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HIST2H4B (histone cluster 2 H4 family member b)

Identity

Alias_nameshistone 2, H4b
histone cluster 2, H4b
Alias_symbol (synonym)H4/o
Other alias
HGNC (Hugo) HIST2H4B
LocusID (NCBI) 554313
Atlas_Id 55495
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 149832657 and ends at 149833052 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HIST2H4B   29607
Cards
Entrez_Gene (NCBI)HIST2H4B  554313  histone cluster 2 H4 family member b
AliasesH4/o
GeneCards (Weizmann)HIST2H4B
Ensembl hg19 (Hinxton)ENSG00000270276 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000270276 [Gene_View]  chr1:149832657-149833052 [Contig_View]  HIST2H4B [Vega]
ICGC DataPortalENSG00000270276
TCGA cBioPortalHIST2H4B
AceView (NCBI)HIST2H4B
Genatlas (Paris)HIST2H4B
WikiGenes554313
SOURCE (Princeton)HIST2H4B
Genetics Home Reference (NIH)HIST2H4B
Genomic and cartography
GoldenPath hg38 (UCSC)HIST2H4B  -     chr1:149832657-149833052 +  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIST2H4B  -     1q21.2   [Description]    (hg19-Feb_2009)
EnsemblHIST2H4B - 1q21.2 [CytoView hg19]  HIST2H4B - 1q21.2 [CytoView hg38]
Mapping of homologs : NCBIHIST2H4B [Mapview hg19]  HIST2H4B [Mapview hg38]
Gene and transcription
Genbank (Entrez)BC019846 BC093969 BC108260 BC112193 CR542172
RefSeq transcript (Entrez)NM_001034077
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIST2H4B
Cluster EST : UnigeneHs.706635 [ NCBI ]
CGAP (NCI)Hs.706635
Alternative Splicing GalleryENSG00000270276
Gene ExpressionHIST2H4B [ NCBI-GEO ]   HIST2H4B [ EBI - ARRAY_EXPRESS ]   HIST2H4B [ SEEK ]   HIST2H4B [ MEM ]
Gene Expression Viewer (FireBrowse)HIST2H4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)554313
GTEX Portal (Tissue expression)HIST2H4B
Human Protein AtlasENSG00000270276-HIST2H4B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62805   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62805  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62805
Splice isoforms : SwissVarP62805
PhosPhoSitePlusP62805
Domaine pattern : Prosite (Expaxy)HISTONE_H4 (PS00047)   
Domains : Interpro (EBI)Histone-fold    Histone_H4    Histone_H4_CS    TAF_TATA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)H4 (SM00417)  TAF (SM00803)  
Conserved Domain (NCBI)HIST2H4B
DMDM Disease mutations554313
Blocks (Seattle)HIST2H4B
PDB (SRS)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
PDB (PDBSum)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
PDB (IMB)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
PDB (RSDB)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
Structural Biology KnowledgeBase1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
SCOP (Structural Classification of Proteins)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
CATH (Classification of proteins structures)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
SuperfamilyP62805
Human Protein Atlas [tissue]ENSG00000270276-HIST2H4B [tissue]
Peptide AtlasP62805
IPIIPI00453473   IPI01013176   
Protein Interaction databases
DIP (DOE-UCLA)P62805
IntAct (EBI)P62805
FunCoupENSG00000270276
BioGRIDHIST2H4B
STRING (EMBL)HIST2H4B
ZODIACHIST2H4B
Ontologies - Pathways
QuickGOP62805
Ontology : AmiGOchromatin silencing at rDNA  nuclear chromosome  nuclear chromosome, telomeric region  nucleosome  nucleosome  nuclear nucleosome  nuclear nucleosome  DNA binding  DNA binding  RNA binding  protein binding  extracellular region  nucleus  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  nucleosome assembly  nucleosome assembly  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  DNA-templated transcription, initiation  membrane  telomere capping  protein domain specific binding  extracellular matrix  telomere organization  CENP-A containing nucleosome assembly  histone binding  protein complex  cellular protein metabolic process  regulation of megakaryocyte differentiation  negative regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  positive regulation of gene expression, epigenetic  protein heterodimerization activity  protein heterotetramerization  regulation of gene silencing by miRNA  extracellular exosome  regulation of hematopoietic stem cell differentiation  beta-catenin-TCF complex assembly  
Ontology : EGO-EBIchromatin silencing at rDNA  nuclear chromosome  nuclear chromosome, telomeric region  nucleosome  nucleosome  nuclear nucleosome  nuclear nucleosome  DNA binding  DNA binding  RNA binding  protein binding  extracellular region  nucleus  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  nucleosome assembly  nucleosome assembly  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  DNA-templated transcription, initiation  membrane  telomere capping  protein domain specific binding  extracellular matrix  telomere organization  CENP-A containing nucleosome assembly  histone binding  protein complex  cellular protein metabolic process  regulation of megakaryocyte differentiation  negative regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  positive regulation of gene expression, epigenetic  protein heterodimerization activity  protein heterotetramerization  regulation of gene silencing by miRNA  extracellular exosome  regulation of hematopoietic stem cell differentiation  beta-catenin-TCF complex assembly  
NDEx NetworkHIST2H4B
Atlas of Cancer Signalling NetworkHIST2H4B
Wikipedia pathwaysHIST2H4B
Orthology - Evolution
OrthoDB554313
GeneTree (enSembl)ENSG00000270276
Phylogenetic Trees/Animal Genes : TreeFamHIST2H4B
HOVERGENP62805
HOGENOMP62805
Homologs : HomoloGeneHIST2H4B
Homology/Alignments : Family Browser (UCSC)HIST2H4B
Gene fusions - Rearrangements
Fusion : QuiverHIST2H4B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIST2H4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIST2H4B
dbVarHIST2H4B
ClinVarHIST2H4B
1000_GenomesHIST2H4B 
Exome Variant ServerHIST2H4B
ExAC (Exome Aggregation Consortium)ENSG00000270276
GNOMAD BrowserENSG00000270276
Genetic variants : HAPMAP554313
Genomic Variants (DGV)HIST2H4B [DGVbeta]
DECIPHERHIST2H4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIST2H4B 
Mutations
ICGC Data PortalHIST2H4B 
TCGA Data PortalHIST2H4B 
Broad Tumor PortalHIST2H4B
OASIS PortalHIST2H4B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHIST2H4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIST2H4B
DgiDB (Drug Gene Interaction Database)HIST2H4B
DoCM (Curated mutations)HIST2H4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIST2H4B (select a term)
intoGenHIST2H4B
Cancer3DHIST2H4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETHIST2H4B
MedgenHIST2H4B
Genetic Testing Registry HIST2H4B
NextProtP62805 [Medical]
TSGene554313
GENETestsHIST2H4B
Target ValidationHIST2H4B
Huge Navigator HIST2H4B [HugePedia]
snp3D : Map Gene to Disease554313
BioCentury BCIQHIST2H4B
ClinGenHIST2H4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD554313
Chemical/Pharm GKB GenePA145148733
Clinical trialHIST2H4B
Miscellaneous
canSAR (ICR)HIST2H4B (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIST2H4B
EVEXHIST2H4B
GoPubMedHIST2H4B
iHOPHIST2H4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:16:12 CET 2018

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