA-bd_sf    Orange_dom   
Domain families : Pfam (Sanger)Hairy_orange (PF07527)    HLH (PF00010)   
Domain families : Pfam (NCBI)pfam07527    pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  ORANGE (SM00511)  
Conserved Domain (NCBI)HES2
SuperfamilyQ9Y543
AlphaFold pdb e-kbQ9Y543   
Human Protein Atlas [tissue]ENSG00000069812-HES2 [tissue]
HPRD13649
Protein Interaction databases
DIP (DOE-UCLA)Q9Y543
IntAct (EBI)Q9Y543
BioGRIDHES2
STRING (EMBL)HES2
ZODIACHES2
Ontologies - Pathways
QuickGOQ9Y543
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  nucleus  regulation of transcription by RNA polymerase II  anterior/posterior pattern specification  protein dimerization activity  regulation of neurogenesis  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  nucleus  regulation of transcription by RNA polymerase II  anterior/posterior pattern specification  protein dimerization activity  regulation of neurogenesis  sequence-specific double-stranded DNA binding  
NDEx NetworkHES2
Atlas of Cancer Signalling NetworkHES2
Wikipedia pathwaysHES2
Orthology - Evolution
OrthoDB54626
GeneTree (enSembl)ENSG00000069812
Phylogenetic Trees/Animal Genes : TreeFamHES2
Homologs : HomoloGeneHES2
Homology/Alignments : Family Browser (UCSC)HES2
Gene fusions - Rearrangements
Fusion : QuiverHES2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHES2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HES2
dbVarHES2
ClinVarHES2
MonarchHES2
1000_GenomesHES2 
Exome Variant ServerHES2
GNOMAD BrowserENSG00000069812
Varsome BrowserHES2
ACMGHES2 variants
VarityQ9Y543
Genomic Variants (DGV)HES2 [DGVbeta]
DECIPHERHES2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHES2 
Mutations
ICGC Data PortalHES2 
TCGA Data PortalHES2 
Broad Tumor PortalHES2
OASIS PortalHES2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHES2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHES2
Mutations and Diseases : HGMDHES2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHES2
DgiDB (Drug Gene Interaction Database)HES2
DoCM (Curated mutations)HES2
CIViC (Clinical Interpretations of Variants in Cancer)HES2
Cancer3DHES2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609970   
Orphanet
DisGeNETHES2
MedgenHES2
Genetic Testing Registry HES2
NextProtQ9Y543 [Medical]
GENETestsHES2
Target ValidationHES2
Huge Navigator HES2 [HugePedia]
ClinGenHES2
Clinical trials, drugs, therapy
MyCancerGenomeHES2
Protein Interactions : CTDHES2
Pharm GKB GenePA134958805
PharosQ9Y543
Clinical trialHES2
Miscellaneous
canSAR (ICR)HES2
HarmonizomeHES2
ARCHS4HES2
DataMed IndexHES2
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHES2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:36:48 CET 2022

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