| Nomenclature |
|---|
| HGNC (Hugo) | HIF1AN 17113 |
| Cards |
|---|
| Entrez_Gene (NCBI) | HIF1AN 55662 hypoxia inducible factor 1 subunit alpha inhibitor |
| Aliases | FIH1 |
| GeneCards (Weizmann) | HIF1AN |
| Ensembl hg19 (Hinxton) | ENSG00000166135 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000166135 [Gene_View] ENSG00000166135 [Sequence] chr10:100535884-100553924 [Contig_View] HIF1AN [Vega] |
| ICGC DataPortal | ENSG00000166135 |
| TCGA cBioPortal | HIF1AN |
| AceView (NCBI) | HIF1AN |
| Genatlas (Paris) | HIF1AN |
| WikiGenes | 55662 |
| SOURCE (Princeton) | HIF1AN |
| Genetics Home Reference (NIH) | HIF1AN |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | HIF1AN - chr10:100535884-100553924 + 10q24.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | HIF1AN - 10q24.31 [Description] (hg19-Feb_2009) |
| Ensembl | HIF1AN - 10q24.31 [CytoView hg19] HIF1AN - 10q24.31 [CytoView hg38] |
| Mapping of homologs : NCBI | HIF1AN [Mapview hg19] HIF1AN [Mapview hg38] |
| OMIM | 606615 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF395830 AK000622 AK025680 AK295353 AL359615 |
| RefSeq transcript (Entrez) | NM_017902 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | HIF1AN |
| Cluster EST : Unigene | Hs.500788 [ NCBI ] |
| CGAP (NCI) | Hs.500788 |
| Alternative Splicing Gallery | ENSG00000166135 |
| Gene Expression | HIF1AN [ NCBI-GEO ] HIF1AN [ EBI - ARRAY_EXPRESS ]
HIF1AN [ SEEK ] HIF1AN [ MEM ] |
| Gene Expression Viewer (FireBrowse) | HIF1AN [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 55662 |
| GTEX Portal (Tissue expression) | HIF1AN |
| Human Protein Atlas | ENSG00000166135-HIF1AN [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9NWT6 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9NWT6 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9NWT6 |
| Splice isoforms : SwissVar | Q9NWT6 |
| Catalytic activity : Enzyme | 1.14.11.30 [ Enzyme-Expasy ] 1.14.11.301.14.11.30 [ IntEnz-EBI ] 1.14.11.30 [ BRENDA ] 1.14.11.30 [ KEGG ] |
| PhosPhoSitePlus | Q9NWT6 |
| Domaine pattern : Prosite (Expaxy) | JMJC (PS51184) |
| Domains : Interpro (EBI) | FIH-1 FIH-1_dom_II JmjC_dom |
| Domain families : Pfam (Sanger) | |
| Domain families : Pfam (NCBI) | |
| Domain families : Smart (EMBL) | JmjC (SM00558) |
| Conserved Domain (NCBI) | HIF1AN |
| DMDM Disease mutations | 55662 |
| Blocks (Seattle) | HIF1AN |
| PDB (SRS) | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC |
| PDB (PDBSum) | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC |
| PDB (IMB) | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC |
| PDB (RSDB) | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC |
| Structural Biology KnowledgeBase | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC |
| SCOP (Structural Classification of Proteins) | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC |
| CATH (Classification of proteins structures) | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC |
| Superfamily | Q9NWT6 |
| Human Protein Atlas [tissue] | ENSG00000166135-HIF1AN [tissue] |
| Peptide Atlas | Q9NWT6 |
| HPRD | 09426 |
| IPI | IPI00941238 IPI00299906 IPI00386223 IPI00978147 IPI00980221 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9NWT6 |
| IntAct (EBI) | Q9NWT6 |
| FunCoup | ENSG00000166135 |
| BioGRID | HIF1AN |
| STRING (EMBL) | HIF1AN |
| ZODIAC | HIF1AN |
| Ontologies - Pathways |
|---|
| QuickGO | Q9NWT6 |
| Ontology : AmiGO | Notch binding iron ion binding protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol zinc ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxygen sensor activity carboxylic acid binding peptidyl-histidine hydroxylation peptidyl-histidine hydroxylation peptidyl-histidine dioxygenase activity peptidyl-histidine dioxygenase activity peptidyl-asparagine 3-dioxygenase activity peptidyl-asparagine 3-dioxygenase activity peptidyl-asparagine 3-dioxygenase activity peptidyl-aspartic acid hydroxylation peptidyl-aspartic acid hydroxylation peptidyl-asparagine hydroxylation peptidyl-asparagine hydroxylation peptidyl-asparagine hydroxylation protein homodimerization activity positive regulation of myoblast differentiation negative regulation of Notch signaling pathway negative regulation of Notch signaling pathway cofactor binding perinuclear region of cytoplasm NF-kappaB binding oxidation-reduction process regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of transcription from RNA polymerase II promoter in response to hypoxia ankyrin repeat binding ankyrin repeat binding hypoxia-inducible factor-asparagine oxygenase activity positive regulation of vasculogenesis |
