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HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1)

Identity

Other namesCD
CELIAC1
DQ-A1
GSE
HLA-DQA
HGNC (Hugo) HLA-DQA1
LocusID (NCBI) 3117
Location 6p21.32
Location_base_pair Starts at 32605183 and ends at 32611429 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HLA-DQA1   4942
Cards
Entrez_Gene (NCBI)HLA-DQA1  3117  major histocompatibility complex, class II, DQ alpha 1
GeneCards (Weizmann)HLA-DQA1
Ensembl (Hinxton)ENSG00000196735 [Gene_View]  chr6:32605183-32611429 [Contig_View]  HLA-DQA1 [Vega]
ICGC DataPortalENSG00000196735
AceView (NCBI)HLA-DQA1
Genatlas (Paris)HLA-DQA1
WikiGenes3117
SOURCE (Princeton)NM_002122
Genomic and cartography
GoldenPath (UCSC)HLA-DQA1  -  6p21.32   chr6:32605183-32611429 +  6p21.32   [Description]    (hg19-Feb_2009)
EnsemblHLA-DQA1 - 6p21.32 [CytoView]
Mapping of homologs : NCBIHLA-DQA1 [Mapview]
OMIM146880   212750   
Gene and transcription
Genbank (Entrez)AB209628 AF012768 AF522250 AF533895 AF533896
RefSeq transcript (Entrez)NM_002122
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_032876 NT_007592 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249 NW_001838980 NW_004929326
Consensus coding sequences : CCDS (NCBI)HLA-DQA1
Cluster EST : UnigeneHs.706240 [ NCBI ]
CGAP (NCI)Hs.706240
Alternative Splicing : Fast-db (Paris)GSHG0025635
Alternative Splicing GalleryENSG00000196735
Gene ExpressionHLA-DQA1 [ NCBI-GEO ]     HLA-DQA1 [ SEEK ]   HLA-DQA1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01909 (Uniprot)
NextProtP01909  [Medical]
With graphics : InterProP01909
Splice isoforms : SwissVarP01909 (Swissvar)
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_a_N   
Related proteins : CluSTrP01909
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_alpha (PF00993)   
Domain families : Pfam (NCBI)pfam07654    pfam00993   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_alpha (SM00920)  
DMDM Disease mutations3117
Blocks (Seattle)P01909
PDB (SRS)1JK8    1NBN    1S9V    1UVQ    2NNA    4GG6    4OZF    4OZG    4OZH    4OZI   
PDB (PDBSum)1JK8    1NBN    1S9V    1UVQ    2NNA    4GG6    4OZF    4OZG    4OZH    4OZI   
PDB (IMB)1JK8    1NBN    1S9V    1UVQ    2NNA    4GG6    4OZF    4OZG    4OZH    4OZI   
PDB (RSDB)1JK8    1NBN    1S9V    1UVQ    2NNA    4GG6    4OZF    4OZG    4OZH    4OZI   
Human Protein AtlasENSG00000196735
Peptide AtlasP01909
HPRD06765
IPIIPI00740326   
Protein Interaction databases
DIP (DOE-UCLA)P01909
IntAct (EBI)P01909
FunCoupENSG00000196735
BioGRIDHLA-DQA1
InParanoidP01909
Interologous Interaction database P01909
IntegromeDBHLA-DQA1
STRING (EMBL)HLA-DQA1
Ontologies - Pathways
Ontology : AmiGOGolgi membrane  lysosomal membrane  plasma membrane  integral component of plasma membrane  immune response  endosome membrane  ER to Golgi transport vesicle membrane  membrane  cytokine-mediated signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  T cell costimulation  MHC class II receptor activity  MHC class II receptor activity  trans-Golgi network membrane  peptide antigen binding  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  lysosomal membrane  plasma membrane  integral component of plasma membrane  immune response  endosome membrane  ER to Golgi transport vesicle membrane  membrane  cytokine-mediated signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  T cell costimulation  MHC class II receptor activity  MHC class II receptor activity  trans-Golgi network membrane  peptide antigen binding  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Pathways : KEGGPhagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Intestinal immune network for IgA production    Type I diabetes mellitus    Leishmaniasis    Toxoplasmosis    Staphylococcus aureus infection    Tuberculosis    Influenza A    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Systemic lupus erythematosus    Rheumatoid arthritis    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
Protein Interaction DatabaseHLA-DQA1
Wikipedia pathwaysHLA-DQA1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)HLA-DQA1
SNP (GeneSNP Utah)HLA-DQA1
SNP : HGBaseHLA-DQA1
Genetic variants : HAPMAPHLA-DQA1
1000_GenomesHLA-DQA1 
ICGC programENSG00000196735 
CONAN: Copy Number AnalysisHLA-DQA1 
Somatic Mutations in Cancer : COSMICHLA-DQA1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDHLA-DQA1
OMIM146880    212750   
MedgenHLA-DQA1
GENETestsHLA-DQA1
Disease Genetic AssociationHLA-DQA1
Huge Navigator HLA-DQA1 [HugePedia]  HLA-DQA1 [HugeCancerGEM]
Genomic VariantsHLA-DQA1  HLA-DQA1 [DGVbeta]
Exome VariantHLA-DQA1
dbVarHLA-DQA1
ClinVarHLA-DQA1
snp3D : Map Gene to Disease3117
General knowledge
Homologs : HomoloGeneHLA-DQA1
Homology/Alignments : Family Browser (UCSC)HLA-DQA1
Phylogenetic Trees/Animal Genes : TreeFamHLA-DQA1
Chemical/Protein Interactions : CTD3117
Chemical/Pharm GKB GenePA35066
Clinical trialHLA-DQA1
Cancer Resource (Charite)ENSG00000196735
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineHLA-DQA1
iHOPHLA-DQA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:50:50 CEST 2014

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