HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)

2011-07-01  

Identity

HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
DP(W3),DP(W4),DPA1,HLA-DP1A,HLA-DPA,HLA-DPB1,HLADP,HLASB,PLT1
FUSION GENES

Other Information

Locus ID:

NCBI: 3113
MIM: 142880
HGNC: 4938
Ensembl: ENSG00000231389

Variants:

dbSNP: 3113
ClinVar: 3113
TCGA: ENSG00000231389
COSMIC: HLA-DPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000231389ENST00000417724F6V115
ENSG00000231389ENST00000419277P20036
ENSG00000231389ENST00000419277X5CKE2
ENSG00000231389ENST00000437811H0Y6F8
ENSG00000231389ENST00000453337J3KQ99

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Antigen processing and presentationKEGGko04612
Hematopoietic cell lineageKEGGko04640
Type I diabetes mellitusKEGGko04940
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Graft-versus-host diseaseKEGGko05332
Cell adhesion molecules (CAMs)KEGGhsa04514
Antigen processing and presentationKEGGhsa04612
Hematopoietic cell lineageKEGGhsa04640
Type I diabetes mellitusKEGGhsa04940
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Graft-versus-host diseaseKEGGhsa05332
Viral myocarditisKEGGhsa05416
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Translocation of ZAP-70 to Immunological synapseREACTOMER-HSA-202430
Generation of second messenger moleculesREACTOMER-HSA-202433
Downstream TCR signalingREACTOMER-HSA-202424
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948
MHC class II antigen presentationREACTOMER-HSA-2132295
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164784024peginterferon alfa-2bChemicalClinicalAnnotationassociatedPD26387494
PA446862Hepatitis B, ChronicDiseaseClinicalAnnotationassociatedPD26387494

References

Pubmed IDYearTitleCitations
177855832007High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.316
193499832009A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.180
193499832009A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.180
151919522004Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome.153
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
221056892012Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.63
227372292012Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.58
224962242012A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection.54
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
218145172011Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.51

Citation

Dessen P

HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52523/hla-dpa1