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HIST4H4 (histone cluster 4 H4)

Identity

Alias_nameshistone 4, H4
histone cluster 4, H4
Alias_symbol (synonym)MGC24116
Other aliasH4/p
HGNC (Hugo) HIST4H4
LocusID (NCBI) 121504
Atlas_Id 45565
Location 12p12.3  [Link to chromosome band 12p12]
Location_base_pair Starts at 14770720 and ends at 14771131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HIST4H4   20510
Cards
Entrez_Gene (NCBI)HIST4H4  121504  histone cluster 4 H4
AliasesH4/p
GeneCards (Weizmann)HIST4H4
Ensembl hg19 (Hinxton)ENSG00000197837 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197837 [Gene_View]  chr12:14770720-14771131 [Contig_View]  HIST4H4 [Vega]
ICGC DataPortalENSG00000197837
TCGA cBioPortalHIST4H4
AceView (NCBI)HIST4H4
Genatlas (Paris)HIST4H4
WikiGenes121504
SOURCE (Princeton)HIST4H4
Genetics Home Reference (NIH)HIST4H4
Genomic and cartography
GoldenPath hg38 (UCSC)HIST4H4  -     chr12:14770720-14771131 -  12p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HIST4H4  -     12p12.3   [Description]    (hg19-Feb_2009)
EnsemblHIST4H4 - 12p12.3 [CytoView hg19]  HIST4H4 - 12p12.3 [CytoView hg38]
Mapping of homologs : NCBIHIST4H4 [Mapview hg19]  HIST4H4 [Mapview hg38]
OMIM615069   
Gene and transcription
Genbank (Entrez)AK311916 BC020884
RefSeq transcript (Entrez)NM_175054
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HIST4H4
Cluster EST : UnigeneHs.745457 [ NCBI ]
CGAP (NCI)Hs.745457
Alternative Splicing GalleryENSG00000197837
Gene ExpressionHIST4H4 [ NCBI-GEO ]   HIST4H4 [ EBI - ARRAY_EXPRESS ]   HIST4H4 [ SEEK ]   HIST4H4 [ MEM ]
Gene Expression Viewer (FireBrowse)HIST4H4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)121504
GTEX Portal (Tissue expression)HIST4H4
Human Protein AtlasENSG00000197837-HIST4H4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62805   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62805  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62805
Splice isoforms : SwissVarP62805
PhosPhoSitePlusP62805
Domaine pattern : Prosite (Expaxy)HISTONE_H4 (PS00047)   
Domains : Interpro (EBI)Histone-fold    Histone_H4    Histone_H4_CS    TAF_TATA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)H4 (SM00417)  TAF (SM00803)  
Conserved Domain (NCBI)HIST4H4
DMDM Disease mutations121504
Blocks (Seattle)HIST4H4
PDB (SRS)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
PDB (PDBSum)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
PDB (IMB)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
PDB (RSDB)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
Structural Biology KnowledgeBase1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
SCOP (Structural Classification of Proteins)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
CATH (Classification of proteins structures)1ZKK    2BQZ    2CV5    2IG0    2KWN    2KWO    2LVM    2QQS    2RJE    2RNY    2RS9    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3CFS    3CFV    3F9W    3F9X    3F9Y    3F9Z    3IJ1    3JPX    3NQJ    3NQU    3O36    3QBY    3QZS    3QZT    3QZV    3R45    3UVW    3UVX    3UVY    3UW9    3W96    3W97    3W98    3W99    3WA9    3WAA    3WKJ    3WTP    3X1S    3X1T    3X1U    3X1V    4GQB    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4M38    4N3W    4N4F    4QUT    4QUU    4QYD    4U9W    4YM5    4YM6    4YY6    4YYD    4YYG    4YYH    4YYI    4YYJ    4YYK    4YYM    4YYN    4Z2M    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5BNV    5BNX    5BO0    5C3I    5CPI    5CPJ    5CPK    5FA5    5FFW    5FWE    5JA4    5KDM   
SuperfamilyP62805
Human Protein Atlas [tissue]ENSG00000197837-HIST4H4 [tissue]
Peptide AtlasP62805
HPRD13662
Protein Interaction databases
DIP (DOE-UCLA)P62805
IntAct (EBI)P62805
FunCoupENSG00000197837
BioGRIDHIST4H4
STRING (EMBL)HIST4H4
ZODIACHIST4H4
Ontologies - Pathways
QuickGOP62805
