Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)

Identity

Other alias-
HGNC (Hugo) HLA-DRB5
LocusID (NCBI) 3127
Atlas_Id 51522
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32517377 and ends at 32530229 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DTX3L (3q21.1) / HLA-DRB5 (6p21.32)HLA-DRB5 (6p21.32) / DTX3L (3q21.1)HLA-DRB5 (6p21.32) / FGR (1p36.11)
HLA-DRB5 (6p21.32) / HLA-DRB5 (6p21.32)RETSAT (2p11.2) / HLA-DRB5 (6p21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLA-DRB5   4953
Cards
Entrez_Gene (NCBI)HLA-DRB5  3127  major histocompatibility complex, class II, DR beta 5
Aliases
GeneCards (Weizmann)HLA-DRB5
Ensembl hg19 (Hinxton)ENSG00000198502 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198502 [Gene_View]  ENSG00000198502 [Sequence]  chr6:32517377-32530229 [Contig_View]  HLA-DRB5 [Vega]
ICGC DataPortalENSG00000198502
TCGA cBioPortalHLA-DRB5
AceView (NCBI)HLA-DRB5
Genatlas (Paris)HLA-DRB5
WikiGenes3127
SOURCE (Princeton)HLA-DRB5
Genetics Home Reference (NIH)HLA-DRB5
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DRB5  -     chr6:32517377-32530229 -  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DRB5  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblHLA-DRB5 - 6p21.32 [CytoView hg19]  HLA-DRB5 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIHLA-DRB5 [Mapview hg19]  HLA-DRB5 [Mapview hg38]
OMIM604776   
Gene and transcription
Genbank (Entrez)AB062112 AF004817 AF097680 AF490771 AJ297582
RefSeq transcript (Entrez)NM_002125
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HLA-DRB5
Cluster EST : UnigeneHs.736560 [ NCBI ]
CGAP (NCI)Hs.736560
Alternative Splicing GalleryENSG00000198502
Gene ExpressionHLA-DRB5 [ NCBI-GEO ]   HLA-DRB5 [ EBI - ARRAY_EXPRESS ]   HLA-DRB5 [ SEEK ]   HLA-DRB5 [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DRB5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3127
GTEX Portal (Tissue expression)HLA-DRB5
Human Protein AtlasENSG00000198502-HLA-DRB5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ30154   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ30154  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ30154
Splice isoforms : SwissVarQ30154
PhosPhoSitePlusQ30154
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_b_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_beta (PF00969)   
Domain families : Pfam (NCBI)pfam07654    pfam00969   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_beta (SM00921)  
Domain structure : Prodom (Prabi Lyon)MHC_II_b_N (PD000328)   
Conserved Domain (NCBI)HLA-DRB5
DMDM Disease mutations3127
Blocks (Seattle)HLA-DRB5
PDB (SRS)1FV1    1H15    1HQR    1ZGL   
PDB (PDBSum)1FV1    1H15    1HQR    1ZGL   
PDB (IMB)1FV1    1H15    1HQR    1ZGL   
PDB (RSDB)1FV1    1H15    1HQR    1ZGL   
Structural Biology KnowledgeBase1FV1    1H15    1HQR    1ZGL   
SCOP (Structural Classification of Proteins)1FV1    1H15    1HQR    1ZGL   
CATH (Classification of proteins structures)1FV1    1H15    1HQR    1ZGL   
SuperfamilyQ30154
Human Protein Atlas [tissue]ENSG00000198502-HLA-DRB5 [tissue]
Peptide AtlasQ30154
HPRD09209
Protein Interaction databases
DIP (DOE-UCLA)Q30154
IntAct (EBI)Q30154
FunCoupENSG00000198502
BioGRIDHLA-DRB5
STRING (EMBL)HLA-DRB5
ZODIACHLA-DRB5
Ontologies - Pathways
QuickGOQ30154
Ontology : AmiGOGolgi membrane  lysosomal membrane  lysosomal membrane  plasma membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  late endosome membrane  trans-Golgi network membrane  peptide antigen binding  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  extracellular exosome  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  lysosomal membrane  lysosomal membrane  plasma membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  late endosome membrane  trans-Golgi network membrane  peptide antigen binding  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  extracellular exosome  integral component of lumenal side of endoplasmic reticulum membrane  
Pathways : KEGGPhagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Hematopoietic cell lineage    Intestinal immune network for IgA production    Type I diabetes mellitus    Leishmaniasis    Toxoplasmosis    Staphylococcus aureus infection    Tuberculosis    Influenza A    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Systemic lupus erythematosus    Rheumatoid arthritis    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
NDEx NetworkHLA-DRB5
Atlas of Cancer Signalling NetworkHLA-DRB5
Wikipedia pathwaysHLA-DRB5
Orthology - Evolution
OrthoDB3127
GeneTree (enSembl)ENSG00000198502
Phylogenetic Trees/Animal Genes : TreeFamHLA-DRB5
HOVERGENQ30154
HOGENOMQ30154
Homologs : HomoloGeneHLA-DRB5
Homology/Alignments : Family Browser (UCSC)HLA-DRB5
Gene fusions - Rearrangements
Fusion : QuiverHLA-DRB5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DRB5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DRB5
dbVarHLA-DRB5
ClinVarHLA-DRB5
1000_GenomesHLA-DRB5 
Exome Variant ServerHLA-DRB5
ExAC (Exome Aggregation Consortium)ENSG00000198502
GNOMAD BrowserENSG00000198502
Varsome BrowserHLA-DRB5
Genetic variants : HAPMAP3127
Genomic Variants (DGV)HLA-DRB5 [DGVbeta]
DECIPHERHLA-DRB5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DRB5 
Mutations
ICGC Data PortalHLA-DRB5 
TCGA Data PortalHLA-DRB5 
Broad Tumor PortalHLA-DRB5
OASIS PortalHLA-DRB5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLA-DRB5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHLA-DRB5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-DRB5
DgiDB (Drug Gene Interaction Database)HLA-DRB5
DoCM (Curated mutations)HLA-DRB5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DRB5 (select a term)
intoGenHLA-DRB5
Cancer3DHLA-DRB5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604776   
Orphanet
DisGeNETHLA-DRB5
MedgenHLA-DRB5
Genetic Testing Registry HLA-DRB5
NextProtQ30154 [Medical]
TSGene3127
GENETestsHLA-DRB5
Target ValidationHLA-DRB5
Huge Navigator HLA-DRB5 [HugePedia]
snp3D : Map Gene to Disease3127
BioCentury BCIQHLA-DRB5
ClinGenHLA-DRB5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3127
Chemical/Pharm GKB GenePA35076
Clinical trialHLA-DRB5
Miscellaneous
canSAR (ICR)HLA-DRB5 (select the gene name)
Probes
Litterature
PubMed202 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DRB5
EVEXHLA-DRB5
GoPubMedHLA-DRB5
iHOPHLA-DRB5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:11:12 CET 2018

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