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HLA-B (major histocompatibility complex, class I, B)

Identity

Other namesAS
HLAB
SPDA1
HGNC (Hugo) HLA-B
LocusID (NCBI) 3106
Location 6p21.33
Location_base_pair Starts at 31321649 and ends at 31324989 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HLA-B   4932
Cards
Entrez_Gene (NCBI)HLA-B  3106  major histocompatibility complex, class I, B
GeneCards (Weizmann)HLA-B
Ensembl (Hinxton)ENSG00000234745 [Gene_View]  chr6:31321649-31324989 [Contig_View]  HLA-B [Vega]
ICGC DataPortalENSG00000234745
cBioPortalHLA-B
AceView (NCBI)HLA-B
Genatlas (Paris)HLA-B
WikiGenes3106
SOURCE (Princeton)NM_005514
Genomic and cartography
GoldenPath (UCSC)HLA-B  -  6p21.33   chr6:31321649-31324989 -  6p21.33   [Description]    (hg19-Feb_2009)
EnsemblHLA-B - 6p21.33 [CytoView]
Mapping of homologs : NCBIHLA-B [Mapview]
OMIM106300   142830   608579   
Gene and transcription
Genbank (Entrez)AB008102 AF004370 AF016641 AF022783 AF026218
RefSeq transcript (Entrez)NM_005514
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_023187 NT_007592 NT_113891 NT_167246 NT_167247 NT_167248 NT_167249 NW_001838980 NW_004929326
Consensus coding sequences : CCDS (NCBI)HLA-B
Cluster EST : UnigeneHs.654404 [ NCBI ]
CGAP (NCI)Hs.654404
Alternative Splicing : Fast-db (Paris)GSHG0026462
Alternative Splicing GalleryENSG00000234745
Gene ExpressionHLA-B [ NCBI-GEO ]     HLA-B [ SEEK ]   HLA-B [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ95365 (Uniprot)
NextProtQ95365  [Medical]
With graphics : InterProQ95365
Splice isoforms : SwissVarQ95365 (Swissvar)
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom [organisation]   Ig-like_fold [organisation]   Ig/MHC_CS [organisation]   Ig_C1-set [organisation]   MHC_I-like_Ag-recog [organisation]   MHC_I/II-like_Ag-recog [organisation]   MHC_I_a [organisation]   MHC_I_a_a1/a2 [organisation]   MHC_I_a_C [organisation]  
Related proteins : CluSTrQ95365
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_I (PF00129)    MHC_I_C (PF06623)   
Domain families : Pfam (NCBI)pfam07654    pfam00129    pfam06623   
Domain families : Smart (EMBL)IGc1 (SM00407)  
DMDM Disease mutations3106
Blocks (Seattle)Q95365
Human Protein AtlasENSG00000234745 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ95365
HPRD00828
Protein Interaction databases
DIP (DOE-UCLA)Q95365
IntAct (EBI)Q95365
FunCoupENSG00000234745
BioGRIDHLA-B
InParanoidQ95365
Interologous Interaction database Q95365
IntegromeDBHLA-B
STRING (EMBL)HLA-B
Ontologies - Pathways
Ontology : AmiGOGolgi membrane  positive regulation of T cell mediated cytotoxicity  positive regulation of T cell mediated cytotoxicity  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent  regulation of T cell anergy  receptor binding  endoplasmic reticulum  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  plasma membrane  integral component of plasma membrane  defense response  immune response  immune response  immune response  cell surface  cell surface  ER to Golgi transport vesicle membrane  membrane  membrane  integral component of membrane  viral process  detection of bacterium  cytokine-mediated signaling pathway  phagocytic vesicle membrane  early endosome membrane  regulation of interleukin-12 production  regulation of interleukin-6 production  protection from natural killer cell mediated cytotoxicity  antigen processing and presentation of exogenous peptide antigen via MHC class I  peptide antigen binding  peptide antigen binding  MHC class I protein complex  MHC class I protein complex  innate immune response  TAP binding  TAP binding  regulation of immune response  chaperone binding  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  extracellular vesicular exosome  integral component of lumenal side of endoplasmic reticulum membrane  regulation of dendritic cell differentiation  
Ontology : EGO-EBIGolgi membrane  positive regulation of T cell mediated cytotoxicity  positive regulation of T cell mediated cytotoxicity  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent  regulation of T cell anergy  receptor binding  endoplasmic reticulum  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  plasma membrane  integral component of plasma membrane  defense response  immune response  immune response  immune response  cell surface  cell surface  ER to Golgi transport vesicle membrane  membrane  membrane  integral component of membrane  viral process  detection of bacterium  cytokine-mediated signaling pathway  phagocytic vesicle membrane  early endosome membrane  regulation of interleukin-12 production  regulation of interleukin-6 production  protection from natural killer cell mediated cytotoxicity  antigen processing and presentation of exogenous peptide antigen via MHC class I  peptide antigen binding  peptide antigen binding  MHC class I protein complex  MHC class I protein complex  innate immune response  TAP binding  TAP binding  regulation of immune response  chaperone binding  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  extracellular vesicular exosome  integral component of lumenal side of endoplasmic reticulum membrane  regulation of dendritic cell differentiation  
Pathways : KEGGEndocytosis    Phagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Natural killer cell mediated cytotoxicity    Type I diabetes mellitus    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Viral carcinogenesis    Autoimmune thyroid disease    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
Protein Interaction DatabaseHLA-B
Wikipedia pathwaysHLA-B
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)HLA-B
snp3D : Map Gene to Disease3106
SNP (GeneSNP Utah)HLA-B
SNP : HGBaseHLA-B
Genetic variants : HAPMAPHLA-B
Exome VariantHLA-B
1000_GenomesHLA-B 
ICGC programENSG00000234745 
Somatic Mutations in Cancer : COSMICHLA-B 
CONAN: Copy Number AnalysisHLA-B 
Mutations and Diseases : HGMDHLA-B
Genomic VariantsHLA-B  HLA-B [DGVbeta]
dbVarHLA-B
ClinVarHLA-B
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM106300    142830    608579   
MedgenHLA-B
GENETestsHLA-B
Disease Genetic AssociationHLA-B
Huge Navigator HLA-B [HugePedia]  HLA-B [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneHLA-B
Homology/Alignments : Family Browser (UCSC)HLA-B
Phylogenetic Trees/Animal Genes : TreeFamHLA-B
Chemical/Protein Interactions : CTD3106
Chemical/Pharm GKB GenePA35056
Clinical trialHLA-B
Cancer Resource (Charite)ENSG00000234745
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineHLA-B
iHOPHLA-B
OncoSearchHLA-B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:58:04 CEST 2014

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