Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HLA-B (major histocompatibility complex, class I, B)

Identity

Other namesAS
Bw-47
Bw-50
HLAB
SPDA1
HGNC (Hugo) HLA-B
LocusID (NCBI) 3106
Atlas_Id 46594
Location 6p21.33
Location_base_pair Starts at 31321643 and ends at 31325022 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACTR1B (2q11.2) / HLA-B (6p21.33)ANKLE2 (12q24.33) / HLA-B (6p21.33)HLA-A (6p22.1) / HLA-B (6p21.33)
HLA-B (6p21.33) / APOL3 (22q12.3)HLA-B (6p21.33) / CAMK4 (5q22.1)HLA-B (6p21.33) / CCT7 (2p13.2)
HLA-B (6p21.33) / CYTH2 (19q13.33)HLA-B (6p21.33) / FECH (18q21.31)HLA-B (6p21.33) / FKBP8 (19p13.11)
HLA-B (6p21.33) / HLA-B (6p21.33)HLA-B (6p21.33) / IGKC (2p11.2)HLA-B (6p21.33) / OGT (Xq13.1)
HLA-B (6p21.33) / ORAI2 (7q22.1)HLA-B (6p21.33) / PSMB3 (17q12)HLA-B (6p21.33) / RNASEH2B (13q14.3)
HLA-B (6p21.33) / RPL3 (22q13.1)HLA-B (6p21.33) / SBK1 (16p11.2)HLA-B (6p21.33) / SEPT2 (2q37.3)
HLA-B (6p21.33) / TACC1 (8p11.22)HLA-C (6p21.33) / HLA-B (6p21.33)HLA-E (6p21.33) / HLA-B (6p21.33)
HLA-G (6p22.1) / HLA-B (6p21.33)HLA-H (6p22.1) / HLA-B (6p21.33)HLA-J (6p22.1) / HLA-B (6p21.33)
HLA-L (6p22.1) / HLA-B (6p21.33)KCNQ1 (11p15.5) / HLA-B (6p21.33)MUC16 (19p13.2) / HLA-B (6p21.33)
NACA (12q13.3) / HLA-B (6p21.33)TRPC6 (11q22.1) / HLA-B (6p21.33)HLA-B 6p21.33 / RNASEH2B 13q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLA-B   4932
Cards
Entrez_Gene (NCBI)HLA-B  3106  major histocompatibility complex, class I, B
GeneCards (Weizmann)HLA-B
Ensembl hg19 (Hinxton)ENSG00000234745 [Gene_View]  chr6:31321643-31325022 [Contig_View]  HLA-B [Vega]
Ensembl hg38 (Hinxton)ENSG00000234745 [Gene_View]  chr6:31321643-31325022 [Contig_View]  HLA-B [Vega]
ICGC DataPortalENSG00000234745
TCGA cBioPortalHLA-B
AceView (NCBI)HLA-B
Genatlas (Paris)HLA-B
WikiGenes3106
SOURCE (Princeton)HLA-B
Genomic and cartography
GoldenPath hg19 (UCSC)HLA-B  -     chr6:31321643-31325022 -  6p21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HLA-B  -     6p21.33   [Description]    (hg38-Dec_2013)
EnsemblHLA-B - 6p21.33 [CytoView hg19]  HLA-B - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIHLA-B [Mapview hg19]  HLA-B [Mapview hg38]
OMIM106300   142830   608579   
Gene and transcription
Genbank (Entrez)AB008102 AF004370 AF016641 AF022783 AF026218
RefSeq transcript (Entrez)NM_005514
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_023187 NT_007592 NT_113891 NT_167246 NT_167247 NT_167248 NT_167249 NW_004929326
Consensus coding sequences : CCDS (NCBI)HLA-B
Cluster EST : UnigeneHs.654404 [ NCBI ]
CGAP (NCI)Hs.654404
Alternative Splicing GalleryENSG00000234745
Gene ExpressionHLA-B [ NCBI-GEO ]   HLA-B [ EBI - ARRAY_EXPRESS ]   HLA-B [ SEEK ]   HLA-B [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3106
GTEX Portal (Tissue expression)HLA-B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ95365 (Uniprot)
NextProtQ95365  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ95365
Splice isoforms : SwissVarQ95365 (Swissvar)
PhosPhoSitePlusQ95365
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I-like_Ag-recog    MHC_I/II-like_Ag-recog    MHC_I_a    MHC_I_a_a1/a2    MHC_I_a_C   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_I (PF00129)    MHC_I_C (PF06623)   
Domain families : Pfam (NCBI)pfam07654    pfam00129    pfam06623   
Domain families : Smart (EMBL)IGc1 (SM00407)  
DMDM Disease mutations3106
Blocks (Seattle)HLA-B
SuperfamilyQ95365
Human Protein AtlasENSG00000234745
Peptide AtlasQ95365
HPRD00828
Protein Interaction databases
DIP (DOE-UCLA)Q95365
IntAct (EBI)Q95365
FunCoupENSG00000234745
BioGRIDHLA-B
STRING (EMBL)HLA-B
ZODIACHLA-B
Ontologies - Pathways
QuickGOQ95365
