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HLA-A (major histocompatibility complex, class I, A)

Identity

Other namesHLAA
HGNC (Hugo) HLA-A
LocusID (NCBI) 3105
Location 6p22.1
Location_base_pair Starts at 29910247 and ends at 29913661 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HLA-A   4931
Cards
Entrez_Gene (NCBI)HLA-A  3105  major histocompatibility complex, class I, A
GeneCards (Weizmann)HLA-A
Ensembl (Hinxton)ENSG00000206503 [Gene_View]  chr6:29910247-29913661 [Contig_View]  HLA-A [Vega]
ICGC DataPortalENSG00000206503
AceView (NCBI)HLA-A
Genatlas (Paris)HLA-A
WikiGenes3105
SOURCE (Princeton)NM_001242758 NM_002116
Genomic and cartography
GoldenPath (UCSC)HLA-A  -  6p22.1   chr6:29910247-29913661 +  6p22.1   [Description]    (hg19-Feb_2009)
EnsemblHLA-A - 6p22.1 [CytoView]
Mapping of homologs : NCBIHLA-A [Mapview]
OMIM142800   608579   
Gene and transcription
Genbank (Entrez)AB209117 AF008933 AF012766 AF012767 AF015930
RefSeq transcript (Entrez)NM_001242758 NM_002116
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_029217 NT_007592 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249 NW_001838980 NW_004929326
Consensus coding sequences : CCDS (NCBI)HLA-A
Cluster EST : UnigeneHs.713441 [ NCBI ]
CGAP (NCI)Hs.713441
Alternative Splicing : Fast-db (Paris)GSHG0025568
Alternative Splicing GalleryENSG00000206503
Gene ExpressionHLA-A [ NCBI-GEO ]     HLA-A [ SEEK ]   HLA-A [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ09160 (Uniprot)
NextProtQ09160  [Medical]
With graphics : InterProQ09160
Splice isoforms : SwissVarQ09160 (Swissvar)
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I-like_Ag-recog    MHC_I/II-like_Ag-recog    MHC_I_a    MHC_I_a_a1/a2    MHC_I_a_C   
Related proteins : CluSTrQ09160
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_I (PF00129)    MHC_I_C (PF06623)   
Domain families : Pfam (NCBI)pfam07654    pfam00129    pfam06623   
Domain families : Smart (EMBL)IGc1 (SM00407)  
DMDM Disease mutations3105
Blocks (Seattle)Q09160
Human Protein AtlasENSG00000206503
Peptide AtlasQ09160
HPRD00826
IPIIPI00004657   IPI00472882   IPI00876963   IPI00471986   IPI00651697   IPI00647634   IPI00742968   IPI00472825   IPI00760554   IPI00472138   IPI00642409   IPI00472448   IPI00472112   IPI00472855   IPI00646225   IPI00472013   IPI00472652   IPI00718924   IPI00472434   IPI00026569   IPI00472151   IPI00743359   IPI00743503   IPI00644748   IPI00472222   IPI00479242   IPI00472458   IPI00472130   IPI00646083   IPI00827612   IPI00472800   IPI00026602   IPI00472676   IPI00743117   IPI00472416   IPI00744375   IPI00472402   IPI00472057   IPI00472456   IPI00471955   IPI00744689   IPI00655604   IPI00472282   IPI00472767   IPI00472284   IPI00746605   IPI00026650   IPI00472605   IPI00472903   IPI00743716   IPI00749025   IPI00472921   IPI00746105   IPI00471951   IPI00472736   IPI00472210   IPI00472867   IPI00472162   IPI00472073   IPI00745649   IPI00472035   IPI00744964   IPI00107380   IPI00472753   IPI00472943   IPI00473068   IPI00473006   IPI01024763   IPI01025173   IPI00983188   IPI00983570   IPI00941538   IPI01021347   IPI00965409   IPI00970930   IPI00976110   IPI00969040   IPI00970871   IPI00939700   IPI01021945   IPI00922944   IPI00893176   IPI01015390   IPI00940896   IPI01022401   IPI00976023   IPI01021656   IPI01020664   IPI00816779   IPI00969635   IPI00877003   IPI00719361   IPI00854735   IPI01019023   IPI00816439   IPI00719238   IPI00973057   IPI00300884   IPI00969584   IPI00974409   IPI01025929   IPI01021784   IPI00976456   IPI01025518   IPI01019058   IPI00893810   IPI00794678   IPI00969511   IPI00386363   IPI00795906   IPI01021782   IPI01018990   IPI00885217   IPI00977881   IPI01025214   IPI00973583   IPI00976771   IPI00785070   IPI00646129   IPI00942026   IPI00657976   IPI00643183   IPI00647457   IPI00745699   IPI00794679   IPI00797359   IPI00789627   IPI00914624   IPI00798352   IPI00788914   IPI00789567   IPI00790240   IPI00797121   IPI00790450   IPI00796489   IPI00893949   IPI00893131   IPI00894106   IPI00893894   IPI00892834   IPI01024754   IPI00892768   IPI00887461   IPI00887572   IPI00892868   IPI00893004   IPI00747198   IPI01026199   IPI00893023   IPI00893133   IPI00889629   IPI00892655   IPI00892982   IPI00893421   IPI00894325   IPI00853096   IPI00942114   IPI00844122   IPI01010897   IPI00890726   IPI00916352   IPI00917391   IPI00982121   IPI00980243   IPI00974087   IPI00980405   IPI00981298   IPI01011764   IPI01011050   IPI00976355   IPI00974114   IPI01014046   IPI00983782   IPI01014600   IPI00976792   IPI00980758   
Protein Interaction databases
