HHLA2 (HERV-H LTR-associating 2)

2015-03-01  

Identity

HGNC
HHLA2
LOCATION
3q13.13
LOCUSID
11148
ALIAS
B7-H5,B7-H7,B7H7,B7y
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11148
MIM: 604371
HGNC: 4905
Ensembl: ENSG00000114455

Variants:

dbSNP: 11148
ClinVar: 11148
TCGA: ENSG00000114455
COSMIC: HHLA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114455ENST00000357759Q9UM44
ENSG00000114455ENST00000462629C9JY43
ENSG00000114455ENST00000463019C9JY13
ENSG00000114455ENST00000467282C9JD07
ENSG00000114455ENST00000467562Q9UM44
ENSG00000114455ENST00000467761Q9UM44
ENSG00000114455ENST00000482099H7C523
ENSG00000114455ENST00000482430C9J8J7
ENSG00000114455ENST00000489514Q9UM44
ENSG00000114455ENST00000491820C9J7D0
ENSG00000114455ENST00000619531Q9UM44

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
237840062013B7-H5 costimulates human T cells via CD28H.50
237166852013HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.48
255497242015Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein.37
275312812016HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival.22
275538312017HHLA2, a New Immune Checkpoint Member of the B7 Family, Is Widely Expressed in Human Lung Cancer and Associated with EGFR Mutational Status.21
299671342019Upregulated immune checkpoint HHLA2 in clear cell renal cell carcinoma: a novel prognostic biomarker and potential therapeutic target.12
255199282015Expression of the Novel Costimulatory Molecule B7-H5 in Pancreatic Cancer.11
304472552019HHLA2 is a novel immune checkpoint protein in pancreatic ductal adenocarcinoma and predicts post-surgical survival.9
308852762019HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1.7
306021542019Immune Checkpoint Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 is Upregulated and Independently Predicts Unfavorable Prognosis in Bladder Urothelial Carcinoma.5

Citation

Dessen P

HHLA2 (HERV-H LTR-associating 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55630/hhla2