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HIST1H2AC (histone cluster 1 H2A family member c)

Identity

Alias_namesH2AFL
H2A histone family, member L
histone 1, H2ac
histone cluster 1, H2ac
Other aliasH2A/l
dJ221C16.4
HGNC (Hugo) HIST1H2AC
LocusID (NCBI) 8334
Atlas_Id 40825
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 26124145 and ends at 26124690 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTN2A1 (6p22.2) / HIST1H2AC (6p22.2)BTN3A2 (6p22.2) / HIST1H2AC (6p22.2)GLTSCR1L (6p21.1) / HIST1H2AC (6p22.2)
HIST1H2AC (6p22.2) / LHFPL2 (5q14.1)HIST1H2AC (6p22.2) / SLC17A4 (6p22.2)KLHL8 (4q22.1) / HIST1H2AC (6p22.2)
LHFPL2 (5q14.1) / HIST1H2AC (6p22.2)MRPS28 (8q21.13) / HIST1H2AC (6p22.2)BTN2A1 6p22.2 / HIST1H2AC 6p22.2
BTN3A2 6p22.2 / HIST1H2AC 6p22.2HIST1H2AC 6p22.2 / LHFPL2 5q14.1HIST1H2AC 6p22.2 / SLC17A4 6p22.2
KIAA0240 HIST1H2AC 6p22.2LHFPL2 5q14.1 / HIST1H2AC 6p22.2MRPS28 8q21.13 / HIST1H2AC 6p22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(5;6)(q14;p22) HIST1H2AC/LHFPL2
t(5;6)(q14;p22) LHFPL2/HIST1H2AC
BTN2A1/HIST1H2AC (6p22)
BTN3A2/HIST1H2AC (6p22)
HIST1H2AC/SLC17A4 (6p22)
t(6;8)(p22;q21) MRPS28/HIST1H2AC


