Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HLX (H2.0 like homeobox)

Identity

Alias_namesHLX1
H2.0 (Drosophila)-like homeo box 1
H2.0-like homeobox 1 (Drosophila)
H2.0-like homeobox 1
H2.0-like homeobox
Alias_symbol (synonym)HB24
Other alias
HGNC (Hugo) HLX
LocusID (NCBI) 3142
Atlas_Id 52930
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 220879443 and ends at 220885058 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HLX   4978
Cards
Entrez_Gene (NCBI)HLX  3142  H2.0 like homeobox
AliasesHB24; HLX1
GeneCards (Weizmann)HLX
Ensembl hg19 (Hinxton)ENSG00000136630 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136630 [Gene_View]  ENSG00000136630 [Sequence]  chr1:220879443-220885058 [Contig_View]  HLX [Vega]
ICGC DataPortalENSG00000136630
TCGA cBioPortalHLX
AceView (NCBI)HLX
Genatlas (Paris)HLX
WikiGenes3142
SOURCE (Princeton)HLX
Genetics Home Reference (NIH)HLX
Genomic and cartography
GoldenPath hg38 (UCSC)HLX  -     chr1:220879443-220885058 +  1q41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLX  -     1q41   [Description]    (hg19-Feb_2009)
GoldenPathHLX - 1q41 [CytoView hg19]  HLX - 1q41 [CytoView hg38]
Genome Data Viewer NCBIHLX [Mapview hg19]  
OMIM142995   
Gene and transcription
Genbank (Entrez)AB208812 AK056326 AK127923 AK313298 BC007294
RefSeq transcript (Entrez)NM_021958
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HLX
Alternative Splicing GalleryENSG00000136630
Gene ExpressionHLX [ NCBI-GEO ]   HLX [ EBI - ARRAY_EXPRESS ]   HLX [ SEEK ]   HLX [ MEM ]
Gene Expression Viewer (FireBrowse)HLX [ Firebrowse - Broad ]
GenevisibleExpression of HLX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3142
GTEX Portal (Tissue expression)HLX
Human Protein AtlasENSG00000136630-HLX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14774   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14774  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14774
Splice isoforms : SwissVarQ14774
PhosPhoSitePlusQ14774
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HLX
DMDM Disease mutations3142
SuperfamilyQ14774
Human Protein Atlas [tissue]ENSG00000136630-HLX [tissue]
Peptide AtlasQ14774
HPRD00875
IPIIPI00292164   IPI00643042   
Protein Interaction databases
DIP (DOE-UCLA)Q14774
IntAct (EBI)Q14774
FunCoupENSG00000136630
BioGRIDHLX
STRING (EMBL)HLX
ZODIACHLX
Ontologies - Pathways
QuickGOQ14774
Ontology : AmiGOnuclear chromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  liver development  protein binding  regulation of transcription by RNA polymerase II  multicellular organism development  skeletal muscle tissue development  positive regulation of cell proliferation  cell differentiation  sequence-specific DNA binding  positive regulation of T-helper 1 cell differentiation  negative regulation of T-helper 2 cell differentiation  positive regulation of organ growth  enteric nervous system development  embryonic digestive tract morphogenesis  
Ontology : EGO-EBInuclear chromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  liver development  protein binding  regulation of transcription by RNA polymerase II  multicellular organism development  skeletal muscle tissue development  positive regulation of cell proliferation  cell differentiation  sequence-specific DNA binding  positive regulation of T-helper 1 cell differentiation  negative regulation of T-helper 2 cell differentiation  positive regulation of organ growth  enteric nervous system development  embryonic digestive tract morphogenesis  
NDEx NetworkHLX
Atlas of Cancer Signalling NetworkHLX
Wikipedia pathwaysHLX
Orthology - Evolution
OrthoDB3142
GeneTree (enSembl)ENSG00000136630
Phylogenetic Trees/Animal Genes : TreeFamHLX
HOGENOMQ14774
Homologs : HomoloGeneHLX
Homology/Alignments : Family Browser (UCSC)HLX
Gene fusions - Rearrangements
Fusion : QuiverHLX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLX
dbVarHLX
ClinVarHLX
1000_GenomesHLX 
Exome Variant ServerHLX
GNOMAD BrowserENSG00000136630
Varsome BrowserHLX
Genetic variants : HAPMAP3142
Genomic Variants (DGV)HLX [DGVbeta]
DECIPHERHLX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLX 
Mutations
ICGC Data PortalHLX 
TCGA Data PortalHLX 
Broad Tumor PortalHLX
OASIS PortalHLX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHLX
Mutations and Diseases : HGMDHLX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect HLX
DgiDB (Drug Gene Interaction Database)HLX
DoCM (Curated mutations)HLX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLX (select a term)
intoGenHLX
Cancer3DHLX (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142995   
Orphanet
DisGeNETHLX
MedgenHLX
Genetic Testing Registry HLX
NextProtQ14774 [Medical]
TSGene3142
GENETestsHLX
Open Targets GeneticsENSG00000136630  [validation]
snp3D : Map Gene to Disease3142
BioCentury BCIQHLX
ClinGenHLX
Clinical trials, drugs, therapy
Protein Interactions : CTD3142
Pharm GKB GenePA162391017
Clinical trialHLX
Miscellaneous
canSAR (ICR)HLX (select the gene name)
HarmonizomeHLX
DataMed IndexHLX
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLX
EVEXHLX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:52:05 CEST 2020
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