Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HMX3 (H6 family homeobox 3)

Identity

Alias (NCBI)NKX-5.1
NKX5.1
Nkx5-1
HGNC (Hugo) HMX3
HGNC Alias symbNKX5-1
HGNC Previous namehomeo box (H6 family) 3
LocusID (NCBI) 340784
Atlas_Id 64357
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 123136051 and ends at 123137731 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HMX3   5019
Cards
Entrez_Gene (NCBI)HMX3    H6 family homeobox 3
AliasesNKX-5.1; NKX5.1; Nkx5-1
GeneCards (Weizmann)HMX3
Ensembl hg19 (Hinxton)ENSG00000188620 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188620 [Gene_View]  ENSG00000188620 [Sequence]  chr10:123136051-123137731 [Contig_View]  HMX3 [Vega]
ICGC DataPortalENSG00000188620
TCGA cBioPortalHMX3
AceView (NCBI)HMX3
Genatlas (Paris)HMX3
SOURCE (Princeton)HMX3
Genetics Home Reference (NIH)HMX3
Genomic and cartography
GoldenPath hg38 (UCSC)HMX3  -     chr10:123136051-123137731 +  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HMX3  -     10q26.13   [Description]    (hg19-Feb_2009)
GoldenPathHMX3 - 10q26.13 [CytoView hg19]  HMX3 - 10q26.13 [CytoView hg38]
ImmunoBaseENSG00000188620
genome Data Viewer NCBIHMX3 [Mapview hg19]  
OMIM613380   
Gene and transcription
Genbank (Entrez)AW088771
RefSeq transcript (Entrez)NM_001105574
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HMX3
Alternative Splicing GalleryENSG00000188620
Gene ExpressionHMX3 [ NCBI-GEO ]   HMX3 [ EBI - ARRAY_EXPRESS ]   HMX3 [ SEEK ]   HMX3 [ MEM ]
Gene Expression Viewer (FireBrowse)HMX3 [ Firebrowse - Broad ]
GenevisibleExpression of HMX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)340784
GTEX Portal (Tissue expression)HMX3
Human Protein AtlasENSG00000188620-HMX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6NHT5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6NHT5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6NHT5
Splice isoforms : SwissVarA6NHT5
PhosPhoSitePlusA6NHT5
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)HMX3
Blocks (Seattle)HMX3
SuperfamilyA6NHT5
Human Protein Atlas [tissue]ENSG00000188620-HMX3 [tissue]
Peptide AtlasA6NHT5
IPIIPI00869203   
Protein Interaction databases
DIP (DOE-UCLA)A6NHT5
IntAct (EBI)A6NHT5
BioGRIDHMX3
STRING (EMBL)HMX3
ZODIACHMX3
Ontologies - Pathways
QuickGOA6NHT5
Ontology : AmiGOnuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  regulation of transcription by RNA polymerase II  brain development  embryo implantation  cell differentiation  inner ear morphogenesis  neuromuscular process controlling balance  maternal process involved in female pregnancy  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  regulation of transcription by RNA polymerase II  brain development  embryo implantation  cell differentiation  inner ear morphogenesis  neuromuscular process controlling balance  maternal process involved in female pregnancy  
NDEx NetworkHMX3
Atlas of Cancer Signalling NetworkHMX3
Wikipedia pathwaysHMX3
Orthology - Evolution
OrthoDB340784
GeneTree (enSembl)ENSG00000188620
Phylogenetic Trees/Animal Genes : TreeFamHMX3
HOGENOMA6NHT5
Homologs : HomoloGeneHMX3
Homology/Alignments : Family Browser (UCSC)HMX3
Gene fusions - Rearrangements
Fusion : QuiverHMX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHMX3 [hg38]
dbVarHMX3
ClinVarHMX3
MonarchHMX3
1000_GenomesHMX3 
Exome Variant ServerHMX3
GNOMAD BrowserENSG00000188620
Varsome BrowserHMX3
Genomic Variants (DGV)HMX3 [DGVbeta]
DECIPHERHMX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHMX3 
Mutations
ICGC Data PortalHMX3 
TCGA Data PortalHMX3 
Broad Tumor PortalHMX3
OASIS PortalHMX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHMX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHMX3
Mutations and Diseases : HGMDHMX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HMX3
DgiDB (Drug Gene Interaction Database)HMX3
DoCM (Curated mutations)HMX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HMX3 (select a term)
intoGenHMX3
Cancer3DHMX3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613380   
Orphanet
DisGeNETHMX3
MedgenHMX3
Genetic Testing Registry HMX3
NextProtA6NHT5 [Medical]
GENETestsHMX3
Target ValidationHMX3
Huge Navigator HMX3 [HugePedia]
ClinGenHMX3
Clinical trials, drugs, therapy
MyCancerGenomeHMX3
Protein Interactions : CTD
Pharm GKB GenePA29346
Clinical trialHMX3
Miscellaneous
canSAR (ICR)HMX3 (select the gene name)
HarmonizomeHMX3
DataMed IndexHMX3
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHMX3
EVEXHMX3
GoPubMedHMX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 16:57:06 CET 2020
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