Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HK1 (hexokinase 1)

Identity

HGNC (Hugo) HK1
LocusID (NCBI) 3098
Atlas_Id 47112
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 71078603 and ends at 71161637 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CYB561 (17q23.3) / HK1 (10q22.1)HK1 (10q22.1) / EPN2 (17p11.2)HK1 (10q22.1) / GNL1 (6p21.33)
HK1 (10q22.1) / HK1 (10q22.1)HK1 (10q22.1) / MTOR (1p36.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HK1   4922
LRG (Locus Reference Genomic)LRG_365
Cards
Entrez_Gene (NCBI)HK1  3098  hexokinase 1
AliasesHK1-ta; HK1-tb; HK1-tc; HKD; 
HKI; HMSNR; HXK1
GeneCards (Weizmann)HK1
Ensembl hg19 (Hinxton)ENSG00000156515 [Gene_View]  chr10:71078603-71161637 [Contig_View]  HK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000156515 [Gene_View]  chr10:71078603-71161637 [Contig_View]  HK1 [Vega]
ICGC DataPortalENSG00000156515
TCGA cBioPortalHK1
AceView (NCBI)HK1
Genatlas (Paris)HK1
WikiGenes3098
SOURCE (Princeton)HK1
Genetics Home Reference (NIH)HK1
Genomic and cartography
GoldenPath hg19 (UCSC)HK1  -     chr10:71078603-71161637 +  10q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HK1  -     10q22.1   [Description]    (hg38-Dec_2013)
EnsemblHK1 - 10q22.1 [CytoView hg19]  HK1 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBIHK1 [Mapview hg19]  HK1 [Mapview hg38]
OMIM142600   235700   605285   
Gene and transcription
Genbank (Entrez)AB209526 AF073786 AK091267 AK128226 AK292012
RefSeq transcript (Entrez)NM_000188 NM_001322364 NM_001322365 NM_001322366 NM_001322367 NM_033496 NM_033497 NM_033498 NM_033500
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_012077 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)HK1
Cluster EST : UnigeneHs.370365 [ NCBI ]
CGAP (NCI)Hs.370365
Alternative Splicing GalleryENSG00000156515
Gene ExpressionHK1 [ NCBI-GEO ]   HK1 [ EBI - ARRAY_EXPRESS ]   HK1 [ SEEK ]   HK1 [ MEM ]
Gene Expression Viewer (FireBrowse)HK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3098
GTEX Portal (Tissue expression)HK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19367   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19367  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19367
Splice isoforms : SwissVarP19367
Catalytic activity : Enzyme2.7.1.1 [ Enzyme-Expasy ]   2.7.1.12.7.1.1 [ IntEnz-EBI ]   2.7.1.1 [ BRENDA ]   2.7.1.1 [ KEGG ]   
PhosPhoSitePlusP19367
Domaine pattern : Prosite (Expaxy)HEXOKINASE_1 (PS00378)    HEXOKINASE_2 (PS51748)   
Domains : Interpro (EBI)Hexokinase    Hexokinase_BS    Hexokinase_C    Hexokinase_N   
Domain families : Pfam (Sanger)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (NCBI)pfam00349    pfam03727   
Conserved Domain (NCBI)HK1
DMDM Disease mutations3098
Blocks (Seattle)HK1
PDB (SRS)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB (PDBSum)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB (IMB)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
PDB (RSDB)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
Structural Biology KnowledgeBase1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
SCOP (Structural Classification of Proteins)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
CATH (Classification of proteins structures)1CZA    1DGK    1HKB    1HKC    1QHA    4F9O    4FOE    4FOI    4FPA    4FPB   
SuperfamilyP19367
Human Protein AtlasENSG00000156515
Peptide AtlasP19367
HPRD00809
IPIIPI00018246   IPI00220663   IPI00220665   IPI00220667   IPI00903226   IPI01014693   IPI00815786   IPI01008922   
Protein Interaction databases
DIP (DOE-UCLA)P19367
IntAct (EBI)P19367
FunCoupENSG00000156515
BioGRIDHK1
STRING (EMBL)HK1
ZODIACHK1
Ontologies - Pathways
QuickGOP19367
Ontology : AmiGOcellular glucose homeostasis  glucokinase activity  glucokinase activity  hexokinase activity  protein binding  ATP binding  glucose binding  mitochondrion  mitochondrial outer membrane  cytosol  cytosol  glycolytic process  fructokinase activity  glucose transport  mannokinase activity  membrane raft  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  canonical glycolysis  establishment of protein localization to mitochondrion  maintenance of protein location in mitochondrion  sperm principal piece  
Ontology : EGO-EBIcellular glucose homeostasis  glucokinase activity  glucokinase activity  hexokinase activity  protein binding  ATP binding  glucose binding  mitochondrion  mitochondrial outer membrane  cytosol  cytosol  glycolytic process  fructokinase activity  glucose transport  mannokinase activity  membrane raft  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  canonical glycolysis  establishment of protein localization to mitochondrion  maintenance of protein location in mitochondrion  sperm principal piece  
Pathways : BIOCARTAGlycolysis Pathway [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    Fructose and mannose metabolism    Galactose metabolism    Starch and sucrose metabolism    Amino sugar and nucleotide sugar metabolism    Butirosin and neomycin biosynthesis    HIF-1 signaling pathway    Insulin signaling pathway    Type II diabetes mellitus    Carbohydrate digestion and absorption   
NDEx NetworkHK1
Atlas of Cancer Signalling NetworkHK1
Wikipedia pathwaysHK1
Orthology - Evolution
OrthoDB3098
GeneTree (enSembl)ENSG00000156515
Phylogenetic Trees/Animal Genes : TreeFamHK1
HOVERGENP19367
HOGENOMP19367
Homologs : HomoloGeneHK1
Homology/Alignments : Family Browser (UCSC)HK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HK1
dbVarHK1
ClinVarHK1
1000_GenomesHK1 
Exome Variant ServerHK1
ExAC (Exome Aggregation Consortium)HK1 (select the gene name)
Genetic variants : HAPMAP3098
Genomic Variants (DGV)HK1 [DGVbeta]
DECIPHER (Syndromes)10:71078603-71161637  ENSG00000156515
CONAN: Copy Number AnalysisHK1 
Mutations
ICGC Data PortalHK1 
TCGA Data PortalHK1 
Broad Tumor PortalHK1
OASIS PortalHK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HK1
DgiDB (Drug Gene Interaction Database)HK1
DoCM (Curated mutations)HK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HK1 (select a term)
intoGenHK1
Cancer3DHK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142600    235700    605285   
Orphanet11930    14526   
MedgenHK1
Genetic Testing Registry HK1
NextProtP19367 [Medical]
TSGene3098
GENETestsHK1
Huge Navigator HK1 [HugePedia]
snp3D : Map Gene to Disease3098
BioCentury BCIQHK1
ClinGenHK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3098
Chemical/Pharm GKB GenePA29300
Clinical trialHK1
Miscellaneous
canSAR (ICR)HK1 (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHK1
EVEXHK1
GoPubMedHK1
iHOPHK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:39:25 CET 2016

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