Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HES6 (hes family bHLH transcription factor 6)

Identity

Alias_nameshairy and enhancer of split 6 (Drosophila)
Alias_symbol (synonym)bHLHb41
Other aliasC-HAIRY1
HES-6
bHLHc23
HGNC (Hugo) HES6
LocusID (NCBI) 55502
Atlas_Id 40813
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 238238267 and ends at 238240124 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRAK1 (3p22.1) / HES6 (2q37.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HES6   18254
Cards
Entrez_Gene (NCBI)HES6  55502  hes family bHLH transcription factor 6
AliasesC-HAIRY1; HES-6; bHLHb41; bHLHc23
GeneCards (Weizmann)HES6
Ensembl hg19 (Hinxton)ENSG00000144485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144485 [Gene_View]  chr2:238238267-238240124 [Contig_View]  HES6 [Vega]
ICGC DataPortalENSG00000144485
TCGA cBioPortalHES6
AceView (NCBI)HES6
Genatlas (Paris)HES6
WikiGenes55502
SOURCE (Princeton)HES6
Genetics Home Reference (NIH)HES6
Genomic and cartography
GoldenPath hg38 (UCSC)HES6  -     chr2:238238267-238240124 -  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HES6  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblHES6 - 2q37.3 [CytoView hg19]  HES6 - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBIHES6 [Mapview hg19]  HES6 [Mapview hg38]
OMIM610331   
Gene and transcription
Genbank (Entrez)AB035179 AF260237 AK075040 AK293111 BC007939
RefSeq transcript (Entrez)NM_001142853 NM_001282434 NM_018645
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HES6
Cluster EST : UnigeneHs.42949 [ NCBI ]
CGAP (NCI)Hs.42949
Alternative Splicing GalleryENSG00000144485
Gene ExpressionHES6 [ NCBI-GEO ]   HES6 [ EBI - ARRAY_EXPRESS ]   HES6 [ SEEK ]   HES6 [ MEM ]
Gene Expression Viewer (FireBrowse)HES6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55502
GTEX Portal (Tissue expression)HES6
Human Protein AtlasENSG00000144485-HES6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HZ4
Splice isoforms : SwissVarQ96HZ4
PhosPhoSitePlusQ96HZ4
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    ORANGE (PS51054)   
Domains : Interpro (EBI)bHLH_dom    Orange_dom   
Domain families : Pfam (Sanger)Hairy_orange (PF07527)    HLH (PF00010)   
Domain families : Pfam (NCBI)pfam07527    pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)HES6
DMDM Disease mutations55502
Blocks (Seattle)HES6
SuperfamilyQ96HZ4
Human Protein Atlas [tissue]ENSG00000144485-HES6 [tissue]
Peptide AtlasQ96HZ4
HPRD11021
IPIIPI00452727   IPI00452728   IPI00915924   IPI00916815   IPI00916699   IPI00916537   IPI00917515   IPI00917418   IPI00917274   
Protein Interaction databases
DIP (DOE-UCLA)Q96HZ4
IntAct (EBI)Q96HZ4
FunCoupENSG00000144485
BioGRIDHES6
STRING (EMBL)HES6
ZODIACHES6
Ontologies - Pathways
QuickGOQ96HZ4
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  nucleus  transcription factor complex  transcription, DNA-templated  regulation of transcription, DNA-templated  nervous system development  transcription factor binding  cell differentiation  protein dimerization activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  nucleus  transcription factor complex  transcription, DNA-templated  regulation of transcription, DNA-templated  nervous system development  transcription factor binding  cell differentiation  protein dimerization activity  
NDEx NetworkHES6
Atlas of Cancer Signalling NetworkHES6
Wikipedia pathwaysHES6
Orthology - Evolution
OrthoDB55502
GeneTree (enSembl)ENSG00000144485
Phylogenetic Trees/Animal Genes : TreeFamHES6
HOVERGENQ96HZ4
HOGENOMQ96HZ4
Homologs : HomoloGeneHES6
Homology/Alignments : Family Browser (UCSC)HES6
Gene fusions - Rearrangements
Tumor Fusion PortalHES6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHES6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HES6
dbVarHES6
ClinVarHES6
1000_GenomesHES6 
Exome Variant ServerHES6
ExAC (Exome Aggregation Consortium)ENSG00000144485
GNOMAD BrowserENSG00000144485
Genetic variants : HAPMAP55502
Genomic Variants (DGV)HES6 [DGVbeta]
DECIPHERHES6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHES6 
Mutations
ICGC Data PortalHES6 
TCGA Data PortalHES6 
Broad Tumor PortalHES6
OASIS PortalHES6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHES6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHES6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HES6
DgiDB (Drug Gene Interaction Database)HES6
DoCM (Curated mutations)HES6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HES6 (select a term)
intoGenHES6
Cancer3DHES6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610331   
Orphanet
DisGeNETHES6
MedgenHES6
Genetic Testing Registry HES6
NextProtQ96HZ4 [Medical]
TSGene55502
GENETestsHES6
Target ValidationHES6
Huge Navigator HES6 [HugePedia]
snp3D : Map Gene to Disease55502
BioCentury BCIQHES6
ClinGenHES6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55502
Chemical/Pharm GKB GenePA29253
Clinical trialHES6
Miscellaneous
canSAR (ICR)HES6 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHES6
EVEXHES6
GoPubMedHES6
iHOPHES6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:16:01 CET 2017

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