Identity
HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
DP(W3),DP(W4),DPA1,HLA-DP1A,HLA-DPA,HLA-DPB1,HLADP,HLASB,PLT1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3113
MIM: 142880
HGNC: 4938
Ensembl: ENSG00000231389
Variants:
dbSNP: 3113
ClinVar: 3113
TCGA: ENSG00000231389
COSMIC: HLA-DPA1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164784024 | peginterferon alfa-2b | Chemical | ClinicalAnnotation | associated | PD | 26387494 | |
| PA446862 | Hepatitis B, Chronic | Disease | ClinicalAnnotation | associated | PD | 26387494 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37980631 | 2024 | The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced malaria susceptibility. | 0 |
| 38454348 | 2024 | Bioinformatics analysis identifies a key gene HLA_DPA1 in severe influenza-associated immune infiltration. | 0 |
| 38932664 | 2024 | Characterisation of five new variants of HLA-DPA1. | 0 |
| 37980631 | 2024 | The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced malaria susceptibility. | 0 |
| 38454348 | 2024 | Bioinformatics analysis identifies a key gene HLA_DPA1 in severe influenza-associated immune infiltration. | 0 |
| 38932664 | 2024 | Characterisation of five new variants of HLA-DPA1. | 0 |
| 36342183 | 2023 | Identification of the novel HLA-DPA1*01:03:43 allele resulting from an intralocus recombination involving the DPA1*04:01:01:03 and DPA1*01:03:01:27 alleles sequenced by Next Generation Sequencing (NGS). | 0 |
| 36412220 | 2023 | Identification of HLA-DPA1*01:03:01:57 and HLA-DPA1*02:01:01:29 from a case-control study of atopic dermatitis. | 0 |
| 36974749 | 2023 | Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension. | 2 |
| 37899135 | 2023 | HLA-DPA1 overexpression inhibits cancer progression, reduces resistance to cisplatin, and correlates with increased immune infiltration in lung adenocarcinoma. | 1 |
| 36342183 | 2023 | Identification of the novel HLA-DPA1*01:03:43 allele resulting from an intralocus recombination involving the DPA1*04:01:01:03 and DPA1*01:03:01:27 alleles sequenced by Next Generation Sequencing (NGS). | 0 |
| 36412220 | 2023 | Identification of HLA-DPA1*01:03:01:57 and HLA-DPA1*02:01:01:29 from a case-control study of atopic dermatitis. | 0 |
| 36974749 | 2023 | Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension. | 2 |
| 37899135 | 2023 | HLA-DPA1 overexpression inhibits cancer progression, reduces resistance to cisplatin, and correlates with increased immune infiltration in lung adenocarcinoma. | 1 |
| 34536062 | 2022 | Characterization of the novel HLA-DPA1 allele, HLA-DPA1*01:86. | 0 |
Citation
Dessen P
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)
Atlas Genet Cytogenet Oncol Haematol. 2011-07-01
Online version: http://atlasgeneticsoncology.org/gene/52523/hla-dpa1
