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HK3 (hexokinase 3)

Identity

Alias_nameshexokinase 3 (white cell)
Other aliasHKIII
HXK3
HGNC (Hugo) HK3
LocusID (NCBI) 3101
Atlas_Id 46641
Location 5q35.2  [Link to chromosome band 5q35]
Location_base_pair Starts at 176880869 and ends at 176899332 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HK3   4925
Cards
Entrez_Gene (NCBI)HK3  3101  hexokinase 3
AliasesHKIII; HXK3
GeneCards (Weizmann)HK3
Ensembl hg19 (Hinxton)ENSG00000160883 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160883 [Gene_View]  chr5:176880869-176899332 [Contig_View]  HK3 [Vega]
ICGC DataPortalENSG00000160883
TCGA cBioPortalHK3
AceView (NCBI)HK3
Genatlas (Paris)HK3
WikiGenes3101
SOURCE (Princeton)HK3
Genetics Home Reference (NIH)HK3
Genomic and cartography
GoldenPath hg38 (UCSC)HK3  -     chr5:176880869-176899332 -  5q35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HK3  -     5q35.2   [Description]    (hg19-Feb_2009)
EnsemblHK3 - 5q35.2 [CytoView hg19]  HK3 - 5q35.2 [CytoView hg38]
Mapping of homologs : NCBIHK3 [Mapview hg19]  HK3 [Mapview hg38]
OMIM142570   
Gene and transcription
Genbank (Entrez)AB208951 BC028129 BX644742 DQ891078 DQ894260
RefSeq transcript (Entrez)NM_002115
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HK3
Cluster EST : UnigeneHs.411695 [ NCBI ]
CGAP (NCI)Hs.411695
Alternative Splicing GalleryENSG00000160883
Gene ExpressionHK3 [ NCBI-GEO ]   HK3 [ EBI - ARRAY_EXPRESS ]   HK3 [ SEEK ]   HK3 [ MEM ]
Gene Expression Viewer (FireBrowse)HK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3101
GTEX Portal (Tissue expression)HK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52790   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52790  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52790
Splice isoforms : SwissVarP52790
Catalytic activity : Enzyme2.7.1.1 [ Enzyme-Expasy ]   2.7.1.12.7.1.1 [ IntEnz-EBI ]   2.7.1.1 [ BRENDA ]   2.7.1.1 [ KEGG ]   
PhosPhoSitePlusP52790
Domaine pattern : Prosite (Expaxy)HEXOKINASE_1 (PS00378)    HEXOKINASE_2 (PS51748)   
Domains : Interpro (EBI)Hexokinase    Hexokinase_BS    Hexokinase_C    Hexokinase_N   
Domain families : Pfam (Sanger)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (NCBI)pfam00349    pfam03727   
Conserved Domain (NCBI)HK3
DMDM Disease mutations3101
Blocks (Seattle)HK3
PDB (SRS)3HM8   
PDB (PDBSum)3HM8   
PDB (IMB)3HM8   
PDB (RSDB)3HM8   
Structural Biology KnowledgeBase3HM8   
SCOP (Structural Classification of Proteins)3HM8   
CATH (Classification of proteins structures)3HM8   
SuperfamilyP52790
Human Protein AtlasENSG00000160883
Peptide AtlasP52790
HPRD00806
IPIIPI00005118   IPI00815793   IPI00555601   IPI00967098   IPI00966616   
Protein Interaction databases
DIP (DOE-UCLA)P52790
IntAct (EBI)P52790
FunCoupENSG00000160883
BioGRIDHK3
STRING (EMBL)HK3
ZODIACHK3
Ontologies - Pathways
QuickGOP52790
Ontology : AmiGOcellular glucose homeostasis  glucokinase activity  glucokinase activity  hexokinase activity  ATP binding  glucose binding  extracellular region  mitochondrion  cytosol  cytosol  glycolytic process  fructokinase activity  glucose transport  mannokinase activity  secretory granule lumen  neutrophil degranulation  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  canonical glycolysis  ficolin-1-rich granule lumen  
Ontology : EGO-EBIcellular glucose homeostasis  glucokinase activity  glucokinase activity  hexokinase activity  ATP binding  glucose binding  extracellular region  mitochondrion  cytosol  cytosol  glycolytic process  fructokinase activity  glucose transport  mannokinase activity  secretory granule lumen  neutrophil degranulation  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  canonical glycolysis  ficolin-1-rich granule lumen  
Pathways : KEGG   
NDEx NetworkHK3
Atlas of Cancer Signalling NetworkHK3
Wikipedia pathwaysHK3
Orthology - Evolution
OrthoDB3101
GeneTree (enSembl)ENSG00000160883
Phylogenetic Trees/Animal Genes : TreeFamHK3
HOVERGENP52790
HOGENOMP52790
Homologs : HomoloGeneHK3
Homology/Alignments : Family Browser (UCSC)HK3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HK3
dbVarHK3
ClinVarHK3
1000_GenomesHK3 
Exome Variant ServerHK3
ExAC (Exome Aggregation Consortium)HK3 (select the gene name)
Genetic variants : HAPMAP3101
Genomic Variants (DGV)HK3 [DGVbeta]
DECIPHERHK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHK3 
Mutations
ICGC Data PortalHK3 
TCGA Data PortalHK3 
Broad Tumor PortalHK3
OASIS PortalHK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HK3
DgiDB (Drug Gene Interaction Database)HK3
DoCM (Curated mutations)HK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HK3 (select a term)
intoGenHK3
Cancer3DHK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142570   
Orphanet
MedgenHK3
Genetic Testing Registry HK3
NextProtP52790 [Medical]
TSGene3101
GENETestsHK3
Target ValidationHK3
Huge Navigator HK3 [HugePedia]
snp3D : Map Gene to Disease3101
BioCentury BCIQHK3
ClinGenHK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3101
Chemical/Pharm GKB GenePA29303
Clinical trialHK3
Miscellaneous
canSAR (ICR)HK3 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHK3
EVEXHK3
GoPubMedHK3
iHOPHK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:03:05 CEST 2017

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