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HLA-DRA (major histocompatibility complex, class II, DR alpha)

Identity

Alias_namesHLA-DRA1
Other alias
HGNC (Hugo) HLA-DRA
LocusID (NCBI) 3122
Atlas_Id 46550
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32439842 and ends at 32445051 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRD8 (5q31.2) / HLA-DRA (6p21.32)HLA-DQA1 (6p21.32) / HLA-DRA (6p21.32)HLA-DRA (6p21.32) / HLA-DRA (6p21.32)
HLA-DRA (6p21.32) / PEX5L (3q26.33)HLA-DRA (6p21.32) / PHGDH (1p12)HLA-DRA (6p21.32) / PPIG (2q31.1)
LITAF (16p13.13) / HLA-DRA (6p21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLA-DRA   4947
Cards
Entrez_Gene (NCBI)HLA-DRA  3122  major histocompatibility complex, class II, DR alpha
AliasesHLA-DRA1
GeneCards (Weizmann)HLA-DRA
Ensembl hg19 (Hinxton)ENSG00000204287 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204287 [Gene_View]  ENSG00000204287 [Sequence]  chr6:32439842-32445051 [Contig_View]  HLA-DRA [Vega]
ICGC DataPortalENSG00000204287
TCGA cBioPortalHLA-DRA
AceView (NCBI)HLA-DRA
Genatlas (Paris)HLA-DRA
WikiGenes3122
SOURCE (Princeton)HLA-DRA
Genetics Home Reference (NIH)HLA-DRA
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DRA  -     chr6:32439842-32445051 +  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DRA  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblHLA-DRA - 6p21.32 [CytoView hg19]  HLA-DRA - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIHLA-DRA [Mapview hg19]  HLA-DRA [Mapview hg38]
OMIM142860   
Gene and transcription
Genbank (Entrez)AI492718 AK297032 AK301134 AK301190 AK301354
RefSeq transcript (Entrez)NM_019111
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249 NT_187692
Consensus coding sequences : CCDS (NCBI)HLA-DRA
Cluster EST : UnigeneHs.520048 [ NCBI ]
CGAP (NCI)Hs.520048
Alternative Splicing GalleryENSG00000204287
Gene ExpressionHLA-DRA [ NCBI-GEO ]   HLA-DRA [ EBI - ARRAY_EXPRESS ]   HLA-DRA [ SEEK ]   HLA-DRA [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DRA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3122
GTEX Portal (Tissue expression)HLA-DRA
Human Protein AtlasENSG00000204287-HLA-DRA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01903   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01903  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01903
Splice isoforms : SwissVarP01903
PhosPhoSitePlusP01903
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_a_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_alpha (PF00993)   
Domain families : Pfam (NCBI)pfam07654    pfam00993   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_alpha (SM00920)  
Conserved Domain (NCBI)HLA-DRA
DMDM Disease mutations3122
Blocks (Seattle)HLA-DRA
PDB (SRS)1A6A    1AQD    1BX2    1D5M    1D5X    1D5Z    1D6E    1DLH    1FV1    1FYT    1H15    1HQR    1HXY    1J8H    1JWM    1JWS    1JWU    1KG0    1KLG    1KLU    1LO5    1PYW    1R5I    1SEB    1SJE    1SJH    1T5W    1T5X    1YMM    1ZGL    2FSE    2G9H    2IAM    2IAN    2ICW    2IPK    2OJE    2Q6W    2SEB    2WBJ    2XN9    3C5J    3L6F    3O6F    3PDO    3PGC    3PGD    3QXA    3QXD    3S4S    3S5L    3T0E    4AEN    4AH2    4C56    4E41    4FQX    4GBX    4H1L    4H25    4H26    4I5B    4IS6    4MCY    4MCZ    4MD0    4MD4    4MD5    4MDI    4MDJ    4OV5    4X5W    4X5X    4Y19    4Y1A    5JLZ    5LAX    5V4M    5V4N    6ATF    6ATI    6ATZ    6BIJ    6BIL    6BIN    6BIR    6BIV    6BIX    6BIY    6BIZ   
