Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HMOX1 (heme oxygenase 1)

Identity

Alias_namesheme oxygenase (decycling) 1
Alias_symbol (synonym)bK286B10
HO-1
Other aliasHMOX1D
HSP32
HGNC (Hugo) HMOX1
LocusID (NCBI) 3162
Atlas_Id 40838
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 35381067 and ends at 35394214 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MCM5 (22q12.3) / HMOX1 (22q12.3)MCM5 22q12.3 / HMOX1 22q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(22;22)(q12;q12) MCM5/HMOX1

External links

Nomenclature
HGNC (Hugo)HMOX1   5013
Cards
Entrez_Gene (NCBI)HMOX1  3162  heme oxygenase 1
AliasesHMOX1D; HO-1; HSP32; bK286B10
GeneCards (Weizmann)HMOX1
Ensembl hg19 (Hinxton)ENSG00000100292 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100292 [Gene_View]  chr22:35381067-35394214 [Contig_View]  HMOX1 [Vega]
ICGC DataPortalENSG00000100292
TCGA cBioPortalHMOX1
AceView (NCBI)HMOX1
Genatlas (Paris)HMOX1
WikiGenes3162
SOURCE (Princeton)HMOX1
Genetics Home Reference (NIH)HMOX1
Genomic and cartography
GoldenPath hg38 (UCSC)HMOX1  -     chr22:35381067-35394214 +  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HMOX1  -     22q12.3   [Description]    (hg19-Feb_2009)
EnsemblHMOX1 - 22q12.3 [CytoView hg19]  HMOX1 - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBIHMOX1 [Mapview hg19]  HMOX1 [Mapview hg38]
OMIM141250   606963   614034   
Gene and transcription
Genbank (Entrez)AF051791 AK313120 BC001491 BP288767 BT019785
RefSeq transcript (Entrez)NM_002133
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HMOX1
Cluster EST : UnigeneHs.727017 [ NCBI ]
CGAP (NCI)Hs.727017
Alternative Splicing GalleryENSG00000100292
Gene ExpressionHMOX1 [ NCBI-GEO ]   HMOX1 [ EBI - ARRAY_EXPRESS ]   HMOX1 [ SEEK ]   HMOX1 [ MEM ]
Gene Expression Viewer (FireBrowse)HMOX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3162
GTEX Portal (Tissue expression)HMOX1
Human Protein AtlasENSG00000100292-HMOX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09601   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09601  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09601
Splice isoforms : SwissVarP09601
PhosPhoSitePlusP09601
Domaine pattern : Prosite (Expaxy)HEME_OXYGENASE (PS00593)   
Domains : Interpro (EBI)Haem_Oase    Haem_Oase-like    Haem_Oase-like_multi-hlx    Haem_oxygenase_CS   
Domain families : Pfam (Sanger)Heme_oxygenase (PF01126)   
Domain families : Pfam (NCBI)pfam01126   
Conserved Domain (NCBI)HMOX1
DMDM Disease mutations3162
Blocks (Seattle)HMOX1
PDB (SRS)1N3U    1N45    1NI6    1OYK    1OYL    1OZE    1OZL    1OZR    1OZW    1S13    1S8C    1T5P    1TWN    1TWR    1XJZ    1XK0    1XK1    1XK2    1XK3    3CZY    3HOK    3K4F    3TGM    4WD4    5BTQ   
PDB (PDBSum)1N3U    1N45    1NI6    1OYK    1OYL    1OZE    1OZL    1OZR    1OZW    1S13    1S8C    1T5P    1TWN    1TWR    1XJZ    1XK0    1XK1    1XK2    1XK3    3CZY    3HOK    3K4F    3TGM    4WD4    5BTQ   
PDB (IMB)1N3U    1N45    1NI6    1OYK    1OYL    1OZE    1OZL    1OZR    1OZW    1S13    1S8C    1T5P    1TWN    1TWR    1XJZ    1XK0    1XK1    1XK2    1XK3    3CZY    3HOK    3K4F    3TGM    4WD4    5BTQ   
PDB (RSDB)1N3U    1N45    1NI6    1OYK    1OYL    1OZE    1OZL    1OZR    1OZW    1S13    1S8C    1T5P    1TWN    1TWR    1XJZ    1XK0    1XK1    1XK2    1XK3    3CZY    3HOK    3K4F    3TGM    4WD4    5BTQ   
Structural Biology KnowledgeBase1N3U    1N45    1NI6    1OYK    1OYL    1OZE    1OZL    1OZR    1OZW    1S13    1S8C    1T5P    1TWN    1TWR    1XJZ    1XK0    1XK1    1XK2    1XK3    3CZY    3HOK    3K4F    3TGM    4WD4    5BTQ   
SCOP (Structural Classification of Proteins)1N3U    1N45    1NI6    1OYK    1OYL    1OZE    1OZL    1OZR    1OZW    1S13    1S8C    1T5P    1TWN    1TWR    1XJZ    1XK0    1XK1    1XK2    1XK3    3CZY    3HOK    3K4F    3TGM    4WD4    5BTQ   
