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HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)

Identity

Alias_namesHLA-DR4B
Other aliasDR4
DRB4
HGNC (Hugo) HLA-DRB4
LocusID (NCBI) 3126
Atlas_Id 45821
Location 6_GL000256v2_alt  [Link to chromosome band 6]
Location_base_pair Starts at 3981462 and ends at 3985255 bp from pter ( according to hg38-Dec_2013)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)HLA-DRB4   4952
Cards
Entrez_Gene (NCBI)HLA-DRB4  3126  major histocompatibility complex, class II, DR beta 4
AliasesDR4; DRB4; HLA-DR4B
GeneCards (Weizmann)HLA-DRB4
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr6_GL000256v2_alt:3981462-3985255 [Contig_View]  HLA-DRB4 [Vega]
TCGA cBioPortalHLA-DRB4
AceView (NCBI)HLA-DRB4
Genatlas (Paris)HLA-DRB4
WikiGenes3126
SOURCE (Princeton)HLA-DRB4
Genetics Home Reference (NIH)HLA-DRB4
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DRB4  -     chr6_GL000256v2_alt:3981462-3985255 -  6_GL000256v2_alt   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DRB4  -     6_GL000256v2_alt   [Description]    (hg19-Feb_2009)
EnsemblHLA-DRB4 - 6_GL000256v2_alt [CytoView hg19]  HLA-DRB4 - 6_GL000256v2_alt [CytoView hg38]
Mapping of homologs : NCBIHLA-DRB4 [Mapview hg19]  HLA-DRB4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_021983
RefSeq genomic (Entrez)NG_002433 NT_167246 NT_167247 NT_167249
Consensus coding sequences : CCDS (NCBI)HLA-DRB4
Cluster EST : UnigeneHs.723344 [ NCBI ]
CGAP (NCI)Hs.723344
Gene ExpressionHLA-DRB4 [ NCBI-GEO ]   HLA-DRB4 [ EBI - ARRAY_EXPRESS ]   HLA-DRB4 [ SEEK ]   HLA-DRB4 [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DRB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3126
GTEX Portal (Tissue expression)HLA-DRB4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13762   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13762  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13762
Splice isoforms : SwissVarP13762
PhosPhoSitePlusP13762
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_b_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_beta (PF00969)   
Domain families : Pfam (NCBI)pfam07654    pfam00969   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_beta (SM00921)  
Domain structure : Prodom (Prabi Lyon)MHC_II_b_N (PD000328)   
Conserved Domain (NCBI)HLA-DRB4
DMDM Disease mutations3126
Blocks (Seattle)HLA-DRB4
SuperfamilyP13762
Peptide AtlasP13762
HPRD09986
Protein Interaction databases
DIP (DOE-UCLA)P13762
IntAct (EBI)P13762
BioGRIDHLA-DRB4
STRING (EMBL)HLA-DRB4
ZODIACHLA-DRB4
Ontologies - Pathways
QuickGOP13762
Ontology : AmiGOGolgi membrane  lysosome  lysosomal membrane  lysosomal membrane  plasma membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  T cell costimulation  late endosome membrane  trans-Golgi network membrane  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  lysosome  lysosomal membrane  lysosomal membrane  plasma membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  T cell costimulation  late endosome membrane  trans-Golgi network membrane  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Pathways : KEGG   
NDEx NetworkHLA-DRB4
Atlas of Cancer Signalling NetworkHLA-DRB4
Wikipedia pathwaysHLA-DRB4
Orthology - Evolution
OrthoDB3126
Phylogenetic Trees/Animal Genes : TreeFamHLA-DRB4
HOVERGENP13762
HOGENOMP13762
Homologs : HomoloGeneHLA-DRB4
Homology/Alignments : Family Browser (UCSC)HLA-DRB4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DRB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DRB4
dbVarHLA-DRB4
ClinVarHLA-DRB4
1000_GenomesHLA-DRB4 
Exome Variant ServerHLA-DRB4
ExAC (Exome Aggregation Consortium)HLA-DRB4 (select the gene name)
Genetic variants : HAPMAP3126
Genomic Variants (DGV)HLA-DRB4 [DGVbeta]
DECIPHERHLA-DRB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DRB4 
Mutations
ICGC Data PortalHLA-DRB4 
TCGA Data PortalHLA-DRB4 
Broad Tumor PortalHLA-DRB4
OASIS PortalHLA-DRB4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHLA-DRB4
BioMutasearch HLA-DRB4
DgiDB (Drug Gene Interaction Database)HLA-DRB4
DoCM (Curated mutations)HLA-DRB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DRB4 (select a term)
intoGenHLA-DRB4
Cancer3DHLA-DRB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenHLA-DRB4
Genetic Testing Registry HLA-DRB4
NextProtP13762 [Medical]
TSGene3126
GENETestsHLA-DRB4
Target ValidationHLA-DRB4
Huge Navigator HLA-DRB4 [HugePedia]
snp3D : Map Gene to Disease3126
BioCentury BCIQHLA-DRB4
ClinGenHLA-DRB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3126
Chemical/Pharm GKB GenePA35075
Clinical trialHLA-DRB4
Miscellaneous
canSAR (ICR)HLA-DRB4 (select the gene name)
Probes
Litterature
PubMed188 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DRB4
EVEXHLA-DRB4
GoPubMedHLA-DRB4
iHOPHLA-DRB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:11:46 CEST 2017

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