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HIST1H2BC (histone cluster 1 H2B family member c)

Identity

Alias_namesH2BFL
H2B histone family, member L
histone 1, H2bc
histone cluster 1, H2bc
Alias_symbol (synonym)H2B/l
H2B.1
Other aliasdJ221C16.3
HGNC (Hugo) HIST1H2BC
LocusID (NCBI) 8347
Atlas_Id 64290
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 26123467 and ends at 26123904 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTN2A1 (6p22.2) / HIST1H2BC (6p22.2)C2orf61 (2p21) / HIST1H2BC (6p22.2)CLIC1 (6p21.33) / HIST1H2BC (6p22.2)
HIST1H2BC (6p22.2) / SECISBP2 (9q22.2)HIST1H2BC (6p22.2) / TNFRSF1A (12p13.31)CLIC1 HIST1H2BC
BTN2A1 HIST1H2BC

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(p21;p22) CLIC1/HIST1H2BC
t(6;6)(p22;p22) BTN2A1/HIST1H2BC


External links

Nomenclature
HGNC (Hugo)HIST1H2BC   4757
Cards
Entrez_Gene (NCBI)HIST1H2BC  8347  histone cluster 1 H2B family member c
AliasesH2B.1; H2B/l; H2BFL; dJ221C16.3
GeneCards (Weizmann)HIST1H2BC
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr6:26123467-26123904 [Contig_View]  HIST1H2BC [Vega]
TCGA cBioPortalHIST1H2BC
AceView (NCBI)HIST1H2BC
Genatlas (Paris)HIST1H2BC
WikiGenes8347
SOURCE (Princeton)HIST1H2BC
Genetics Home Reference (NIH)HIST1H2BC
Genomic and cartography
GoldenPath hg38 (UCSC)HIST1H2BC  -     chr6:26123467-26123904 -  6p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIST1H2BC  -     6p22.2   [Description]    (hg19-Feb_2009)
EnsemblHIST1H2BC - 6p22.2 [CytoView hg19]  HIST1H2BC - 6p22.2 [CytoView hg38]
Mapping of homologs : NCBIHIST1H2BC [Mapview hg19]  HIST1H2BC [Mapview hg38]
OMIM602847   
Gene and transcription
Genbank (Entrez)AK312096 BC009612 BC105595 BC106899 BC160109
RefSeq transcript (Entrez)NM_003526
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIST1H2BC
Cluster EST : UnigeneHs.726509 [ NCBI ]
CGAP (NCI)Hs.726509
Gene ExpressionHIST1H2BC [ NCBI-GEO ]   HIST1H2BC [ EBI - ARRAY_EXPRESS ]   HIST1H2BC [ SEEK ]   HIST1H2BC [ MEM ]
Gene Expression Viewer (FireBrowse)HIST1H2BC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8347
GTEX Portal (Tissue expression)HIST1H2BC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62807   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62807  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62807
Splice isoforms : SwissVarP62807
PhosPhoSitePlusP62807
Domaine pattern : Prosite (Expaxy)HISTONE_H2B (PS00357)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A/H2B/H3    Histone_H2B   
Domain families : Pfam (Sanger)Histone (PF00125)   
Domain families : Pfam (NCBI)pfam00125   
Domain families : Smart (EMBL)H2B (SM00427)  
Conserved Domain (NCBI)HIST1H2BC
DMDM Disease mutations8347
Blocks (Seattle)HIST1H2BC
PDB (SRS)5KGF   
PDB (PDBSum)5KGF   
PDB (IMB)5KGF   
PDB (RSDB)5KGF   
Structural Biology KnowledgeBase5KGF   
SCOP (Structural Classification of Proteins)5KGF   
CATH (Classification of proteins structures)5KGF   
SuperfamilyP62807
Peptide AtlasP62807
HPRD13656
Protein Interaction databases
DIP (DOE-UCLA)P62807
IntAct (EBI)P62807
BioGRIDHIST1H2BC
STRING (EMBL)HIST1H2BC
ZODIACHIST1H2BC
Ontologies - Pathways
QuickGOP62807
Ontology : AmiGO###############################################################################################################################################################################################################################################################                                  
Ontology : EGO-EBI###############################################################################################################################################################################################################################################################                                  
NDEx NetworkHIST1H2BC
Atlas of Cancer Signalling NetworkHIST1H2BC
Wikipedia pathwaysHIST1H2BC
Orthology - Evolution
OrthoDB8347
Phylogenetic Trees/Animal Genes : TreeFamHIST1H2BC
HOVERGENP62807
HOGENOMP62807
Homologs : HomoloGeneHIST1H2BC
Homology/Alignments : Family Browser (UCSC)HIST1H2BC
Gene fusions - Rearrangements
Fusion: TCGA_MDACCCLIC1 HIST1H2BC
Fusion: TCGA_MDACCBTN2A1 HIST1H2BC
Fusion PortalCLIC1 HIST1H2BC
Fusion PortalBTN2A1 HIST1H2BC
Fusion : QuiverHIST1H2BC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIST1H2BC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIST1H2BC
dbVarHIST1H2BC
ClinVarHIST1H2BC
1000_GenomesHIST1H2BC 
Exome Variant ServerHIST1H2BC
Genetic variants : HAPMAP8347
Genomic Variants (DGV)HIST1H2BC [DGVbeta]
DECIPHERHIST1H2BC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIST1H2BC 
Mutations
ICGC Data PortalHIST1H2BC 
TCGA Data PortalHIST1H2BC 
Broad Tumor PortalHIST1H2BC
OASIS PortalHIST1H2BC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIST1H2BC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIST1H2BC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIST1H2BC
DgiDB (Drug Gene Interaction Database)HIST1H2BC
DoCM (Curated mutations)HIST1H2BC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIST1H2BC (select a term)
intoGenHIST1H2BC
Cancer3DHIST1H2BC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602847   
Orphanet
DisGeNETHIST1H2BC
MedgenHIST1H2BC
Genetic Testing Registry HIST1H2BC
NextProtP62807 [Medical]
TSGene8347
GENETestsHIST1H2BC
Target ValidationHIST1H2BC
Huge Navigator HIST1H2BC [HugePedia]
snp3D : Map Gene to Disease8347
BioCentury BCIQHIST1H2BC
ClinGenHIST1H2BC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8347
Chemical/Pharm GKB GenePA29132
Clinical trialHIST1H2BC
Miscellaneous
canSAR (ICR)HIST1H2BC (select the gene name)
Probes
Litterature
PubMed1 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIST1H2BC
EVEXHIST1H2BC
GoPubMedHIST1H2BC
iHOPHIST1H2BC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:21:18 CET 2018

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