Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HINT1 (histidine triad nucleotide binding protein 1)

Identity

Alias_namesPRKCNH1
HINT
histidine triad nucleotide-binding protein
Alias_symbol (synonym)PKCI-1
Other aliasNMAN
HGNC (Hugo) HINT1
LocusID (NCBI) 3094
Atlas_Id 51577
Location 5q23.3  [Link to chromosome band 5q23]
Location_base_pair Starts at 131159283 and ends at 131165348 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CENPL (1q25.1) / HINT1 (5q23.3)HINT1 (5q23.3) / DYNC2H1 (11q22.3)HINT1 (5q23.3) / HINT1 (5q23.3)
HINT1 (5q23.3) / MYL12A (18p11.31)HINT1 (5q23.3) / RAPGEF6 (5q31.1)HINT1 (5q23.3) / USP34 (2p15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HINT1   4912
Cards
Entrez_Gene (NCBI)HINT1  3094  histidine triad nucleotide binding protein 1
AliasesHINT; NMAN; PKCI-1; PRKCNH1
GeneCards (Weizmann)HINT1
Ensembl hg19 (Hinxton)ENSG00000169567 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169567 [Gene_View]  chr5:131159283-131165348 [Contig_View]  HINT1 [Vega]
ICGC DataPortalENSG00000169567
TCGA cBioPortalHINT1
AceView (NCBI)HINT1
Genatlas (Paris)HINT1
WikiGenes3094
SOURCE (Princeton)HINT1
Genetics Home Reference (NIH)HINT1
Genomic and cartography
GoldenPath hg38 (UCSC)HINT1  -     chr5:131159283-131165348 -  5q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HINT1  -     5q23.3   [Description]    (hg19-Feb_2009)
EnsemblHINT1 - 5q23.3 [CytoView hg19]  HINT1 - 5q23.3 [CytoView hg38]
Mapping of homologs : NCBIHINT1 [Mapview hg19]  HINT1 [Mapview hg38]
OMIM137200   601314   
Gene and transcription
Genbank (Entrez)AA076103 AK026557 AK054976 AK056902 BC001287
RefSeq transcript (Entrez)NM_005340
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HINT1
Cluster EST : UnigeneHs.483305 [ NCBI ]
CGAP (NCI)Hs.483305
Alternative Splicing GalleryENSG00000169567
Gene ExpressionHINT1 [ NCBI-GEO ]   HINT1 [ EBI - ARRAY_EXPRESS ]   HINT1 [ SEEK ]   HINT1 [ MEM ]
Gene Expression Viewer (FireBrowse)HINT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3094
GTEX Portal (Tissue expression)HINT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49773   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49773  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49773
Splice isoforms : SwissVarP49773
Catalytic activity : Enzyme3.-.-.- [ Enzyme-Expasy ]   3.-.-.-3.-.-.- [ IntEnz-EBI ]   3.-.-.- [ BRENDA ]   3.-.-.- [ KEGG ]   
PhosPhoSitePlusP49773
Domaine pattern : Prosite (Expaxy)HIT_1 (PS00892)    HIT_2 (PS51084)   
Domains : Interpro (EBI)Histidine_triad_CS    Histidine_triad_HIT    HIT-like   
Domain families : Pfam (Sanger)HIT (PF01230)   
Domain families : Pfam (NCBI)pfam01230   
Conserved Domain (NCBI)HINT1
DMDM Disease mutations3094
Blocks (Seattle)HINT1
PDB (SRS)1AV5    1KPA    1KPB    1KPC    1KPE    1KPF    3TW2    4EQE    4EQG    4EQH    4ZKL    4ZKV    5ED3    5ED6    5EMT    5I2E    5I2F   
PDB (PDBSum)1AV5    1KPA    1KPB    1KPC    1KPE    1KPF    3TW2    4EQE    4EQG    4EQH    4ZKL    4ZKV    5ED3    5ED6    5EMT    5I2E    5I2F   
PDB (IMB)1AV5    1KPA    1KPB    1KPC    1KPE    1KPF    3TW2    4EQE    4EQG    4EQH    4ZKL    4ZKV    5ED3    5ED6    5EMT    5I2E    5I2F   
PDB (RSDB)1AV5    1KPA    1KPB    1KPC    1KPE    1KPF    3TW2    4EQE    4EQG    4EQH    4ZKL    4ZKV    5ED3    5ED6    5EMT    5I2E    5I2F   
