Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor)

Identity

Alias (NCBI)FIH1
HGNC (Hugo) HIF1AN
HGNC Alias symbFLJ20615
DKFZp762F1811
FLJ22027
FIH1
HGNC Alias namePeptide-aspartate beta-dioxygenase
LocusID (NCBI) 55662
Atlas_Id 40822
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 100535943 and ends at 100559995 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTRC (10q24.32) / HIF1AN (10q24.31)HIF1AN (10q24.31) / HIF1AN (10q24.31)BTRC 10q24.32 / HIF1AN 10q24.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)HIF1AN   17113
Cards
Entrez_Gene (NCBI)HIF1AN    hypoxia inducible factor 1 subunit alpha inhibitor
AliasesFIH1
GeneCards (Weizmann)HIF1AN
Ensembl hg19 (Hinxton)ENSG00000166135 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166135 [Gene_View]  ENSG00000166135 [Sequence]  chr10:100535943-100559995 [Contig_View]  HIF1AN [Vega]
ICGC DataPortalENSG00000166135
TCGA cBioPortalHIF1AN
AceView (NCBI)HIF1AN
Genatlas (Paris)HIF1AN
SOURCE (Princeton)HIF1AN
Genetics Home Reference (NIH)HIF1AN
Genomic and cartography
GoldenPath hg38 (UCSC)HIF1AN  -     chr10:100535943-100559995 +  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIF1AN  -     10q24.31   [Description]    (hg19-Feb_2009)
GoldenPathHIF1AN - 10q24.31 [CytoView hg19]  HIF1AN - 10q24.31 [CytoView hg38]
ImmunoBaseENSG00000166135
Genome Data Viewer NCBIHIF1AN [Mapview hg19]  
OMIM606615   
Gene and transcription
Genbank (Entrez)AF395830 AK000622 AK025680 AK295353 AL359615
RefSeq transcript (Entrez)NM_017902
Consensus coding sequences : CCDS (NCBI)HIF1AN
Gene ExpressionHIF1AN [ NCBI-GEO ]   HIF1AN [ EBI - ARRAY_EXPRESS ]   HIF1AN [ SEEK ]   HIF1AN [ MEM ]
Gene Expression Viewer (FireBrowse)HIF1AN [ Firebrowse - Broad ]
GenevisibleExpression of HIF1AN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55662
GTEX Portal (Tissue expression)HIF1AN
Human Protein AtlasENSG00000166135-HIF1AN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NWT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NWT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NWT6
Catalytic activity : Enzyme1.14.11.30 [ Enzyme-Expasy ]   1.14.11.301.14.11.30 [ IntEnz-EBI ]   1.14.11.30 [ BRENDA ]   1.14.11.30 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NWT6
Domaine pattern : Prosite (Expaxy)JMJC (PS51184)   
Domains : Interpro (EBI)Cupin_8    FIH-1    FIH-1_dom_II    JmjC_dom   
Domain families : Pfam (Sanger)Cupin_8 (PF13621)   
Domain families : Pfam (NCBI)pfam13621   
Domain families : Smart (EMBL)JmjC (SM00558)  
Conserved Domain (NCBI)HIF1AN
PDB (RSDB)1H2K    1H2L    1H2M    1H2N    1IZ3    1MZE    1MZF    1YCI    2CGN    2CGO    2ILM    2W0X    2WA3    2WA4    2XUM    2Y0I    2YC0    2YDE    3D8C    3KCX    3KCY    3OD4    3P3N    3P3P    4AI8    4B7E    4B7K    4BIO    4JAA    4NR1    4Z1V    4Z2W    5JWK    5JWL    5JWP    5OP6    5OP8    5OPC    6H9J    6HA6    6HC8    6HKP    6HL5    6HL6    6RUJ   
PDB Europe1H2K    1H2L    1H2M    1H2N    1IZ3    1MZE    1MZF    1YCI    2CGN    2CGO    2ILM    2W0X    2WA3    2WA4    2XUM    2Y0I    2YC0    2YDE    3D8C    3KCX    3KCY    3OD4    3P3N    3P3P    4AI8    4B7E    4B7K    4BIO    4JAA    4NR1    4Z1V    4Z2W    5JWK    5JWL    5JWP    5OP6    5OP8    5OPC    6H9J    6HA6    6HC8    6HKP    6HL5    6HL6    6RUJ   
