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HFM1 (helicase for meiosis 1)

Identity

Alias (NCBI)MER3
POF9
SEC63D1
Si-11
Si-11-6
helicase
HGNC (Hugo) HFM1
HGNC Alias symbMER3
FLJ39011
FLJ36760
HGNC Previous nameSEC63D1
HGNC Previous nameSEC63 domain containing 1
 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
LocusID (NCBI) 164045
Atlas_Id 64250
Location 1p22.2  [Link to chromosome band 1p22]
Location_base_pair Starts at 91260766 and ends at 91404869 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HFM1 (1p22.2) / C11orf24 (11q13.2)HFM1 (1p22.2) / CLINT1 (5q33.3)HFM1 (1p22.2) / HGF (7q21.11)
HFM1 (1p22.2) / NPIPB7 (16q23.1)HFM1 (1p22.2) / SEC24A (5q31.1)TET1 (10q21.3) / HFM1 (1p22.2)
TMED5 (1p22.1) / HFM1 (1p22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TMED5/HFM1 (1p22)


External links

Nomenclature
HGNC (Hugo)HFM1   20193
Cards
Entrez_Gene (NCBI)HFM1  164045  helicase for meiosis 1
AliasesMER3; POF9; SEC63D1; Si-11; 
Si-11-6; helicase
GeneCards (Weizmann)HFM1
Ensembl hg19 (Hinxton)ENSG00000162669 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162669 [Gene_View]  ENSG00000162669 [Sequence]  chr1:91260766-91404869 [Contig_View]  HFM1 [Vega]
ICGC DataPortalENSG00000162669
TCGA cBioPortalHFM1
AceView (NCBI)HFM1
Genatlas (Paris)HFM1
WikiGenes164045
SOURCE (Princeton)HFM1
Genetics Home Reference (NIH)HFM1
Genomic and cartography
GoldenPath hg38 (UCSC)HFM1  -     chr1:91260766-91404869 -  1p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HFM1  -     1p22.2   [Description]    (hg19-Feb_2009)
GoldenPathHFM1 - 1p22.2 [CytoView hg19]  HFM1 - 1p22.2 [CytoView hg38]
ImmunoBaseENSG00000162669
genome Data Viewer NCBIHFM1 [Mapview hg19]  
OMIM615684   615724   
Gene and transcription
Genbank (Entrez)AB044787 AB044788 AB058636 AB058637 AB074274
RefSeq transcript (Entrez)NM_001017975
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HFM1
Alternative Splicing GalleryENSG00000162669
Gene ExpressionHFM1 [ NCBI-GEO ]   HFM1 [ EBI - ARRAY_EXPRESS ]   HFM1 [ SEEK ]   HFM1 [ MEM ]
Gene Expression Viewer (FireBrowse)HFM1 [ Firebrowse - Broad ]
GenevisibleExpression of HFM1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)164045
GTEX Portal (Tissue expression)HFM1
Human Protein AtlasENSG00000162669-HFM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA2PYH4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA2PYH4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA2PYH4
Splice isoforms : SwissVarA2PYH4
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusA2PYH4
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    Sec63-dom    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)    Sec63 (PF02889)   
Domain families : Pfam (NCBI)pfam00270    pfam00271    pfam02889   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  Sec63 (SM00973)  
Conserved Domain (NCBI)HFM1
DMDM Disease mutations164045
Blocks (Seattle)HFM1
SuperfamilyA2PYH4
Human Protein Atlas [tissue]ENSG00000162669-HFM1 [tissue]
Peptide AtlasA2PYH4
HPRD13423
IPIIPI00852603   IPI00374013   IPI00852573   IPI01010399   IPI01012804   IPI00852835   IPI00852791   IPI00078033   
Protein Interaction databases
DIP (DOE-UCLA)A2PYH4
IntAct (EBI)A2PYH4
FunCoupENSG00000162669
BioGRIDHFM1
STRING (EMBL)HFM1
ZODIACHFM1
Ontologies - Pathways
QuickGOA2PYH4
Ontology : AmiGOresolution of meiotic recombination intermediates  nucleic acid binding  DNA helicase activity  ATP binding  DNA duplex unwinding  
Ontology : EGO-EBIresolution of meiotic recombination intermediates  nucleic acid binding  DNA helicase activity  ATP binding  DNA duplex unwinding  
NDEx NetworkHFM1
Atlas of Cancer Signalling NetworkHFM1
Wikipedia pathwaysHFM1
Orthology - Evolution
OrthoDB164045
GeneTree (enSembl)ENSG00000162669
Phylogenetic Trees/Animal Genes : TreeFamHFM1
HOGENOMA2PYH4
Homologs : HomoloGeneHFM1
Homology/Alignments : Family Browser (UCSC)HFM1
Gene fusions - Rearrangements
Fusion : QuiverHFM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHFM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HFM1
dbVarHFM1
ClinVarHFM1
1000_GenomesHFM1 
Exome Variant ServerHFM1
GNOMAD BrowserENSG00000162669
Varsome BrowserHFM1
Genetic variants : HAPMAP164045
Genomic Variants (DGV)HFM1 [DGVbeta]
DECIPHERHFM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHFM1 
Mutations
ICGC Data PortalHFM1 
TCGA Data PortalHFM1 
Broad Tumor PortalHFM1
OASIS PortalHFM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHFM1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHFM1
Mutations and Diseases : HGMDHFM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HFM1
DgiDB (Drug Gene Interaction Database)HFM1
DoCM (Curated mutations)HFM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HFM1 (select a term)
intoGenHFM1
Cancer3DHFM1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615684    615724   
Orphanet
DisGeNETHFM1
MedgenHFM1
Genetic Testing Registry HFM1
NextProtA2PYH4 [Medical]
TSGene164045
GENETestsHFM1
Target ValidationHFM1
Huge Navigator HFM1 [HugePedia]
snp3D : Map Gene to Disease164045
BioCentury BCIQHFM1
ClinGenHFM1
Clinical trials, drugs, therapy
Protein Interactions : CTD164045
Pharm GKB GenePA142671690
Clinical trialHFM1
Miscellaneous
canSAR (ICR)HFM1 (select the gene name)
HarmonizomeHFM1
DataMed IndexHFM1
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHFM1
EVEXHFM1
GoPubMedHFM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:58:14 CEST 2020

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