HMGN2 (high mobility group nucleosomal binding domain 2)

2003-02-01  

Identity

HGNC
HMGN2
LOCATION
1p36.11
LOCUSID
3151
ALIAS
HMG17
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3151
MIM: 163910
HGNC: 4986
Ensembl: ENSG00000198830

Variants:

dbSNP: 3151
ClinVar: 3151
TCGA: ENSG00000198830
COSMIC: HMGN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198830ENST00000361427P05204
ENSG00000198830ENST00000619352P05204

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
120323022002A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo.77
217301812011Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR.72
195245412009HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.33
182993912008Delineation of the protein module that anchors HMGN proteins to nucleosomes in the chromatin of living cells.32
182875272008Cell cycle-dependent binding of HMGN proteins to chromatin.20
222673242012Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex.14
162046302005HMGN2: a novel antimicrobial effector molecule of human mononuclear leukocytes?13
273581102016HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth.9
289734352017HMGN1 and 2 remodel core and linker histone tail domains within chromatin.9
218169012011HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription.8

Citation

Dessen P

HMGN2 (high mobility group nucleosomal binding domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40836/hmgn2