Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HLCS (holocarboxylase synthetase)

Identity

Alias_namesholocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Alias_symbol (synonym)HCS
Other alias
HGNC (Hugo) HLCS
LocusID (NCBI) 3141
Atlas_Id 55984
Location 21q22.13  [Link to chromosome band 21q22]
Location_base_pair Starts at 36750888 and ends at 36990245 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP6V0A1 (17q21.2) / HLCS (21q22.13)BRWD1 (21q22.2) / HLCS (21q22.13)HLCS (21q22.13) / CD53 (1p13.3)
HLCS (21q22.13) / GRIK1 (21q21.3)HLCS (21q22.13) / STRA8 (7q33)HLCS (21q22.13) / YBEY (21q22.3)
PFN2 (3q25.1) / HLCS (21q22.13)SCAF4 (21q22.11) / HLCS (21q22.13)TASP1 (20p12.1) / HLCS (21q22.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLCS   4976
Cards
Entrez_Gene (NCBI)HLCS  3141  holocarboxylase synthetase
AliasesHCS
GeneCards (Weizmann)HLCS
Ensembl hg19 (Hinxton)ENSG00000159267 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159267 [Gene_View]  chr21:36750888-36990245 [Contig_View]  HLCS [Vega]
ICGC DataPortalENSG00000159267
TCGA cBioPortalHLCS
AceView (NCBI)HLCS
Genatlas (Paris)HLCS
WikiGenes3141
SOURCE (Princeton)HLCS
Genetics Home Reference (NIH)HLCS
Genomic and cartography
GoldenPath hg38 (UCSC)HLCS  -     chr21:36750888-36990245 -  21q22.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLCS  -     21q22.13   [Description]    (hg19-Feb_2009)
EnsemblHLCS - 21q22.13 [CytoView hg19]  HLCS - 21q22.13 [CytoView hg38]
Mapping of homologs : NCBIHLCS [Mapview hg19]  HLCS [Mapview hg38]
OMIM253270   609018   
Gene and transcription
Genbank (Entrez)AJ001864 AK307940 AK314189 BC060787 BI094308
RefSeq transcript (Entrez)NM_000411 NM_001242784 NM_001242785
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HLCS
Cluster EST : UnigeneHs.732538 [ NCBI ]
CGAP (NCI)Hs.732538
Alternative Splicing GalleryENSG00000159267
Gene ExpressionHLCS [ NCBI-GEO ]   HLCS [ EBI - ARRAY_EXPRESS ]   HLCS [ SEEK ]   HLCS [ MEM ]
Gene Expression Viewer (FireBrowse)HLCS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3141
GTEX Portal (Tissue expression)HLCS
Human Protein AtlasENSG00000159267-HLCS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50747   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50747  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50747
Splice isoforms : SwissVarP50747
Catalytic activity : Enzyme6.3.4.- [ Enzyme-Expasy ]   6.3.4.-6.3.4.- [ IntEnz-EBI ]   6.3.4.- [ BRENDA ]   6.3.4.- [ KEGG ]   
PhosPhoSitePlusP50747
Domaine pattern : Prosite (Expaxy)BPL_LPL_CATALYTIC (PS51733)   
Domains : Interpro (EBI)Biotin-prot_ligase_N    Biotin_CoA_COase_ligase    BPL_C    BPL_LPL_catalytic   
Domain families : Pfam (Sanger)BPL_C (PF02237)    BPL_LplA_LipB (PF03099)    BPL_N (PF09825)   
Domain families : Pfam (NCBI)pfam02237    pfam03099    pfam09825   
Conserved Domain (NCBI)HLCS
DMDM Disease mutations3141
Blocks (Seattle)HLCS
SuperfamilyP50747
Human Protein Atlas [tissue]ENSG00000159267-HLCS [tissue]
Peptide AtlasP50747
HPRD08360
IPIIPI00301907   IPI00790061   IPI00790737   IPI00793410   
Protein Interaction databases
DIP (DOE-UCLA)P50747
IntAct (EBI)P50747
FunCoupENSG00000159267
BioGRIDHLCS
STRING (EMBL)HLCS
ZODIACHLCS
Ontologies - Pathways
QuickGOP50747
Ontology : AmiGOchromatin  biotin-[acetyl-CoA-carboxylase] ligase activity  biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity  biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity  biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity  protein binding  ATP binding  nuclear lamina  mitochondrion  cytosol  cytosol  biotin metabolic process  cell proliferation  protein biotinylation  biotin binding  nuclear matrix  histone modification  biotin-protein ligase activity  biotin-protein ligase activity  biotin-protein ligase activity  enzyme binding  protein homodimerization activity  response to biotin  histone biotinylation  
Ontology : EGO-EBIchromatin  biotin-[acetyl-CoA-carboxylase] ligase activity  biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity  biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity  biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity  protein binding  ATP binding  nuclear lamina  mitochondrion  cytosol  cytosol  biotin metabolic process  cell proliferation  protein biotinylation  biotin binding  nuclear matrix  histone modification  biotin-protein ligase activity  biotin-protein ligase activity  biotin-protein ligase activity  enzyme binding  protein homodimerization activity  response to biotin  histone biotinylation  
Pathways : KEGGBiotin metabolism   
NDEx NetworkHLCS
Atlas of Cancer Signalling NetworkHLCS
Wikipedia pathwaysHLCS
Orthology - Evolution
OrthoDB3141
GeneTree (enSembl)ENSG00000159267
Phylogenetic Trees/Animal Genes : TreeFamHLCS
HOVERGENP50747
HOGENOMP50747
Homologs : HomoloGeneHLCS
Homology/Alignments : Family Browser (UCSC)HLCS
Gene fusions - Rearrangements
Tumor Fusion PortalHLCS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLCS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLCS
dbVarHLCS
ClinVarHLCS
1000_GenomesHLCS 
Exome Variant ServerHLCS
ExAC (Exome Aggregation Consortium)ENSG00000159267
GNOMAD BrowserENSG00000159267
Genetic variants : HAPMAP3141
Genomic Variants (DGV)HLCS [DGVbeta]
DECIPHERHLCS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLCS 
Mutations
ICGC Data PortalHLCS 
TCGA Data PortalHLCS 
Broad Tumor PortalHLCS
OASIS PortalHLCS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLCS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHLCS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HLCS
DgiDB (Drug Gene Interaction Database)HLCS
DoCM (Curated mutations)HLCS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLCS (select a term)
intoGenHLCS
Cancer3DHLCS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM253270    609018   
Orphanet11268   
DisGeNETHLCS
MedgenHLCS
Genetic Testing Registry HLCS
NextProtP50747 [Medical]
TSGene3141
GENETestsHLCS
Target ValidationHLCS
Huge Navigator HLCS [HugePedia]
snp3D : Map Gene to Disease3141
BioCentury BCIQHLCS
ClinGenHLCS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3141
Chemical/Pharm GKB GenePA29310
Clinical trialHLCS
Miscellaneous
canSAR (ICR)HLCS (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLCS
EVEXHLCS
GoPubMedHLCS
iHOPHLCS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:16:22 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.