PDB (PDBSum)1H2K    1H2L    1H2M    1H2N    1IZ3    1MZE    1MZF    1YCI    2CGN    2CGO    2ILM    2W0X    2WA3    2WA4    2XUM    2Y0I    2YC0    2YDE    3D8C    3KCX    3KCY    3OD4    3P3N    3P3P    4AI8    4B7E    4B7K    4BIO    4JAA    4NR1    4Z1V    4Z2W    5JWK    5JWL    5JWP    5OP6    5OP8    5OPC    6H9J    6HA6    6HC8    6HKP    6HL5    6HL6    6RUJ   
PDB (IMB)1H2K    1H2L    1H2M    1H2N    1IZ3    1MZE    1MZF    1YCI    2CGN    2CGO    2ILM    2W0X    2WA3    2WA4    2XUM    2Y0I    2YC0    2YDE    3D8C    3KCX    3KCY    3OD4    3P3N    3P3P    4AI8    4B7E    4B7K    4BIO    4JAA    4NR1    4Z1V    4Z2W    5JWK    5JWL    5JWP    5OP6    5OP8    5OPC    6H9J    6HA6    6HC8    6HKP    6HL5    6HL6    6RUJ   
Structural Biology KnowledgeBase1H2K    1H2L    1H2M    1H2N    1IZ3    1MZE    1MZF    1YCI    2CGN    2CGO    2ILM    2W0X    2WA3    2WA4    2XUM    2Y0I    2YC0    2YDE    3D8C    3KCX    3KCY    3OD4    3P3N    3P3P    4AI8    4B7E    4B7K    4BIO    4JAA    4NR1    4Z1V    4Z2W    5JWK    5JWL    5JWP    5OP6    5OP8    5OPC    6H9J    6HA6    6HC8    6HKP    6HL5    6HL6    6RUJ   
SCOP (Structural Classification of Proteins)1H2K    1H2L    1H2M    1H2N    1IZ3    1MZE    1MZF    1YCI    2CGN    2CGO    2ILM    2W0X    2WA3    2WA4    2XUM    2Y0I    2YC0    2YDE    3D8C    3KCX    3KCY    3OD4    3P3N    3P3P    4AI8    4B7E    4B7K    4BIO    4JAA    4NR1    4Z1V    4Z2W    5JWK    5JWL    5JWP    5OP6    5OP8    5OPC    6H9J    6HA6    6HC8    6HKP    6HL5    6HL6    6RUJ   
CATH (Classification of proteins structures)1H2K    1H2L    1H2M    1H2N    1IZ3    1MZE    1MZF    1YCI    2CGN    2CGO    2ILM    2W0X    2WA3    2WA4    2XUM    2Y0I    2YC0    2YDE    3D8C    3KCX    3KCY    3OD4    3P3N    3P3P    4AI8    4B7E    4B7K    4BIO    4JAA    4NR1    4Z1V    4Z2W    5JWK    5JWL    5JWP    5OP6    5OP8    5OPC    6H9J    6HA6    6HC8    6HKP    6HL5    6HL6    6RUJ   
SuperfamilyQ9NWT6
AlphaFold pdb e-kbQ9NWT6   
Human Protein Atlas [tissue]ENSG00000166135-HIF1AN [tissue]
HPRD09426
Protein Interaction databases
DIP (DOE-UCLA)Q9NWT6
IntAct (EBI)Q9NWT6
BioGRIDHIF1AN
STRING (EMBL)HIF1AN
ZODIACHIF1AN
Ontologies - Pathways
QuickGOQ9NWT6
Ontology : AmiGONotch binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  ferrous iron binding  zinc ion binding  2-oxoglutarate-dependent dioxygenase activity  oxygen sensor activity  carboxylic acid binding  peptidyl-histidine hydroxylation  peptidyl-histidine hydroxylation  peptidyl-histidine dioxygenase activity  peptidyl-histidine dioxygenase activity  peptidyl-asparagine 3-dioxygenase activity  peptidyl-asparagine 3-dioxygenase activity  peptidyl-asparagine 3-dioxygenase activity  peptidyl-aspartic acid hydroxylation  peptidyl-aspartic acid hydroxylation  peptidyl-asparagine hydroxylation  peptidyl-asparagine hydroxylation  peptidyl-asparagine hydroxylation  protein homodimerization activity  positive regulation of myoblast differentiation  negative regulation of Notch signaling pathway  negative regulation of Notch signaling pathway  perinuclear region of cytoplasm  NF-kappaB binding  regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  ankyrin repeat binding  ankyrin repeat binding  hypoxia-inducible factor-asparagine oxygenase activity  positive regulation of vasculogenesis  