PDB (PDBSum)1A6A    1AQD    1BX2    1D5M    1D5X    1D5Z    1D6E    1DLH    1FV1    1FYT    1H15    1HQR    1HXY    1J8H    1JWM    1JWS    1JWU    1KG0    1KLG    1KLU    1LO5    1PYW    1R5I    1SEB    1SJE    1SJH    1T5W    1T5X    1YMM    1ZGL    2FSE    2G9H    2IAM    2IAN    2ICW    2IPK    2OJE    2Q6W    2SEB    2WBJ    2XN9    3C5J    3L6F    3O6F    3PDO    3PGC    3PGD    3QXA    3QXD    3S4S    3S5L    3T0E    4AEN    4AH2    4C56    4E41    4FQX    4GBX    4H1L    4H25    4H26    4I5B    4IS6    4MCY    4MCZ    4MD0    4MD4    4MD5    4MDI    4MDJ    4OV5    4X5W    4X5X    4Y19    4Y1A    5JLZ    5LAX    5V4M    5V4N    6ATF    6ATI    6ATZ    6BIJ    6BIL    6BIN    6BIR    6BIV    6BIX    6BIY    6BIZ   
PDB (IMB)1A6A    1AQD    1BX2    1D5M    1D5X    1D5Z    1D6E    1DLH    1FV1    1FYT    1H15    1HQR    1HXY    1J8H    1JWM    1JWS    1JWU    1KG0    1KLG    1KLU    1LO5    1PYW    1R5I    1SEB    1SJE    1SJH    1T5W    1T5X    1YMM    1ZGL    2FSE    2G9H    2IAM    2IAN    2ICW    2IPK    2OJE    2Q6W    2SEB    2WBJ    2XN9    3C5J    3L6F    3O6F    3PDO    3PGC    3PGD    3QXA    3QXD    3S4S    3S5L    3T0E    4AEN    4AH2    4C56    4E41    4FQX    4GBX    4H1L    4H25    4H26    4I5B    4IS6    4MCY    4MCZ    4MD0    4MD4    4MD5    4MDI    4MDJ    4OV5    4X5W    4X5X    4Y19    4Y1A    5JLZ    5LAX    5V4M    5V4N    6ATF    6ATI    6ATZ    6BIJ    6BIL    6BIN    6BIR    6BIV    6BIX    6BIY    6BIZ   
PDB (RSDB)1A6A    1AQD    1BX2    1D5M    1D5X    1D5Z    1D6E    1DLH    1FV1    1FYT    1H15    1HQR    1HXY    1J8H    1JWM    1JWS    1JWU    1KG0    1KLG    1KLU    1LO5    1PYW    1R5I    1SEB    1SJE    1SJH    1T5W    1T5X    1YMM    1ZGL    2FSE    2G9H    2IAM    2IAN    2ICW    2IPK    2OJE    2Q6W    2SEB    2WBJ    2XN9    3C5J    3L6F    3O6F    3PDO    3PGC    3PGD    3QXA    3QXD    3S4S    3S5L    3T0E    4AEN    4AH2    4C56    4E41    4FQX    4GBX    4H1L    4H25    4H26    4I5B    4IS6    4MCY    4MCZ    4MD0    4MD4    4MD5    4MDI    4MDJ    4OV5    4X5W    4X5X    4Y19    4Y1A    5JLZ    5LAX    5V4M    5V4N    6ATF    6ATI    6ATZ    6BIJ    6BIL    6BIN    6BIR    6BIV    6BIX    6BIY    6BIZ   
Structural Biology KnowledgeBase1A6A    1AQD    1BX2    1D5M    1D5X    1D5Z    1D6E    1DLH    1FV1    1FYT    1H15    1HQR    1HXY    1J8H    1JWM    1JWS    1JWU    1KG0    1KLG    1KLU    1LO5    1PYW    1R5I    1SEB    1SJE    1SJH    1T5W    1T5X    1YMM    1ZGL    2FSE    2G9H    2IAM    2IAN    2ICW    2IPK    2OJE    2Q6W    2SEB    2WBJ    2XN9    3C5J    3L6F    3O6F    3PDO    3PGC    3PGD    3QXA    3QXD    3S4S    3S5L    3T0E    4AEN    4AH2    4C56    4E41    4FQX    4GBX    4H1L    4H25    4H26    4I5B    4IS6    4MCY    4MCZ    4MD0    4MD4    4MD5    4MDI    4MDJ    4OV5    4X5W    4X5X    4Y19    4Y1A    5JLZ    5LAX    5V4M    5V4N    6ATF    6ATI    6ATZ    6BIJ    6BIL    6BIN    6BIR    6BIV    6BIX    6BIY    6BIZ   
