Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HIPK1 (homeodomain interacting protein kinase 1)

Identity

Alias (NCBI)Myak
Nbak2
HGNC (Hugo) HIPK1
HGNC Alias symbKIAA0630
Myak
MGC26642
Nbak2
MGC33446
MGC33548
LocusID (NCBI) 204851
Atlas_Id 43307
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 113951145 and ends at 113977869 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRN (17q21.31) / HIPK1 (1p13.2)HIPK1 (1p13.2) / UROD (1p34.1)PAX5 (9p13.2) / HIPK1 (1p13.2)
UBE4A (11q23.3) / HIPK1 (1p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;9)(p13;p12) PAX5/HIPK1

External links

Nomenclature
HGNC (Hugo)HIPK1   19006
Cards
Entrez_Gene (NCBI)HIPK1    homeodomain interacting protein kinase 1
AliasesMyak; Nbak2
GeneCards (Weizmann)HIPK1
Ensembl hg19 (Hinxton)ENSG00000163349 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163349 [Gene_View]  ENSG00000163349 [Sequence]  chr1:113951145-113977869 [Contig_View]  HIPK1 [Vega]
ICGC DataPortalENSG00000163349
TCGA cBioPortalHIPK1
AceView (NCBI)HIPK1
Genatlas (Paris)HIPK1
SOURCE (Princeton)HIPK1
Genetics Home Reference (NIH)HIPK1
Genomic and cartography
GoldenPath hg38 (UCSC)HIPK1  -     chr1:113951145-113977869 +  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIPK1  -     1p13.2   [Description]    (hg19-Feb_2009)
GoldenPathHIPK1 - 1p13.2 [CytoView hg19]  HIPK1 - 1p13.2 [CytoView hg38]
ImmunoBaseENSG00000163349
genome Data Viewer NCBIHIPK1 [Mapview hg19]  
OMIM608003   
Gene and transcription
Genbank (Entrez)AA995033 AB014530 AB089957 AK122662 AK302726
RefSeq transcript (Entrez)NM_001369806 NM_001369807 NM_152696 NM_181358 NM_198268 NM_198269
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIPK1
Alternative Splicing GalleryENSG00000163349
Gene ExpressionHIPK1 [ NCBI-GEO ]   HIPK1 [ EBI - ARRAY_EXPRESS ]   HIPK1 [ SEEK ]   HIPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)HIPK1 [ Firebrowse - Broad ]
GenevisibleExpression of HIPK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)204851
GTEX Portal (Tissue expression)HIPK1
Human Protein AtlasENSG00000163349-HIPK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86Z02   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86Z02  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86Z02
Splice isoforms : SwissVarQ86Z02
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ86Z02
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)HIPK1
Blocks (Seattle)HIPK1
SuperfamilyQ86Z02
Human Protein Atlas [tissue]ENSG00000163349-HIPK1 [tissue]
Peptide AtlasQ86Z02
HPRD06418
IPIIPI00942467   IPI00302302   IPI00178582   IPI00383559   IPI00647293   IPI00639959   IPI00747261   IPI00966150   IPI00967797   IPI00963931   
Protein Interaction databases
DIP (DOE-UCLA)Q86Z02
IntAct (EBI)Q86Z02
BioGRIDHIPK1
STRING (EMBL)HIPK1
ZODIACHIPK1
Ontologies - Pathways
QuickGOQ86Z02
Ontology : AmiGOeye development  protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  centrosome  cytosol  protein phosphorylation  smoothened signaling pathway  positive regulation of cell proliferation  anterior/posterior pattern specification  regulation of tumor necrosis factor-mediated signaling pathway  retina layer formation  PML body  nuclear speck  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  neuron differentiation  adherens junction assembly  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of angiogenesis  embryonic camera-type eye morphogenesis  embryonic retina morphogenesis in camera-type eye  definitive hemopoiesis  lens induction in camera-type eye  iris morphogenesis  endothelial cell apoptotic process  extrinsic apoptotic signaling pathway  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIeye development  protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  centrosome  cytosol  protein phosphorylation  smoothened signaling pathway  positive regulation of cell proliferation  anterior/posterior pattern specification  regulation of tumor necrosis factor-mediated signaling pathway  retina layer formation  PML body  nuclear speck  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  neuron differentiation  adherens junction assembly  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of angiogenesis  embryonic camera-type eye morphogenesis  embryonic retina morphogenesis in camera-type eye  definitive hemopoiesis  lens induction in camera-type eye  iris morphogenesis  endothelial cell apoptotic process  extrinsic apoptotic signaling pathway  regulation of signal transduction by p53 class mediator  
NDEx NetworkHIPK1
Atlas of Cancer Signalling NetworkHIPK1
Wikipedia pathwaysHIPK1
Orthology - Evolution
OrthoDB204851
GeneTree (enSembl)ENSG00000163349
Phylogenetic Trees/Animal Genes : TreeFamHIPK1
HOGENOMQ86Z02
Homologs : HomoloGeneHIPK1
Homology/Alignments : Family Browser (UCSC)HIPK1
Gene fusions - Rearrangements
Fusion : MitelmanPAX5/HIPK1 [9p13.2/1p13.2]  
Fusion : QuiverHIPK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIPK1 [hg38]
dbVarHIPK1
ClinVarHIPK1
MonarchHIPK1
1000_GenomesHIPK1 
Exome Variant ServerHIPK1
GNOMAD BrowserENSG00000163349
Varsome BrowserHIPK1
Genomic Variants (DGV)HIPK1 [DGVbeta]
DECIPHERHIPK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIPK1 
Mutations
ICGC Data PortalHIPK1 
TCGA Data PortalHIPK1 
Broad Tumor PortalHIPK1
OASIS PortalHIPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIPK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHIPK1
Mutations and Diseases : HGMDHIPK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIPK1
DgiDB (Drug Gene Interaction Database)HIPK1
DoCM (Curated mutations)HIPK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIPK1 (select a term)
intoGenHIPK1
Cancer3DHIPK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608003   
Orphanet
DisGeNETHIPK1
MedgenHIPK1
Genetic Testing Registry HIPK1
NextProtQ86Z02 [Medical]
GENETestsHIPK1
Target ValidationHIPK1
Huge Navigator HIPK1 [HugePedia]
ClinGenHIPK1
Clinical trials, drugs, therapy
MyCancerGenomeHIPK1
Protein Interactions : CTD
Pharm GKB GenePA134897980
PharosQ86Z02
Clinical trialHIPK1
Miscellaneous
canSAR (ICR)HIPK1 (select the gene name)
HarmonizomeHIPK1
DataMed IndexHIPK1
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHIPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:18:44 CET 2021
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