Ontology : EGO-EBINotch binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  ferrous iron binding  zinc ion binding  2-oxoglutarate-dependent dioxygenase activity  oxygen sensor activity  carboxylic acid binding  peptidyl-histidine hydroxylation  peptidyl-histidine hydroxylation  peptidyl-histidine dioxygenase activity  peptidyl-histidine dioxygenase activity  peptidyl-asparagine 3-dioxygenase activity  peptidyl-asparagine 3-dioxygenase activity  peptidyl-asparagine 3-dioxygenase activity  peptidyl-aspartic acid hydroxylation  peptidyl-aspartic acid hydroxylation  peptidyl-asparagine hydroxylation  peptidyl-asparagine hydroxylation  peptidyl-asparagine hydroxylation  protein homodimerization activity  positive regulation of myoblast differentiation  negative regulation of Notch signaling pathway  negative regulation of Notch signaling pathway  perinuclear region of cytoplasm  NF-kappaB binding  regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  ankyrin repeat binding  ankyrin repeat binding  hypoxia-inducible factor-asparagine oxygenase activity  positive regulation of vasculogenesis  
NDEx NetworkHIF1AN
Atlas of Cancer Signalling NetworkHIF1AN
Wikipedia pathwaysHIF1AN
Orthology - Evolution
OrthoDB55662
GeneTree (enSembl)ENSG00000166135
Phylogenetic Trees/Animal Genes : TreeFamHIF1AN
Homologs : HomoloGeneHIF1AN
Homology/Alignments : Family Browser (UCSC)HIF1AN
Gene fusions - Rearrangements
Fusion : MitelmanBTRC/HIF1AN [10q24.32/10q24.31]  
Fusion : QuiverHIF1AN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIF1AN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIF1AN
dbVarHIF1AN
ClinVarHIF1AN
MonarchHIF1AN
1000_GenomesHIF1AN 
Exome Variant ServerHIF1AN
GNOMAD BrowserENSG00000166135
Varsome BrowserHIF1AN
ACMGHIF1AN variants
VarityQ9NWT6
Genomic Variants (DGV)HIF1AN [DGVbeta]
DECIPHERHIF1AN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIF1AN 
Mutations
ICGC Data PortalHIF1AN 
TCGA Data PortalHIF1AN 
Broad Tumor PortalHIF1AN
OASIS PortalHIF1AN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIF1AN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHIF1AN
Mutations and Diseases : HGMDHIF1AN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHIF1AN
DgiDB (Drug Gene Interaction Database)HIF1AN
DoCM (Curated mutations)HIF1AN
CIViC (Clinical Interpretations of Variants in Cancer)HIF1AN
Cancer3DHIF1AN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606615   
Orphanet
DisGeNETHIF1AN
MedgenHIF1AN
Genetic Testing Registry HIF1AN
NextProtQ9NWT6 [Medical]
GENETestsHIF1AN
Target ValidationHIF1AN
Huge Navigator HIF1AN [HugePedia]
ClinGenHIF1AN
Clinical trials, drugs, therapy
MyCancerGenomeHIF1AN
Protein Interactions : CTDHIF1AN
Pharm GKB GenePA29284
PharosQ9NWT6
Clinical trialHIF1AN
Miscellaneous
canSAR (ICR)HIF1AN
HarmonizomeHIF1AN
DataMed IndexHIF1AN
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHIF1AN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:24 CEST 2021
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