Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HLA-C (major histocompatibility complex, class I, C)

Identity

Alias_namesHLA-JY3
D6S204
PSORS1
psoriasis susceptibility 1
Other aliasHLAC
HLC-C
MHC
HGNC (Hugo) HLA-C
LocusID (NCBI) 3107
Atlas_Id 40831
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31268749 and ends at 31272136 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AES (19p13.3) / HLA-C (6p21.33)BTNL3 (5q35.3) / HLA-C (6p21.33)DAPL1 (2q24.1) / HLA-C (6p21.33)
HLA-A (6p22.1) / HLA-C (6p21.33)HLA-C (6p21.33) / ANP32A (15q23)HLA-C (6p21.33) / CFB (6p21.33)
HLA-C (6p21.33) / FOXP1 (3p13)HLA-C (6p21.33) / HEPH (Xq12)HLA-C (6p21.33) / HLA-B (6p21.33)
HLA-C (6p21.33) / HSP90AA1 (14q32.31)HLA-C (6p21.33) / TCOF1 (5q32)HLA-C (6p21.33) / ZMIZ2 (7p13)
HLA-C (6p21.33) / ZNF664 (12q24.31)HLA-G (6p22.1) / HLA-C (6p21.33)HLA-H (6p22.1) / HLA-C (6p21.33)
HLA-J (6p22.1) / HLA-C (6p21.33)HLA-L (6p22.1) / HLA-C (6p21.33)LIF (22q12.2) / HLA-C (6p21.33)
LOC100507412 (-) / HLA-C (6p21.33)NUMA1 (11q13.4) / HLA-C (6p21.33)S100A11 (1q21.3) / HLA-C (6p21.33)
STX4 (16p11.2) / HLA-C (6p21.33)TGFBI (5q31.1) / HLA-C (6p21.33)HLA-C 6p21.33 / CFB 6p21.33
HLA-C 6p21.33 / FOXP1 3p13HLA-C 6p21.33 / TCOF1 5q32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(3;6)(p13;p21) HLA-C/FOXP1
t(5;6)(q32;p21) HLA-C/TCOF1
HLA-C/CFB (6p21)

External links

Nomenclature
HGNC (Hugo)HLA-C   4933
Cards
Entrez_Gene (NCBI)HLA-C  3107  major histocompatibility complex, class I, C
AliasesD6S204; HLA-JY3; HLAC; HLC-C; 
MHC; PSORS1
GeneCards (Weizmann)HLA-C
Ensembl hg19 (Hinxton)ENSG00000204525 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204525 [Gene_View]  ENSG00000204525 [Sequence]  chr6:31268749-31272136 [Contig_View]  HLA-C [Vega]
ICGC DataPortalENSG00000204525
TCGA cBioPortalHLA-C
AceView (NCBI)HLA-C
Genatlas (Paris)HLA-C
WikiGenes3107
SOURCE (Princeton)HLA-C
Genetics Home Reference (NIH)HLA-C
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-C  -     chr6:31268749-31272136 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-C  -     6p21.33   [Description]    (hg19-Feb_2009)
GoldenPathHLA-C - 6p21.33 [CytoView hg19]  HLA-C - 6p21.33 [CytoView hg38]
ImmunoBaseENSG00000204525
Mapping of homologs : NCBIHLA-C [Mapview hg19]  HLA-C [Mapview hg38]
OMIM142840   177900   609423   
Gene and transcription
Genbank (Entrez)AF168611 AF196489 AF405691 AJ005199 AJ010748
RefSeq transcript (Entrez)NM_001243042 NM_002117
RefSeq genomic (Entrez)NC_000006 NG_029422 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)HLA-C
Alternative Splicing GalleryENSG00000204525
Gene ExpressionHLA-C [ NCBI-GEO ]   HLA-C [ EBI - ARRAY_EXPRESS ]   HLA-C [ SEEK ]   HLA-C [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3107
GTEX Portal (Tissue expression)HLA-C
Human Protein AtlasENSG00000204525-HLA-C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)HLA-C
DMDM Disease mutations3107
Blocks (Seattle)HLA-C
Human Protein Atlas [tissue]ENSG00000204525-HLA-C [tissue]
HPRD00829
Protein Interaction databases
FunCoupENSG00000204525
BioGRIDHLA-C
STRING (EMBL)HLA-C
ZODIACHLA-C
Ontologies - Pathways
Huge Navigator HLA-C [HugePedia]
snp3D : Map Gene to Disease3107
BioCentury BCIQHLA-C
ClinGenHLA-C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3107
Chemical/Pharm GKB GenePA35057
Clinical trialHLA-C
Miscellaneous
canSAR (ICR)HLA-C (select the gene name)
HarmonizomeHLA-C
DataMed IndexHLA-C
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-C
EVEXHLA-C
GoPubMedHLA-C
iHOPHLA-C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 10 12:17:29 CEST 2020
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