| Nomenclature |
|---|
| HGNC (Hugo) | HLA-C 4933 |
| Cards |
|---|
| Entrez_Gene (NCBI) | HLA-C 3107 major histocompatibility complex, class I, C |
| GeneCards (Weizmann) | HLA-C |
| Ensembl hg19 (Hinxton) | ENSG00000204525 [Gene_View] chr6:31236526-31239913 [Contig_View] HLA-C [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000204525 [Gene_View] chr6:31236526-31239913 [Contig_View] HLA-C [Vega] |
| ICGC DataPortal | ENSG00000204525 |
| cBioPortal | HLA-C |
| AceView (NCBI) | HLA-C |
| Genatlas (Paris) | HLA-C |
| WikiGenes | 3107 |
| SOURCE (Princeton) | HLA-C |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | HLA-C - chr6:31236526-31239913 - 6p21.33 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | HLA-C - 6p21.33 [Description] (hg38-Dec_2013) |
| Ensembl | HLA-C - 6p21.33 [CytoView hg19] HLA-C - 6p21.33 [CytoView hg38] |
| Mapping of homologs : NCBI | HLA-C [Mapview hg19] HLA-C [Mapview hg38] |
| OMIM | 142840 177900 609423 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF168611 AF196489 AF405691 AJ005199 AJ010748 |
| RefSeq transcript (Entrez) | NM_001243042 NM_002117 |
| RefSeq genomic (Entrez) | AC_000138 NC_000006 NC_018917 NG_029422 NT_007592 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249 NW_001838980 NW_004929326 |
| Consensus coding sequences : CCDS (NCBI) | HLA-C |
| Cluster EST : Unigene | Hs.743218 [ NCBI ] |
| CGAP (NCI) | Hs.743218 |
| Alternative Splicing : Fast-db (Paris) | GSHG0026461 |
| Alternative Splicing Gallery | ENSG00000204525 |
| Gene Expression | HLA-C [ NCBI-GEO ] HLA-C [ SEEK ] HLA-C [ MEM ] |
| SOURCE (Princeton) | Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9TNN7 (Uniprot) |
| NextProt | Q9TNN7 [Medical] |
| With graphics : InterPro | Q9TNN7 |
| Splice isoforms : SwissVar | Q9TNN7 (Swissvar) |
| Domaine pattern : Prosite (Expaxy) | IG_LIKE (PS50835) IG_MHC (PS00290) |
| Domains : Interpro (EBI) | Ig-like_dom Ig-like_fold Ig/MHC_CS Ig_C1-set MHC_I-like_Ag-recog MHC_I/II-like_Ag-recog MHC_I_a MHC_I_a_a1/a2 MHC_I_a_C |
| Related proteins : CluSTr | Q9TNN7 |
| Domain families : Pfam (Sanger) | C1-set (PF07654) MHC_I (PF00129) MHC_I_C (PF06623) |
| Domain families : Pfam (NCBI) | pfam07654 pfam00129 pfam06623 |
| Domain families : Smart (EMBL) | IGc1 (SM00407) |
| DMDM Disease mutations | 3107 |
| Blocks (Seattle) | Q9TNN7 |
| Human Protein Atlas | ENSG00000204525 |
| Peptide Atlas | Q9TNN7 |
| HPRD | 00829 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9TNN7 |
| IntAct (EBI) | Q9TNN7 |
| FunCoup | ENSG00000204525 |
| BioGRID | HLA-C |
| IntegromeDB | HLA-C |
| STRING (EMBL) | HLA-C |
| Ontologies - Pathways |
|---|
| QuickGO | Q9TNN7 |
| Ontology : AmiGO | Golgi membrane positive regulation of T cell mediated cytotoxicity antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent extracellular region endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus plasma membrane integral component of plasma membrane immune response cell surface cell surface ER to Golgi transport vesicle membrane viral process cytokine-mediated signaling pathway phagocytic vesicle membrane early endosome membrane antigen processing and presentation of exogenous peptide antigen via MHC class I peptide antigen binding peptide antigen binding MHC class I protein complex MHC class I protein complex innate immune response TAP binding regulation of immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway extracellular vesicular exosome integral component of lumenal side of endoplasmic reticulum membrane |
| Ontology : EGO-EBI | Golgi membrane positive regulation of T cell mediated cytotoxicity antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent extracellular region endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus plasma membrane integral component of plasma membrane immune response cell surface cell surface ER to Golgi transport vesicle membrane viral process cytokine-mediated signaling pathway phagocytic vesicle membrane early endosome membrane antigen processing and presentation of exogenous peptide antigen via MHC class I peptide antigen binding peptide antigen binding MHC class I protein complex MHC class I protein complex innate immune response TAP binding regulation of immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway extracellular vesicular exosome integral component of lumenal side of endoplasmic reticulum membrane |
| Pathways : KEGG | Endocytosis Phagosome Cell adhesion molecules (CAMs) Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus HTLV-I infection Herpes simplex infection Epstein-Barr virus infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis |
| Protein Interaction Database | HLA-C |
| DoCM (Curated mutations) | HLA-C |
| Wikipedia pathways | HLA-C |
| Gene fusion - rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | HLA-C [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | HLA-C |
| dbVar | HLA-C |
| ClinVar | HLA-C |
| 1000_Genomes | HLA-C |
| Exome Variant Server | HLA-C |
| SNP (GeneSNP Utah) | HLA-C |
| SNP : HGBase | HLA-C |
| Genetic variants : HAPMAP | HLA-C |
| Genomic Variants | HLA-C HLA-C [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | ENSG00000204525 |
| Somatic Mutations in Cancer : COSMIC | HLA-C |
| CONAN: Copy Number Analysis | HLA-C |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 6:31236526-31239913 |
| Mutations and Diseases : HGMD | HLA-C |
| OMIM | 142840 177900 609423 |
| Medgen | HLA-C |
| NextProt | Q9TNN7 [Medical] |
| GENETests | HLA-C |
| Disease Genetic Association | HLA-C |
| Huge Navigator |
HLA-C [HugePedia] HLA-C [HugeCancerGEM] |
| snp3D : Map Gene to Disease | 3107 |
| DGIdb (Drug Gene Interaction db) | HLA-C |
| General knowledge |
|---|
| Homologs : HomoloGene | HLA-C |
| Homology/Alignments : Family Browser (UCSC) | HLA-C |
| Phylogenetic Trees/Animal Genes : TreeFam | HLA-C |
| Chemical/Protein Interactions : CTD | 3107 |
| Chemical/Pharm GKB Gene | PA35057 |
| Clinical trial | HLA-C |
| Cancer Resource (Charite) | ENSG00000204525 |
| Other databases |
|---|
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| CoreMine | HLA-C |
| GoPubMed | HLA-C |
| iHOP | HLA-C |
