Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)

Identity

Alias (NCBI)HRS
HGNC (Hugo) HGS
HGNC Alias symbHrs
ZFYVE8
Vps27
LocusID (NCBI) 9146
Atlas_Id 40816
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81684011 and ends at 81702121 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDHR5 (11p15.5) / HGS (17q25.3)HGS (17q25.3) / GNAO1 (16q12.2)HGS (17q25.3) / HGS (17q25.3)
HGS (17q25.3) / SIGIRR (11p15.5)SLC25A10 (17q25.3) / HGS (17q25.3)TLE3 (15q23) / HGS (17q25.3)
ZNF7 (8q24.3) / HGS (17q25.3)HGS 17q25.3 / GNAO1 16q12.2SLC25A10 17q25.3 / HGS 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HGS   4897
Cards
Entrez_Gene (NCBI)HGS    hepatocyte growth factor-regulated tyrosine kinase substrate
AliasesHRS
GeneCards (Weizmann)HGS
Ensembl hg19 (Hinxton)ENSG00000185359 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185359 [Gene_View]  ENSG00000185359 [Sequence]  chr17:81684011-81702121 [Contig_View]  HGS [Vega]
ICGC DataPortalENSG00000185359
TCGA cBioPortalHGS
AceView (NCBI)HGS
Genatlas (Paris)HGS
SOURCE (Princeton)HGS
Genetics Home Reference (NIH)HGS
Genomic and cartography
GoldenPath hg38 (UCSC)HGS  -     chr17:81684011-81702121 +  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HGS  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathHGS - 17q25.3 [CytoView hg19]  HGS - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000185359
Genome Data Viewer NCBIHGS [Mapview hg19]  
OMIM604375   
Gene and transcription
Genbank (Entrez)AF260566 AI365104 AK021483 AK097197 AK294190
RefSeq transcript (Entrez)NM_004712
Consensus coding sequences : CCDS (NCBI)HGS
Gene ExpressionHGS [ NCBI-GEO ]   HGS [ EBI - ARRAY_EXPRESS ]   HGS [ SEEK ]   HGS [ MEM ]
Gene Expression Viewer (FireBrowse)HGS [ Firebrowse - Broad ]
GenevisibleExpression of HGS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9146
GTEX Portal (Tissue expression)HGS
Human Protein AtlasENSG00000185359-HGS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14964   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14964  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14964
PhosPhoSitePlusO14964
Domaine pattern : Prosite (Expaxy)UIM (PS50330)    VHS (PS50179)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)ENTH_VHS    HRS_helical    Ubi-bd_Hrs_VPS27    UIM_dom    VHS_dom    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    Hrs_helical (PF12210)    VHS (PF00790)   
Domain families : Pfam (NCBI)pfam01363    pfam12210    pfam00790   
Domain families : Smart (EMBL)FYVE (SM00064)  VHS (SM00288)  
Conserved Domain (NCBI)HGS
PDB (RSDB)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
PDB Europe2D3G    3F1I    3OBQ    3ZYQ    4AVX   
PDB (PDBSum)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
PDB (IMB)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
Structural Biology KnowledgeBase2D3G    3F1I    3OBQ    3ZYQ    4AVX   
SCOP (Structural Classification of Proteins)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
CATH (Classification of proteins structures)2D3G    3F1I    3OBQ    3ZYQ    4AVX   
SuperfamilyO14964
AlphaFold pdb e-kbO14964   
Human Protein Atlas [tissue]ENSG00000185359-HGS [tissue]
HPRD05085
Protein Interaction databases
DIP (DOE-UCLA)O14964
IntAct (EBI)O14964
BioGRIDHGS
STRING (EMBL)HGS
ZODIACHGS
Ontologies - Pathways
QuickGOO14964
Ontology : AmiGOprotein binding  lysosome  endosome  early endosome  cytosol  cytosol  protein targeting to lysosome  post-Golgi vesicle-mediated transport  signal transduction  negative regulation of cell population proliferation  membrane invagination  positive regulation of gene expression  negative regulation of platelet-derived growth factor receptor signaling pathway  endosomal transport  endosomal transport  macroautophagy  negative regulation of angiogenesis  protein deubiquitination  protein domain specific binding  negative regulation of vascular endothelial growth factor receptor signaling