HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)

2003-02-01  

Identity

HGNC
HGS
LOCATION
17q25.3
LOCUSID
9146
ALIAS
HRS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9146
MIM: 604375
HGNC: 4897
Ensembl: ENSG00000185359

Variants:

dbSNP: 9146
ClinVar: 9146
TCGA: ENSG00000185359
COSMIC: HGS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185359ENST00000329138O14964
ENSG00000185359ENST00000329138A0A0S2Z4R4
ENSG00000185359ENST00000570652I3L346
ENSG00000185359ENST00000571237I3L1E3
ENSG00000185359ENST00000571518I3L2H4
ENSG00000185359ENST00000572392I3L1P5
ENSG00000185359ENST00000573320I3L1F1
ENSG00000185359ENST00000575078I3L326
ENSG00000185359ENST00000577012I3L165

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
ESCRT-0 complexKEGGhsa_M00408
ESCRT-0 complexKEGGM00408
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Signaling by METREACTOMER-HSA-6806834
Negative regulation of MET activityREACTOMER-HSA-6807004
Listeria monocytogenes entry into host cellsREACTOMER-HSA-8876384
InlB-mediated entry of Listeria monocytogenes into host cellREACTOMER-HSA-8875360

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
167075692006Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation.99
159447372005Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling.61
213049332011The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.58
242042762013Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.55
221382152012Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway.46
157721612005CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.45
176752982007Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor.34
170146992006Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function.32
171385652007A novel sorting sequence in the beta2-adrenergic receptor switches recycling from default to the Hrs-dependent mechanism.32
187679042008Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.30

Citation

Dessen P

HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40816/hgs