DIP (DOE-UCLA)Q09160
IntAct (EBI)Q09160
FunCoupENSG00000206503
BioGRIDHLA-A
IntegromeDBHLA-A
STRING (EMBL)HLA-A
Ontologies - Pathways
QuickGOQ09160
Ontology : AmiGOGolgi membrane  positive regulation of T cell mediated cytotoxicity  positive regulation of T cell mediated cytotoxicity  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent  receptor binding  protein binding  endoplasmic reticulum  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  Golgi medial cisterna  plasma membrane  integral component of plasma membrane  immune response  immune response  cell surface  cell surface  ER to Golgi transport vesicle membrane  membrane  viral process  viral process  detection of bacterium  cytokine-mediated signaling pathway  phagocytic vesicle membrane  beta-2-microglobulin binding  beta-2-microglobulin binding  early endosome membrane  positive regulation of interferon-gamma production  protection from natural killer cell mediated cytotoxicity  antigen processing and presentation of exogenous peptide antigen via MHC class I  peptide antigen binding  peptide antigen binding  T cell receptor binding  MHC class I protein complex  MHC class I protein complex  poly(A) RNA binding  TAP binding  regulation of defense response to virus by virus  regulation of immune response  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  extracellular vesicular exosome  endoplasmic reticulum exit site  integral component of lumenal side of endoplasmic reticulum membrane  positive regulation of memory T cell activation  
Ontology : EGO-EBIGolgi membrane  positive regulation of T cell mediated cytotoxicity  positive regulation of T cell mediated cytotoxicity  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent  receptor binding  protein binding  endoplasmic reticulum  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  Golgi medial cisterna  plasma membrane  integral component of plasma membrane  immune response  immune response  cell surface  cell surface  ER to Golgi transport vesicle membrane  membrane  viral process  viral process  detection of bacterium  cytokine-mediated signaling pathway  phagocytic vesicle membrane  beta-2-microglobulin binding  beta-2-microglobulin binding  early endosome membrane  positive regulation of interferon-gamma production  protection from natural killer cell mediated cytotoxicity  antigen processing and presentation of exogenous peptide antigen via MHC class I  peptide antigen binding  peptide antigen binding  T cell receptor binding  MHC class I protein complex  MHC class I protein complex  poly(A) RNA binding  TAP binding  regulation of defense response to virus by virus  regulation of immune response  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  extracellular vesicular exosome  endoplasmic reticulum exit site  integral component of lumenal side of endoplasmic reticulum membrane  positive regulation of memory T cell activation  
Pathways : BIOCARTARas-Independent pathway in NK cell-mediated cytotoxicity [Genes]    CTL mediated immune response against target cells [Genes]    Antigen Processing and Presentation [Genes]   
Pathways : KEGGEndocytosis    Phagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Natural killer cell mediated cytotoxicity    Type I diabetes mellitus    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Viral carcinogenesis    Autoimmune thyroid disease    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
Protein Interaction DatabaseHLA-A
Wikipedia pathwaysHLA-A
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)HLA-A
SNP (GeneSNP Utah)HLA-A
SNP : HGBaseHLA-A
Genetic variants : HAPMAPHLA-A
1000_GenomesHLA-A 
ICGC programENSG00000206503 
CONAN: Copy Number AnalysisHLA-A 
Somatic Mutations in Cancer : COSMICHLA-A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)6:29910247-29913661
Mutations and Diseases : HGMDHLA-A
OMIM142800    608579   
MedgenHLA-A
GENETestsHLA-A
Disease Genetic AssociationHLA-A
Huge Navigator HLA-A [HugePedia]  HLA-A [HugeCancerGEM]
Genomic VariantsHLA-A  HLA-A [DGVbeta]
Exome VariantHLA-A
dbVarHLA-A
ClinVarHLA-A
snp3D : Map Gene to Disease3105
General knowledge
Homologs : HomoloGeneHLA-A
Homology/Alignments : Family Browser (UCSC)HLA-A
Phylogenetic Trees/Animal Genes : TreeFamHLA-A
Chemical/Protein Interactions : CTD3105
Chemical/Pharm GKB GenePA35055
Clinical trialHLA-A
Cancer Resource (Charite)ENSG00000206503
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineHLA-A
GoPubMedHLA-A
iHOPHLA-A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:31:35 CET 2014

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