pathway  early endosome membrane  multivesicular body membrane  ESCRT-0 complex  ESCRT-0 complex  phosphatidylinositol binding  multivesicular body assembly  negative regulation of epidermal growth factor receptor signaling pathway  regulation of protein catabolic process  ubiquitin binding  intracellular membrane-bounded organelle  regulation of MAP kinase activity  modulation by symbiont of host process  ubiquitin-like protein ligase binding  negative regulation of receptor signaling pathway via JAK-STAT  metal ion binding  membrane organization  extracellular exosome  protein localization to membrane  phagocytic vesicle lumen  positive regulation of exosomal secretion  
Ontology : EGO-EBIprotein binding  lysosome  endosome  early endosome  cytosol  cytosol  protein targeting to lysosome  post-Golgi vesicle-mediated transport  signal transduction  negative regulation of cell population proliferation  membrane invagination  positive regulation of gene expression  negative regulation of platelet-derived growth factor receptor signaling pathway  endosomal transport  endosomal transport  macroautophagy  negative regulation of angiogenesis  protein deubiquitination  protein domain specific binding  negative regulation of vascular endothelial growth factor receptor signaling pathway  early endosome membrane  multivesicular body membrane  ESCRT-0 complex  ESCRT-0 complex  phosphatidylinositol binding  multivesicular body assembly  negative regulation of epidermal growth factor receptor signaling pathway  regulation of protein catabolic process  ubiquitin binding  intracellular membrane-bounded organelle  regulation of MAP kinase activity  modulation by symbiont of host process  ubiquitin-like protein ligase binding  negative regulation of receptor signaling pathway via JAK-STAT  metal ion binding  membrane organization  extracellular exosome  protein localization to membrane  phagocytic vesicle lumen  positive regulation of exosomal secretion  
Pathways : BIOCARTAThe role of FYVE-finger proteins in vesicle transport [Genes]   
Pathways : KEGGEndocytosis    Phagosome   
NDEx NetworkHGS
Atlas of Cancer Signalling NetworkHGS
Wikipedia pathwaysHGS
Orthology - Evolution
OrthoDB9146
GeneTree (enSembl)ENSG00000185359
Phylogenetic Trees/Animal Genes : TreeFamHGS
Homologs : HomoloGeneHGS
Homology/Alignments : Family Browser (UCSC)HGS
Gene fusions - Rearrangements
Fusion : MitelmanHGS/GNAO1 [17q25.3/16q12.2]  
Fusion : MitelmanSLC25A10/HGS [17q25.3/17q25.3]  
Fusion : QuiverHGS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHGS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HGS
dbVarHGS
ClinVarHGS
MonarchHGS
1000_GenomesHGS 
Exome Variant ServerHGS
GNOMAD BrowserENSG00000185359
Varsome BrowserHGS
ACMGHGS variants
VarityO14964
Genomic Variants (DGV)HGS [DGVbeta]
DECIPHERHGS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHGS 
Mutations
ICGC Data PortalHGS 
TCGA Data PortalHGS 
Broad Tumor PortalHGS
OASIS PortalHGS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHGS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHGS
Mutations and Diseases : HGMDHGS
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHGS
DgiDB (Drug Gene Interaction Database)HGS
DoCM (Curated mutations)HGS
CIViC (Clinical Interpretations of Variants in Cancer)HGS
Cancer3DHGS
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604375   
Orphanet
DisGeNETHGS
MedgenHGS
Genetic Testing Registry HGS
NextProtO14964 [Medical]
GENETestsHGS
Target ValidationHGS
Huge Navigator HGS [HugePedia]
ClinGenHGS
Clinical trials, drugs, therapy
MyCancerGenomeHGS
Protein Interactions : CTDHGS
Pharm GKB GenePA29271
PharosO14964
Clinical trialHGS
Miscellaneous
canSAR (ICR)HGS
HarmonizomeHGS
DataMed IndexHGS
Probes
Litterature
PubMed207 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHGS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:12:21 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.