Structural Biology KnowledgeBase1AV5    1KPA    1KPB    1KPC    1KPE    1KPF    3TW2    4EQE    4EQG    4EQH    4ZKL    4ZKV    5ED3    5ED6    5EMT    5I2E    5I2F   
SCOP (Structural Classification of Proteins)1AV5    1KPA    1KPB    1KPC    1KPE    1KPF    3TW2    4EQE    4EQG    4EQH    4ZKL    4ZKV    5ED3    5ED6    5EMT    5I2E    5I2F   
CATH (Classification of proteins structures)1AV5    1KPA    1KPB    1KPC    1KPE    1KPF    3TW2    4EQE    4EQG    4EQH    4ZKL    4ZKV    5ED3    5ED6    5EMT    5I2E    5I2F   
SuperfamilyP49773
Human Protein AtlasENSG00000169567
Peptide AtlasP49773
HPRD03204
IPIIPI00239077   IPI00968242   IPI00967744   IPI00966135   IPI00967474   IPI00983355   
Protein Interaction databases
DIP (DOE-UCLA)P49773
IntAct (EBI)P49773
FunCoupENSG00000169567
BioGRIDHINT1
STRING (EMBL)HINT1
ZODIACHINT1
Ontologies - Pathways
QuickGOP49773
Ontology : AmiGOhistone deacetylase complex  nucleotide binding  protein kinase C binding  nucleus  cytosol  cytoskeleton  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  signal transduction  purine ribonucleotide catabolic process  hydrolase activity  positive regulation of calcium-mediated signaling  extracellular exosome  intrinsic apoptotic signaling pathway by p53 class mediator  
Ontology : EGO-EBIhistone deacetylase complex  nucleotide binding  protein kinase C binding  nucleus  cytosol  cytoskeleton  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  signal transduction  purine ribonucleotide catabolic process  hydrolase activity  positive regulation of calcium-mediated signaling  extracellular exosome  intrinsic apoptotic signaling pathway by p53 class mediator  
NDEx NetworkHINT1
Atlas of Cancer Signalling NetworkHINT1
Wikipedia pathwaysHINT1
Orthology - Evolution
OrthoDB3094
GeneTree (enSembl)ENSG00000169567
Phylogenetic Trees/Animal Genes : TreeFamHINT1
HOVERGENP49773
HOGENOMP49773
Homologs : HomoloGeneHINT1
Homology/Alignments : Family Browser (UCSC)HINT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHINT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HINT1
dbVarHINT1
ClinVarHINT1
1000_GenomesHINT1 
Exome Variant ServerHINT1
ExAC (Exome Aggregation Consortium)HINT1 (select the gene name)
Genetic variants : HAPMAP3094
Genomic Variants (DGV)HINT1 [DGVbeta]
DECIPHERHINT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHINT1 
Mutations
ICGC Data PortalHINT1 
TCGA Data PortalHINT1 
Broad Tumor PortalHINT1
OASIS PortalHINT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHINT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHINT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HINT1
DgiDB (Drug Gene Interaction Database)HINT1
DoCM (Curated mutations)HINT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HINT1 (select a term)
intoGenHINT1
Cancer3DHINT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137200    601314   
Orphanet21778   
MedgenHINT1
Genetic Testing Registry HINT1
NextProtP49773 [Medical]
TSGene3094
GENETestsHINT1
Target ValidationHINT1
Huge Navigator HINT1 [HugePedia]
snp3D : Map Gene to Disease3094
BioCentury BCIQHINT1
ClinGenHINT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3094
Chemical/Pharm GKB GenePA29286
Clinical trialHINT1
Miscellaneous
canSAR (ICR)HINT1 (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHINT1
EVEXHINT1
GoPubMedHINT1
iHOPHINT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:36:47 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.