Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)

Identity

Alias_namesHLA-DP1A
Other aliasDP(W3)
DP(W4)
HLADP
HLASB
PLT1
HGNC (Hugo) HLA-DPA1
LocusID (NCBI) 3113
Atlas_Id 52523
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 33064569 and ends at 33073677 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLA-DPA1 (6p21.32) / HLA-DPA1 (6p21.32)HLA-DPA1 (6p21.32) / HLA-DPB1 (6p21.32)HLA-DPA1 (6p21.32) / NEAT1 (11q13.1)
HLA-DPA1 (6p21.32) / NKIRAS1 (3p24.2)HLA-DPA1 (6p21.32) / QKI (6q26)HLA-DPA1 (6p21.32) / SOX12 (20p13)
KMT2B (19q13.12) / HLA-DPA1 (6p21.32)LOC100129931 (4p16.1) / HLA-DPA1 (6p21.32)PSAP (10q22.1) / HLA-DPA1 (6p21.32)
RPLP2 (11p15.5) / HLA-DPA1 (6p21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLA-DPA1   4938
Cards
Entrez_Gene (NCBI)HLA-DPA1  3113  major histocompatibility complex, class II, DP alpha 1
AliasesDP(W3); DP(W4); HLA-DP1A; HLADP; 
HLASB; PLT1
GeneCards (Weizmann)HLA-DPA1
Ensembl hg19 (Hinxton)ENSG00000231389 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000231389 [Gene_View]  ENSG00000231389 [Sequence]  chr6:33064569-33073677 [Contig_View]  HLA-DPA1 [Vega]
ICGC DataPortalENSG00000231389
TCGA cBioPortalHLA-DPA1
AceView (NCBI)HLA-DPA1
Genatlas (Paris)HLA-DPA1
WikiGenes3113
SOURCE (Princeton)HLA-DPA1
Genetics Home Reference (NIH)HLA-DPA1
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DPA1  -     chr6:33064569-33073677 -  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DPA1  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblHLA-DPA1 - 6p21.32 [CytoView hg19]  HLA-DPA1 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIHLA-DPA1 [Mapview hg19]  HLA-DPA1 [Mapview hg38]
OMIM142880   
Gene and transcription
Genbank (Entrez)AB209058 AK292709 BC009956 BI553587 BP338039
RefSeq transcript (Entrez)NM_001242524 NM_001242525 NM_033554
RefSeq genomic (Entrez)NC_000006 NG_033241 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)HLA-DPA1
Cluster EST : UnigeneHs.347270 [ NCBI ]
CGAP (NCI)Hs.347270
Alternative Splicing GalleryENSG00000231389
Gene ExpressionHLA-DPA1 [ NCBI-GEO ]   HLA-DPA1 [ EBI - ARRAY_EXPRESS ]   HLA-DPA1 [ SEEK ]   HLA-DPA1 [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DPA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3113
GTEX Portal (Tissue expression)HLA-DPA1
Human Protein AtlasENSG00000231389-HLA-DPA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20036   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20036  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20036
Splice isoforms : SwissVarP20036
PhosPhoSitePlusP20036
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_a_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_alpha (PF00993)   
Domain families : Pfam (NCBI)pfam07654    pfam00993   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_alpha (SM00920)  
Conserved Domain (NCBI)HLA-DPA1
DMDM Disease mutations3113
Blocks (Seattle)HLA-DPA1
PDB (SRS)3LQZ    4P4K    4P4R    4P57    4P5K    4P5M   
PDB (PDBSum)3LQZ    4P4K    4P4R    4P57    4P5K    4P5M   
PDB (IMB)3LQZ    4P4K    4P4R    4P57    4P5K    4P5M   
PDB (RSDB)3LQZ    4P4K    4P4R    4P57    4P5K    4P5M   
Structural Biology KnowledgeBase3LQZ    4P4K    4P4R    4P57    4P5K    4P5M   
SCOP (Structural Classification of Proteins)3LQZ    4P4K    4P4R    4P57    4P5K    4P5M   
CATH (Classification of proteins structures)3LQZ    4P4K    4P4R    4P57    4P5K    4P5M   
SuperfamilyP20036
Human Protein Atlas [tissue]ENSG00000231389-HLA-DPA1 [tissue]
Peptide AtlasP20036
HPRD00835
IPIIPI00021711   IPI00798162   IPI00930620   IPI00644713   IPI00795909   IPI00797532   
Protein Interaction databases
DIP (DOE-UCLA)P20036
IntAct (EBI)P20036
FunCoupENSG00000231389
BioGRIDHLA-DPA1
STRING (EMBL)HLA-DPA1
ZODIACHLA-DPA1
Ontologies - Pathways
