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HIPK3 (homeodomain interacting protein kinase 3)

Identity

Alias_nameshomeodomain-interacting protein kinase 3
Alias_symbol (synonym)PKY
DYRK6
YAK1
FIST3
HGNC (Hugo) HIPK3
LocusID (NCBI) 10114
Atlas_Id 43308
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 33278868 and ends at 33378568 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HIPK3 (11p13) / ADPGK (15q24.1)HIPK3 (11p13) / CAT (11p13)HIPK3 (11p13) / GYLTL1B (11p11.2)
HIPK3 (11p13) / HIPK3 (11p13)HIPK3 (11p13) / TOLLIP (11p15.5)KIF16B (20p12.1) / HIPK3 (11p13)
MBNL1 (3q25.1) / HIPK3 (11p13)MTL5 (11q13.3) / HIPK3 (11p13)SPARC (5q33.1) / HIPK3 (11p13)
WNT5B (12p13.33) / HIPK3 (11p13)HIPK3 11p13 / CAT 11p13HIPK3 11p13 / GYLTL1B 11p11.2
HIPK3 11p13 / TOLLIP 11p15.5KIF16B 20p12.1 / HIPK3 11p13MTL5 11q13.3 / HIPK3 11p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HIPK3   4915
Cards
Entrez_Gene (NCBI)HIPK3  10114  homeodomain interacting protein kinase 3
AliasesDYRK6; FIST3; PKY; YAK1
GeneCards (Weizmann)HIPK3
Ensembl hg19 (Hinxton)ENSG00000110422 [Gene_View]  chr11:33278868-33378568 [Contig_View]  HIPK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000110422 [Gene_View]  chr11:33278868-33378568 [Contig_View]  HIPK3 [Vega]
ICGC DataPortalENSG00000110422
TCGA cBioPortalHIPK3
AceView (NCBI)HIPK3
Genatlas (Paris)HIPK3
WikiGenes10114
SOURCE (Princeton)HIPK3
Genetics Home Reference (NIH)HIPK3
Genomic and cartography
GoldenPath hg19 (UCSC)HIPK3  -     chr11:33278868-33378568 +  11p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HIPK3  -     11p13   [Description]    (hg38-Dec_2013)
EnsemblHIPK3 - 11p13 [CytoView hg19]  HIPK3 - 11p13 [CytoView hg38]
Mapping of homologs : NCBIHIPK3 [Mapview hg19]  HIPK3 [Mapview hg38]
OMIM604424   
Gene and transcription
Genbank (Entrez)AA456456 AF004849 AF305239 AK293009 AK304063
RefSeq transcript (Entrez)NM_001048200 NM_001278162 NM_001278163 NM_005734
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIPK3
Cluster EST : UnigeneHs.709696 [ NCBI ]
CGAP (NCI)Hs.709696
Alternative Splicing GalleryENSG00000110422
Gene ExpressionHIPK3 [ NCBI-GEO ]   HIPK3 [ EBI - ARRAY_EXPRESS ]   HIPK3 [ SEEK ]   HIPK3 [ MEM ]
Gene Expression Viewer (FireBrowse)HIPK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10114
GTEX Portal (Tissue expression)HIPK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H422   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H422  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H422
Splice isoforms : SwissVarQ9H422
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9H422
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)HIPK3
DMDM Disease mutations10114
Blocks (Seattle)HIPK3
SuperfamilyQ9H422
Human Protein AtlasENSG00000110422
Peptide AtlasQ9H422
HPRD05111
IPIIPI00099522   IPI00554546   IPI00816292   IPI00978474   
Protein Interaction databases
DIP (DOE-UCLA)Q9H422
IntAct (EBI)Q9H422
FunCoupENSG00000110422
BioGRIDHIPK3
STRING (EMBL)HIPK3
ZODIACHIPK3
Ontologies - Pathways
QuickGOQ9H422
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  mRNA transcription  PML body  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  negative regulation of apoptotic process  negative regulation of JUN kinase activity  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  mRNA transcription  PML body  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  negative regulation of apoptotic process  negative regulation of JUN kinase activity  
NDEx NetworkHIPK3
Atlas of Cancer Signalling NetworkHIPK3
Wikipedia pathwaysHIPK3
Orthology - Evolution
OrthoDB10114
GeneTree (enSembl)ENSG00000110422
Phylogenetic Trees/Animal Genes : TreeFamHIPK3
HOVERGENQ9H422
HOGENOMQ9H422
Homologs : HomoloGeneHIPK3
Homology/Alignments : Family Browser (UCSC)HIPK3
Gene fusions - Rearrangements
Fusion : MitelmanHIPK3/GYLTL1B [11p13/11p11.2]  
Fusion : MitelmanHIPK3/TOLLIP [11p13/11p15.5]  [t(11;11)(p13;p15)]  
Fusion : MitelmanKIF16B/HIPK3 [20p12.1/11p13]  [t(11;20)(p13;p12)]  
Fusion : MitelmanMTL5/HIPK3 [11q13.3/11p13]  [t(11;11)(p13;q13)]  
Fusion: TCGAHIPK3 11p13 CAT 11p13 LUAD
Fusion: TCGAHIPK3 11p13 GYLTL1B 11p11.2 LUSC
Fusion: TCGAHIPK3 11p13 TOLLIP 11p15.5 BRCA
Fusion: TCGAKIF16B 20p12.1 HIPK3 11p13 BRCA
Fusion: TCGAMTL5 11q13.3 HIPK3 11p13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIPK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIPK3
dbVarHIPK3
ClinVarHIPK3
1000_GenomesHIPK3 
Exome Variant ServerHIPK3
ExAC (Exome Aggregation Consortium)HIPK3 (select the gene name)
Genetic variants : HAPMAP10114
Genomic Variants (DGV)HIPK3 [DGVbeta]
DECIPHER (Syndromes)11:33278868-33378568  ENSG00000110422
CONAN: Copy Number AnalysisHIPK3 
Mutations
ICGC Data PortalHIPK3 
TCGA Data PortalHIPK3 
Broad Tumor PortalHIPK3
OASIS PortalHIPK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIPK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIPK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIPK3
DgiDB (Drug Gene Interaction Database)HIPK3
DoCM (Curated mutations)HIPK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIPK3 (select a term)
intoGenHIPK3
Cancer3DHIPK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604424   
Orphanet
MedgenHIPK3
Genetic Testing Registry HIPK3
NextProtQ9H422 [Medical]
TSGene10114
GENETestsHIPK3
Huge Navigator HIPK3 [HugePedia]
snp3D : Map Gene to Disease10114
BioCentury BCIQHIPK3
ClinGenHIPK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10114
Chemical/Pharm GKB GenePA29292
Clinical trialHIPK3
Miscellaneous
canSAR (ICR)HIPK3 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIPK3
EVEXHIPK3
GoPubMedHIPK3
iHOPHIPK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 21 16:03:57 CET 2017

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