HHEX (hematopoietically expressed homeobox)

2007-02-01  

Identity

HGNC
LOCATION
10q23.33
LOCUSID
ALIAS
HEX,HMPH,HOX11L-PEN,PRH,PRHX
FUSION GENES

Other Information

Locus ID:

NCBI: 3087
MIM: 604420
HGNC: 4901
Ensembl: ENSG00000152804

Variants:

dbSNP: 3087
ClinVar: 3087
TCGA: ENSG00000152804
COSMIC: HHEX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152804ENST00000282728Q03014
ENSG00000152804ENST00000472590F8VU08
ENSG00000152804ENST00000492654F8VU08

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174632462007Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.1137
174632482007A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.1102
172938762007A genome-wide association study identifies novel risk loci for type 2 diabetes.990
174632492007Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.887
190203232008Genotype score in addition to common risk factors for prediction of type 2 diabetes.304
190203242008Clinical risk factors, DNA variants, and the development of type 2 diabetes.262
185913882008Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.129
184692042008Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.128
184692042008Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.128
193808542009Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry.108

Citation

Dessen P

HHEX (hematopoietically expressed homeobox)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46061/hhex