Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HK1 (hexokinase 1)

Identity

Other namesHK1-ta
HK1-tb
HK1-tc
HKD
HKI
HMSNR
HXK1
HGNC (Hugo) HK1
LocusID (NCBI) 3098
Atlas_Id 47112
Location 10q22.1
Location_base_pair Starts at 71078603 and ends at 71161637 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HK1   4922
Cards
Entrez_Gene (NCBI)HK1  3098  hexokinase 1
GeneCards (Weizmann)HK1
Ensembl hg19 (Hinxton)ENSG00000156515 [Gene_View]  chr10:71078603-71161637 [Contig_View]  HK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000156515 [Gene_View]  chr10:71078603-71161637 [Contig_View]  HK1 [Vega]
ICGC DataPortalENSG00000156515
TCGA cBioPortalHK1
AceView (NCBI)HK1
Genatlas (Paris)HK1
WikiGenes3098
SOURCE (Princeton)HK1
Genomic and cartography
GoldenPath hg19 (UCSC)HK1  -     chr10:71078603-71161637 +  10q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HK1  -     10q22.1   [Description]    (hg38-Dec_2013)
EnsemblHK1 - 10q22.1 [CytoView hg19]  HK1 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBIHK1 [Mapview hg19]  HK1 [Mapview hg38]
OMIM142600   235700   605285   
Gene and transcription
Genbank (Entrez)AB209526 AF073786 AK091267 AK128226 AK292012
RefSeq transcript (Entrez)NM_000188 NM_033496 NM_033497 NM_033498 NM_033500
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_012077 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)HK1
Cluster EST : UnigeneHs.370365 [ NCBI ]
CGAP (NCI)Hs.370365
Alternative Splicing : Fast-db (Paris)GSHG0003420
Alternative Splicing GalleryENSG00000156515
Gene ExpressionHK1 [ NCBI-GEO ]     HK1 [ SEEK ]   HK1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19367 (Uniprot)
NextProtP19367  [Medical]
With graphics : InterProP19367
Splice isoforms : SwissVarP19367 (Swissvar)
Catalytic activity : Enzyme2.7.1.1 [ Enzyme-Expasy ]   2.7.1.12.7.1.1 [ IntEnz-EBI ]   2.7.1.1 [ BRENDA ]   2.7.1.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)HEXOKINASES (PS00378)   
Domains : Interpro (EBI)Hexokinase    Hexokinase_C    Hexokinase_CS    Hexokinase_N   
Related proteins : CluSTrP19367
Domain families : Pfam (Sanger)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (NCBI)pfam00349    pfam03727   
DMDM Disease mutations3098
Blocks (Seattle)P19367
PDB (SRS)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB (PDBSum)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB (IMB)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB (RSDB)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
Human Protein AtlasENSG00000156515
Peptide AtlasP19367
HPRD00809
IPIIPI00018246   IPI00220663   IPI00220665   IPI00220667   IPI00903226   IPI01014693   IPI00815786   IPI01008922   
Protein Interaction databases
DIP (DOE-UCLA)P19367
IntAct (EBI)P19367
FunCoupENSG00000156515
BioGRIDHK1
IntegromeDBHK1
STRING (EMBL)HK1
Ontologies - Pathways
QuickGOP19367
Ontology : AmiGOcellular glucose homeostasis  glucokinase activity  hexokinase activity  protein binding  ATP binding  mitochondrion  mitochondrial outer membrane  cytosol  carbohydrate metabolic process  glycolytic process  hexose transport  fructokinase activity  pathogenesis  glucose transport  mannokinase activity  hexose metabolic process  small molecule metabolic process  membrane raft  carbohydrate phosphorylation  carbohydrate phosphorylation  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  transmembrane transport  sperm principal piece  
Ontology : EGO-EBIcellular glucose homeostasis  glucokinase activity  hexokinase activity  protein binding  ATP binding  mitochondrion  mitochondrial outer membrane  cytosol  carbohydrate metabolic process  glycolytic process  hexose transport  fructokinase activity  pathogenesis  glucose transport  mannokinase activity  hexose metabolic process  small molecule metabolic process  membrane raft  carbohydrate phosphorylation  carbohydrate phosphorylation  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  transmembrane transport  sperm principal piece  
Pathways : BIOCARTAGlycolysis Pathway [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    Fructose and mannose metabolism    Galactose metabolism    Starch and sucrose metabolism    Amino sugar and nucleotide sugar metabolism    Butirosin and neomycin biosynthesis    HIF-1 signaling pathway    Insulin signaling pathway    Type II diabetes mellitus    Carbohydrate digestion and absorption   
Protein Interaction DatabaseHK1
DoCM (Curated mutations)HK1
Wikipedia pathwaysHK1
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerHK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HK1
dbVarHK1
ClinVarHK1
1000_GenomesHK1 
Exome Variant ServerHK1
SNP (GeneSNP Utah)HK1
SNP : HGBaseHK1
Genetic variants : HAPMAPHK1
Genomic Variants (DGV)HK1 [DGVbeta]
Mutations
ICGC Data PortalHK1 
TCGA Data PortalHK1 
Tumor PortalHK1
Somatic Mutations in Cancer : COSMICHK1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)10:71078603-71161637
CONAN: Copy Number AnalysisHK1 
Mutations and Diseases : HGMDHK1
OMIM142600    235700    605285   
MedgenHK1
NextProtP19367 [Medical]
GENETestsHK1
Disease Genetic AssociationHK1
Huge Navigator HK1 [HugePedia]  HK1 [HugeCancerGEM]
snp3D : Map Gene to Disease3098
DGIdb (Drug Gene Interaction db)HK1
General knowledge
Homologs : HomoloGeneHK1
Homology/Alignments : Family Browser (UCSC)HK1
Phylogenetic Trees/Animal Genes : TreeFamHK1
Chemical/Protein Interactions : CTD3098
Chemical/Pharm GKB GenePA29300
Clinical trialHK1
Cancer Resource (Charite)ENSG00000156515
Other databases
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
CoreMineHK1
GoPubMedHK1
iHOPHK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:32:55 CEST 2015

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