HMGB2 (high mobility group box 2)

2003-12-01  

Identity

HGNC
LOCATION
4q34.1
LOCUSID
ALIAS
HMG2
FUSION GENES

Other Information

Locus ID:

NCBI: 3148
MIM: 163906
HGNC: 5000
Ensembl: ENSG00000164104

Variants:

dbSNP: 3148
ClinVar: 3148
TCGA: ENSG00000164104
COSMIC: HMGB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164104ENST00000296503P26583
ENSG00000164104ENST00000438704P26583
ENSG00000164104ENST00000446922P26583
ENSG00000164104ENST00000506267D6R9A6

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
117482322002HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter.64
191393952009Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis.48
158339962005Dual binding modes for an HMG domain from human HMGB2 on DNA.41
277993662016HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci.31
208518542010Overexpression of high-mobility group box 2 is associated with tumor aggressiveness and prognosis of hepatocellular carcinoma.28
259372872015Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.26
179646002007HMGB binding to DNA: single and double box motifs.25
119099732002HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.23
231431102013Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility.23
147392822004The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGB.19

Citation

Dessen P

HMGB2 (high mobility group box 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40835/hmgb2