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HIST2H3C (histone cluster 2 H3 family member c)

Identity

Alias_namesH3F2
H3FM
H3 histone family, member M
histone 2, H3c
histone cluster 2, H3c
Alias_symbol (synonym)MGC9629
H3/m
H3
H3.2
H3/M
Other aliasH3FN
HGNC (Hugo) HIST2H3C
LocusID (NCBI) 126961
Atlas_Id 50806
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 149840687 and ends at 149841193 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HIST2H3C (1q21.2) / HNRNPK (9q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HIST2H3C   20503
Cards
Entrez_Gene (NCBI)HIST2H3C  126961  histone cluster 2 H3 family member c
AliasesH3; H3.2; H3/M; H3F2; 
H3FM; H3FN
GeneCards (Weizmann)HIST2H3C
Ensembl hg19 (Hinxton)ENSG00000203811 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000203811 [Gene_View]  ENSG00000203811 [Sequence]  chr1:149840687-149841193 [Contig_View]  HIST2H3C [Vega]
ICGC DataPortalENSG00000203811
TCGA cBioPortalHIST2H3C
AceView (NCBI)HIST2H3C
Genatlas (Paris)HIST2H3C
WikiGenes126961
SOURCE (Princeton)HIST2H3C
Genetics Home Reference (NIH)HIST2H3C
Genomic and cartography
GoldenPath hg38 (UCSC)HIST2H3C  -     chr1:149840687-149841193 -  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIST2H3C  -     1q21.2   [Description]    (hg19-Feb_2009)
EnsemblHIST2H3C - 1q21.2 [CytoView hg19]  HIST2H3C - 1q21.2 [CytoView hg38]
Mapping of homologs : NCBIHIST2H3C [Mapview hg19]  HIST2H3C [Mapview hg38]
OMIM142780   
Gene and transcription
Genbank (Entrez)BC015544 BC074969 BC130635 BC130637
RefSeq transcript (Entrez)NM_021059
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIST2H3C
Cluster EST : UnigeneHs.706618 [ NCBI ]
CGAP (NCI)Hs.706618
Alternative Splicing GalleryENSG00000203811
Gene ExpressionHIST2H3C [ NCBI-GEO ]   HIST2H3C [ EBI - ARRAY_EXPRESS ]   HIST2H3C [ SEEK ]   HIST2H3C [ MEM ]
Gene Expression Viewer (FireBrowse)HIST2H3C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)126961
GTEX Portal (Tissue expression)HIST2H3C
Human Protein AtlasENSG00000203811-HIST2H3C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ71DI3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ71DI3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ71DI3
Splice isoforms : SwissVarQ71DI3
PhosPhoSitePlusQ71DI3
Domaine pattern : Prosite (Expaxy)HISTONE_H3_1 (PS00322)    HISTONE_H3_2 (PS00959)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A/H2B/H3    Histone_H3/CENP-A   
Domain families : Pfam (Sanger)Histone (PF00125)   
Domain families : Pfam (NCBI)pfam00125   
Domain families : Smart (EMBL)H3 (SM00428)  
Conserved Domain (NCBI)HIST2H3C
DMDM Disease mutations126961
Blocks (Seattle)HIST2H3C
PDB (SRS)2IIJ    2X4W    2X4X    2X4Y    3AV1    3DB3    3MO8    3QO2    3R93    4MZF    4MZG    4MZH    4OUC    5B0Y    5B0Z    5B40    5BO0    5CIU    5VAC   
PDB (PDBSum)2IIJ    2X4W    2X4X    2X4Y    3AV1    3DB3    3MO8    3QO2    3R93    4MZF    4MZG    4MZH    4OUC    5B0Y    5B0Z    5B40    5BO0    5CIU    5VAC   
PDB (IMB)2IIJ    2X4W    2X4X    2X4Y    3AV1    3DB3    3MO8    3QO2    3R93    4MZF    4MZG    4MZH    4OUC    5B0Y    5B0Z    5B40    5BO0    5CIU    5VAC   
PDB (RSDB)2IIJ    2X4W    2X4X    2X4Y    3AV1    3DB3    3MO8    3QO2    3R93    4MZF    4MZG    4MZH    4OUC    5B0Y    5B0Z    5B40    5BO0    5CIU    5VAC   
Structural Biology KnowledgeBase2IIJ    2X4W    2X4X    2X4Y    3AV1    3DB3    3MO8    3QO2    3R93    4MZF    4MZG    4MZH    4OUC    5B0Y    5B0Z    5B40    5BO0    5CIU    5VAC   
SCOP (Structural Classification of Proteins)2IIJ    2X4W    2X4X    2X4Y    3AV1    3DB3    3MO8    3QO2    3R93    4MZF    4MZG    4MZH    4OUC    5B0Y    5B0Z    5B40    5BO0    5CIU    5VAC   
