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HMGXB4 (HMG-box containing 4)

Identity

Alias (NCBI)HMG2L1
HMGBCG
P53N
THC211630
HGNC (Hugo) HMGXB4
HGNC Alias symbTHC211630
P53N
HGNC Previous nameHMG2L1
HGNC Previous namehigh-mobility group protein 2-like 1
 HMG box domain containing 4
LocusID (NCBI) 10042
Atlas_Id 47370
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 35257493 and ends at 35295807 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKHD1 (5q31.3) / HMGXB4 (22q12.3)RAB11FIP2 (10q26.11) / HMGXB4 (22q12.3)TOM1 (22q12.3) / HMGXB4 (22q12.3)
TOM1 22q12.3 / HMGXB4 22q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HMGXB4   5003
Cards
Entrez_Gene (NCBI)HMGXB4    HMG-box containing 4
AliasesHMG2L1; HMGBCG; P53N; THC211630
GeneCards (Weizmann)HMGXB4
Ensembl hg19 (Hinxton)ENSG00000100281 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100281 [Gene_View]  ENSG00000100281 [Sequence]  chr22:35257493-35295807 [Contig_View]  HMGXB4 [Vega]
ICGC DataPortalENSG00000100281
TCGA cBioPortalHMGXB4
AceView (NCBI)HMGXB4
Genatlas (Paris)HMGXB4
SOURCE (Princeton)HMGXB4
Genetics Home Reference (NIH)HMGXB4
Genomic and cartography
GoldenPath hg38 (UCSC)HMGXB4  -     chr22:35257493-35295807 +  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HMGXB4  -     22q12.3   [Description]    (hg19-Feb_2009)
GoldenPathHMGXB4 - 22q12.3 [CytoView hg19]  HMGXB4 - 22q12.3 [CytoView hg38]
ImmunoBaseENSG00000100281
Genome Data Viewer NCBIHMGXB4 [Mapview hg19]  
OMIM604702   
Gene and transcription
Genbank (Entrez)AI471703 AJ010069 AJ010070 AK299833 AL079310
RefSeq transcript (Entrez)NM_001003681 NM_001362972 NM_005487 NM_014250
Consensus coding sequences : CCDS (NCBI)HMGXB4
Gene ExpressionHMGXB4 [ NCBI-GEO ]   HMGXB4 [ EBI - ARRAY_EXPRESS ]   HMGXB4 [ SEEK ]   HMGXB4 [ MEM ]
Gene Expression Viewer (FireBrowse)HMGXB4 [ Firebrowse - Broad ]
GenevisibleExpression of HMGXB4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10042
GTEX Portal (Tissue expression)HMGXB4
Human Protein AtlasENSG00000100281-HMGXB4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGU5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGU5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGU5
PhosPhoSitePlusQ9UGU5
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)DUF4171    HMG_box_dom    HMG_box_dom_sf    HMGXB4   
Domain families : Pfam (Sanger)DUF4171 (PF13775)    HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam13775    pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)HMGXB4
SuperfamilyQ9UGU5
AlphaFold pdb e-kbQ9UGU5   
Human Protein Atlas [tissue]ENSG00000100281-HMGXB4 [tissue]
HPRD05267
Protein Interaction databases
DIP (DOE-UCLA)Q9UGU5
IntAct (EBI)Q9UGU5
BioGRIDHMGXB4
STRING (EMBL)HMGXB4
ZODIACHMGXB4
Ontologies - Pathways
QuickGOQ9UGU5
Ontology : AmiGODNA binding  protein binding  endosome to lysosome transport  Wnt signaling pathway  NURF complex  negative regulation of Wnt signaling pathway  identical protein binding  
Ontology : EGO-EBIDNA binding  protein binding  endosome to lysosome transport  Wnt signaling pathway  NURF complex  negative regulation of Wnt signaling pathway  identical protein binding  
NDEx NetworkHMGXB4
Atlas of Cancer Signalling NetworkHMGXB4
Wikipedia pathwaysHMGXB4
Orthology - Evolution
OrthoDB10042
GeneTree (enSembl)ENSG00000100281
Phylogenetic Trees/Animal Genes : TreeFamHMGXB4
Homologs : HomoloGeneHMGXB4
Homology/Alignments : Family Browser (UCSC)HMGXB4
Gene fusions - Rearrangements
Fusion : MitelmanTOM1/HMGXB4 [22q12.3/22q12.3]  
Fusion : QuiverHMGXB4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHMGXB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HMGXB4
dbVarHMGXB4
ClinVarHMGXB4
MonarchHMGXB4
1000_GenomesHMGXB4 
Exome Variant ServerHMGXB4
GNOMAD BrowserENSG00000100281
Varsome BrowserHMGXB4
ACMGHMGXB4 variants
VarityQ9UGU5
Genomic Variants (DGV)HMGXB4 [DGVbeta]
DECIPHERHMGXB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHMGXB4 
Mutations
ICGC Data PortalHMGXB4 
TCGA Data PortalHMGXB4 
Broad Tumor PortalHMGXB4
OASIS PortalHMGXB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHMGXB4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHMGXB4
Mutations and Diseases : HGMDHMGXB4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHMGXB4
DgiDB (Drug Gene Interaction Database)HMGXB4
DoCM (Curated mutations)HMGXB4
CIViC (Clinical Interpretations of Variants in Cancer)HMGXB4
Cancer3DHMGXB4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604702   
Orphanet
DisGeNETHMGXB4
MedgenHMGXB4
Genetic Testing Registry HMGXB4
NextProtQ9UGU5 [Medical]
GENETestsHMGXB4
Target ValidationHMGXB4
Huge Navigator HMGXB4 [HugePedia]
ClinGenHMGXB4
Clinical trials, drugs, therapy
MyCancerGenomeHMGXB4
Protein Interactions : CTDHMGXB4
Pharm GKB GenePA164720673
PharosQ9UGU5
Clinical trialHMGXB4
Miscellaneous
canSAR (ICR)HMGXB4
HarmonizomeHMGXB4
DataMed IndexHMGXB4
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHMGXB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:37 CEST 2021

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