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HIC2 (HIC ZBTB transcriptional repressor 2)

Identity

Alias_nameshypermethylated in cancer 2
Alias_symbol (synonym)KIAA1020
HRG22
ZBTB30
ZNF907
Other alias
HGNC (Hugo) HIC2
LocusID (NCBI) 23119
Atlas_Id 40820
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 21417404 and ends at 21451461 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HIC2   18595
Cards
Entrez_Gene (NCBI)HIC2  23119  HIC ZBTB transcriptional repressor 2
AliasesHRG22; ZBTB30; ZNF907
GeneCards (Weizmann)HIC2
Ensembl hg19 (Hinxton)ENSG00000169635 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169635 [Gene_View]  chr22:21417404-21451461 [Contig_View]  HIC2 [Vega]
ICGC DataPortalENSG00000169635
TCGA cBioPortalHIC2
AceView (NCBI)HIC2
Genatlas (Paris)HIC2
WikiGenes23119
SOURCE (Princeton)HIC2
Genetics Home Reference (NIH)HIC2
Genomic and cartography
GoldenPath hg38 (UCSC)HIC2  -     chr22:21417404-21451461 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIC2  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblHIC2 - 22q11.21 [CytoView hg19]  HIC2 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIHIC2 [Mapview hg19]  HIC2 [Mapview hg38]
OMIM607712   
Gene and transcription
Genbank (Entrez)AB028943 AF349035 AJ313204 AK023021 AL162003
RefSeq transcript (Entrez)NM_015094
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIC2
Cluster EST : UnigeneHs.632767 [ NCBI ]
CGAP (NCI)Hs.632767
Alternative Splicing GalleryENSG00000169635
Gene ExpressionHIC2 [ NCBI-GEO ]   HIC2 [ EBI - ARRAY_EXPRESS ]   HIC2 [ SEEK ]   HIC2 [ MEM ]
Gene Expression Viewer (FireBrowse)HIC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23119
GTEX Portal (Tissue expression)HIC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96JB3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96JB3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96JB3
Splice isoforms : SwissVarQ96JB3
PhosPhoSitePlusQ96JB3
Domaine pattern : Prosite (Expaxy)BTB (PS50097)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)BTB/POZ_dom    SKP1/BTB/POZ    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)BTB (PF00651)    zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00651    pfam00096   
Domain families : Smart (EMBL)BTB (SM00225)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)HIC2
DMDM Disease mutations23119
Blocks (Seattle)HIC2
SuperfamilyQ96JB3
Human Protein AtlasENSG00000169635
Peptide AtlasQ96JB3
HPRD07412
IPIIPI00376570   IPI00219839   
Protein Interaction databases
DIP (DOE-UCLA)Q96JB3
IntAct (EBI)Q96JB3
FunCoupENSG00000169635
BioGRIDHIC2
STRING (EMBL)HIC2
ZODIACHIC2
Ontologies - Pathways
QuickGOQ96JB3
Ontology : AmiGODNA binding  nucleus  transcription, DNA-templated  protein C-terminus binding  negative regulation of transcription, DNA-templated  metal ion binding  
Ontology : EGO-EBIDNA binding  nucleus  transcription, DNA-templated  protein C-terminus binding  negative regulation of transcription, DNA-templated  metal ion binding  
NDEx NetworkHIC2
Atlas of Cancer Signalling NetworkHIC2
Wikipedia pathwaysHIC2
Orthology - Evolution
OrthoDB23119
GeneTree (enSembl)ENSG00000169635
Phylogenetic Trees/Animal Genes : TreeFamHIC2
HOVERGENQ96JB3
HOGENOMQ96JB3
Homologs : HomoloGeneHIC2
Homology/Alignments : Family Browser (UCSC)HIC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIC2
dbVarHIC2
ClinVarHIC2
1000_GenomesHIC2 
Exome Variant ServerHIC2
ExAC (Exome Aggregation Consortium)HIC2 (select the gene name)
Genetic variants : HAPMAP23119
Genomic Variants (DGV)HIC2 [DGVbeta]
DECIPHERHIC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIC2 
Mutations
ICGC Data PortalHIC2 
TCGA Data PortalHIC2 
Broad Tumor PortalHIC2
OASIS PortalHIC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIC2
DgiDB (Drug Gene Interaction Database)HIC2
DoCM (Curated mutations)HIC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIC2 (select a term)
intoGenHIC2
Cancer3DHIC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607712   
Orphanet
MedgenHIC2
Genetic Testing Registry HIC2
NextProtQ96JB3 [Medical]
TSGene23119
GENETestsHIC2
Target ValidationHIC2
Huge Navigator HIC2 [HugePedia]
snp3D : Map Gene to Disease23119
BioCentury BCIQHIC2
ClinGenHIC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23119
Chemical/Pharm GKB GenePA38357
Clinical trialHIC2
Miscellaneous
canSAR (ICR)HIC2 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIC2
EVEXHIC2
GoPubMedHIC2
iHOPHIC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:11:27 CEST 2017

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