CATH (Classification of proteins structures)2IIJ    2X4W    2X4X    2X4Y    3AV1    3DB3    3MO8    3QO2    3R93    4MZF    4MZG    4MZH    4OUC    5B0Y    5B0Z    5B40    5BO0    5CIU    5VAC   
SuperfamilyQ71DI3
Human Protein Atlas [tissue]ENSG00000203811-HIST2H3C [tissue]
Peptide AtlasQ71DI3
HPRD11822
IPIIPI00171611   
Protein Interaction databases
DIP (DOE-UCLA)Q71DI3
IntAct (EBI)Q71DI3
FunCoupENSG00000203811
BioGRIDHIST2H3C
STRING (EMBL)HIST2H3C
ZODIACHIST2H3C
Ontologies - Pathways
QuickGOQ71DI3
Ontology : AmiGOchromatin silencing at rDNA  nucleosome  nucleosome  protein binding  extracellular region  nucleus  nucleus  nucleus  nucleoplasm  chromatin organization  nucleosome assembly  nucleosome assembly  blood coagulation  nucleosomal DNA binding  interleukin-7-mediated signaling pathway  cellular protein metabolic process  regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  protein heterodimerization activity  regulation of gene silencing by miRNA  extracellular exosome  
Ontology : EGO-EBIchromatin silencing at rDNA  nucleosome  nucleosome  protein binding  extracellular region  nucleus  nucleus  nucleus  nucleoplasm  chromatin organization  nucleosome assembly  nucleosome assembly  blood coagulation  nucleosomal DNA binding  interleukin-7-mediated signaling pathway  cellular protein metabolic process  regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  protein heterodimerization activity  regulation of gene silencing by miRNA  extracellular exosome  
Pathways : KEGGAlcoholism    Transcriptional misregulation in cancer    Systemic lupus erythematosus   
NDEx NetworkHIST2H3C
Atlas of Cancer Signalling NetworkHIST2H3C
Wikipedia pathwaysHIST2H3C
Orthology - Evolution
OrthoDB126961
GeneTree (enSembl)ENSG00000203811
Phylogenetic Trees/Animal Genes : TreeFamHIST2H3C
HOVERGENQ71DI3
HOGENOMQ71DI3
Homologs : HomoloGeneHIST2H3C
Homology/Alignments : Family Browser (UCSC)HIST2H3C
Gene fusions - Rearrangements
Fusion : QuiverHIST2H3C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIST2H3C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIST2H3C
dbVarHIST2H3C
ClinVarHIST2H3C
1000_GenomesHIST2H3C 
Exome Variant ServerHIST2H3C
ExAC (Exome Aggregation Consortium)ENSG00000203811
GNOMAD BrowserENSG00000203811
Varsome BrowserHIST2H3C
Genetic variants : HAPMAP126961
Genomic Variants (DGV)HIST2H3C [DGVbeta]
DECIPHERHIST2H3C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIST2H3C 
Mutations
ICGC Data PortalHIST2H3C 
TCGA Data PortalHIST2H3C 
Broad Tumor PortalHIST2H3C
OASIS PortalHIST2H3C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIST2H3C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIST2H3C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIST2H3C
DgiDB (Drug Gene Interaction Database)HIST2H3C
DoCM (Curated mutations)HIST2H3C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIST2H3C (select a term)
intoGenHIST2H3C
Cancer3DHIST2H3C(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142780   
Orphanet
DisGeNETHIST2H3C
MedgenHIST2H3C
Genetic Testing Registry HIST2H3C
NextProtQ71DI3 [Medical]
TSGene126961
GENETestsHIST2H3C
Target ValidationHIST2H3C
Huge Navigator HIST2H3C [HugePedia]
snp3D : Map Gene to Disease126961
BioCentury BCIQHIST2H3C
ClinGenHIST2H3C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD126961
Chemical/Pharm GKB GenePA29152
Clinical trialHIST2H3C
Miscellaneous
canSAR (ICR)HIST2H3C (select the gene name)
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIST2H3C
EVEXHIST2H3C
GoPubMedHIST2H3C
iHOPHIST2H3C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:27:04 CEST 2018

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