SCOP (Structural Classification of Proteins)1A6A    1AQD    1BX2    1D5M    1D5X    1D5Z    1D6E    1DLH    1FV1    1FYT    1H15    1HQR    1HXY    1J8H    1JWM    1JWS    1JWU    1KG0    1KLG    1KLU    1LO5    1PYW    1R5I    1SEB    1SJE    1SJH    1T5W    1T5X    1YMM    1ZGL    2FSE    2G9H    2IAM    2IAN    2ICW    2IPK    2OJE    2Q6W    2SEB    2WBJ    2XN9    3C5J    3L6F    3O6F    3PDO    3PGC    3PGD    3QXA    3QXD    3S4S    3S5L    3T0E    4AEN    4AH2    4C56    4E41    4FQX    4GBX    4H1L    4H25    4H26    4I5B    4IS6    4MCY    4MCZ    4MD0    4MD4    4MD5    4MDI    4MDJ    4OV5    4X5W    4X5X    4Y19    4Y1A    5JLZ    5LAX    5V4M    5V4N    6ATF    6ATI    6ATZ    6BIJ    6BIL    6BIN    6BIR    6BIV    6BIX    6BIY    6BIZ   
CATH (Classification of proteins structures)1A6A    1AQD    1BX2    1D5M    1D5X    1D5Z    1D6E    1DLH    1FV1    1FYT    1H15    1HQR    1HXY    1J8H    1JWM    1JWS    1JWU    1KG0    1KLG    1KLU    1LO5    1PYW    1R5I    1SEB    1SJE    1SJH    1T5W    1T5X    1YMM    1ZGL    2FSE    2G9H    2IAM    2IAN    2ICW    2IPK    2OJE    2Q6W    2SEB    2WBJ    2XN9    3C5J    3L6F    3O6F    3PDO    3PGC    3PGD    3QXA    3QXD    3S4S    3S5L    3T0E    4AEN    4AH2    4C56    4E41    4FQX    4GBX    4H1L    4H25    4H26    4I5B    4IS6    4MCY    4MCZ    4MD0    4MD4    4MD5    4MDI    4MDJ    4OV5    4X5W    4X5X    4Y19    4Y1A    5JLZ    5LAX    5V4M    5V4N    6ATF    6ATI    6ATZ    6BIJ    6BIL    6BIN    6BIR    6BIV    6BIX    6BIY    6BIZ   
SuperfamilyP01903
Human Protein Atlas [tissue]ENSG00000204287-HLA-DRA [tissue]
Peptide AtlasP01903
HPRD00833
IPIIPI00005171   IPI00930188   IPI01021249   IPI01020800   IPI00908657   IPI01020991   IPI01021068   IPI00936417   IPI00464948   IPI00645572   
Protein Interaction databases
DIP (DOE-UCLA)P01903
IntAct (EBI)P01903
FunCoupENSG00000204287
BioGRIDHLA-DRA
STRING (EMBL)HLA-DRA
ZODIACHLA-DRA
Ontologies - Pathways
QuickGOP01903
Ontology : AmiGOGolgi membrane  peptide antigen assembly with MHC class II protein complex  antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  polysaccharide assembly with MHC class II protein complex  protein binding  lysosome  lysosomal membrane  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  immune response  cell surface  ER to Golgi transport vesicle membrane  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  MHC class II protein complex binding  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  late endosome membrane  MHC class II receptor activity  trans-Golgi network membrane  peptide antigen binding  MHC class II protein complex  MHC class II protein complex  T cell receptor signaling pathway  cognition  interferon-gamma-mediated signaling pathway  extracellular exosome  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  peptide antigen assembly with MHC class II protein complex  antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  polysaccharide assembly with MHC class II protein