Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)

Identity

Alias_symbol (synonym)Hrs
ZFYVE8
Vps27
Other aliasHRS
HGNC (Hugo) HGS
LocusID (NCBI) 9146
Atlas_Id 40816
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81683932 and ends at 81702121 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDHR5 (11p15.5) / HGS (17q25.3)HGS (17q25.3) / GNAO1 (16q12.2)HGS (17q25.3) / HGS (17q25.3)
HGS (17q25.3) / SIGIRR (11p15.5)SLC25A10 (17q25.3) / HGS (17q25.3)TLE3 (15q23) / HGS (17q25.3)
ZNF7 (8q24.3) / HGS (17q25.3)HGS 17q25.3 / GNAO1 16q12.2SLC25A10 17q25.3 / HGS 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HGS   4897
Cards
Entrez_Gene (NCBI)HGS  9146  hepatocyte growth factor-regulated tyrosine kinase substrate
AliasesHRS
GeneCards (Weizmann)HGS
Ensembl hg19 (Hinxton)ENSG00000185359 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185359 [Gene_View]  chr17:81683932-81702121 [Contig_View]  HGS [Vega]
ICGC DataPortalENSG00000185359
TCGA cBioPortalHGS
AceView (NCBI)HGS
Genatlas (Paris)HGS
WikiGenes9146
SOURCE (Princeton)HGS
Genetics Home Reference (NIH)HGS
Genomic and cartography
GoldenPath hg38 (UCSC)HGS  -     chr17:81683932-81702121 +  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HGS  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblHGS - 17q25.3 [CytoView hg19]  HGS - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBIHGS [Mapview hg19]  HGS [Mapview hg38]
OMIM604375   
Gene and transcription
Genbank (Entrez)AF260566 AI365104 AK021483 AK097197 AK294190
RefSeq transcript (Entrez)NM_004712
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HGS
Cluster EST : UnigeneHs.661056 [ NCBI ]
CGAP (NCI)Hs.661056
Alternative Splicing GalleryENSG00000185359
Gene ExpressionHGS [ NCBI-GEO ]   HGS [ EBI - ARRAY_EXPRESS ]   HGS [ SEEK ]   HGS [ MEM ]
Gene Expression Viewer (FireBrowse)HGS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9146
GTEX Portal (Tissue expression)HGS
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14964   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14964  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14964
Splice isoforms : SwissVarO14964
PhosPhoSitePlusO14964
Domaine pattern : Prosite (Expaxy)UIM (PS50330)    VHS (PS50179)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)ENTH_VHS    HRS_helical    Ubi-bd_Hrs_VPS27    UIM_dom    VHS_dom    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    Hrs_helical (PF12210)    VHS (PF00790)   
Domain families : Pfam (NCBI)pfam01363    pfam12210    pfam00790   
Domain families : Smart (EMBL)FYVE (SM00064)  VHS (SM00288)  
Conserved Domain (NCBI)HGS
DMDM Disease mutations9146
Blocks (Seattle)HGS
PDB (SRS)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
PDB (PDBSum)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
PDB (IMB)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
PDB (RSDB)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
Structural Biology KnowledgeBase2D3G    3F1I    3OBQ    3ZYQ    4AVX   
SCOP (Structural Classification of Proteins)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
CATH (Classification of proteins structures)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
SuperfamilyO14964
Human Protein AtlasENSG00000185359
Peptide AtlasO14964
HPRD05085
IPIIPI00006176   IPI00916785   IPI00939822   
Protein Interaction databases
DIP (DOE-UCLA)O14964
IntAct (EBI)O14964
FunCoupENSG00000185359
BioGRIDHGS
STRING (EMBL)HGS
ZODIACHGS
Ontologies - Pathways
QuickGOO14964
Ontology : AmiGOprotein binding  lysosome  endosome  early endosome  cytosol  cytosol  protein targeting to lysosome  signal transduction  negative regulation of cell proliferation  membrane invagination  positive regulation of gene expression  endosomal transport  endosomal transport  macroautophagy  protein deubiquitination  protein domain specific binding  early endosome membrane  multivesicular body membrane  ESCRT-0 complex  multivesicular body assembly  negative regulation of epidermal growth factor receptor signaling pathway  regulation of protein catabolic process  intracellular membrane-bounded organelle  regulation of MAP kinase activity  negative regulation of JAK-STAT cascade  metal ion binding  membrane organization  extracellular exosome  protein localization to membrane  positive regulation of exosomal secretion  
Ontology : EGO-EBIprotein binding  lysosome  endosome  early endosome  cytosol  cytosol  protein targeting to lysosome  signal transduction  negative regulation of cell proliferation  membrane invagination  positive regulation of gene expression  endosomal transport  endosomal transport  macroautophagy  protein deubiquitination  protein domain specific binding  early endosome membrane  multivesicular body membrane  ESCRT-0 complex  multivesicular body assembly  negative regulation of epidermal growth factor receptor signaling pathway  regulation of protein catabolic process  intracellular membrane-bounded organelle  regulation of MAP kinase activity  negative regulation of JAK-STAT cascade  metal ion binding  membrane organization  extracellular exosome  protein localization to membrane  positive regulation of exosomal secretion  
Pathways : BIOCARTAThe role of FYVE-finger proteins in vesicle transport [Genes]   
Pathways : KEGGEndocytosis    Phagosome   
NDEx NetworkHGS
Atlas of Cancer Signalling NetworkHGS
Wikipedia pathwaysHGS
Orthology - Evolution
OrthoDB9146
GeneTree (enSembl)ENSG00000185359
Phylogenetic Trees/Animal Genes : TreeFamHGS
HOVERGENO14964
HOGENOMO14964
Homologs : HomoloGeneHGS
Homology/Alignments : Family Browser (UCSC)HGS
Gene fusions - Rearrangements
Fusion : MitelmanHGS/GNAO1 [17q25.3/16q12.2]  
Fusion : MitelmanSLC25A10/HGS [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion: TCGAHGS 17q25.3 GNAO1 16q12.2 LUSC
Fusion: TCGASLC25A10 17q25.3 HGS 17q25.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHGS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HGS
dbVarHGS
ClinVarHGS
1000_GenomesHGS 
Exome Variant ServerHGS
ExAC (Exome Aggregation Consortium)HGS (select the gene name)
Genetic variants : HAPMAP9146
Genomic Variants (DGV)HGS [DGVbeta]
DECIPHERHGS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHGS 
Mutations
ICGC Data PortalHGS 
TCGA Data PortalHGS 
Broad Tumor PortalHGS
OASIS PortalHGS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHGS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHGS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HGS
DgiDB (Drug Gene Interaction Database)HGS
DoCM (Curated mutations)HGS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HGS (select a term)
intoGenHGS
Cancer3DHGS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604375   
Orphanet
MedgenHGS
Genetic Testing Registry HGS
NextProtO14964 [Medical]
TSGene9146
GENETestsHGS
Target ValidationHGS
Huge Navigator HGS [HugePedia]
snp3D : Map Gene to Disease9146
BioCentury BCIQHGS
ClinGenHGS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9146
Chemical/Pharm GKB GenePA29271
Clinical trialHGS
Miscellaneous
canSAR (ICR)HGS (select the gene name)
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHGS
EVEXHGS
GoPubMedHGS
iHOPHGS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:36:43 CEST 2017

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