| Nomenclature | | HGNC (Hugo) | HLA-C 4933 |
| Cards | | Entrez_Gene (NCBI) | HLA-C 3107 major histocompatibility complex, class I, C |
| GeneCards (Weizmann) | HLA-C |
| Ensembl (Hinxton) | ENSG00000204525 [Gene_View] chr6:31236526-31239913 [Contig_View] HLA-C [Vega] |
| ICGC DataPortal | ENSG00000204525 |
| cBioPortal | HLA-C |
| AceView (NCBI) | HLA-C |
| Genatlas (Paris) | HLA-C |
| WikiGenes | 3107 |
| SOURCE (Princeton) | NM_001243042 NM_002117 |
| Genomic and cartography | | GoldenPath (UCSC) | HLA-C - 6p21.33 chr6:31236526-31239913 - 6p21.33 [Description] (hg19-Feb_2009) |
| Ensembl | HLA-C - 6p21.33 [CytoView] |
| Mapping of homologs : NCBI | HLA-C [Mapview] |
| OMIM | 142840 177900 609423 |
| Gene and transcription |
| Genbank (Entrez) | AF168611 AF196489 AF405691 AJ005199 AJ010748 |
| RefSeq transcript (Entrez) | NM_001243042 NM_002117 |
| RefSeq genomic (Entrez) | AC_000138 NC_000006 NC_018917 NG_029422 NT_007592 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249 NW_001838980 NW_004929326 |
| Consensus coding sequences : CCDS (NCBI) | HLA-C |
| Cluster EST : Unigene | Hs.743218 [ NCBI ] |
| CGAP (NCI) | Hs.743218 |
| Alternative Splicing : Fast-db (Paris) | GSHG0026461 |
| Alternative Splicing Gallery | ENSG00000204525 |
| Gene Expression | HLA-C [ NCBI-GEO ] HLA-C [ SEEK ] HLA-C [ MEM ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9TNN7 (Uniprot) |
| NextProt | Q9TNN7 [Medical] |
| With graphics : InterPro | Q9TNN7 |
| Splice isoforms : SwissVar | Q9TNN7 (Swissvar) |
| Domaine pattern : Prosite (Expaxy) | IG_LIKE (PS50835) IG_MHC (PS00290) |
| Domains : Interpro (EBI) | Ig-like_dom [organisation] Ig-like_fold [organisation] Ig/MHC_CS [organisation] Ig_C1-set [organisation] MHC_I-like_Ag-recog [organisation] MHC_I/II-like_Ag-recog [organisation] MHC_I_a [organisation] MHC_I_a_a1/a2 [organisation] MHC_I_a_C [organisation] |
| Related proteins : CluSTr | Q9TNN7 |
| Domain families : Pfam (Sanger) | C1-set (PF07654) MHC_I (PF00129) MHC_I_C (PF06623) |
| Domain families : Pfam (NCBI) | pfam07654 pfam00129 pfam06623 |
| Domain families : Smart (EMBL) | IGc1 (SM00407) |
| DMDM Disease mutations | 3107 |
| Blocks (Seattle) | Q9TNN7 |
| Human Protein Atlas | ENSG00000204525 [gene] [tissue] [antibody] [cell] [cancer] |
| Peptide Atlas | Q9TNN7 |
| HPRD | 00829 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9TNN7 |
| IntAct (EBI) | Q9TNN7 |
| FunCoup | ENSG00000204525 |
| BioGRID | HLA-C |
| InParanoid | Q9TNN7 |
| Interologous Interaction database | Q9TNN7 |
| IntegromeDB | HLA-C |
| STRING (EMBL) | HLA-C |
| Ontologies - Pathways | | Ontology : AmiGO | Golgi membrane positive regulation of T cell mediated cytotoxicity antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent receptor binding extracellular region plasma membrane integral to plasma membrane immune response ER to Golgi transport vesicle membrane modulation by virus of host morphology or physiology cytokine-mediated signaling pathway phagocytic vesicle membrane early endosome membrane antigen processing and presentation of exogenous peptide antigen via MHC class I peptide antigen binding peptide antigen binding MHC class I protein complex innate immune response regulation of immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway integral to lumenal side of endoplasmic reticulum membrane |
| Ontology : EGO-EBI | Golgi membrane positive regulation of T cell mediated cytotoxicity antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent receptor binding extracellular region plasma membrane integral to plasma membrane immune response ER to Golgi transport vesicle membrane modulation by virus of host morphology or physiology cytokine-mediated signaling pathway phagocytic vesicle membrane early endosome membrane antigen processing and presentation of exogenous peptide antigen via MHC class I peptide antigen binding peptide antigen binding MHC class I protein complex innate immune response regulation of immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway integral to lumenal side of endoplasmic reticulum membrane |
| Pathways : KEGG | Endocytosis Phagosome Cell adhesion molecules (CAMs) Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus HTLV-I infection Herpes simplex infection Epstein-Barr virus infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis |
| Protein Interaction Database | HLA-C |
| Wikipedia pathways | HLA-C |
| Gene fusion - rearrangments | | Polymorphisms : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | HLA-C |
| snp3D : Map Gene to Disease | 3107 |
| SNP (GeneSNP Utah) | HLA-C |
| SNP : HGBase | HLA-C |
| Genetic variants : HAPMAP | HLA-C |
| Exome Variant | HLA-C |
| 1000_Genomes | HLA-C |
| ICGC program | ENSG00000204525 |
| Somatic Mutations in Cancer : COSMIC | HLA-C |
| CONAN: Copy Number Analysis | HLA-C |
| Mutations and Diseases : HGMD | HLA-C |
| Genomic Variants | HLA-C HLA-C [DGVbeta] |
| dbVar | HLA-C |
| ClinVar | HLA-C |
| Pred. of missenses | PolyPhen-2 SIFT(SG) SIFT(JCVI) Align-GVGD MutAssessor Mutanalyser |
| Pred. splices | GeneSplicer Human Splicing Finder MaxEntScan |
| Diseases | | OMIM | 142840 177900 609423 |
| Medgen | HLA-C |
| GENETests | HLA-C |
| Disease Genetic Association | HLA-C |
| Huge Navigator |
HLA-C [HugePedia] HLA-C [HugeCancerGEM] |
| General knowledge |
|---|
| Homologs : HomoloGene | HLA-C |
| Homology/Alignments : Family Browser (UCSC) | HLA-C |
| Phylogenetic Trees/Animal Genes : TreeFam | HLA-C |
| Chemical/Protein Interactions : CTD | 3107 |
| Chemical/Pharm GKB Gene | PA35057 |
| Clinical trial | HLA-C |
| Cancer Resource (Charite) | ENSG00000204525 |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 499 Pubmed reference(s) in Entrez |
| CoreMine | HLA-C |
| iHOP | HLA-C |
