HEXIM2 (HEXIM P-TEFb complex subunit 2)

2014-08-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
L3
FUSION GENES

Other Information

Locus ID:

NCBI: 124790
MIM: 615695
HGNC: 28591
Ensembl: ENSG00000168517

Variants:

dbSNP: 124790
ClinVar: 124790
TCGA: ENSG00000168517
COSMIC: HEXIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168517ENST00000307275Q96MH2
ENSG00000168517ENST00000585340K7ERG7
ENSG00000168517ENST00000586681K7EJA3
ENSG00000168517ENST00000589230K7ELS4
ENSG00000168517ENST00000591070K7EIM4
ENSG00000168517ENST00000591576Q96MH2
ENSG00000168517ENST00000592695Q96MH2
ENSG00000168517ENST00000593138K7ESM2

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159652332005Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.103
157136622005HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.61
157136612005Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.52
198836592010Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.12

Citation

Dessen P

HEXIM2 (HEXIM P-TEFb complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54358/hexim2