CATH (Classification of proteins structures)1N3U    1N45    1NI6    1OYK    1OYL    1OZE    1OZL    1OZR    1OZW    1S13    1S8C    1T5P    1TWN    1TWR    1XJZ    1XK0    1XK1    1XK2    1XK3    3CZY    3HOK    3K4F    3TGM    4WD4    5BTQ   
SuperfamilyP09601
Human Protein Atlas [tissue]ENSG00000100292-HMOX1 [tissue]
Peptide AtlasP09601
HPRD00782
IPIIPI00215893   IPI00877645   
Protein Interaction databases
DIP (DOE-UCLA)P09601
IntAct (EBI)P09601
FunCoupENSG00000100292
BioGRIDHMOX1
STRING (EMBL)HMOX1
ZODIACHMOX1
Ontologies - Pathways
QuickGOP09601
Ontology : AmiGOangiogenesis  endothelial cell proliferation  wound healing involved in inflammatory response  negative regulation of leukocyte migration  heme oxygenase (decyclizing) activity  heme oxygenase (decyclizing) activity  heme oxygenase (decyclizing) activity  phospholipase D activity  signal transducer activity  protein binding  extracellular space  nucleus  nucleolus  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  caveola  heme oxidation  cellular iron ion homeostasis  cellular iron ion homeostasis  response to oxidative stress  small GTPase mediated signal transduction  excretion  regulation of blood pressure  cell death  intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of muscle cell apoptotic process  smooth muscle hyperplasia  membrane  positive regulation of macroautophagy  negative regulation of macroautophagy  cytokine-mediated signaling pathway  enzyme binding  heme binding  cellular response to nutrient  negative regulation of mast cell cytokine production  erythrocyte homeostasis  low-density lipoprotein particle clearance  regulation of transcription from RNA polymerase II promoter in response to iron  cellular response to heat  response to nicotine  intracellular signal transduction  heme catabolic process  heme catabolic process  response to hydrogen peroxide  protein homodimerization activity  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of mast cell degranulation  negative regulation of DNA binding  negative regulation of DNA binding transcription factor activity  negative regulation of neuron apoptotic process  regulation of transcription from RNA polymerase II promoter in response to oxidative stress  response to estrogen  positive regulation of chemokine biosynthetic process  regulation of angiogenesis  positive regulation of angiogenesis  metal ion binding  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  negative regulation of smooth muscle cell proliferation  regulation of DNA binding transcription factor activity  protein homooligomerization  iron ion homeostasis  iron ion homeostasis  cellular response to arsenic-containing substance  cellular response to cadmium ion  cellular response to hypoxia  cellular response to cisplatin  positive regulation of cell migration involved in sprouting angiogenesis  liver regeneration  positive regulation of blood vessel diameter  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  negative regulation of epithelial cell apoptotic process  negative regulation of vascular smooth muscle cell proliferation  
Ontology : EGO-EBIangiogenesis  endothelial cell proliferation  wound healing involved in inflammatory response  negative regulation of leukocyte migration  heme oxygenase (decyclizing) activity  heme oxygenase (decyclizing) activity  heme oxygenase (decyclizing) activity  phospholipase D activity  signal transducer activity  protein binding  extracellular space  nucleus  nucleolus  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  caveola  heme oxidation  cellular iron ion homeostasis  cellular iron ion homeostasis  response to oxidative stress  small GTPase mediated signal transduction  excretion  regulation of blood pressure  cell death  intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of muscle cell apoptotic process  smooth muscle hyperplasia  membrane  positive regulation of macroautophagy  negative regulation of macroautophagy  cytokine-mediated