HLX (H2.0 like homeobox)

2012-11-01  

Identity

HGNC
LOCATION
1q41
LOCUSID
ALIAS
HB24,HLX1

Other Information

Locus ID:

NCBI: 3142
MIM: 142995
HGNC: 4978
Ensembl: ENSG00000136630

Variants:

dbSNP: 3142
ClinVar: 3142
TCGA: ENSG00000136630
COSMIC: HLX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136630ENST00000366903Q14774
ENSG00000136630ENST00000427693F8VWZ5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
228978502012H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia.22
193623572009TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.17
193623572009TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.17
212244702011The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells.15
171104502007Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells.13
200081302010Downstream targets of homeobox gene HLX show altered expression in human idiopathic fetal growth restriction.12
164366652006Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction.10
169021452006Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia.10
192954292009Gene-environmental interaction in the development of atopic asthma: new developments.10
194598832009Sequence variants in the HLX gene at chromosome 1q41-1q42 in patients with diaphragmatic hernia.10

Citation

Dessen P

HLX (H2.0 like homeobox)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52930/hlx