complex  protein binding  lysosome  lysosomal membrane  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  immune response  cell surface  ER to Golgi transport vesicle membrane  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  MHC class II protein complex binding  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  late endosome membrane  MHC class II receptor activity  trans-Golgi network membrane  peptide antigen binding  MHC class II protein complex  MHC class II protein complex  T cell receptor signaling pathway  cognition  interferon-gamma-mediated signaling pathway  extracellular exosome  integral component of lumenal side of endoplasmic reticulum membrane  
Pathways : KEGGPhagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Hematopoietic cell lineage    Intestinal immune network for IgA production    Type I diabetes mellitus    Leishmaniasis    Toxoplasmosis    Staphylococcus aureus infection    Tuberculosis    Influenza A    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Systemic lupus erythematosus    Rheumatoid arthritis    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
NDEx NetworkHLA-DRA
Atlas of Cancer Signalling NetworkHLA-DRA
Wikipedia pathwaysHLA-DRA
Orthology - Evolution
OrthoDB3122
GeneTree (enSembl)ENSG00000204287
Phylogenetic Trees/Animal Genes : TreeFamHLA-DRA
HOVERGENP01903
HOGENOMP01903
Homologs : HomoloGeneHLA-DRA
Homology/Alignments : Family Browser (UCSC)HLA-DRA
Gene fusions - Rearrangements
Fusion : QuiverHLA-DRA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DRA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DRA
dbVarHLA-DRA
ClinVarHLA-DRA
1000_GenomesHLA-DRA 
Exome Variant ServerHLA-DRA
ExAC (Exome Aggregation Consortium)ENSG00000204287
GNOMAD BrowserENSG00000204287
Varsome BrowserHLA-DRA
Genetic variants : HAPMAP3122
Genomic Variants (DGV)HLA-DRA [DGVbeta]
DECIPHERHLA-DRA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DRA 
Mutations
ICGC Data PortalHLA-DRA 
TCGA Data PortalHLA-DRA 
Broad Tumor PortalHLA-DRA
OASIS PortalHLA-DRA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLA-DRA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHLA-DRA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-DRA
DgiDB (Drug Gene Interaction Database)HLA-DRA
DoCM (Curated mutations)HLA-DRA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DRA (select a term)
intoGenHLA-DRA
Cancer3DHLA-DRA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142860   
Orphanet8575   
DisGeNETHLA-DRA
MedgenHLA-DRA
Genetic Testing Registry HLA-DRA
NextProtP01903 [Medical]
TSGene3122
GENETestsHLA-DRA
Target ValidationHLA-DRA
Huge Navigator HLA-DRA [HugePedia]
snp3D : Map Gene to Disease3122
BioCentury BCIQHLA-DRA
ClinGenHLA-DRA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3122
Chemical/Pharm GKB GenePA35071
Clinical trialHLA-DRA
Miscellaneous
canSAR (ICR)HLA-DRA (select the gene name)
Probes
Litterature
PubMed266 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DRA
EVEXHLA-DRA
GoPubMedHLA-DRA
iHOPHLA-DRA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:11:11 CET 2018

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