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HIST2H4A (histone cluster 2 H4 family member a)

Identity

Alias_namesH4F2
H4FN
HIST2H4
H4/n
H4 histone, family 2
histone 2, H4
histone 2, H4a
histone cluster 2, H4a
Other aliasFO108
H4
HGNC (Hugo) HIST2H4A
LocusID (NCBI) 8370
Atlas_Id 55470
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 149832657 and ends at 149833052 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK/NUP214 in Childhood


External links

Nomenclature
HGNC (Hugo)HIST2H4A   4794
Cards
Entrez_Gene (NCBI)HIST2H4A  8370  histone cluster 2 H4 family member a
AliasesFO108; H4; H4/n; H4F2; 
H4FN; HIST2H4
GeneCards (Weizmann)HIST2H4A
Ensembl hg19 (Hinxton)ENSG00000270882 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000270882 [Gene_View]  chr1:149832657-149833052 [Contig_View]  HIST2H4A [Vega]
ICGC DataPortalENSG00000270882
TCGA cBioPortalHIST2H4A
AceView (NCBI)HIST2H4A
Genatlas (Paris)HIST2H4A
WikiGenes8370
SOURCE (Princeton)HIST2H4A
Genetics Home Reference (NIH)HIST2H4A
Genomic and cartography
GoldenPath hg38 (UCSC)HIST2H4A  -     chr1:149832657-149833052 +  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIST2H4A  -     1q21.2   [Description]    (hg19-Feb_2009)
EnsemblHIST2H4A - 1q21.2 [CytoView hg19]  HIST2H4A - 1q21.2 [CytoView hg38]
Mapping of homologs : NCBIHIST2H4A [Mapview hg19]  HIST2H4A [Mapview hg38]
OMIM142750   
Gene and transcription
Genbank (Entrez)BC019846 BC093969 BC108260 BC112193 BC146448
RefSeq transcript (Entrez)NM_003548
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIST2H4A
Cluster EST : UnigeneHs.706635 [ NCBI ]
CGAP (NCI)Hs.706635
Alternative Splicing GalleryENSG00000270882
Gene ExpressionHIST2H4A [ NCBI-GEO ]   HIST2H4A [ EBI - ARRAY_EXPRESS ]   HIST2H4A [ SEEK ]   HIST2H4A [ MEM ]
Gene Expression Viewer (FireBrowse)HIST2H4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8370
GTEX Portal (Tissue expression)HIST2H4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62805   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62805  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62805
Splice isoforms : SwissVarP62805
PhosPhoSitePlusP62805
Domaine pattern : Prosite (Expaxy)HISTONE_H4 (PS00047)   
Domains : Interpro (EBI)Histone-fold    Histone_H4    Histone_H4_CS    TAF_TATA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)H4 (SM00417)  TAF (SM00803)  
Conserved Domain (NCBI)HIST2H4A
DMDM Disease mutations8370
Blocks (Seattle)HIST2H4A
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP62805
Human Protein AtlasENSG00000270882
Peptide AtlasP62805
HPRD11821
Protein Interaction databases
DIP (DOE-UCLA)P62805
IntAct (EBI)P62805
FunCoupENSG00000270882
BioGRIDHIST2H4A
STRING (EMBL)HIST2H4A
ZODIACHIST2H4A
Ontologies - Pathways
QuickGOP62805
Ontology : AmiGOchromatin silencing at rDNA  nuclear chromosome  nuclear chromosome, telomeric region  nucleosome  nucleosome  nuclear nucleosome  DNA binding  DNA binding  RNA binding  protein binding  extracellular region  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  nucleosome assembly  nucleosome assembly  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  DNA-templated transcription, initiation  membrane  telomere capping  protein domain specific binding  extracellular matrix  gene silencing by RNA  telomere organization  CENP-A containing nucleosome assembly  histone binding  histone binding  protein complex  cellular protein metabolic process  negative regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  positive regulation of gene expression, epigenetic  protein heterodimerization activity  protein heterotetramerization  extracellular exosome  beta-catenin-TCF complex assembly  
Ontology : EGO-EBIchromatin silencing at rDNA  nuclear chromosome  nuclear chromosome, telomeric region  nucleosome  nucleosome  nuclear nucleosome  DNA binding  DNA binding  RNA binding  protein binding  extracellular region  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  nucleosome assembly  nucleosome assembly  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  DNA-templated transcription, initiation  membrane  telomere capping  protein domain specific binding  extracellular matrix  gene silencing by RNA  telomere organization  CENP-A containing nucleosome assembly  histone binding  histone binding  protein complex  cellular protein metabolic process  negative regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  positive regulation of gene expression, epigenetic  protein heterodimerization activity  protein heterotetramerization  extracellular exosome  beta-catenin-TCF complex assembly  
Pathways : KEGGAlcoholism    Viral carcinogenesis    Systemic lupus erythematosus   
NDEx NetworkHIST2H4A
Atlas of Cancer Signalling NetworkHIST2H4A
Wikipedia pathwaysHIST2H4A
Orthology - Evolution
OrthoDB8370
GeneTree (enSembl)ENSG00000270882
Phylogenetic Trees/Animal Genes : TreeFamHIST2H4A
HOVERGENP62805
HOGENOMP62805
Homologs : HomoloGeneHIST2H4A
Homology/Alignments : Family Browser (UCSC)HIST2H4A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIST2H4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIST2H4A
dbVarHIST2H4A
ClinVarHIST2H4A
1000_GenomesHIST2H4A 
Exome Variant ServerHIST2H4A
ExAC (Exome Aggregation Consortium)HIST2H4A (select the gene name)
Genetic variants : HAPMAP8370
Genomic Variants (DGV)HIST2H4A [DGVbeta]
DECIPHERHIST2H4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIST2H4A 
Mutations
ICGC Data PortalHIST2H4A 
TCGA Data PortalHIST2H4A 
Broad Tumor PortalHIST2H4A
OASIS PortalHIST2H4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIST2H4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIST2H4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIST2H4A
DgiDB (Drug Gene Interaction Database)HIST2H4A
DoCM (Curated mutations)HIST2H4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIST2H4A (select a term)
intoGenHIST2H4A
Cancer3DHIST2H4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142750   
Orphanet
MedgenHIST2H4A
Genetic Testing Registry HIST2H4A
NextProtP62805 [Medical]
TSGene8370
GENETestsHIST2H4A
Target ValidationHIST2H4A
Huge Navigator HIST2H4A [HugePedia]
snp3D : Map Gene to Disease8370
BioCentury BCIQHIST2H4A
ClinGenHIST2H4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8370
Chemical/Pharm GKB GenePA29169
Clinical trialHIST2H4A
Miscellaneous
canSAR (ICR)HIST2H4A (select the gene name)
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIST2H4A
EVEXHIST2H4A
GoPubMedHIST2H4A
iHOPHIST2H4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:36:56 CEST 2017

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