Ontology : AmiGOchromatin silencing at rDNA  nuclear chromosome  nuclear chromosome, telomeric region  nucleosome  nucleosome  nuclear nucleosome  nuclear nucleosome  DNA binding  DNA binding  RNA binding  protein binding  extracellular region  nucleus  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  nucleosome assembly  nucleosome assembly  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  DNA-templated transcription, initiation  membrane  telomere capping  protein domain specific binding  extracellular matrix  telomere organization  CENP-A containing nucleosome assembly  histone binding  protein complex  cellular protein metabolic process  regulation of megakaryocyte differentiation  negative regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  positive regulation of gene expression, epigenetic  protein heterodimerization activity  protein heterotetramerization  regulation of gene silencing by miRNA  extracellular exosome  regulation of hematopoietic stem cell differentiation  beta-catenin-TCF complex assembly  
Ontology : EGO-EBIchromatin silencing at rDNA  nuclear chromosome  nuclear chromosome, telomeric region  nucleosome  nucleosome  nuclear nucleosome  nuclear nucleosome  DNA binding  DNA binding  RNA binding  protein binding  extracellular region  nucleus  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  nucleosome assembly  nucleosome assembly  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  DNA-templated transcription, initiation  membrane  telomere capping  protein domain specific binding  extracellular matrix  telomere organization  CENP-A containing nucleosome assembly  histone binding  protein complex  cellular protein metabolic process  regulation of megakaryocyte differentiation  negative regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  positive regulation of gene expression, epigenetic  protein heterodimerization activity  protein heterotetramerization  regulation of gene silencing by miRNA  extracellular exosome  regulation of hematopoietic stem cell differentiation  beta-catenin-TCF complex assembly  
NDEx NetworkHIST4H4
Atlas of Cancer Signalling NetworkHIST4H4
Wikipedia pathwaysHIST4H4
Orthology - Evolution
OrthoDB121504
GeneTree (enSembl)ENSG00000197837
Phylogenetic Trees/Animal Genes : TreeFamHIST4H4
HOVERGENP62805
HOGENOMP62805
Homologs : HomoloGeneHIST4H4
Homology/Alignments : Family Browser (UCSC)HIST4H4
Gene fusions - Rearrangements
Fusion : QuiverHIST4H4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHIST4H4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HIST4H4
dbVarHIST4H4
ClinVarHIST4H4
1000_GenomesHIST4H4 
Exome Variant ServerHIST4H4
ExAC (Exome Aggregation Consortium)ENSG00000197837
GNOMAD BrowserENSG00000197837
Genetic variants : HAPMAP121504
Genomic Variants (DGV)HIST4H4 [DGVbeta]
DECIPHERHIST4H4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHIST4H4 
Mutations
ICGC Data PortalHIST4H4 
TCGA Data PortalHIST4H4 
Broad Tumor PortalHIST4H4
OASIS PortalHIST4H4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHIST4H4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHIST4H4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HIST4H4
DgiDB (Drug Gene Interaction Database)HIST4H4
DoCM (Curated mutations)HIST4H4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HIST4H4 (select a term)
intoGenHIST4H4
Cancer3DHIST4H4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615069   
Orphanet
DisGeNETHIST4H4
MedgenHIST4H4
Genetic Testing Registry HIST4H4
NextProtP62805 [Medical]
TSGene121504
GENETestsHIST4H4
Target ValidationHIST4H4
Huge Navigator HIST4H4 [HugePedia]
snp3D : Map Gene to Disease121504
BioCentury BCIQHIST4H4
ClinGenHIST4H4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD121504
Chemical/Pharm GKB GenePA134931035
Clinical trialHIST4H4
Miscellaneous
canSAR (ICR)HIST4H4 (select the gene name)
Probes
Litterature
PubMed206 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHIST4H4
EVEXHIST4H4
GoPubMedHIST4H4
iHOPHIST4H4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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