HKDC1 (hexokinase domain containing 1)

2018-07-01  

Identity

HGNC
HKDC1
LOCATION
10q22.1
LOCUSID
80201
ALIAS
-

Other Information

Locus ID:

NCBI: 80201
MIM: 617221
HGNC: 23302
Ensembl: ENSG00000156510

Variants:

dbSNP: 80201
ClinVar: 80201
TCGA: ENSG00000156510
COSMIC: HKDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156510ENST00000354624Q2TB90

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fructose and mannose metabolismKEGGko00051
Galactose metabolismKEGGko00052
Starch and sucrose metabolismKEGGko00500
Amino sugar and nucleotide sugar metabolismKEGGko00520
Insulin signaling pathwayKEGGko04910
Type II diabetes mellitusKEGGko04930
Glycolysis / GluconeogenesisKEGGhsa00010
Fructose and mannose metabolismKEGGhsa00051
Galactose metabolismKEGGhsa00052
Starch and sucrose metabolismKEGGhsa00500
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Insulin signaling pathwayKEGGhsa04910
Type II diabetes mellitusKEGGhsa04930
Metabolic pathwaysKEGGhsa01100
Neomycin, kanamycin and gentamicin biosynthesisKEGGko00524
Neomycin, kanamycin and gentamicin biosynthesisKEGGhsa00524
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGhsa_M00549
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGM00549
HIF-1 signaling pathwayKEGGhsa04066
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
207326272010Case-control genome-wide association study of attention-deficit/hyperactivity disorder.58
239033562013Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.39
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
273467362016Hexokinase Domain Containing 1 (HKDC1) Gene Variants and their Association with Gestational Diabetes Mellitus in a South Indian Population.4
294014042018Studies on the Tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans.4
294205612018Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response.4
305176262019Hepatic HKDC1 Expression Contributes to Liver Metabolism.4
277031472016Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.2

Citation

Dessen P

HKDC1 (hexokinase domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57598/hkdc1