HIF3A (hypoxia inducible factor 3 subunit alpha)

2007-04-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
HIF-3A,HIF3-alpha-1,IPAS,MOP7,PASD7,bHLHe17

Other Information

Locus ID:

NCBI: 64344
MIM: 609976
HGNC: 15825
Ensembl: ENSG00000124440

Variants:

dbSNP: 64344
ClinVar: 64344
TCGA: ENSG00000124440
COSMIC: HIF3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124440ENST00000244303Q9Y2N7
ENSG00000124440ENST00000300862Q9Y2N7
ENSG00000124440ENST00000377670Q9Y2N7
ENSG00000124440ENST00000472815H0YDZ5
ENSG00000124440ENST00000526506E9PJR0
ENSG00000124440ENST00000528563E9PJR0
ENSG00000124440ENST00000531043H0YE02
ENSG00000124440ENST00000533145E9PLC8
ENSG00000124440ENST00000533789E9PNQ7
ENSG00000124440ENST00000600383M0R104
ENSG00000124440ENST00000600879E9PJR0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaREACTOMER-HSA-1234176
Regulation of gene expression by Hypoxia-inducible FactorREACTOMER-HSA-1234158

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125386442003Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.76
214798712011Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response.50
161269072005Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma.48
167756262006Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha.38
268617842016DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework.38
204163952010Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.35
196946162009The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.31
179988052007Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression.29
270189752016Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma.29
259368622015Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review).22

Citation

Dessen P

HIF3A (hypoxia inducible factor 3 subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47300/hif3a