External links

Nomenclature
HGNC (Hugo)HIST1H2AC   4733
Cards
Entrez_Gene (NCBI)HIST1H2AC  8334  histone cluster 1 H2A family member c
AliasesH2A/l; H2AFL; dJ221C16.4
GeneCards (Weizmann)HIST1H2AC
Ensembl hg19 (Hinxton)ENSG00000180573 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180573 [Gene_View]  ENSG00000180573 [Sequence]  chr6:26124145-26124690 [Contig_View]  HIST1H2AC [Vega]
ICGC DataPortalENSG00000180573
TCGA cBioPortalHIST1H2AC
AceView (NCBI)HIST1H2AC
Genatlas (Paris)HIST1H2AC
WikiGenes8334
SOURCE (Princeton)HIST1H2AC
Genetics Home Reference (NIH)HIST1H2AC
Genomic and cartography
GoldenPath hg38 (UCSC)HIST1H2AC  -     chr6:26124145-26124690 +  6p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIST1H2AC  -     6p22.2   [Description]    (hg19-Feb_2009)
EnsemblHIST1H2AC - 6p22.2 [CytoView hg19]  HIST1H2AC - 6p22.2 [CytoView hg38]
Mapping of homologs : NCBIHIST1H2AC [Mapview hg19]  HIST1H2AC [Mapview hg38]
OMIM602794   
Gene and transcription
Genbank (Entrez)AK311811 BC017379 BC050602 BC085010 U90551
RefSeq transcript (Entrez)NM_003512
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIST1H2AC
Cluster EST : UnigeneHs.484950 [ NCBI ]
CGAP (NCI)Hs.484950
Alternative Splicing GalleryENSG00000180573
Gene ExpressionHIST1H2AC [ NCBI-GEO ]   HIST1H2AC [ EBI - ARRAY_EXPRESS ]   HIST1H2AC [ SEEK ]   HIST1H2AC [ MEM ]
Gene Expression Viewer (FireBrowse)HIST1H2AC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8334
GTEX Portal (Tissue expression)HIST1H2AC
Human Protein AtlasENSG00000180573-HIST1H2AC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93077   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93077  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93077
Splice isoforms : SwissVarQ93077
PhosPhoSitePlusQ93077
Domaine pattern : Prosite (Expaxy)HISTONE_H2A (PS00046)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A    Histone_H2A/H2B/H3    Histone_H2A_C    Histone_H2A_CS   
Domain families : Pfam (Sanger)Histone (PF00125)    Histone_H2A_C (PF16211)   
Domain families : Pfam (NCBI)pfam00125    pfam16211   
Domain families : Smart (EMBL)H2A (SM00414)  
Conserved Domain (NCBI)HIST1H2AC
DMDM Disease mutations8334
Blocks (Seattle)HIST1H2AC
PDB (SRS)6C0W   
PDB (PDBSum)6C0W   
PDB (IMB)6C0W   
PDB (RSDB)6C0W   
Structural Biology KnowledgeBase6C0W   
SCOP (Structural Classification of Proteins)6C0W   
CATH (Classification of proteins structures)6C0W   
SuperfamilyQ93077
Human Protein Atlas [tissue]ENSG00000180573-HIST1H2AC [tissue]
Peptide AtlasQ93077
HPRD09104
IPIIPI00216456   
Protein Interaction databases
DIP (DOE-UCLA)Q93077
IntAct (EBI)Q93077
FunCoupENSG00000180573
BioGRIDHIST1H2AC
STRING (EMBL)HIST1H2AC
ZODIACHIST1H2AC
Ontologies - Pathways
QuickGOQ93077
Ontology : AmiGOnucleosome  nuclear chromatin  molecular_function  DNA binding  nucleus  nucleus  nucleoplasm  chromatin organization  chromatin silencing  negative regulation of cell proliferation  protein heterodimerization activity  extracellular exosome  
Ontology : EGO-EBInucleosome  nuclear chromatin  molecular_function  DNA binding  nucleus  nucleus  nucleoplasm  chromatin organization  chromatin silencing  negative regulation of cell proliferation  protein heterodimerization activity  extracellular exosome  
Pathways : KEGGAlcoholism    Systemic lupus erythematosus   
NDEx NetworkHIST1H2AC
Atlas of Cancer Signalling NetworkHIST1H2AC
Wikipedia pathwaysHIST1H2AC
Orthology - Evolution
OrthoDB8334
GeneTree (enSembl)ENSG00000180573
Phylogenetic Trees/Animal Genes : TreeFamHIST1H2AC
HOVERGENQ93077
HOGENOMQ93077
Homologs : HomoloGeneHIST1H2AC
Homology/Alignments : Family Browser (UCSC)HIST1H2AC
Gene fusions - Rearrangements
Fusion : MitelmanBTN2A1/HIST1H2AC [6p22.2/6p22.2]  [t(6;6)(p22;p22)]  
Fusion : MitelmanBTN3A2/HIST1H2AC [6p22.2/6p22.2]  [t(6;6)(p22;p22)]  
Fusion : MitelmanGLTSCR1L/HIST1H2AC [6p21.1/6p22.2]  [t(6;6)(p21;p22)]  
Fusion : MitelmanHIST1H2AC/LHFPL2 [6p22.2/5q14.1]  [t(5;6)(q14;p22)]  
Fusion : MitelmanHIST1H2AC/SLC17A4 [6p22.2/6p22.2]  [t(6;6)(p22;p22)]  
Fusion : MitelmanLHFPL2/HIST1H2AC [5q14.1/6p22.2]  [t(5;6)(q14;p22)]  
Fusion : MitelmanMRPS28/HIST1H2AC [8q21.13/6p22.2]  [t(6;8)(p22;q21)]  
Fusion PortalBTN2A1 6p22.2 HIST1H2AC 6p22.2 BRCA
Fusion PortalBTN3A2 6p22.2 HIST1H2AC 6p22.2 BRCA
Fusion PortalHIST1H2AC 6p22.2 LHFPL2 5q14.1 KIRC
Fusion PortalHIST1H2AC 6p22.2 SLC17A4 6p22.2 BRCA
Fusion PortalKIAA0240 HIST1H2AC 6p22.2 BRCA
Fusion PortalLHFPL2 5q14.1 HIST1H2AC 6p22.2 KIRC
Fusion PortalMRPS28 8q21.13 HIST1H2AC 6p22.2 BRCA
Fusion : QuiverHIST1H2AC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIST1H2AC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIST1H2AC
dbVarHIST1H2AC
ClinVarHIST1H2AC
1000_GenomesHIST1H2AC 
Exome Variant ServerHIST1H2AC
ExAC (Exome Aggregation Consortium)ENSG00000180573
GNOMAD BrowserENSG00000180573
Varsome BrowserHIST1H2AC
Genetic variants : HAPMAP8334
Genomic Variants (DGV)HIST1H2AC [DGVbeta]
DECIPHERHIST1H2AC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIST1H2AC 
Mutations
ICGC Data PortalHIST1H2AC 
TCGA Data PortalHIST1H2AC 
Broad Tumor PortalHIST1H2AC
OASIS PortalHIST1H2AC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIST1H2AC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIST1H2AC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIST1H2AC
DgiDB (Drug Gene Interaction Database)HIST1H2AC
DoCM (Curated mutations)HIST1H2AC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIST1H2AC (select a term)
intoGenHIST1H2AC
Cancer3DHIST1H2AC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602794   
Orphanet
DisGeNETHIST1H2AC
MedgenHIST1H2AC
Genetic Testing Registry HIST1H2AC
NextProtQ93077 [Medical]
TSGene8334
GENETestsHIST1H2AC
Target ValidationHIST1H2AC
Huge Navigator HIST1H2AC [HugePedia]
snp3D : Map Gene to Disease8334
BioCentury BCIQHIST1H2AC
ClinGenHIST1H2AC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8334
Chemical/Pharm GKB GenePA29110
Clinical trialHIST1H2AC
Miscellaneous
canSAR (ICR)HIST1H2AC (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIST1H2AC
EVEXHIST1H2AC
GoPubMedHIST1H2AC
iHOPHIST1H2AC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:26:57 CEST 2018

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