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HLA-DRB3 (major histocompatibility complex, class II, DR beta 3)

Identity

Alias_namesHLA-DR3B
Other aliasHLA-DR1B
HGNC (Hugo) HLA-DRB3
LocusID (NCBI) 3125
Atlas_Id 50186
Location 6_GL000255v2_alt  [Link to chromosome band 6]
Location_base_pair Starts at 3715352 and ends at 3728418 bp from pter ( according to hg38-Dec_2013)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)HLA-DRB3   4951
Cards
Entrez_Gene (NCBI)HLA-DRB3  3125  major histocompatibility complex, class II, DR beta 3
AliasesHLA-DR1B; HLA-DR3B
GeneCards (Weizmann)HLA-DRB3
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr6_GL000255v2_alt:3715352-3728418 [Contig_View]  HLA-DRB3 [Vega]
TCGA cBioPortalHLA-DRB3
AceView (NCBI)HLA-DRB3
Genatlas (Paris)HLA-DRB3
WikiGenes3125
SOURCE (Princeton)HLA-DRB3
Genetics Home Reference (NIH)HLA-DRB3
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DRB3  -     chr6_GL000255v2_alt:3715352-3728418 -  6_GL000255v2_alt   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DRB3  -     6_GL000255v2_alt   [Description]    (hg19-Feb_2009)
EnsemblHLA-DRB3 - 6_GL000255v2_alt [CytoView hg19]  HLA-DRB3 - 6_GL000255v2_alt [CytoView hg38]
Mapping of homologs : NCBIHLA-DRB3 [Mapview hg19]  HLA-DRB3 [Mapview hg38]
OMIM612735   
Gene and transcription
Genbank (Entrez)A06800 AF000448 AF192258 AF192259 AF199236
RefSeq transcript (Entrez)NM_022555
RefSeq genomic (Entrez)NG_002392 NT_113891 NT_167244 NT_167248
Consensus coding sequences : CCDS (NCBI)HLA-DRB3
Cluster EST : UnigeneHs.696211 [ NCBI ]
CGAP (NCI)Hs.696211
Gene ExpressionHLA-DRB3 [ NCBI-GEO ]   HLA-DRB3 [ EBI - ARRAY_EXPRESS ]   HLA-DRB3 [ SEEK ]   HLA-DRB3 [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DRB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3125
GTEX Portal (Tissue expression)HLA-DRB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP79483   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP79483  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP79483
Splice isoforms : SwissVarP79483
PhosPhoSitePlusP79483
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_b_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_beta (PF00969)   
Domain families : Pfam (NCBI)pfam07654    pfam00969   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_beta (SM00921)  
Domain structure : Prodom (Prabi Lyon)MHC_II_b_N (PD000328)   
Conserved Domain (NCBI)HLA-DRB3
DMDM Disease mutations3125
Blocks (Seattle)HLA-DRB3
PDB (SRS)2Q6W    3C5J    4H1L   
PDB (PDBSum)2Q6W    3C5J    4H1L   
PDB (IMB)2Q6W    3C5J    4H1L   
PDB (RSDB)2Q6W    3C5J    4H1L   
Structural Biology KnowledgeBase2Q6W    3C5J    4H1L   
SCOP (Structural Classification of Proteins)2Q6W    3C5J    4H1L   
CATH (Classification of proteins structures)2Q6W    3C5J    4H1L   
SuperfamilyP79483
Peptide AtlasP79483
HPRD09985
Protein Interaction databases
DIP (DOE-UCLA)P79483
IntAct (EBI)P79483
BioGRIDHLA-DRB3
STRING (EMBL)HLA-DRB3
ZODIACHLA-DRB3
Ontologies - Pathways
QuickGOP79483
Ontology : AmiGOGolgi membrane  lysosome  lysosomal membrane  lysosomal membrane  plasma membrane  integral component of plasma membrane  signal transduction  ER to Golgi transport vesicle membrane  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  T cell costimulation  late endosome membrane  MHC class II receptor activity  trans-Golgi network membrane  peptide antigen binding  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  lysosome  lysosomal membrane  lysosomal membrane  plasma membrane  integral component of plasma membrane  signal transduction  ER to Golgi transport vesicle membrane  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  T cell costimulation  late endosome membrane  MHC class II receptor activity  trans-Golgi network membrane  peptide antigen binding  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Pathways : KEGG   
NDEx NetworkHLA-DRB3
Atlas of Cancer Signalling NetworkHLA-DRB3
Wikipedia pathwaysHLA-DRB3
Orthology - Evolution
OrthoDB3125
Phylogenetic Trees/Animal Genes : TreeFamHLA-DRB3
HOVERGENP79483
HOGENOMP79483
Homologs : HomoloGeneHLA-DRB3
Homology/Alignments : Family Browser (UCSC)HLA-DRB3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DRB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DRB3
dbVarHLA-DRB3
ClinVarHLA-DRB3
1000_GenomesHLA-DRB3 
Exome Variant ServerHLA-DRB3
ExAC (Exome Aggregation Consortium)HLA-DRB3 (select the gene name)
Genetic variants : HAPMAP3125
Genomic Variants (DGV)HLA-DRB3 [DGVbeta]
DECIPHERHLA-DRB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DRB3 
Mutations
ICGC Data PortalHLA-DRB3 
TCGA Data PortalHLA-DRB3 
Broad Tumor PortalHLA-DRB3
OASIS PortalHLA-DRB3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHLA-DRB3
BioMutasearch HLA-DRB3
DgiDB (Drug Gene Interaction Database)HLA-DRB3
DoCM (Curated mutations)HLA-DRB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DRB3 (select a term)
intoGenHLA-DRB3
Cancer3DHLA-DRB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612735   
Orphanet
MedgenHLA-DRB3
Genetic Testing Registry HLA-DRB3
NextProtP79483 [Medical]
TSGene3125
GENETestsHLA-DRB3
Target ValidationHLA-DRB3
Huge Navigator HLA-DRB3 [HugePedia]
snp3D : Map Gene to Disease3125
BioCentury BCIQHLA-DRB3
ClinGenHLA-DRB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3125
Chemical/Pharm GKB GenePA35074
Clinical trialHLA-DRB3
Miscellaneous
canSAR (ICR)HLA-DRB3 (select the gene name)
Probes
Litterature
PubMed199 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DRB3
EVEXHLA-DRB3
GoPubMedHLA-DRB3
iHOPHLA-DRB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:11:46 CEST 2017

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