Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HHEX (hematopoietically expressed homeobox)

Identity

Alias (NCBI)HEX
HMPH
HOX11L-PEN
PRH
PRHX
HGNC (Hugo) HHEX
HGNC Alias symbHEX
HOX11L-PEN
HGNC Previous namePRHX
LocusID (NCBI) 3087
Atlas_Id 46061
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 92689955 and ends at 92695647 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUP98 (11p15.4) / HHEX (10q23.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;11)(q23;p15) NUP98/HHEX


External links

 

Nomenclature
HGNC (Hugo)HHEX   4901
Cards
Entrez_Gene (NCBI)HHEX    hematopoietically expressed homeobox
AliasesHEX; HMPH; HOX11L-PEN; PRH; 
PRHX
GeneCards (Weizmann)HHEX
Ensembl hg19 (Hinxton)ENSG00000152804 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152804 [Gene_View]  ENSG00000152804 [Sequence]  chr10:92689955-92695647 [Contig_View]  HHEX [Vega]
ICGC DataPortalENSG00000152804
TCGA cBioPortalHHEX
AceView (NCBI)HHEX
Genatlas (Paris)HHEX
SOURCE (Princeton)HHEX
Genetics Home Reference (NIH)HHEX
Genomic and cartography
GoldenPath hg38 (UCSC)HHEX  -     chr10:92689955-92695647 +  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HHEX  -     10q23.33   [Description]    (hg19-Feb_2009)
GoldenPathHHEX - 10q23.33 [CytoView hg19]  HHEX - 10q23.33 [CytoView hg38]
ImmunoBaseENSG00000152804
Genome Data Viewer NCBIHHEX [Mapview hg19]  
OMIM604420   
Gene and transcription
Genbank (Entrez)AA810064 AK309463 AK314891 BC014336 BC015110
RefSeq transcript (Entrez)NM_002729
Consensus coding sequences : CCDS (NCBI)HHEX
Gene ExpressionHHEX [ NCBI-GEO ]   HHEX [ EBI - ARRAY_EXPRESS ]   HHEX [ SEEK ]   HHEX [ MEM ]
Gene Expression Viewer (FireBrowse)HHEX [ Firebrowse - Broad ]
GenevisibleExpression of HHEX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3087
GTEX Portal (Tissue expression)HHEX
Human Protein AtlasENSG00000152804-HHEX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03014   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03014  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03014
PhosPhoSitePlusQ03014
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HHEX
PDB (RSDB)2E1O   
PDB Europe2E1O   
PDB (PDBSum)2E1O   
PDB (IMB)2E1O   
Structural Biology KnowledgeBase2E1O   
SCOP (Structural Classification of Proteins)2E1O   
CATH (Classification of proteins structures)2E1O   
SuperfamilyQ03014
AlphaFold pdb e-kbQ03014   
Human Protein Atlas [tissue]ENSG00000152804-HHEX [tissue]
HPRD06829
Protein Interaction databases
DIP (DOE-UCLA)Q03014
IntAct (EBI)Q03014
BioGRIDHHEX
STRING (EMBL)HHEX
ZODIACHHEX
Ontologies - Pathways
QuickGOQ03014
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  transcription cis-regulatory region binding  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  protein binding  nucleus  cytoplasm  regulation of transcription by RNA polymerase II  mRNA export from nucleus  transcription factor binding  eukaryotic initiation factor 4E binding  DNA binding, bending  response to wounding  anterior/posterior pattern specification  negative regulation of transcription by transcription factor localization  negative regulation of transcription by competitive promoter binding  Wnt signaling pathway  negative regulation of angiogenesis  poly(A)+ mRNA export from nucleus  TBP-class protein binding  cell differentiation  cell differentiation  positive regulation of Wnt signaling pathway  B cell differentiation  negative regulation of vascular endothelial growth factor receptor signaling pathway  protein-DNA complex  protein localization to nucleus  protein homodimerization activity  response to peptide hormone  sequence-specific DNA binding  negative regulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of leukocyte proliferation  DNA conformation change  positive regulation of canonical Wnt signaling pathway  DNA-binding transcription factor binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  transcription cis-regulatory region binding  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  protein binding  nucleus  cytoplasm  regulation of transcription by RNA polymerase II  mRNA export from nucleus  transcription factor binding  eukaryotic initiation factor 4E binding  DNA binding, bending  response to wounding  anterior/posterior pattern specification  negative regulation of transcription by transcription factor localization  negative regulation of transcription by competitive promoter binding  Wnt signaling pathway  negative regulation of angiogenesis  poly(A)+ mRNA export from nucleus  TBP-class protein binding  cell differentiation  cell differentiation  positive regulation of Wnt signaling pathway  B cell differentiation  negative regulation of vascular endothelial growth factor receptor signaling pathway  protein-DNA complex  protein localization to nucleus  protein homodimerization activity  response to peptide hormone  sequence-specific DNA binding  negative regulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of leukocyte proliferation  DNA conformation change  positive regulation of canonical Wnt signaling pathway  DNA-binding transcription factor binding  
Pathways : KEGGMaturity onset diabetes of the young    Transcriptional misregulation in cancer   
NDEx NetworkHHEX
Atlas of Cancer Signalling NetworkHHEX
Wikipedia pathwaysHHEX
Orthology - Evolution
OrthoDB3087
GeneTree (enSembl)ENSG00000152804
Phylogenetic Trees/Animal Genes : TreeFamHHEX
Homologs : HomoloGeneHHEX
Homology/Alignments : Family Browser (UCSC)HHEX
Gene fusions - Rearrangements
Fusion : MitelmanNUP98/HHEX [11p15.4/10q23.33]  
Fusion : QuiverHHEX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHHEX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HHEX
dbVarHHEX
ClinVarHHEX
MonarchHHEX
1000_GenomesHHEX 
Exome Variant ServerHHEX
GNOMAD BrowserENSG00000152804
Varsome BrowserHHEX
ACMGHHEX variants
VarityQ03014
Genomic Variants (DGV)HHEX [DGVbeta]
DECIPHERHHEX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHHEX 
Mutations
ICGC Data PortalHHEX 
TCGA Data PortalHHEX 
Broad Tumor PortalHHEX
OASIS PortalHHEX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHHEX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHHEX
Mutations and Diseases : HGMDHHEX
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHHEX
DgiDB (Drug Gene Interaction Database)HHEX
DoCM (Curated mutations)HHEX
CIViC (Clinical Interpretations of Variants in Cancer)HHEX
Cancer3DHHEX
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604420   
Orphanet
DisGeNETHHEX
MedgenHHEX
Genetic Testing Registry HHEX
NextProtQ03014 [Medical]
GENETestsHHEX
Target ValidationHHEX
Huge Navigator HHEX [HugePedia]
ClinGenHHEX
Clinical trials, drugs, therapy
MyCancerGenomeHHEX
Protein Interactions : CTDHHEX
Pharm GKB GenePA29274
PharosQ03014
Clinical trialHHEX
Miscellaneous
canSAR (ICR)HHEX
HarmonizomeHHEX
DataMed IndexHHEX
Probes
Litterature
PubMed178 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHHEX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:12:22 CEST 2021

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