Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HIPK4 (homeodomain interacting protein kinase 4)

Identity

Alias_symbol (synonym)FLJ32818
Other alias-
HGNC (Hugo) HIPK4
LocusID (NCBI) 147746
Atlas_Id 43309
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 40379271 and ends at 40390221 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCL3 (19q13.32) / HIPK4 (19q13.2)HIPK4 (19q13.2) / MAP1A (15q15.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)HIPK4   19007
Cards
Entrez_Gene (NCBI)HIPK4  147746  homeodomain interacting protein kinase 4
Aliases
GeneCards (Weizmann)HIPK4
Ensembl hg19 (Hinxton)ENSG00000160396 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160396 [Gene_View]  chr19:40379271-40390221 [Contig_View]  HIPK4 [Vega]
ICGC DataPortalENSG00000160396
TCGA cBioPortalHIPK4
AceView (NCBI)HIPK4
Genatlas (Paris)HIPK4
WikiGenes147746
SOURCE (Princeton)HIPK4
Genetics Home Reference (NIH)HIPK4
Genomic and cartography
GoldenPath hg38 (UCSC)HIPK4  -     chr19:40379271-40390221 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIPK4  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblHIPK4 - 19q13.2 [CytoView hg19]  HIPK4 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIHIPK4 [Mapview hg19]  HIPK4 [Mapview hg38]
OMIM611712   
Gene and transcription
Genbank (Entrez)AK057380 AK292228 AK301713 AK302301 BC034501
RefSeq transcript (Entrez)NM_144685
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIPK4
Cluster EST : UnigeneHs.79363 [ NCBI ]
CGAP (NCI)Hs.79363
Alternative Splicing GalleryENSG00000160396
Gene ExpressionHIPK4 [ NCBI-GEO ]   HIPK4 [ EBI - ARRAY_EXPRESS ]   HIPK4 [ SEEK ]   HIPK4 [ MEM ]
Gene Expression Viewer (FireBrowse)HIPK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)147746
GTEX Portal (Tissue expression)HIPK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NE63   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NE63  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NE63
Splice isoforms : SwissVarQ8NE63
PhosPhoSitePlusQ8NE63
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)HIPK4
DMDM Disease mutations147746
Blocks (Seattle)HIPK4
SuperfamilyQ8NE63
Human Protein AtlasENSG00000160396
Peptide AtlasQ8NE63
HPRD13652
IPIIPI00302130   IPI00387062   IPI01015188   
Protein Interaction databases
DIP (DOE-UCLA)Q8NE63
IntAct (EBI)Q8NE63
FunCoupENSG00000160396
BioGRIDHIPK4
STRING (EMBL)HIPK4
ZODIACHIPK4
Ontologies - Pathways
QuickGOQ8NE63
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  histone phosphorylation  peptidyl-serine phosphorylation  protein autophosphorylation  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  histone phosphorylation  peptidyl-serine phosphorylation  protein autophosphorylation  regulation of signal transduction by p53 class mediator  
NDEx NetworkHIPK4
Atlas of Cancer Signalling NetworkHIPK4
Wikipedia pathwaysHIPK4
Orthology - Evolution
OrthoDB147746
GeneTree (enSembl)ENSG00000160396
Phylogenetic Trees/Animal Genes : TreeFamHIPK4
HOVERGENQ8NE63
HOGENOMQ8NE63
Homologs : HomoloGeneHIPK4
Homology/Alignments : Family Browser (UCSC)HIPK4
Gene fusions - Rearrangements
Fusion : MitelmanBCL3/HIPK4 [19q13.32/19q13.2]  [t(19;19)(q13;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIPK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIPK4
dbVarHIPK4
ClinVarHIPK4
1000_GenomesHIPK4 
Exome Variant ServerHIPK4
ExAC (Exome Aggregation Consortium)HIPK4 (select the gene name)
Genetic variants : HAPMAP147746
Genomic Variants (DGV)HIPK4 [DGVbeta]
DECIPHERHIPK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIPK4 
Mutations
ICGC Data PortalHIPK4 
TCGA Data PortalHIPK4 
Broad Tumor PortalHIPK4
OASIS PortalHIPK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIPK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIPK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIPK4
DgiDB (Drug Gene Interaction Database)HIPK4
DoCM (Curated mutations)HIPK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIPK4 (select a term)
intoGenHIPK4
Cancer3DHIPK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611712   
Orphanet
MedgenHIPK4
Genetic Testing Registry HIPK4
NextProtQ8NE63 [Medical]
TSGene147746
GENETestsHIPK4
Target ValidationHIPK4
Huge Navigator HIPK4 [HugePedia]
snp3D : Map Gene to Disease147746
BioCentury BCIQHIPK4
ClinGenHIPK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD147746
Chemical/Pharm GKB GenePA134883524
Clinical trialHIPK4
Miscellaneous
canSAR (ICR)HIPK4 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIPK4
EVEXHIPK4
GoPubMedHIPK4
iHOPHIPK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:36:48 CEST 2017

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