Ontology : AmiGOGolgi membrane  positive regulation of T cell mediated cytotoxicity  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent  regulation of T cell anergy  antigen binding  receptor binding  endoplasmic reticulum  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  defense response  immune response  immune response  cell surface  cell surface  ER to Golgi transport vesicle membrane  membrane  membrane  viral process  detection of bacterium  antigen processing and presentation  phagocytic vesicle membrane  early endosome membrane  regulation of interleukin-12 production  regulation of interleukin-6 production  protection from natural killer cell mediated cytotoxicity  peptide antigen binding  peptide antigen binding  MHC class I protein complex  MHC class I protein complex  innate immune response  TAP binding  TAP binding  regulation of immune response  chaperone binding  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  extracellular exosome  integral component of lumenal side of endoplasmic reticulum membrane  regulation of dendritic cell differentiation  
Ontology : EGO-EBIGolgi membrane  positive regulation of T cell mediated cytotoxicity  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent  regulation of T cell anergy  antigen binding  receptor binding  endoplasmic reticulum  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  defense response  immune response  immune response  cell surface  cell surface  ER to Golgi transport vesicle membrane  membrane  membrane  viral process  detection of bacterium  antigen processing and presentation  phagocytic vesicle membrane  early endosome membrane  regulation of interleukin-12 production  regulation of interleukin-6 production  protection from natural killer cell mediated cytotoxicity  peptide antigen binding  peptide antigen binding  MHC class I protein complex  MHC class I protein complex  innate immune response  TAP binding  TAP binding  regulation of immune response  chaperone binding  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  extracellular exosome  integral component of lumenal side of endoplasmic reticulum membrane  regulation of dendritic cell differentiation  
Pathways : KEGGEndocytosis    Phagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Natural killer cell mediated cytotoxicity    Type I diabetes mellitus    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Viral carcinogenesis    Autoimmune thyroid disease    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
NDEx Network
Atlas of Cancer Signalling NetworkHLA-B
Wikipedia pathwaysHLA-B
Orthology - Evolution
OrthoDB3106
GeneTree (enSembl)ENSG00000234745
Phylogenetic Trees/Animal Genes : TreeFamHLA-B
Homologs : HomoloGeneHLA-B
Homology/Alignments : Family Browser (UCSC)HLA-B
Gene fusions - Rearrangements
Fusion: TCGAHLA-B 6p21.33 RNASEH2B 13q14.3 THCA
Polymorphisms : SNP, variants
NCBI Variation ViewerHLA-B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-B
dbVarHLA-B
ClinVarHLA-B
1000_GenomesHLA-B 
Exome Variant ServerHLA-B
ExAC (Exome Aggregation Consortium)HLA-B (select the gene name)
Genetic variants : HAPMAP3106
Genomic Variants (DGV)HLA-B [DGVbeta]
Mutations
ICGC Data PortalHLA-B 
TCGA Data PortalHLA-B 
Broad Tumor PortalHLA-B
OASIS PortalHLA-B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLA-B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-B
DgiDB (Drug Gene Interaction Database)HLA-B
DoCM (Curated mutations)HLA-B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-B (select a term)
intoGenHLA-B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:31321643-31325022  ENSG00000234745
CONAN: Copy Number AnalysisHLA-B 
Mutations and Diseases : HGMDHLA-B
OMIM106300    142830    608579   
MedgenHLA-B
Genetic Testing Registry HLA-B
NextProtQ95365 [Medical]
TSGene3106
GENETestsHLA-B
Huge Navigator HLA-B [HugePedia]
snp3D : Map Gene to Disease3106
BioCentury BCIQHLA-B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3106
Chemical/Pharm GKB GenePA35056
Clinical trialHLA-B
Miscellaneous
canSAR (ICR)HLA-B (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-B
EVEXHLA-B
GoPubMedHLA-B
iHOPHLA-B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun May 8 18:49:17 CEST 2016

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