Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HES2 (hes family bHLH transcription factor 2)

Identity

Alias_nameshairy and enhancer of split 2 (Drosophila)
Alias_symbol (synonym)bHLHb40
Other alias
HGNC (Hugo) HES2
LocusID (NCBI) 54626
Atlas_Id 40812
Location 1p36.31  [Link to chromosome band 1p36]
Location_base_pair Starts at 6415234 and ends at 6419919 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANP32A (15q23) / HES2 (1p36.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HES2   16005
Cards
Entrez_Gene (NCBI)HES2  54626  hes family bHLH transcription factor 2
AliasesbHLHb40
GeneCards (Weizmann)HES2
Ensembl hg19 (Hinxton)ENSG00000069812 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069812 [Gene_View]  chr1:6415234-6419919 [Contig_View]  HES2 [Vega]
ICGC DataPortalENSG00000069812
TCGA cBioPortalHES2
AceView (NCBI)HES2
Genatlas (Paris)HES2
WikiGenes54626
SOURCE (Princeton)HES2
Genetics Home Reference (NIH)HES2
Genomic and cartography
GoldenPath hg38 (UCSC)HES2  -     chr1:6415234-6419919 -  1p36.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HES2  -     1p36.31   [Description]    (hg19-Feb_2009)
EnsemblHES2 - 1p36.31 [CytoView hg19]  HES2 - 1p36.31 [CytoView hg38]
Mapping of homologs : NCBIHES2 [Mapview hg19]  HES2 [Mapview hg38]
OMIM609970   
Gene and transcription
Genbank (Entrez)AK023754 AK091122 BC012091 BC132698 BC136963
RefSeq transcript (Entrez)NM_019089
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HES2
Cluster EST : UnigeneHs.118727 [ NCBI ]
CGAP (NCI)Hs.118727
Alternative Splicing GalleryENSG00000069812
Gene ExpressionHES2 [ NCBI-GEO ]   HES2 [ EBI - ARRAY_EXPRESS ]   HES2 [ SEEK ]   HES2 [ MEM ]
Gene Expression Viewer (FireBrowse)HES2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54626
GTEX Portal (Tissue expression)HES2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y543   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y543  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y543
Splice isoforms : SwissVarQ9Y543
PhosPhoSitePlusQ9Y543
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    ORANGE (PS51054)   
Domains : Interpro (EBI)bHLH_dom    Orange_dom   
Domain families : Pfam (Sanger)Hairy_orange (PF07527)    HLH (PF00010)   
Domain families : Pfam (NCBI)pfam07527    pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  ORANGE (SM00511)  
Conserved Domain (NCBI)HES2
DMDM Disease mutations54626
Blocks (Seattle)HES2
SuperfamilyQ9Y543
Human Protein AtlasENSG00000069812
Peptide AtlasQ9Y543
HPRD13649
IPIIPI00001055   IPI00061562   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y543
IntAct (EBI)Q9Y543
FunCoupENSG00000069812
BioGRIDHES2
STRING (EMBL)HES2
ZODIACHES2
Ontologies - Pathways
QuickGOQ9Y543
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleus  transcription, DNA-templated  transcription factor binding  protein dimerization activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleus  transcription, DNA-templated  transcription factor binding  protein dimerization activity  
NDEx NetworkHES2
Atlas of Cancer Signalling NetworkHES2
Wikipedia pathwaysHES2
Orthology - Evolution
OrthoDB54626
GeneTree (enSembl)ENSG00000069812
Phylogenetic Trees/Animal Genes : TreeFamHES2
HOVERGENQ9Y543
HOGENOMQ9Y543
Homologs : HomoloGeneHES2
Homology/Alignments : Family Browser (UCSC)HES2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHES2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HES2
dbVarHES2
ClinVarHES2
1000_GenomesHES2 
Exome Variant ServerHES2
ExAC (Exome Aggregation Consortium)HES2 (select the gene name)
Genetic variants : HAPMAP54626
Genomic Variants (DGV)HES2 [DGVbeta]
DECIPHERHES2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHES2 
Mutations
ICGC Data PortalHES2 
TCGA Data PortalHES2 
Broad Tumor PortalHES2
OASIS PortalHES2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHES2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHES2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HES2
DgiDB (Drug Gene Interaction Database)HES2
DoCM (Curated mutations)HES2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HES2 (select a term)
intoGenHES2
Cancer3DHES2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609970   
Orphanet
MedgenHES2
Genetic Testing Registry HES2
NextProtQ9Y543 [Medical]
TSGene54626
GENETestsHES2
Huge Navigator HES2 [HugePedia]
snp3D : Map Gene to Disease54626
BioCentury BCIQHES2
ClinGenHES2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54626
Chemical/Pharm GKB GenePA134958805
Clinical trialHES2
Miscellaneous
canSAR (ICR)HES2 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHES2
EVEXHES2
GoPubMedHES2
iHOPHES2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:18:39 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.