Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HLA-A (major histocompatibility complex, class I, A)

Identity

Other aliasHLAA
HGNC (Hugo) HLA-A
LocusID (NCBI) 3105
Atlas_Id 46138
Location 6p22.1  [Link to chromosome band 6p22]
Location_base_pair Starts at 29942470 and ends at 29945884 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HLA-A (6p22.1) / HLA-A (6p22.1)HLA-A (6p22.1) / HLA-B (6p21.33)HLA-A (6p22.1) / HLA-C (6p21.33)
HLA-A (6p22.1) / HLA-H (6p22.1)HLA-A (6p22.1) / IFI16 (1q23.1)HLA-A (6p22.1) / IGBP1 (Xq13.1)
HLA-A (6p22.1) / IGHG1 (14q32.33)HLA-A (6p22.1) / ROS1 (6q22.1)IFITM2 (11p15.5) / HLA-A (6p22.1)
HLA-A 6p22.1 / ROS1 6q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLA-A   4931
Cards
Entrez_Gene (NCBI)HLA-A  3105  major histocompatibility complex, class I, A
AliasesHLAA
GeneCards (Weizmann)HLA-A
Ensembl hg19 (Hinxton)ENSG00000206503 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000206503 [Gene_View]  chr6:29942470-29945884 [Contig_View]  HLA-A [Vega]
ICGC DataPortalENSG00000206503
TCGA cBioPortalHLA-A
AceView (NCBI)HLA-A
Genatlas (Paris)HLA-A
WikiGenes3105
SOURCE (Princeton)HLA-A
Genetics Home Reference (NIH)HLA-A
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-A  -     chr6:29942470-29945884 +  6p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-A  -     6p22.1   [Description]    (hg19-Feb_2009)
EnsemblHLA-A - 6p22.1 [CytoView hg19]  HLA-A - 6p22.1 [CytoView hg38]
Mapping of homologs : NCBIHLA-A [Mapview hg19]  HLA-A [Mapview hg38]
OMIM142800   608579   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001242758 NM_002116
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_029217 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)HLA-A
Cluster EST : UnigeneHs.713441 [ NCBI ]
CGAP (NCI)Hs.713441
Alternative Splicing GalleryENSG00000206503
Gene ExpressionHLA-A [ NCBI-GEO ]   HLA-A [ EBI - ARRAY_EXPRESS ]   HLA-A [ SEEK ]   HLA-A [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3105
GTEX Portal (Tissue expression)HLA-A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ09160   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ09160  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ09160
Splice isoforms : SwissVarQ09160
PhosPhoSitePlusQ09160
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I-like_Ag-recog    MHC_I/II-like_Ag-recog    MHC_I_a_a1/a2    MHC_I_a_C   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_I (PF00129)    MHC_I_C (PF06623)   
Domain families : Pfam (NCBI)pfam07654    pfam00129    pfam06623   
Domain families : Smart (EMBL)IGc1 (SM00407)  
Conserved Domain (NCBI)HLA-A
DMDM Disease mutations3105
Blocks (Seattle)HLA-A
SuperfamilyQ09160
Human Protein AtlasENSG00000206503
Peptide AtlasQ09160
HPRD00826
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q09160
IntAct (EBI)Q09160
FunCoupENSG00000206503
BioGRIDHLA-A
STRING (EMBL)HLA-A
ZODIACHLA-A
Ontologies - Pathways
QuickGOQ09160
Ontology : AmiGOGolgi membrane  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  RNA binding  receptor binding  protein binding  endoplasmic reticulum  Golgi apparatus  plasma membrane  plasma membrane  cell surface  ER to Golgi transport vesicle membrane  viral process  phagocytic vesicle membrane  beta-2-microglobulin binding  beta-2-microglobulin binding  early endosome membrane  peptide antigen binding  peptide antigen binding  MHC class I protein complex  regulation of immune response  recycling endosome membrane  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  RNA binding  receptor binding  protein binding  endoplasmic reticulum  Golgi apparatus  plasma membrane  plasma membrane  cell surface  ER to Golgi transport vesicle membrane  viral process  phagocytic vesicle membrane  beta-2-microglobulin binding  beta-2-microglobulin binding  early endosome membrane  peptide antigen binding  peptide antigen binding  MHC class I protein complex  regulation of immune response  recycling endosome membrane  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Pathways : BIOCARTARas-Independent pathway in NK cell-mediated cytotoxicity [Genes]    CTL mediated immune response against target cells [Genes]    Antigen Processing and Presentation [Genes]   
Pathways : KEGG   
NDEx NetworkHLA-A
Atlas of Cancer Signalling NetworkHLA-A
Wikipedia pathwaysHLA-A
Orthology - Evolution
OrthoDB3105
GeneTree (enSembl)ENSG00000206503
Phylogenetic Trees/Animal Genes : TreeFamHLA-A
HOVERGENQ09160
HOGENOMQ09160
Homologs : HomoloGeneHLA-A
Homology/Alignments : Family Browser (UCSC)HLA-A
Gene fusions - Rearrangements
Fusion Cancer (Beijing)HLA-A [6p22.1]  -  HLA-B [6p21.33]  [FUSC002417]  [FUSC002417]  [FUSC002417]  [FUSC002417]  [FUSC002417]  [FUSC002417]  [FUSC002417]  [FUSC002417]
Fusion Cancer (Beijing)HLA-A [6p22.1]  -  HLA-C [6p21.33]  [FUSC002269]  [FUSC002269]  [FUSC002269]  [FUSC002269]  [FUSC002269]  [FUSC002269]  [FUSC002269]  [FUSC002269]  [FUSC002269]  [FUSC002269]
Fusion Cancer (Beijing)HLA-A [6p22.1]  -  HLA-H [6p22.1]  [FUSC002503]  [FUSC002503]
Fusion Cancer (Beijing)HLA-A [6p22.1]  -  IFI16 [1q23.1]  [FUSC000440]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-A
dbVarHLA-A
ClinVarHLA-A
1000_GenomesHLA-A 
Exome Variant ServerHLA-A
ExAC (Exome Aggregation Consortium)HLA-A (select the gene name)
Genetic variants : HAPMAP3105
Genomic Variants (DGV)HLA-A [DGVbeta]
DECIPHERHLA-A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-A 
Mutations
ICGC Data PortalHLA-A 
TCGA Data PortalHLA-A 
Broad Tumor PortalHLA-A
OASIS PortalHLA-A [ Somatic mutations - Copy number]
Cancer Gene: CensusHLA-A 
Somatic Mutations in Cancer : COSMICHLA-A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHLA-A
intOGen PortalHLA-A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-A
DgiDB (Drug Gene Interaction Database)HLA-A
DoCM (Curated mutations)HLA-A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-A (select a term)
intoGenHLA-A
Cancer3DHLA-A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142800    608579   
Orphanet3404   
MedgenHLA-A
Genetic Testing Registry HLA-A
NextProtQ09160 [Medical]
TSGene3105
GENETestsHLA-A
Huge Navigator HLA-A [HugePedia]
snp3D : Map Gene to Disease3105
BioCentury BCIQHLA-A
ClinGenHLA-A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3105
Chemical/Pharm GKB GenePA35055
Clinical trialHLA-A
Miscellaneous
canSAR (ICR)HLA-A (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-A
EVEXHLA-A
GoPubMedHLA-A
iHOPHLA-A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:18:58 CEST 2017

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