Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HMOX2 (heme oxygenase 2)

Identity

Alias_namesheme oxygenase (decycling) 2
Alias_symbol (synonym)HO-2
Other alias
HGNC (Hugo) HMOX2
LocusID (NCBI) 3163
Atlas_Id 40839
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 4476340 and ends at 4510347 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HMOX2 (16p13.3) / CDIP1 (16p13.3)HMOX2 16p13.3 C16orf5

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HMOX2   5014
Cards
Entrez_Gene (NCBI)HMOX2  3163  heme oxygenase 2
AliasesHO-2
GeneCards (Weizmann)HMOX2
Ensembl hg19 (Hinxton)ENSG00000103415 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103415 [Gene_View]  chr16:4476340-4510347 [Contig_View]  HMOX2 [Vega]
ICGC DataPortalENSG00000103415
TCGA cBioPortalHMOX2
AceView (NCBI)HMOX2
Genatlas (Paris)HMOX2
WikiGenes3163
SOURCE (Princeton)HMOX2
Genetics Home Reference (NIH)HMOX2
Genomic and cartography
GoldenPath hg38 (UCSC)HMOX2  -     chr16:4476340-4510347 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HMOX2  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblHMOX2 - 16p13.3 [CytoView hg19]  HMOX2 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIHMOX2 [Mapview hg19]  HMOX2 [Mapview hg38]
OMIM141251   
Gene and transcription
Genbank (Entrez)AF051306 AK093388 AK222629 AK313660 BC002396
RefSeq transcript (Entrez)NM_001127204 NM_001127205 NM_001127206 NM_001286267 NM_001286268 NM_001286269 NM_001286270 NM_001286271 NM_002134
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_187608
Consensus coding sequences : CCDS (NCBI)HMOX2
Cluster EST : UnigeneHs.284279 [ NCBI ]
CGAP (NCI)Hs.284279
Alternative Splicing GalleryENSG00000103415
Gene ExpressionHMOX2 [ NCBI-GEO ]   HMOX2 [ EBI - ARRAY_EXPRESS ]   HMOX2 [ SEEK ]   HMOX2 [ MEM ]
Gene Expression Viewer (FireBrowse)HMOX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3163
GTEX Portal (Tissue expression)HMOX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30519   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30519  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30519
Splice isoforms : SwissVarP30519
PhosPhoSitePlusP30519
Domaine pattern : Prosite (Expaxy)HEME_OXYGENASE (PS00593)   
Domains : Interpro (EBI)Haem_Oase    Haem_Oase-like    Haem_Oase-like_multi-hlx    Haem_oxygenase_CS   
Domain families : Pfam (Sanger)Heme_oxygenase (PF01126)   
Domain families : Pfam (NCBI)pfam01126   
Conserved Domain (NCBI)HMOX2
DMDM Disease mutations3163
Blocks (Seattle)HMOX2
PDB (SRS)2Q32    2QPP    2RGZ    4WMH   
PDB (PDBSum)2Q32    2QPP    2RGZ    4WMH   
PDB (IMB)2Q32    2QPP    2RGZ    4WMH   
PDB (RSDB)2Q32    2QPP    2RGZ    4WMH   
Structural Biology KnowledgeBase2Q32    2QPP    2RGZ    4WMH   
SCOP (Structural Classification of Proteins)2Q32    2QPP    2RGZ    4WMH   
CATH (Classification of proteins structures)2Q32    2QPP    2RGZ    4WMH   
SuperfamilyP30519
Human Protein AtlasENSG00000103415
Peptide AtlasP30519
HPRD00783
IPIIPI00026824   
Protein Interaction databases
DIP (DOE-UCLA)P30519
IntAct (EBI)P30519
FunCoupENSG00000103415
BioGRIDHMOX2
STRING (EMBL)HMOX2
ZODIACHMOX2
Ontologies - Pathways
QuickGOP30519
Ontology : AmiGOresponse to hypoxia  heme oxygenase (decyclizing) activity  heme oxygenase (decyclizing) activity  protein binding  endoplasmic reticulum membrane  plasma membrane  plasma membrane  heme oxidation  cellular iron ion homeostasis  response to oxidative stress  membrane  heme binding  specific granule membrane  heme catabolic process  heme catabolic process  neutrophil degranulation  metal ion binding  iron ion homeostasis  
Ontology : EGO-EBIresponse to hypoxia  heme oxygenase (decyclizing) activity  heme oxygenase (decyclizing) activity  protein binding  endoplasmic reticulum membrane  plasma membrane  plasma membrane  heme oxidation  cellular iron ion homeostasis  response to oxidative stress  membrane  heme binding  specific granule membrane  heme catabolic process  heme catabolic process  neutrophil degranulation  metal ion binding  iron ion homeostasis  
Pathways : BIOCARTAOxidative Stress Induced Gene Expression Via Nrf2 [Genes]   
Pathways : KEGGPorphyrin and chlorophyll metabolism    Mineral absorption   
NDEx NetworkHMOX2
Atlas of Cancer Signalling NetworkHMOX2
Wikipedia pathwaysHMOX2
Orthology - Evolution
OrthoDB3163
GeneTree (enSembl)ENSG00000103415
Phylogenetic Trees/Animal Genes : TreeFamHMOX2
HOVERGENP30519
HOGENOMP30519
Homologs : HomoloGeneHMOX2
Homology/Alignments : Family Browser (UCSC)HMOX2
Gene fusions - Rearrangements
Fusion: TCGAHMOX2 16p13.3 C16orf5 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHMOX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HMOX2
dbVarHMOX2
ClinVarHMOX2
1000_GenomesHMOX2 
Exome Variant ServerHMOX2
ExAC (Exome Aggregation Consortium)HMOX2 (select the gene name)
Genetic variants : HAPMAP3163
Genomic Variants (DGV)HMOX2 [DGVbeta]
DECIPHERHMOX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHMOX2 
Mutations
ICGC Data PortalHMOX2 
TCGA Data PortalHMOX2 
Broad Tumor PortalHMOX2
OASIS PortalHMOX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHMOX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHMOX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HMOX2
DgiDB (Drug Gene Interaction Database)HMOX2
DoCM (Curated mutations)HMOX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HMOX2 (select a term)
intoGenHMOX2
Cancer3DHMOX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM141251   
Orphanet
MedgenHMOX2
Genetic Testing Registry HMOX2
NextProtP30519 [Medical]
TSGene3163
GENETestsHMOX2
Huge Navigator HMOX2 [HugePedia]
snp3D : Map Gene to Disease3163
BioCentury BCIQHMOX2
ClinGenHMOX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3163
Chemical/Pharm GKB GenePA29342
Clinical trialHMOX2
Miscellaneous
canSAR (ICR)HMOX2 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHMOX2
EVEXHMOX2
GoPubMedHMOX2
iHOPHMOX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:19:07 CEST 2017

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