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HIPK3 (homeodomain interacting protein kinase 3)

Identity

Alias (NCBI)DYRK6
FIST3
PKY
YAK1
HGNC (Hugo) HIPK3
HGNC Alias symbPKY
DYRK6
YAK1
FIST3
HGNC Previous namehomeodomain-interacting protein kinase 3
LocusID (NCBI) 10114
Atlas_Id 43308
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 33257381 and ends at 33357022 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HIPK3 (11p13) / ADPGK (15q24.1)HIPK3 (11p13) / CAT (11p13)HIPK3 (11p13) / GYLTL1B (11p11.2)
HIPK3 (11p13) / HIPK3 (11p13)HIPK3 (11p13) / TOLLIP (11p15.5)KIF16B (20p12.1) / HIPK3 (11p13)
MBNL1 (3q25.1) / HIPK3 (11p13)MTL5 (11q13.3) / HIPK3 (11p13)SPARC (5q33.1) / HIPK3 (11p13)
WNT5B (12p13.33) / HIPK3 (11p13)HIPK3 11p13 / CAT 11p13HIPK3 11p13 / GYLTL1B 11p11.2
HIPK3 11p13 / TOLLIP 11p15.5KIF16B 20p12.1 / HIPK3 11p13MTL5 11q13.3 / HIPK3 11p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HIPK3   4915
Cards
Entrez_Gene (NCBI)HIPK3    homeodomain interacting protein kinase 3
AliasesDYRK6; FIST3; PKY; YAK1
GeneCards (Weizmann)HIPK3
Ensembl hg19 (Hinxton)ENSG00000110422 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110422 [Gene_View]  ENSG00000110422 [Sequence]  chr11:33257381-33357022 [Contig_View]  HIPK3 [Vega]
ICGC DataPortalENSG00000110422
TCGA cBioPortalHIPK3
AceView (NCBI)HIPK3
Genatlas (Paris)HIPK3
SOURCE (Princeton)HIPK3
Genetics Home Reference (NIH)HIPK3
Genomic and cartography
GoldenPath hg38 (UCSC)HIPK3  -     chr11:33257381-33357022 +  11p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIPK3  -     11p13   [Description]    (hg19-Feb_2009)
GoldenPathHIPK3 - 11p13 [CytoView hg19]  HIPK3 - 11p13 [CytoView hg38]
ImmunoBaseENSG00000110422
Genome Data Viewer NCBIHIPK3 [Mapview hg19]  
OMIM604424   
Gene and transcription
Genbank (Entrez)AA456456 AF004849 AF305239 AK293009 AK304063
RefSeq transcript (Entrez)NM_001048200 NM_001278162 NM_001278163 NM_005734
Consensus coding sequences : CCDS (NCBI)HIPK3
Gene ExpressionHIPK3 [ NCBI-GEO ]   HIPK3 [ EBI - ARRAY_EXPRESS ]   HIPK3 [ SEEK ]   HIPK3 [ MEM ]
Gene Expression Viewer (FireBrowse)HIPK3 [ Firebrowse - Broad ]
GenevisibleExpression of HIPK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10114
GTEX Portal (Tissue expression)HIPK3
Human Protein AtlasENSG00000110422-HIPK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H422   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H422  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H422
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H422
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)HIPK3
SuperfamilyQ9H422
AlphaFold pdb e-kbQ9H422   
Human Protein Atlas [tissue]ENSG00000110422-HIPK3 [tissue]
HPRD05111
Protein Interaction databases
DIP (DOE-UCLA)Q9H422
IntAct (EBI)Q9H422
BioGRIDHIPK3
STRING (EMBL)HIPK3
ZODIACHIPK3
Ontologies - Pathways
QuickGOQ9H422
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein tyrosine kinase activity  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  protein phosphorylation  apoptotic process  mRNA transcription  nuclear body  PML body  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  negative regulation of apoptotic process  negative regulation of JUN kinase activity  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein tyrosine kinase activity  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  protein phosphorylation  apoptotic process  mRNA transcription  nuclear body  PML body  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  negative regulation of apoptotic process  negative regulation of JUN kinase activity  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkHIPK3
Atlas of Cancer Signalling NetworkHIPK3
Wikipedia pathwaysHIPK3
Orthology - Evolution
OrthoDB10114
GeneTree (enSembl)ENSG00000110422
Phylogenetic Trees/Animal Genes : TreeFamHIPK3
Homologs : HomoloGeneHIPK3
Homology/Alignments : Family Browser (UCSC)HIPK3
Gene fusions - Rearrangements
Fusion : MitelmanHIPK3/GYLTL1B [11p13/11p11.2]  
Fusion : MitelmanHIPK3/TOLLIP [11p13/11p15.5]  
Fusion : MitelmanKIF16B/HIPK3 [20p12.1/11p13]  
Fusion : MitelmanMTL5/HIPK3 [11q13.3/11p13]  
Fusion : QuiverHIPK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIPK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIPK3
dbVarHIPK3
ClinVarHIPK3
MonarchHIPK3
1000_GenomesHIPK3 
Exome Variant ServerHIPK3
GNOMAD BrowserENSG00000110422
Varsome BrowserHIPK3
ACMGHIPK3 variants
VarityQ9H422
Genomic Variants (DGV)HIPK3 [DGVbeta]
DECIPHERHIPK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIPK3 
Mutations
ICGC Data PortalHIPK3 
TCGA Data PortalHIPK3 
Broad Tumor PortalHIPK3
OASIS PortalHIPK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIPK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHIPK3
Mutations and Diseases : HGMDHIPK3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHIPK3
DgiDB (Drug Gene Interaction Database)HIPK3
DoCM (Curated mutations)HIPK3
CIViC (Clinical Interpretations of Variants in Cancer)HIPK3
Cancer3DHIPK3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604424   
Orphanet
DisGeNETHIPK3
MedgenHIPK3
Genetic Testing Registry HIPK3
NextProtQ9H422 [Medical]
GENETestsHIPK3
Target ValidationHIPK3
Huge Navigator HIPK3 [HugePedia]
ClinGenHIPK3
Clinical trials, drugs, therapy
MyCancerGenomeHIPK3
Protein Interactions : CTDHIPK3
Pharm GKB GenePA29292
PharosQ9H422
Clinical trialHIPK3
Miscellaneous
canSAR (ICR)HIPK3
HarmonizomeHIPK3
DataMed IndexHIPK3
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHIPK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:12:26 CEST 2021

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