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HHIP (hedgehog interacting protein)

Identity

Alias_nameshedgehog-interacting protein
Alias_symbol (synonym)HIP
FLJ20992
Other alias
HGNC (Hugo) HHIP
LocusID (NCBI) 64399
Atlas_Id 43958
Location 4q31.21  [Link to chromosome band 4q31]
Location_base_pair Starts at 145567148 and ends at 145659881 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HHIP (4q31.21) / DDX46 (5q31.1)LOC389906 (Xp22.33) / HHIP (4q31.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HHIP   14866
Cards
Entrez_Gene (NCBI)HHIP  64399  hedgehog interacting protein
AliasesHIP
GeneCards (Weizmann)HHIP
Ensembl hg19 (Hinxton)ENSG00000164161 [Gene_View]  chr4:145567148-145659881 [Contig_View]  HHIP [Vega]
Ensembl hg38 (Hinxton)ENSG00000164161 [Gene_View]  chr4:145567148-145659881 [Contig_View]  HHIP [Vega]
ICGC DataPortalENSG00000164161
TCGA cBioPortalHHIP
AceView (NCBI)HHIP
Genatlas (Paris)HHIP
WikiGenes64399
SOURCE (Princeton)HHIP
Genetics Home Reference (NIH)HHIP
Genomic and cartography
GoldenPath hg19 (UCSC)HHIP  -     chr4:145567148-145659881 +  4q31.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HHIP  -     4q31.21   [Description]    (hg38-Dec_2013)
EnsemblHHIP - 4q31.21 [CytoView hg19]  HHIP - 4q31.21 [CytoView hg38]
Mapping of homologs : NCBIHHIP [Mapview hg19]  HHIP [Mapview hg38]
OMIM606178   
Gene and transcription
Genbank (Entrez)AK024645 AK074711 AK098525 AK291849 AY009317
RefSeq transcript (Entrez)NM_022475
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_011496 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)HHIP
Cluster EST : UnigeneHs.507991 [ NCBI ]
CGAP (NCI)Hs.507991
Alternative Splicing GalleryENSG00000164161
Gene ExpressionHHIP [ NCBI-GEO ]   HHIP [ EBI - ARRAY_EXPRESS ]   HHIP [ SEEK ]   HHIP [ MEM ]
Gene Expression Viewer (FireBrowse)HHIP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64399
GTEX Portal (Tissue expression)HHIP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96QV1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96QV1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96QV1
Splice isoforms : SwissVarQ96QV1
PhosPhoSitePlusQ96QV1
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    EGF-like_CS    EGF-like_dom    Folate_rcpt-like    Glc/Sorbosone_DH    Quinoprot_gluc/sorb_DH   
Domain families : Pfam (Sanger)Folate_rec (PF03024)    GSDH (PF07995)   
Domain families : Pfam (NCBI)pfam03024    pfam07995   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)HHIP
DMDM Disease mutations64399
Blocks (Seattle)HHIP
PDB (SRS)2WFT    2WFX    2WG3    2WG4    3HO3    3HO4    3HO5   
PDB (PDBSum)2WFT    2WFX    2WG3    2WG4    3HO3    3HO4    3HO5   
PDB (IMB)2WFT    2WFX    2WG3    2WG4    3HO3    3HO4    3HO5   
PDB (RSDB)2WFT    2WFX    2WG3    2WG4    3HO3    3HO4    3HO5   
Structural Biology KnowledgeBase2WFT    2WFX    2WG3    2WG4    3HO3    3HO4    3HO5   
SCOP (Structural Classification of Proteins)2WFT    2WFX    2WG3    2WG4    3HO3    3HO4    3HO5   
CATH (Classification of proteins structures)2WFT    2WFX    2WG3    2WG4    3HO3    3HO4    3HO5   
SuperfamilyQ96QV1
Human Protein AtlasENSG00000164161
Peptide AtlasQ96QV1
HPRD06937
IPIIPI00556597   IPI00045106   
Protein Interaction databases
DIP (DOE-UCLA)Q96QV1
IntAct (EBI)Q96QV1
FunCoupENSG00000164161
BioGRIDHHIP
STRING (EMBL)HHIP
ZODIACHHIP
Ontologies - Pathways
QuickGOQ96QV1
Ontology : AmiGOprotein binding  extracellular region  cytoplasm  integral component of plasma membrane  carbohydrate metabolic process  smoothened signaling pathway  neuroblast proliferation  zinc ion binding  dorsal/ventral pattern formation  negative regulation of signal transduction  cell surface  oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor  regulation of fibroblast growth factor receptor signaling pathway  negative regulation of smoothened signaling pathway  negative regulation of smoothened signaling pathway  quinone binding  skeletal system morphogenesis  oxidation-reduction process  ciliary membrane  epithelial tube branching involved in lung morphogenesis  hedgehog family protein binding  
Ontology : EGO-EBIprotein binding  extracellular region  cytoplasm  integral component of plasma membrane  carbohydrate metabolic process  smoothened signaling pathway  neuroblast proliferation  zinc ion binding  dorsal/ventral pattern formation  negative regulation of signal transduction  cell surface  oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor  regulation of fibroblast growth factor receptor signaling pathway  negative regulation of smoothened signaling pathway  negative regulation of smoothened signaling pathway  quinone binding  skeletal system morphogenesis  oxidation-reduction process  ciliary membrane  epithelial tube branching involved in lung morphogenesis  hedgehog family protein binding  
Pathways : KEGGHedgehog signaling pathway    Pathways in cancer    Basal cell carcinoma   
NDEx NetworkHHIP
Atlas of Cancer Signalling NetworkHHIP
Wikipedia pathwaysHHIP
Orthology - Evolution
OrthoDB64399
GeneTree (enSembl)ENSG00000164161
Phylogenetic Trees/Animal Genes : TreeFamHHIP
HOVERGENQ96QV1
HOGENOMQ96QV1
Homologs : HomoloGeneHHIP
Homology/Alignments : Family Browser (UCSC)HHIP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHHIP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HHIP
dbVarHHIP
ClinVarHHIP
1000_GenomesHHIP 
Exome Variant ServerHHIP
ExAC (Exome Aggregation Consortium)HHIP (select the gene name)
Genetic variants : HAPMAP64399
Genomic Variants (DGV)HHIP [DGVbeta]
DECIPHER (Syndromes)4:145567148-145659881  ENSG00000164161
CONAN: Copy Number AnalysisHHIP 
Mutations
ICGC Data PortalHHIP 
TCGA Data PortalHHIP 
Broad Tumor PortalHHIP
OASIS PortalHHIP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHHIP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHHIP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HHIP
DgiDB (Drug Gene Interaction Database)HHIP
DoCM (Curated mutations)HHIP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HHIP (select a term)
intoGenHHIP
Cancer3DHHIP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606178   
Orphanet
MedgenHHIP
Genetic Testing Registry HHIP
NextProtQ96QV1 [Medical]
TSGene64399
GENETestsHHIP
Huge Navigator HHIP [HugePedia]
snp3D : Map Gene to Disease64399
BioCentury BCIQHHIP
ClinGenHHIP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64399
Chemical/Pharm GKB GenePA29276
Clinical trialHHIP
Miscellaneous
canSAR (ICR)HHIP (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHHIP
EVEXHHIP
GoPubMedHHIP
iHOPHHIP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:08:58 CET 2017

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