signaling pathway  enzyme binding  heme binding  cellular response to nutrient  negative regulation of mast cell cytokine production  erythrocyte homeostasis  low-density lipoprotein particle clearance  regulation of transcription from RNA polymerase II promoter in response to iron  cellular response to heat  response to nicotine  intracellular signal transduction  heme catabolic process  heme catabolic process  response to hydrogen peroxide  protein homodimerization activity  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of mast cell degranulation  negative regulation of DNA binding  negative regulation of DNA binding transcription factor activity  negative regulation of neuron apoptotic process  regulation of transcription from RNA polymerase II promoter in response to oxidative stress  response to estrogen  positive regulation of chemokine biosynthetic process  regulation of angiogenesis  positive regulation of angiogenesis  metal ion binding  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  negative regulation of smooth muscle cell proliferation  regulation of DNA binding transcription factor activity  protein homooligomerization  iron ion homeostasis  iron ion homeostasis  cellular response to arsenic-containing substance  cellular response to cadmium ion  cellular response to hypoxia  cellular response to cisplatin  positive regulation of cell migration involved in sprouting angiogenesis  liver regeneration  positive regulation of blood vessel diameter  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  negative regulation of epithelial cell apoptotic process  negative regulation of vascular smooth muscle cell proliferation  
Pathways : BIOCARTAIL-10 Anti-inflammatory Signaling Pathway [Genes]    Oxidative Stress Induced Gene Expression Via Nrf2 [Genes]   
Pathways : KEGGPorphyrin and chlorophyll metabolism   
NDEx NetworkHMOX1
Atlas of Cancer Signalling NetworkHMOX1
Wikipedia pathwaysHMOX1
Orthology - Evolution
OrthoDB3162
GeneTree (enSembl)ENSG00000100292
Phylogenetic Trees/Animal Genes : TreeFamHMOX1
HOVERGENP09601
HOGENOMP09601
Homologs : HomoloGeneHMOX1
Homology/Alignments : Family Browser (UCSC)HMOX1
Gene fusions - Rearrangements
Fusion : MitelmanMCM5/HMOX1 [22q12.3/22q12.3]  [t(22;22)(q12;q12)]  
Fusion: TCGA_MDACCMCM5 22q12.3 HMOX1 22q12.3 BRCA
Fusion PortalMCM5 22q12.3 HMOX1 22q12.3 BRCA
Fusion : QuiverHMOX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHMOX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HMOX1
dbVarHMOX1
ClinVarHMOX1
1000_GenomesHMOX1 
Exome Variant ServerHMOX1
ExAC (Exome Aggregation Consortium)ENSG00000100292
GNOMAD BrowserENSG00000100292
Genetic variants : HAPMAP3162
Genomic Variants (DGV)HMOX1 [DGVbeta]
DECIPHERHMOX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHMOX1 
Mutations
ICGC Data PortalHMOX1 
TCGA Data PortalHMOX1 
Broad Tumor PortalHMOX1
OASIS PortalHMOX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHMOX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHMOX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HMOX1
DgiDB (Drug Gene Interaction Database)HMOX1
DoCM (Curated mutations)HMOX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HMOX1 (select a term)
intoGenHMOX1
Cancer3DHMOX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM141250    606963    614034   
Orphanet
DisGeNETHMOX1
MedgenHMOX1
Genetic Testing Registry HMOX1
NextProtP09601 [Medical]
TSGene3162
GENETestsHMOX1
Target ValidationHMOX1
Huge Navigator HMOX1 [HugePedia]
snp3D : Map Gene to Disease3162
BioCentury BCIQHMOX1
ClinGenHMOX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3162
Chemical/Pharm GKB GenePA29341
Clinical trialHMOX1
Miscellaneous
canSAR (ICR)HMOX1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHMOX1
EVEXHMOX1
GoPubMedHMOX1
iHOPHMOX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jun 18 19:24:23 CEST 2018
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