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HLA-DOB (major histocompatibility complex, class II, DO beta)

Identity

Other aliasDOB
HLA_DOB
HGNC (Hugo) HLA-DOB
LocusID (NCBI) 3112
Atlas_Id 46359
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32812763 and ends at 32817048 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLA-DOB (6p21.32) / HLA-DOB (6p21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLA-DOB   4937
Cards
Entrez_Gene (NCBI)HLA-DOB  3112  major histocompatibility complex, class II, DO beta
AliasesDOB; HLA_DOB
GeneCards (Weizmann)HLA-DOB
Ensembl hg19 (Hinxton)ENSG00000241106 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000241106 [Gene_View]  ENSG00000241106 [Sequence]  chr6:32812763-32817048 [Contig_View]  HLA-DOB [Vega]
ICGC DataPortalENSG00000241106
TCGA cBioPortalHLA-DOB
AceView (NCBI)HLA-DOB
Genatlas (Paris)HLA-DOB
WikiGenes3112
SOURCE (Princeton)HLA-DOB
Genetics Home Reference (NIH)HLA-DOB
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DOB  -     chr6:32812763-32817048 -  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DOB  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblHLA-DOB - 6p21.32 [CytoView hg19]  HLA-DOB - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIHLA-DOB [Mapview hg19]  HLA-DOB [Mapview hg38]
OMIM600629   
Gene and transcription
Genbank (Entrez)AK301415 AK316197 AY645723 BC006097 BC020226
RefSeq transcript (Entrez)NM_002120
RefSeq genomic (Entrez)NC_000006 NG_009793 NG_012008 NT_113891 NT_167244 NT_167245 NT_167247 NT_167249
Consensus coding sequences : CCDS (NCBI)HLA-DOB
Cluster EST : UnigeneHs.1802 [ NCBI ]
CGAP (NCI)Hs.1802
Alternative Splicing GalleryENSG00000241106
Gene ExpressionHLA-DOB [ NCBI-GEO ]   HLA-DOB [ EBI - ARRAY_EXPRESS ]   HLA-DOB [ SEEK ]   HLA-DOB [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DOB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3112
GTEX Portal (Tissue expression)HLA-DOB
Human Protein AtlasENSG00000241106-HLA-DOB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13765   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13765  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13765
Splice isoforms : SwissVarP13765
PhosPhoSitePlusP13765
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_b_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_beta (PF00969)   
Domain families : Pfam (NCBI)pfam07654    pfam00969   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_beta (SM00921)  
Domain structure : Prodom (Prabi Lyon)MHC_II_b_N (PD000328)   
Conserved Domain (NCBI)HLA-DOB
DMDM Disease mutations3112
Blocks (Seattle)HLA-DOB
PDB (SRS)4I0P   
PDB (PDBSum)4I0P   
PDB (IMB)4I0P   
PDB (RSDB)4I0P   
Structural Biology KnowledgeBase4I0P   
SCOP (Structural Classification of Proteins)4I0P   
CATH (Classification of proteins structures)4I0P   
SuperfamilyP13765
Human Protein Atlas [tissue]ENSG00000241106-HLA-DOB [tissue]
Peptide AtlasP13765
HPRD08368
IPIIPI00010410   IPI00967352   IPI00893461   IPI00980984   IPI00983213   IPI00981470   
Protein Interaction databases
DIP (DOE-UCLA)P13765
IntAct (EBI)P13765
FunCoupENSG00000241106
BioGRIDHLA-DOB
STRING (EMBL)HLA-DOB
ZODIACHLA-DOB
Ontologies - Pathways
QuickGOP13765
Ontology : AmiGOnegative regulation of antigen processing and presentation of peptide antigen via MHC class II  lysosome  lysosomal membrane  immune response  endosome membrane  integral component of membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  MHC class II protein complex binding  MHC class II receptor activity  MHC class II protein complex  
Ontology : EGO-EBInegative regulation of antigen processing and presentation of peptide antigen via MHC class II  lysosome  lysosomal membrane  immune response  endosome membrane  integral component of membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  MHC class II protein complex binding  MHC class II receptor activity  MHC class II protein complex  
Pathways : KEGGPhagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Intestinal immune network for IgA production    Type I diabetes mellitus    Leishmaniasis    Toxoplasmosis    Staphylococcus aureus infection    Tuberculosis    Influenza A    HTLV-I infection    Herpes simplex infection    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Systemic lupus erythematosus    Rheumatoid arthritis    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
NDEx NetworkHLA-DOB
Atlas of Cancer Signalling NetworkHLA-DOB
Wikipedia pathwaysHLA-DOB
Orthology - Evolution
OrthoDB3112
GeneTree (enSembl)ENSG00000241106
Phylogenetic Trees/Animal Genes : TreeFamHLA-DOB
HOVERGENP13765
HOGENOMP13765
Homologs : HomoloGeneHLA-DOB
Homology/Alignments : Family Browser (UCSC)HLA-DOB
Gene fusions - Rearrangements
Fusion : QuiverHLA-DOB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DOB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DOB
dbVarHLA-DOB
ClinVarHLA-DOB
1000_GenomesHLA-DOB 
Exome Variant ServerHLA-DOB
ExAC (Exome Aggregation Consortium)ENSG00000241106
GNOMAD BrowserENSG00000241106
Varsome BrowserHLA-DOB
Genetic variants : HAPMAP3112
Genomic Variants (DGV)HLA-DOB [DGVbeta]
DECIPHERHLA-DOB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DOB 
Mutations
ICGC Data PortalHLA-DOB 
TCGA Data PortalHLA-DOB 
Broad Tumor PortalHLA-DOB
OASIS PortalHLA-DOB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLA-DOB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHLA-DOB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-DOB
DgiDB (Drug Gene Interaction Database)HLA-DOB
DoCM (Curated mutations)HLA-DOB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DOB (select a term)
intoGenHLA-DOB
Cancer3DHLA-DOB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600629   
Orphanet
DisGeNETHLA-DOB
MedgenHLA-DOB
Genetic Testing Registry HLA-DOB
NextProtP13765 [Medical]
TSGene3112
GENETestsHLA-DOB
Target ValidationHLA-DOB
Huge Navigator HLA-DOB [HugePedia]
snp3D : Map Gene to Disease3112
BioCentury BCIQHLA-DOB
ClinGenHLA-DOB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3112
Chemical/Pharm GKB GenePA35061
Clinical trialHLA-DOB
Miscellaneous
canSAR (ICR)HLA-DOB (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DOB
EVEXHLA-DOB
GoPubMedHLA-DOB
iHOPHLA-DOB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:11:09 CET 2018

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