Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HIPK1 (homeodomain interacting protein kinase 1)

Identity

Alias_symbol (synonym)KIAA0630
Myak
MGC26642
Nbak2
MGC33446
MGC33548
Other alias
HGNC (Hugo) HIPK1
LocusID (NCBI) 204851
Atlas_Id 43307
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 113929374 and ends at 113972076 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GRN (17q21.31) / HIPK1 (1p13.2)HIPK1 (1p13.2) / UROD (1p34.1)PAX5 (9p13.2) / HIPK1 (1p13.2)
UBE4A (11q23.3) / HIPK1 (1p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;9)(p13;p12) PAX5/HIPK1


External links

Nomenclature
HGNC (Hugo)HIPK1   19006
Cards
Entrez_Gene (NCBI)HIPK1  204851  homeodomain interacting protein kinase 1
AliasesMyak; Nbak2
GeneCards (Weizmann)HIPK1
Ensembl hg19 (Hinxton)ENSG00000163349 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163349 [Gene_View]  chr1:113929374-113972076 [Contig_View]  HIPK1 [Vega]
ICGC DataPortalENSG00000163349
TCGA cBioPortalHIPK1
AceView (NCBI)HIPK1
Genatlas (Paris)HIPK1
WikiGenes204851
SOURCE (Princeton)HIPK1
Genetics Home Reference (NIH)HIPK1
Genomic and cartography
GoldenPath hg38 (UCSC)HIPK1  -     chr1:113929374-113972076 +  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIPK1  -     1p13.2   [Description]    (hg19-Feb_2009)
EnsemblHIPK1 - 1p13.2 [CytoView hg19]  HIPK1 - 1p13.2 [CytoView hg38]
Mapping of homologs : NCBIHIPK1 [Mapview hg19]  HIPK1 [Mapview hg38]
OMIM608003   
Gene and transcription
Genbank (Entrez)AA995033 AB014530 AB089957 AK122662 AK302726
RefSeq transcript (Entrez)NM_152696 NM_181358 NM_198268 NM_198269
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIPK1
Cluster EST : UnigeneHs.532363 [ NCBI ]
CGAP (NCI)Hs.532363
Alternative Splicing GalleryENSG00000163349
Gene ExpressionHIPK1 [ NCBI-GEO ]   HIPK1 [ EBI - ARRAY_EXPRESS ]   HIPK1 [ SEEK ]   HIPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)HIPK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)204851
GTEX Portal (Tissue expression)HIPK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86Z02   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86Z02  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86Z02
Splice isoforms : SwissVarQ86Z02
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ86Z02
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)HIPK1
DMDM Disease mutations204851
Blocks (Seattle)HIPK1
SuperfamilyQ86Z02
Human Protein AtlasENSG00000163349
Peptide AtlasQ86Z02
HPRD06418
IPIIPI00942467   IPI00302302   IPI00178582   IPI00383559   IPI00647293   IPI00639959   IPI00747261   IPI00966150   IPI00967797   IPI00963931   
Protein Interaction databases
DIP (DOE-UCLA)Q86Z02
IntAct (EBI)Q86Z02
FunCoupENSG00000163349
BioGRIDHIPK1
STRING (EMBL)HIPK1
ZODIACHIPK1
Ontologies - Pathways
QuickGOQ86Z02
Ontology : AmiGOeye development  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  centrosome  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  smoothened signaling pathway  positive regulation of cell proliferation  anterior/posterior pattern specification  regulation of tumor necrosis factor-mediated signaling pathway  retina layer formation  PML body  nuclear speck  neuron differentiation  adherens junction assembly  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of angiogenesis  embryonic camera-type eye morphogenesis  embryonic retina morphogenesis in camera-type eye  definitive hemopoiesis  lens induction in camera-type eye  iris morphogenesis  endothelial cell apoptotic process  extrinsic apoptotic signaling pathway  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIeye development  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  centrosome  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  smoothened signaling pathway  positive regulation of cell proliferation  anterior/posterior pattern specification  regulation of tumor necrosis factor-mediated signaling pathway  retina layer formation  PML body  nuclear speck  neuron differentiation  adherens junction assembly  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of angiogenesis  embryonic camera-type eye morphogenesis  embryonic retina morphogenesis in camera-type eye  definitive hemopoiesis  lens induction in camera-type eye  iris morphogenesis  endothelial cell apoptotic process  extrinsic apoptotic signaling pathway  regulation of signal transduction by p53 class mediator  
NDEx NetworkHIPK1
Atlas of Cancer Signalling NetworkHIPK1
Wikipedia pathwaysHIPK1
Orthology - Evolution
OrthoDB204851
GeneTree (enSembl)ENSG00000163349
Phylogenetic Trees/Animal Genes : TreeFamHIPK1
HOVERGENQ86Z02
HOGENOMQ86Z02
Homologs : HomoloGeneHIPK1
Homology/Alignments : Family Browser (UCSC)HIPK1
Gene fusions - Rearrangements
Fusion : MitelmanPAX5/HIPK1 [9p13.2/1p13.2]  [t(1;9)(p13;p12)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIPK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIPK1
dbVarHIPK1
ClinVarHIPK1
1000_GenomesHIPK1 
Exome Variant ServerHIPK1
ExAC (Exome Aggregation Consortium)HIPK1 (select the gene name)
Genetic variants : HAPMAP204851
Genomic Variants (DGV)HIPK1 [DGVbeta]
DECIPHERHIPK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIPK1 
Mutations
ICGC Data PortalHIPK1 
TCGA Data PortalHIPK1 
Broad Tumor PortalHIPK1
OASIS PortalHIPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIPK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIPK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIPK1
DgiDB (Drug Gene Interaction Database)HIPK1
DoCM (Curated mutations)HIPK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIPK1 (select a term)
intoGenHIPK1
Cancer3DHIPK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608003   
Orphanet
MedgenHIPK1
Genetic Testing Registry HIPK1
NextProtQ86Z02 [Medical]
TSGene204851
GENETestsHIPK1
Target ValidationHIPK1
Huge Navigator HIPK1 [HugePedia]
snp3D : Map Gene to Disease204851
BioCentury BCIQHIPK1
ClinGenHIPK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD204851
Chemical/Pharm GKB GenePA134897980
Clinical trialHIPK1
Miscellaneous
canSAR (ICR)HIPK1 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIPK1
EVEXHIPK1
GoPubMedHIPK1
iHOPHIPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:36:48 CEST 2017

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