QuickGOP20036
Ontology : AmiGOGolgi membrane  lysosomal membrane  plasma membrane  integral component of plasma membrane  immune response  cell surface  endosome membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  MHC class II receptor activity  trans-Golgi network membrane  positive regulation of interferon-gamma production  positive regulation of T cell proliferation  peptide antigen binding  MHC class II protein complex  intracellular membrane-bounded organelle  T cell receptor signaling pathway  positive regulation of T cell activation  interferon-gamma-mediated signaling pathway  cellular response to interferon-gamma  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  lysosomal membrane  plasma membrane  integral component of plasma membrane  immune response  cell surface  endosome membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  MHC class II receptor activity  trans-Golgi network membrane  positive regulation of interferon-gamma production  positive regulation of T cell proliferation  peptide antigen binding  MHC class II protein complex  intracellular membrane-bounded organelle  T cell receptor signaling pathway  positive regulation of T cell activation  interferon-gamma-mediated signaling pathway  cellular response to interferon-gamma  integral component of lumenal side of endoplasmic reticulum membrane  
Pathways : KEGGPhagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Intestinal immune network for IgA production    Type I diabetes mellitus    Leishmaniasis    Toxoplasmosis    Staphylococcus aureus infection    Tuberculosis    Influenza A    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Systemic lupus erythematosus    Rheumatoid arthritis    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
NDEx NetworkHLA-DPA1
Atlas of Cancer Signalling NetworkHLA-DPA1
Wikipedia pathwaysHLA-DPA1
Orthology - Evolution
OrthoDB3113
GeneTree (enSembl)ENSG00000231389
Phylogenetic Trees/Animal Genes : TreeFamHLA-DPA1
HOVERGENP20036
HOGENOMP20036
Homologs : HomoloGeneHLA-DPA1
Homology/Alignments : Family Browser (UCSC)HLA-DPA1
Gene fusions - Rearrangements
Fusion : QuiverHLA-DPA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DPA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DPA1
dbVarHLA-DPA1
ClinVarHLA-DPA1
1000_GenomesHLA-DPA1 
Exome Variant ServerHLA-DPA1
ExAC (Exome Aggregation Consortium)ENSG00000231389
GNOMAD BrowserENSG00000231389
Varsome BrowserHLA-DPA1
Genetic variants : HAPMAP3113
Genomic Variants (DGV)HLA-DPA1 [DGVbeta]
DECIPHERHLA-DPA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DPA1 
Mutations
ICGC Data PortalHLA-DPA1 
TCGA Data PortalHLA-DPA1 
Broad Tumor PortalHLA-DPA1
OASIS PortalHLA-DPA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLA-DPA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHLA-DPA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-DPA1
DgiDB (Drug Gene Interaction Database)HLA-DPA1
DoCM (Curated mutations)HLA-DPA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DPA1 (select a term)
intoGenHLA-DPA1
Cancer3DHLA-DPA1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142880   
Orphanet
DisGeNETHLA-DPA1
MedgenHLA-DPA1
Genetic Testing Registry HLA-DPA1
NextProtP20036 [Medical]
TSGene3113
GENETestsHLA-DPA1
Target ValidationHLA-DPA1
Huge Navigator HLA-DPA1 [HugePedia]
snp3D : Map Gene to Disease3113
BioCentury BCIQHLA-DPA1
ClinGenHLA-DPA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3113
Chemical/Pharm GKB GenePA35062
Clinical trialHLA-DPA1
Miscellaneous
canSAR (ICR)HLA-DPA1 (select the gene name)
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DPA1
EVEXHLA-DPA1
GoPubMedHLA-DPA1
iHOPHLA-DPA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:11:09 CET 2018

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