| Ontology : EGO-EBI | Notch binding iron ion binding protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol zinc ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxygen sensor activity carboxylic acid binding peptidyl-histidine hydroxylation peptidyl-histidine hydroxylation peptidyl-histidine dioxygenase activity peptidyl-histidine dioxygenase activity peptidyl-asparagine 3-dioxygenase activity peptidyl-asparagine 3-dioxygenase activity peptidyl-asparagine 3-dioxygenase activity peptidyl-aspartic acid hydroxylation peptidyl-aspartic acid hydroxylation peptidyl-asparagine hydroxylation peptidyl-asparagine hydroxylation peptidyl-asparagine hydroxylation protein homodimerization activity positive regulation of myoblast differentiation negative regulation of Notch signaling pathway negative regulation of Notch signaling pathway cofactor binding perinuclear region of cytoplasm NF-kappaB binding oxidation-reduction process regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of transcription from RNA polymerase II promoter in response to hypoxia ankyrin repeat binding ankyrin repeat binding hypoxia-inducible factor-asparagine oxygenase activity positive regulation of vasculogenesis |
| NDEx Network | HIF1AN |
| Atlas of Cancer Signalling Network | HIF1AN |
| Wikipedia pathways | HIF1AN |
| Orthology - Evolution |
|---|
| OrthoDB | 55662 |
| GeneTree (enSembl) | ENSG00000166135 |
| Phylogenetic Trees/Animal Genes : TreeFam | HIF1AN |
| HOGENOM | Q9NWT6 |
| Homologs : HomoloGene | HIF1AN |
| Homology/Alignments : Family Browser (UCSC) | HIF1AN |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | BTRC/HIF1AN [10q24.32/10q24.31] [t(10;10)(q24;q24)] |
| Fusion Portal | BTRC 10q24.32 HIF1AN 10q24.31 KIRC |
| Fusion : Quiver | HIF1AN |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | HIF1AN [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | HIF1AN |
| dbVar | HIF1AN |
| ClinVar | HIF1AN |
| 1000_Genomes | HIF1AN |
| Exome Variant Server | HIF1AN |
| ExAC (Exome Aggregation Consortium) | ENSG00000166135 |
| GNOMAD Browser | ENSG00000166135 |
| Varsome Browser | HIF1AN |
| Genetic variants : HAPMAP | 55662 |
| Genomic Variants (DGV) | HIF1AN [DGVbeta] |
| DECIPHER | HIF1AN [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | HIF1AN |
| Mutations |
|---|
| ICGC Data Portal | HIF1AN |
| TCGA Data Portal | HIF1AN |
| Broad Tumor Portal | HIF1AN |
| OASIS Portal | HIF1AN [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | HIF1AN [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | HIF1AN |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search HIF1AN |
| DgiDB (Drug Gene Interaction Database) | HIF1AN |
| DoCM (Curated mutations) | HIF1AN (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | HIF1AN (select a term) |
| intoGen | HIF1AN |
| Cancer3D | HIF1AN(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 606615 |
| Orphanet | |
| DisGeNET | HIF1AN |
| Medgen | HIF1AN |
| Genetic Testing Registry | HIF1AN
|
| NextProt | Q9NWT6 [Medical] |
| TSGene | 55662 |
| GENETests | HIF1AN |
| Target Validation | HIF1AN |
| Huge Navigator |
HIF1AN [HugePedia] |
| snp3D : Map Gene to Disease | 55662 |
| BioCentury BCIQ | HIF1AN |
| ClinGen | HIF1AN |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 55662 |
| Chemical/Pharm GKB Gene | PA29284 |
| Clinical trial | HIF1AN |
| Miscellaneous |
|---|
| canSAR (ICR) | HIF1AN (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 101 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | HIF1AN |
| EVEX | HIF1AN |
| GoPubMed | HIF1AN |
| iHOP | HIF1AN |
