Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HHEX (hematopoietically expressed homeobox)

Identity

Alias_namesPRHX
Alias_symbol (synonym)HEX
HOX11L-PEN
Other aliasHMPH
PRH
HGNC (Hugo) HHEX
LocusID (NCBI) 3087
Atlas_Id 46061
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 92689924 and ends at 92695651 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NUP98 (11p15.4) / HHEX (10q23.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HHEX   4901
Cards
Entrez_Gene (NCBI)HHEX  3087  hematopoietically expressed homeobox
AliasesHEX; HMPH; HOX11L-PEN; PRH; 
PRHX
GeneCards (Weizmann)HHEX
Ensembl hg19 (Hinxton)ENSG00000152804 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152804 [Gene_View]  chr10:92689924-92695651 [Contig_View]  HHEX [Vega]
ICGC DataPortalENSG00000152804
TCGA cBioPortalHHEX
AceView (NCBI)HHEX
Genatlas (Paris)HHEX
WikiGenes3087
SOURCE (Princeton)HHEX
Genetics Home Reference (NIH)HHEX
Genomic and cartography
GoldenPath hg38 (UCSC)HHEX  -     chr10:92689924-92695651 +  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HHEX  -     10q23.33   [Description]    (hg19-Feb_2009)
EnsemblHHEX - 10q23.33 [CytoView hg19]  HHEX - 10q23.33 [CytoView hg38]
Mapping of homologs : NCBIHHEX [Mapview hg19]  HHEX [Mapview hg38]
OMIM604420   
Gene and transcription
Genbank (Entrez)AA810064 AK309463 AK314891 BC014336 BC015110
RefSeq transcript (Entrez)NM_002729
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HHEX
Cluster EST : UnigeneHs.118651 [ NCBI ]
CGAP (NCI)Hs.118651
Alternative Splicing GalleryENSG00000152804
Gene ExpressionHHEX [ NCBI-GEO ]   HHEX [ EBI - ARRAY_EXPRESS ]   HHEX [ SEEK ]   HHEX [ MEM ]
Gene Expression Viewer (FireBrowse)HHEX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3087
GTEX Portal (Tissue expression)HHEX
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03014   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03014  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03014
Splice isoforms : SwissVarQ03014
PhosPhoSitePlusQ03014
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HHEX
DMDM Disease mutations3087
Blocks (Seattle)HHEX
PDB (SRS)2E1O   
PDB (PDBSum)2E1O   
PDB (IMB)2E1O   
PDB (RSDB)2E1O   
Structural Biology KnowledgeBase2E1O   
SCOP (Structural Classification of Proteins)2E1O   
CATH (Classification of proteins structures)2E1O   
SuperfamilyQ03014
Human Protein AtlasENSG00000152804
Peptide AtlasQ03014
HPRD06829
IPIIPI00008771   IPI01021632   
Protein Interaction databases
DIP (DOE-UCLA)Q03014
IntAct (EBI)Q03014
FunCoupENSG00000152804
BioGRIDHHEX
STRING (EMBL)HHEX
ZODIACHHEX
Ontologies - Pathways
QuickGOQ03014
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  vasculogenesis  in utero embryonic development  myeloid leukocyte differentiation  chromatin binding  protein binding  nucleus  cytoplasm  transcription, DNA-templated  mRNA export from nucleus  Notch signaling pathway  endoderm development  transcription factor binding  eukaryotic initiation factor 4E binding  cell proliferation  DNA binding, bending  response to wounding  anterior/posterior pattern specification  negative regulation of transcription by transcription factor localization  negative regulation of transcription by competitive promoter binding  Wnt signaling pathway  negative regulation of angiogenesis  poly(A)+ mRNA export from nucleus  TBP-class protein binding  interkinetic nuclear migration  cell differentiation  cell differentiation  positive regulation of Wnt signaling pathway  B cell differentiation  thyroid gland development  negative regulation of vascular endothelial growth factor receptor signaling pathway  pancreas development  protein-DNA complex  protein localization to nucleus  embryonic heart tube development  multicellular organism growth  regulation of cell proliferation  protein homodimerization activity  response to peptide hormone  sequence-specific DNA binding  transcription regulatory region DNA binding  transcription regulatory region DNA binding  negative regulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  forebrain morphogenesis  primary lung bud formation  gall bladder development  hepatic duct development  hepatoblast differentiation  hepatocyte differentiation  repressing transcription factor binding  DNA conformation change  HMG box domain binding  primitive streak formation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  vasculogenesis  in utero embryonic development  myeloid leukocyte differentiation  chromatin binding  protein binding  nucleus  cytoplasm  transcription, DNA-templated  mRNA export from nucleus  Notch signaling pathway  endoderm development  transcription factor binding  eukaryotic initiation factor 4E binding  cell proliferation  DNA binding, bending  response to wounding  anterior/posterior pattern specification  negative regulation of transcription by transcription factor localization  negative regulation of transcription by competitive promoter binding  Wnt signaling pathway  negative regulation of angiogenesis  poly(A)+ mRNA export from nucleus  TBP-class protein binding  interkinetic nuclear migration  cell differentiation  cell differentiation  positive regulation of Wnt signaling pathway  B cell differentiation  thyroid gland development  negative regulation of vascular endothelial growth factor receptor signaling pathway  pancreas development  protein-DNA complex  protein localization to nucleus  embryonic heart tube development  multicellular organism growth  regulation of cell proliferation  protein homodimerization activity  response to peptide hormone  sequence-specific DNA binding  transcription regulatory region DNA binding  transcription regulatory region DNA binding  negative regulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  forebrain morphogenesis  primary lung bud formation  gall bladder development  hepatic duct development  hepatoblast differentiation  hepatocyte differentiation  repressing transcription factor binding  DNA conformation change  HMG box domain binding  primitive streak formation  
Pathways : KEGGMaturity onset diabetes of the young    Transcriptional misregulation in cancer   
NDEx NetworkHHEX
Atlas of Cancer Signalling NetworkHHEX
Wikipedia pathwaysHHEX
Orthology - Evolution
OrthoDB3087
GeneTree (enSembl)ENSG00000152804
Phylogenetic Trees/Animal Genes : TreeFamHHEX
HOVERGENQ03014
HOGENOMQ03014
Homologs : HomoloGeneHHEX
Homology/Alignments : Family Browser (UCSC)HHEX
Gene fusions - Rearrangements
Fusion : MitelmanNUP98/HHEX [11p15.4/10q23.33]  [t(10;11)(q23;p15)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHHEX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HHEX
dbVarHHEX
ClinVarHHEX
1000_GenomesHHEX 
Exome Variant ServerHHEX
ExAC (Exome Aggregation Consortium)HHEX (select the gene name)
Genetic variants : HAPMAP3087
Genomic Variants (DGV)HHEX [DGVbeta]
DECIPHERHHEX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHHEX 
Mutations
ICGC Data PortalHHEX 
TCGA Data PortalHHEX 
Broad Tumor PortalHHEX
OASIS PortalHHEX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHHEX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHHEX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HHEX
DgiDB (Drug Gene Interaction Database)HHEX
DoCM (Curated mutations)HHEX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HHEX (select a term)
intoGenHHEX
Cancer3DHHEX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604420   
Orphanet
MedgenHHEX
Genetic Testing Registry HHEX
NextProtQ03014 [Medical]
TSGene3087
GENETestsHHEX
Target ValidationHHEX
Huge Navigator HHEX [HugePedia]
snp3D : Map Gene to Disease3087
BioCentury BCIQHHEX
ClinGenHHEX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3087
Chemical/Pharm GKB GenePA29274
Clinical trialHHEX
Miscellaneous
canSAR (ICR)HHEX (select the gene name)
Probes
Litterature
PubMed160 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHHEX
EVEXHHEX
GoPubMedHHEX
iHOPHHEX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:02:57 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.