Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3127
MIM: 604776
HGNC: 4953
Ensembl: ENSG00000198502
Variants:
dbSNP: 3127
ClinVar: 3127
TCGA: ENSG00000198502
COSMIC: HLA-DRB5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198502 | ENST00000374975 | Q30154 |
| ENSG00000198502 | ENST00000374975 | A0A2Z4LKS3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164742987 | clavulanate | Chemical | VariantAnnotation | associated | PD | 10535882 | |
| PA443297 | Agranulocytosis | Disease | VariantAnnotation | associated | PD | 11146763 | |
| PA444435 | Hepatitis | Disease | VariantAnnotation | associated | PD | 10535882 | |
| PA444614 | Infection | Disease | VariantAnnotation | associated | PD | 10535882 | |
| PA447216 | Schizophrenia | Disease | VariantAnnotation | associated | PD | 11146763 | |
| PA448406 | amoxicillin | Chemical | VariantAnnotation | associated | PD | 10535882 | |
| PA449061 | clozapine | Chemical | VariantAnnotation | associated | PD | 11146763 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38104778 | 2024 | HLA DRB5∗01:01 is associated with pruritus in individuals with Fitzpatrick skin type IV-VI. | 0 |
| 38104778 | 2024 | HLA DRB5∗01:01 is associated with pruritus in individuals with Fitzpatrick skin type IV-VI. | 0 |
| 36658707 | 2023 | Whole Exome Sequencing Identified Two Single Nucleotide Polymorphisms of Human Leukocyte Antigen-DRB5 in Familial Sarcoidosis in China. | 0 |
| 37688529 | 2023 | Epigenome-wide methylation haplotype association analysis identified HLA-DRB1, HLA-DRB5 and HLA-DQB1 as risk factors for rheumatoid arthritis. | 2 |
| 36658707 | 2023 | Whole Exome Sequencing Identified Two Single Nucleotide Polymorphisms of Human Leukocyte Antigen-DRB5 in Familial Sarcoidosis in China. | 0 |
| 37688529 | 2023 | Epigenome-wide methylation haplotype association analysis identified HLA-DRB1, HLA-DRB5 and HLA-DQB1 as risk factors for rheumatoid arthritis. | 2 |
| 31882398 | 2020 | Increased HLA-DR expression and cortical demyelination in MS links with HLA-DR15. | 14 |
| 31882398 | 2020 | Increased HLA-DR expression and cortical demyelination in MS links with HLA-DR15. | 14 |
| 30679605 | 2019 | Interactions of HLA-DR and Topoisomerase I Epitope Modulated Genetic Risk for Systemic Sclerosis. | 5 |
| 31624234 | 2019 | Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia. | 12 |
| 30679605 | 2019 | Interactions of HLA-DR and Topoisomerase I Epitope Modulated Genetic Risk for Systemic Sclerosis. | 5 |
| 31624234 | 2019 | Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia. | 12 |
| 27713094 | 2017 | Genetic variation associated with the occurrence and progression of neurological disorders. | 7 |
| 28131168 | 2017 | HLA-DRA/HLA-DRB5 polymorphism affects risk of sporadic ALS and survival in a southwest Chinese cohort. | 5 |
| 27713094 | 2017 | Genetic variation associated with the occurrence and progression of neurological disorders. | 7 |
Citation
Dessen P
HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)
Atlas Genet Cytogenet Oncol Haematol. 2010-06-01
Online version: http://atlasgeneticsoncology.org/gene/51522/hla-drb5
