Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HK1 (hexokinase 1)

Identity

Alias (NCBI)HK
HK1-ta
HK1-tb
HK1-tc
HKD
HKI
HMSNR
HXK1
NEDVIBA
RP79
hexokinase
HGNC (Hugo) HK1
LocusID (NCBI) 3098
Atlas_Id 47112
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 69270000 and ends at 69401881 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYB561 (17q23.3) / HK1 (10q22.1)HK1 (10q22.1) / EPN2 (17p11.2)HK1 (10q22.1) / GNL1 (6p21.33)
HK1 (10q22.1) / HK1 (10q22.1)HK1 (10q22.1) / MTOR (1p36.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)HK1   4922
LRG (Locus Reference Genomic)LRG_365
Cards
Entrez_Gene (NCBI)HK1    hexokinase 1
AliasesHK; HK1-ta; HK1-tb; HK1-tc; 
HKD; HKI; HMSNR; HXK1; NEDVIBA; RP79; hexokinase
GeneCards (Weizmann)HK1
Ensembl hg19 (Hinxton)ENSG00000156515 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156515 [Gene_View]  ENSG00000156515 [Sequence]  chr10:69270000-69401881 [Contig_View]  HK1 [Vega]
ICGC DataPortalENSG00000156515
TCGA cBioPortalHK1
AceView (NCBI)HK1
Genatlas (Paris)HK1
SOURCE (Princeton)HK1
Genetics Home Reference (NIH)HK1
Genomic and cartography
GoldenPath hg38 (UCSC)HK1  -     chr10:69270000-69401881 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HK1  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathHK1 - 10q22.1 [CytoView hg19]  HK1 - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000156515
genome Data Viewer NCBIHK1 [Mapview hg19]  
OMIM142600   235700   605285   617460   618547   
Gene and transcription
Genbank (Entrez)AB209526 AF073786 AK091267 AK128226 AK292012
RefSeq transcript (Entrez)NM_000188 NM_001322364 NM_001322365 NM_001322366 NM_001322367 NM_001358263 NM_033496 NM_033497 NM_033498 NM_033500
Consensus coding sequences : CCDS (NCBI)HK1
Alternative Splicing GalleryENSG00000156515
Gene ExpressionHK1 [ NCBI-GEO ]   HK1 [ EBI - ARRAY_EXPRESS ]   HK1 [ SEEK ]   HK1 [ MEM ]
Gene Expression Viewer (FireBrowse)HK1 [ Firebrowse - Broad ]
GenevisibleExpression of HK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3098
GTEX Portal (Tissue expression)HK1
Human Protein AtlasENSG00000156515-HK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19367   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19367  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19367
PhosPhoSitePlusP19367
Domaine pattern : Prosite (Expaxy)HEXOKINASE_1 (PS00378)    HEXOKINASE_2 (PS51748)   
Domains : Interpro (EBI)ATPase_NBD    Hexokinase    Hexokinase_BS    Hexokinase_C    Hexokinase_N   
Domain families : Pfam (Sanger)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (NCBI)pfam00349    pfam03727   
Conserved Domain (NCBI)HK1
PDB (RSDB)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB Europe1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB (PDBSum)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB (IMB)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
Structural Biology KnowledgeBase1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
SCOP (Structural Classification of Proteins)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
CATH (Classification of proteins structures)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
SuperfamilyP19367
AlphaFold pdb e-kbP19367   
Human Protein Atlas [tissue]ENSG00000156515-HK1 [tissue]
HPRD00809
Protein Interaction databases
DIP (DOE-UCLA)P19367
IntAct (EBI)P19367
BioGRIDHK1
STRING (EMBL)HK1
ZODIACHK1
Ontologies - Pathways
QuickGOP19367
Ontology : AmiGOcellular glucose homeostasis  positive regulation of cytokine production involved in immune response  glucokinase activity  glucokinase activity  hexokinase activity  protein binding  ATP binding  glucose binding  mitochondrion  mitochondrion  mitochondrion  mitochondrial outer membrane  cytosol  cytosol  fructose 6-phosphate metabolic process  mannose metabolic process  glycolytic process  inflammatory response  fructokinase activity  fructokinase activity  mannokinase activity  mannokinase activity  positive regulation of interleukin-1 beta production  peptidoglycan binding  innate immune response  membrane raft  carbohydrate phosphorylation  glucosamine kinase activity  glucose 6-phosphate metabolic process  glucose 6-phosphate metabolic process  canonical glycolysis  establishment of protein localization to mitochondrion  maintenance of protein location in mitochondrion  
Ontology : EGO-EBIcellular glucose homeostasis  positive regulation of cytokine production involved in immune response  glucokinase activity  glucokinase activity  hexokinase activity  protein binding  ATP binding  glucose binding  mitochondrion  mitochondrion  mitochondrion  mitochondrial outer membrane  cytosol  cytosol  fructose 6-phosphate metabolic process  mannose metabolic process  glycolytic process  inflammatory response  fructokinase activity  fructokinase activity  mannokinase activity  mannokinase activity  positive regulation of interleukin-1 beta production  peptidoglycan binding  innate immune response  membrane raft  carbohydrate phosphorylation  glucosamine kinase activity  glucose 6-phosphate metabolic process  glucose 6-phosphate metabolic process  canonical glycolysis  establishment of protein localization to mitochondrion  maintenance of protein location in mitochondrion  
Pathways : BIOCARTAGlycolysis Pathway [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    Fructose and mannose metabolism    Galactose metabolism    Starch and sucrose metabolism    Amino sugar and nucleotide sugar metabolism    Butirosin and neomycin biosynthesis    HIF-1 signaling pathway    Insulin signaling pathway    Type II diabetes mellitus    Carbohydrate digestion and absorption   
NDEx NetworkHK1
Atlas of Cancer Signalling NetworkHK1
Wikipedia pathwaysHK1
Orthology - Evolution
OrthoDB3098
GeneTree (enSembl)ENSG00000156515
Phylogenetic Trees/Animal Genes : TreeFamHK1
Homologs : HomoloGeneHK1
Homology/Alignments : Family Browser (UCSC)HK1
Gene fusions - Rearrangements
Fusion : QuiverHK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HK1
dbVarHK1
ClinVarHK1
MonarchHK1
1000_GenomesHK1 
Exome Variant ServerHK1
GNOMAD BrowserENSG00000156515
Varsome BrowserHK1
Genomic Variants (DGV)HK1 [DGVbeta]
DECIPHERHK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHK1 
Mutations
ICGC Data PortalHK1 
TCGA Data PortalHK1 
Broad Tumor PortalHK1
OASIS PortalHK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHK1
Mutations and Diseases : HGMDHK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch HK1
DgiDB (Drug Gene Interaction Database)HK1
DoCM (Curated mutations)HK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HK1 (select a term)
Cancer3DHK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142600    235700    605285    617460    618547   
Orphanet11930    14526   
DisGeNETHK1
MedgenHK1
Genetic Testing Registry HK1
NextProtP19367 [Medical]
GENETestsHK1
Target ValidationHK1
Huge Navigator HK1 [HugePedia]
ClinGenHK1
Clinical trials, drugs, therapy
MyCancerGenomeHK1
Protein Interactions : CTDHK1
Pharm GKB GenePA29300
Pharm GKB PathwaysPA165971634   
PharosP19367
Clinical trialHK1
Miscellaneous
canSAR (ICR)HK1
HarmonizomeHK1
DataMed IndexHK1
Probes
Litterature
PubMed144 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:17:10 CEST 2021

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